In Vivo Recruitment of XPC to UV-induced Cyclobutane Pyrimidine Dimers by the DDB2 Gene Product

Name: Work Video:
Duration: 3 min 30 s
Maureen E. Fitch; Satoshi Nakajima; Akira Yasui; James M. Ford
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[15, 169, 328, 336, 352, 975, 980], 'dimers': [16, 170, 329], '(CPDs)': [17, 171], 'and': [18, 33, 43, 55, 80, 143, 172, 187, 197, 209, 234, 297, 372, 404, 439, 485, 492, 572, 590, 628, 741, 1043, 1140, 1150, 1160, 1182, 1364, 1520, 1625, 1646, 1741, 1758, 1824, 1834, 1840, 1859, 1938, 1983, 2008, 2069, 2131, 2158, 2184, 2230, 2275, 2289, 2319, 2342, 2356, 2370, 2417, 2466, 2514, 2541, 2565, 2680, 2826, 2832, 2900, 2910, 2928, 2945, 2995, 3014, 3029, 3069, 3081, 3267, 3277, 3397, 3438, 3573, 3716, 3791, 3823, 3830, 3899, 3949, 3982, 3997, 4009, 4032, 4054, 4115, 4140, 4150, 4205, 4243, 4448, 4481, 4516, 4563, 4586, 4619, 4795, 4801, 4910], '6–4': [19, 173, 2542, 2639, 2992, 3181, 3223, 3270, 3368, 3486, 3555, 3815, 3853, 3938, 3960, 3971, 4113], 'photoproducts': [20, 174, 355, 361, 1271, 1295, 1413, 1427, 1455, 1632, 1773, 2599, 2866], '(6–4PPs),': [21, 175], 'requires': [22, 176, 1056], 'lesion': [23, 56, 177, 210, 4211], 'recognition.': [24, 178, 1103], 'It': [25, 179, 2655], 'is': [26, 180, 317, 454, 477, 858, 1005, 1049, 1124, 1416, 1428, 1576, 1593, 1853, 2499, 2522, 2656, 3141, 3417, 3460, 3590, 3680, 3688, 3810, 3919, 4048, 4461, 4509, 4591, 4611, 4658, 4812, 4871, 4904], 'believed': [27, 181, 455], 'that': [28, 68, 94, 107, 111, 134, 182, 222, 248, 261, 265, 288, 507, 570, 610, 1006, 1030, 1052, 1148, 1156, 1161, 1567, 1604, 2433, 2500, 2672, 2738, 2748, 2889, 3050, 3070, 3076, 3118, 3142, 3183, 3192, 3287, 3313, 3373, 3427, 3458, 3481, 3526, 3559, 3564, 3578, 3598, 3600, 3686, 3722, 3778, 3787, 3817, 3865, 3871, 3890, 3920, 4018, 4023, 4079, 4091, 4103, 4116, 4191, 4373, 4452, 4571, 4656, 4667, 4684, 4767], 'heterodimeric': [30, 184], 'proteins': [31, 185, 599, 2932], 'XPC/hHR23B': [32, 186], 'UV-DDB': [34, 188, 752, 855, 909, 3314], '(UV-damaged': [35, 189], 'DNA': [36, 190, 311, 345, 582, 602, 624, 627, 767, 989, 1008, 1033, 1038, 1053, 1415, 1793, 2233, 2835, 2936, 4194, 4483, 4544, 4604, 4643, 4837], 'binding': [37, 76, 191, 230, 346, 606, 778, 990, 1003, 1163, 2857, 3016, 3177, 3214, 3405, 3423, 3550, 3596, 3711, 3727, 3783, 3851, 3894, 3910, 4127, 4201, 4227, 4245, 4368, 4560, 4648, 4673, 4689, 4708], 'factor,': [38, 192], 'composed': [39, 193], 'p48': [42, 79, 89, 126, 135, 196, 233, 243, 280, 289, 573, 740, 1149, 1624, 2831, 2860, 3013, 3080, 3113, 3162, 3188, 3216, 3266, 3276, 3301, 3380, 3393, 3687, 3703, 3715, 3723, 3779, 3873, 3891, 3948, 3981, 3998, 4082, 4104, 4124, 4139, 4149, 4176, 4204, 4207, 4244, 4361, 4385, 4460, 4508, 4602, 4679, 4704, 4722, 4778, 4811], 'p127': [44, 198, 743], 'subunits)': [45, 199], 'perform': [46, 200], 'this': [47, 201, 1144, 2980, 3071, 3139, 3249, 4620, 4720], 'function': [48, 202, 4455], 'genomic': [50, 204, 348, 394, 993], 'DNA,': [51, 205], 'but': [52, 206, 503, 2667, 4026, 4396, 4436], 'their': [53, 207], 'requirement': [54, 208], 'specificity': [57, 211], 'vivo': [59, 213, 592, 1090, 1622, 3588, 3684, 3898, 4200, 4440, 4451, 4596], 'remains': [60, 214], 'unknown.': [61, 215], 'Using': [62, 216], 'repair-deficient': [63, 217], 'xeroderma': [64, 218, 382, 986], 'pigmentosum': [65, 219, 383, 987], '(XP)-A': [66, 220], 'cells': [67, 221, 1495, 1603, 1806, 2028, 2039, 2058, 2109, 2117, 2133, 2160, 2186, 2301, 2458, 2536, 2543, 2559, 2569, 2757, 2766, 2792, 2805, 2853, 2881, 2994, 3004, 3132, 3182, 3209, 3224, 3259, 3271, 3282, 3370, 3388, 3432, 3455, 3497, 3556, 3572, 3736, 3816, 3854, 3870, 3884, 3972, 3989, 4078, 4090, 4163, 4166, 4190, 4388, 4447], 'stably': [69, 223, 1605, 2434], 'express': [70, 224, 1606, 2435, 2537, 2544, 3184, 4094, 4192], 'photoproduct-specific': [71, 225], 'photolyases,': [72, 226], 'we': [73, 227, 2850, 2875, 3156, 3944, 4070, 4099, 4119, 4668, 4713], 'determined': [74, 228, 2938, 3160, 3409], 'characteristics': [77, 231, 2845], 'XPC': [81, 101, 112, 120, 140, 235, 255, 266, 274, 294, 484, 571, 611, 1151, 1626, 2833, 2862, 2887, 3015, 3082, 3404, 3422, 3445, 3459, 3474, 3507, 3537, 3568, 3601, 3697, 3705, 3717, 3726, 3782, 3822, 3850, 3859, 3893, 3909, 3996, 4011, 4053, 4084, 4106, 4129, 4141, 4151, 4178, 4242, 4371, 4377, 4431, 4453, 4513, 4562, 4582, 4629, 4651, 4675, 4688, 4710, 4800, 4869], 'to': [82, 91, 104, 123, 141, 236, 245, 258, 277, 295, 377, 456, 498, 759, 1059, 1093, 1132, 1146, 1154, 1319, 1332, 1437, 1448, 1456, 1496, 1574, 1578, 1616, 2071, 2107, 2125, 2176, 2270, 2350, 2573, 2596, 2686, 2767, 2812, 2834, 2854, 2863, 2896, 2905, 2933, 2943, 2983, 3017, 3032, 3048, 3062, 3116, 3138, 3165, 3190, 3217, 3231, 3234, 3381, 3392, 3424, 3446, 3478, 3508, 3533, 3538, 3541, 3551, 3707, 3719, 3728, 3784, 3838, 3844, 3862, 3895, 3915, 3932, 4016, 4123, 4130, 4196, 4209, 4364, 4380, 4432, 4456, 4511, 4514, 4565, 4583, 4588, 4640, 4652, 4676, 4697, 4711, 4727, 4792, 4809, 4915], 'either': [83, 96, 237, 250, 326, 1350, 1409, 1607, 2436, 2883], 'CPDs': [84, 97, 117, 124, 142, 238, 251, 271, 278, 296, 1396, 1586, 2316, 2465, 2607, 2626, 2751, 2774, 2840, 2944, 2999, 3105, 3150, 3171, 3235, 3268, 3288, 3322, 3484, 3529, 3552, 3577, 3695, 3729, 3790, 3868, 3896, 4395, 4438, 4515, 4615, 4627, 4653, 4677], 'or': [85, 98, 239, 252, 351, 1015, 1340, 1353, 1402, 1612, 2317, 2446, 2775, 2841, 2861, 2886, 3167, 4083, 4086, 4105, 4472, 4642], '6–4PPs': [86, 240, 1588, 2318, 2467, 2632, 2645, 2660, 2673, 2799, 2946, 2989, 3120, 3166, 3241, 3278, 3320, 3396, 3429, 3514, 3563, 3750, 3792, 3967, 4008, 4031, 4076, 4404, 4435], 'vivo.': [88, 119, 242, 273, 1138, 2868, 3303, 3467], 'localized': [90, 102, 244, 256, 1107, 2142, 2919, 3115, 3189], 'UV-irradiated': [92, 105, 246, 259, 3785, 4566], 'sites': [93, 106, 247, 260, 1133, 2934, 3075, 3117, 3191, 3220, 3383, 3426, 3448, 3480, 3540, 3786, 3864, 4022], 'contained': [95, 108, 249, 262, 3193, 3428, 3482, 3788], '6–4PPs.': [99, 253, 3841, 4458], 'However,': [100, 254], 'only': [103, 257, 1112, 3164, 3399, 3483, 3867, 4004], '6–4PPs,': [109, 263, 1398, 2776], 'suggesting': [110, 264, 506, 2747, 3286, 3457], 'does': [113, 267, 4397], 'not': [114, 268, 504, 859, 1011, 2515, 2620, 2628, 2657, 2771, 3158, 3256, 3290, 3398, 3476, 3531, 3574, 3580, 3924, 4049, 4072, 4093, 4101, 4398, 4437, 4670, 4681, 4695, 4715], 'efficiently': [115, 269, 3077, 3534], 'recognize': [116, 270, 4434, 4457], 'did': [121, 275, 2619, 2770, 3475, 4071, 4092, 4669], 'localize': [122, 276], 'when': [125, 279, 4630, 4678], 'was': [127, 281, 1676, 1774, 1994, 2110, 2153, 2182, 2234, 2334, 2364, 2583, 2633, 2915, 2973, 2981, 3060, 3126, 3203, 3389, 3407, 3449, 3561, 3855, 3878, 4362, 4378, 4680, 4694], 'overexpressed': [128, 282, 3872, 3946, 3980, 4081, 4682], 'same': [131, 285, 3926, 4038], 'cell,': [132, 286], 'signifying': [133, 287], 'activates': [136, 290], 'recruitment': [138, 292, 4580], 'may': [144, 298, 1099, 2670, 2682, 2758, 3289, 3724, 4577, 4621, 4790], 'be': [145, 299, 387, 457, 867, 1024, 1100, 2671, 2683, 3232, 3291, 3306, 3524, 3542, 4013], 'recognition': [148, 302, 461, 514, 584, 1584, 1628, 3295, 3692, 4625], 'factor': [149, 303, 991, 2669, 3693], 'NER': [152, 306, 375, 385, 1277, 1862, 2518, 4608, 4807, 4909], 'pathway.': [153, 307, 2519, 4609], 'majority': [309, 1569, 2997, 3103, 3239, 3512], 'damage': [312, 583, 1102, 2937, 4484], 'induced': [313, 3019, 3073], 'by': [314, 319, 459, 473, 1013, 1275, 1296, 2032, 2211, 2236, 2391, 2410, 2554, 2779, 3020, 3109, 3245, 3544, 3567, 3582, 3911, 4475, 4528, 4600, 4628, 4700], 'ultraviolet': [315], 'light': [316, 1331, 2075, 2769, 2972], 'caused': [318], 'transformation': [321], 'adjacent': [323], 'pyrimidines': [324], 'into': [325, 390, 1017, 1996], '(CPDs),': [330], '1The': [331], 'abbreviations': [332], 'used': [333, 1143, 1444, 1600, 1643, 1765, 2902, 3042, 3931, 4188], 'are:': [334], 'CPDcyclobutane': [335], 'dimerNERnucleotide': [337], 'repair6–4PPpyrimidine': [339], '(6–4)': [340, 353, 981], 'pyrimidone': [341, 354, 982], 'photoproductPBSphosphate-buffered': [342], 'salineXPxeroderma': [343], 'pigmentosumUV-DDBUV-damaged': [344], 'factorGGRglobal': [347], 'repairTCRtranscription-coupled': [349], 'repair.': [350, 996], '(6–4PPs).': [356], 'In': [357, 604, 3098, 3180, 3468, 3842, 4097], 'human': [358, 1280], 'cells,': [359, 1281, 2157, 2640, 3100, 3487, 4618], 'these': [360, 508, 598, 1000, 1097, 1167, 1322, 2852, 3153, 3519, 3539, 3921, 4521], 'are': [362, 581, 1091, 1117, 1272, 3172, 3740, 3923, 4019, 4028, 4121], 'repaired': [363, 1273, 2662], 'exclusively': [364], 'through': [365, 1119, 2096, 2163, 2508, 2516, 2923, 3024, 3056, 4473, 4606, 4623, 4874], 'pathway,': [371], 'loss': [373, 500], 'leads': [376], 'skin': [379], 'cancer-prone': [380], 'syndrome': [381], '(XP).': [384], 'can': [386, 866, 910, 1169, 3523, 3780, 4012, 4454], 'further': [388, 2030, 2418, 3557], 'subdivided': [389], 'two': [391, 2077, 2603, 2807, 3987], 'pathways,': [392], 'global': [393, 992], '(GGR),': [396], 'which': [397, 408, 754, 2000, 3951, 4047, 4601, 4789], 'repairs': [398], 'lesions': [399, 410, 472, 2922, 3018], 'found': [400, 1025, 2577], 'throughout': [401], 'genome,': [403], 'transcription-coupled': [405, 995], '(TCR),': [407], 'removes': [409], 'selectively': [411], 'from': [412, 587, 1326, 1359, 1661, 1705, 1849, 1909, 1948, 2076, 2085, 2104, 2171, 2440, 2450, 2611, 3518, 3990], 'transcribed': [414], 'strand': [415], 'active': [417], 'genes': [418, 509, 1894], '(reviewed': [419], 'Refs.': [421], '1de': [422], 'Laat': [423], 'W.L.': [424], 'Jaspers': [425], 'N.G.': [426], 'Hoeijmakers': [427, 657, 1244, 1546, 4891], 'J.H.': [428, 658, 1245, 1467], 'Genes': [429, 4893], 'Dev.': [430, 4894], '1999;': [431, 560, 838, 1068, 1080, 2699, 2714, 3766, 4346, 4420, 4500], '13:': [432, 1384, 1931, 2476], '768-785Crossref': [433], 'PubMed': [434, 540, 563, 669, 688, 709, 735, 800, 820, 846, 901, 937, 969, 1071, 1083, 1211, 1226, 1264, 1311, 1386, 1485, 1557, 1730, 1799, 1885, 1933, 2022, 2478, 2494, 2702, 2717, 2731, 2964, 3093, 3337, 3357, 3627, 3648, 3674, 3769, 3803, 4261, 4282, 4308, 4328, 4354, 4423, 4503, 4550, 4760, 4843, 4864], 'Scopus': [435, 541, 564, 670, 689, 710, 736, 801, 847, 902, 938, 970, 1072, 1212, 1227, 1265, 1312, 1387, 1486, 1558, 1731, 1800, 1886, 1934, 2023, 2479, 2495, 2703, 2718, 2732, 2965, 3094, 3338, 3628, 3649, 3675, 3770, 3804, 4262, 4283, 4309, 4355, 4424, 4504, 4551, 4761, 4844, 4865], '(938)': [436], 'Google': [437, 451, 543, 566, 672, 691, 712, 738, 803, 821, 849, 904, 940, 972, 1074, 1084, 1214, 1229, 1267, 1314, 1389, 1488, 1518, 1560, 1733, 1802, 1888, 1936, 2025, 2481, 2497, 2705, 2720, 2734, 2967, 3096, 3340, 3358, 3630, 3651, 3677, 3772, 3806, 4264, 4285, 4311, 4329, 4357, 4426, 4506, 4553, 4763, 4846, 4867], 'Scholar': [438], '2Ford': [440], 'J.M.': [441, 548, 642, 891, 1221, 1792, 2488, 3088, 3754, 3798, 4408, 4488, 4836], 'Hanawalt': [442, 549, 2470, 3755, 4409, 4489], 'P.C.': [443, 550, 2471, 3756, 4410, 4490], 'Curr.': [444], 'Top.': [445], 'Microbiol.': [446], 'Immunol.': [447], '1997;': [448], '221:': [449], '47-70PubMed': [450], 'Scholar).': [452, 567, 739, 850, 973, 1085, 1268, 1315, 1390, 1561, 1803, 1889, 2026, 2706, 2968, 3097, 3359, 3678, 3773, 3807, 4358, 4427, 4898], 'TCR': [453], 'activated': [458], 'a': [463, 499, 618, 630, 761, 774, 1106, 1120, 1125, 1343, 1608, 1613, 1679, 1900, 1939, 2049, 2144, 2172, 2203, 2324, 2392, 2504, 2884, 2924, 3025, 3051, 3057, 3294, 3316, 3418, 3603, 3689, 3811, 3991, 4183, 4214, 4224, 4390, 4556, 4574, 4765, 4775], 'stalled': [464], 'RNA': [465], 'polymerase': [466], 'at': [467, 1644, 1651, 1695, 1701, 1739, 1747, 1766, 1837, 2042, 2245, 2267, 2294, 2375, 2793, 3248, 3462, 4463, 4478, 4690], 'lesion.': [469], 'Recognition': [470], 'GGR': [475, 502, 518, 857, 3745], 'pathway': [476, 519, 1278, 1288], 'less': [478], 'well': [479, 860], 'understood.': [480], 'Mutations': [481], 'DDB2': [486, 579, 2885, 3739], 'genes,': [487], 'resulting': [488], 'XP-C': [491], 'XP-E': [493, 3735, 4387, 4446, 4617], 'complementation': [494], 'groups,': [495], 'respectively,': [496], 'lead': [497, 4791], 'TCR,': [505], 'encode': [510], 'for': [511, 621, 633, 765, 780, 1128, 1289, 1349, 1432, 1654, 1682, 1689, 2189, 2218, 2242, 2264, 2291, 2306, 2314, 2336, 2372, 2570, 2976, 3275, 3300, 3319, 3607, 3694, 3738, 3903, 3966, 4007, 4217, 4229, 4719], 'UV-damage': [513], 'factors': [515, 585, 1168], 'initiating': [516], '(3Venema': [520], 'J.': [521, 682, 794, 811, 830, 835, 926, 958, 1079, 1200, 1382, 1474, 1530, 1539, 1553, 1929, 2017, 2727, 3331, 3348, 3621, 4255, 4319, 4338, 4343, 4541, 4736, 4740], 'van': [522, 529, 647, 1237, 1246, 1249, 1548, 4881], 'Hoffen': [523, 1238], 'A.': [524, 559, 725, 875, 945, 951, 1187, 1193, 1239, 1368, 1380, 1471, 1510, 1545, 1915, 1927, 1984, 2692, 3664, 3765, 4298, 4419, 4499], 'Karcagi': [525], 'V.': [526, 677, 789, 883, 1499, 3326, 3616, 4250, 4849], 'Natarajan': [527], 'A.T.': [528], 'Zeeland': [530, 1250], 'A.A.': [531, 1251, 4543], 'Mullenders': [532, 1252], 'L.H.': [533, 1253], 'Mol.': [534, 659, 683, 795, 1254, 2472, 2697, 3332, 3622, 4256], 'Cell.': [535, 660, 894, 1255, 2473, 4751], 'Biol.': [536, 684, 796, 812, 836, 927, 959, 1201, 1475, 2474, 2698, 3333, 3349, 3623, 4257, 4320, 4344], '1991;': [537, 1727, 2019, 2961], '11:': [538], '4128-4134Crossref': [539], '(296)': [542], 'Scholar,': [544, 673, 692, 713, 804, 822, 941, 1075, 1215, 1230, 2482, 2721, 3341, 3631, 3652, 4265, 4286, 4312, 4330, 4847], '4Hwang': [545], 'B.J.': [546, 3752, 4406, 4486], 'Ford': [547, 1220, 1791, 3087, 3753, 3797, 4407, 4487, 4835], 'Chu': [551, 3757, 4411, 4491], 'G.': [552, 696, 704, 3635, 3643, 3758, 4269, 4277, 4412, 4492, 4539], 'Proc.': [553, 3759, 4413, 4493], 'Natl.': [554, 3760, 4414, 4494], 'Acad.': [555, 3761, 4415, 4495], 'Sci.': [556, 3762, 4416, 4496], 'U.': [557, 889, 2723, 3763, 4417, 4497], 'S.': [558, 646, 700, 721, 806, 810, 834, 921, 949, 1191, 1372, 1469, 1543, 1786, 1877, 1919, 1953, 1957, 3343, 3347, 3639, 3660, 3764, 4273, 4294, 4314, 4318, 4342, 4418, 4498, 4830, 4886], '96:': [561, 3767, 4421, 4501], '424-428Crossref': [562, 3768, 4422, 4502], '(509)': [565, 3771, 4425, 4505], 'Further': [568], 'evidence': [569], '(the': [574], 'protein': [575, 616, 1130, 1675, 2909, 3067], 'product': [576, 744], 'gene)': [580], 'comes': [586], 'vitro': [589, 605, 777, 870, 1002, 3311, 3595, 4239, 4647], 'experiments': [593, 4064], 'interaction': [596], 'with': [600, 613, 1424, 1815, 2166, 2383, 2560, 2585, 2641, 2882, 3260, 3308, 3440, 3593, 3820, 3826, 3833, 3955, 3994, 4108, 4167, 4213, 4442, 4467, 4729], 'lesions.': [603, 4522], 'studies': [607, 1004, 1087, 1563, 3597, 3918, 4240, 4649], 'have': [608, 760, 1142, 1157, 1356, 1441, 1564, 1599, 3040, 3106, 3157, 3515, 3775, 3945, 4187], 'shown': [609, 758, 3196, 4726], 'complexed': [612], 'hHR23B': [615], 'has': [617, 629, 755, 2736, 3315, 3602, 4036, 4723, 4768], 'greater': [619, 631, 763, 3605], 'affinity': [620, 632, 764, 779, 3318, 3606, 4660], 'naked': [622], 'UV-damaged': [623, 766, 988], 'than': [625, 636, 768, 1397, 3610, 3696, 3749], 'undamaged': [626, 769], '6–4PP': [635, 782, 1355, 1943, 2448, 2546, 3299, 3447, 3465, 3609, 4231], 'CPD': [638, 785, 1352, 1904, 2341, 2438, 2539, 2824, 3584, 3612], '(5Sugasawa': [639], 'K.': [640, 698, 719, 1867, 1959, 1971, 2015, 3637, 3658, 4271, 4292, 4748, 4888], 'Ng': [641], 'Masutani': [643, 716, 825, 3655, 4289, 4333], 'C.': [644, 717, 826, 3656, 4290, 4334], 'Iwai': [645, 699, 720, 833, 1956, 3638, 3659, 4272, 4293, 4341], 'der': [648, 1549, 4882], 'Spek': [649], 'P.J.': [650], 'Eker': [651, 1369, 1535, 1916], 'A.P.': [652, 1370, 1917], 'Hanaoka': [653, 701, 728, 831, 3640, 3667, 4274, 4301, 4339], 'F.': [654, 702, 729, 832, 1077, 2725, 3641, 3668, 4275, 4302, 4340], 'Bootsma': [655], 'D.': [656, 675, 787, 3324, 3614, 4248], '1998;': [661, 1975, 2728], '2:': [662, 4548], '223-232Abstract': [663], 'Full': [664, 666, 817, 841, 843, 898, 932, 934, 964, 966, 1206, 1208, 1259, 1261, 1480, 1482, 3354, 4325, 4349, 4351, 4755, 4757], 'Text': [665, 667, 818, 842, 844, 899, 933, 935, 965, 967, 1207, 1209, 1260, 1262, 1481, 1483, 3355, 4326, 4350, 4352, 4756, 4758], 'PDF': [668, 819, 845, 900, 936, 968, 1210, 1263, 1484, 3356, 4327, 4353, 4759], '(753)': [671], '6Batty': [674], "Rapic'-Otrin": [676, 788, 3325, 3615, 4249], 'Levine': [678, 790, 3327, 3617, 4251, 4856], 'A.S.': [679, 791, 3328, 3618, 4252, 4857], 'Wood': [680, 792, 892, 3329, 3619, 4253], 'R.D.': [681, 793, 893, 3330, 3620, 4254], '2000;': [685, 797, 1515, 3334, 3624, 4258], '300:': [686, 798, 3335, 3625, 4259], '275-290Crossref': [687, 799, 3336, 3626, 4260], '(186)': [690, 802, 3339, 3629, 4263], '7Hey': [693, 3632, 4266], 'T.': [694, 727, 828, 925, 953, 957, 1195, 1199, 1376, 1714, 1718, 1720, 1873, 1923, 1967, 2948, 2952, 2954, 3633, 3666, 4267, 4300, 4336], 'Lipps': [695, 3634, 4268], 'Sugasawa': [697, 718, 3636, 3657, 4270, 4291, 4887], 'Krauss': [703, 3642, 4276], 'Biochemistry.': [705, 2713, 3644, 4278], '2002;': [706, 961, 1203, 1554, 3645, 4279, 4861], ':': [707, 1797, 1976, 3646, 4280, 4841, 4896], '6583-6587Crossref': [708, 3647, 4281], '(94)': [711, 3650, 4284], '8Kusumoto': [714, 3653, 4287], 'R.': [715, 1248, 3654, 4288, 4734, 4744], 'Araki': [722, 3661, 4295], 'M.': [723, 877, 887, 915, 917, 943, 1064, 1185, 1232, 1378, 1665, 1716, 1722, 1871, 1925, 1955, 2950, 2956, 3662, 4296, 4742, 4855], 'Uchida': [724, 3663, 4297], 'Mizukoshi': [726, 827, 3665, 4299, 4335], 'Mutat.': [730, 1880, 2489, 3669, 4303], 'Res.': [731, 1307, 1514, 1881, 1974, 2490, 2696, 3670, 4304, 4860], '2001;': [732, 929, 1256, 1477, 3671, 4305], '485:': [733, 3672, 4306], '219-227Crossref': [734, 3673, 4307], '(104)': [737, 3676, 4310], 'DDB1': [747], 'gene': [748, 1858, 1906, 1945, 1993, 4576], 'make': [749], 'up': [750, 2280], 'complex,': [753], 'also': [756, 1055, 1521, 2800, 3371, 3408, 3964, 4524, 4872], 'been': [757, 1158, 1357, 1443, 2348, 2609, 3107, 3243, 3516, 4725], 'much': [762, 2634, 2664, 3604], 'and,': [770], 'like': [771], 'XPC,': [772, 3950, 4220], 'shows': [773, 3009, 3986], 'stronger': [775], 'over': [783, 2155, 3321, 4089, 4232], '(6Batty': [786, 3323, 3613, 4247], '9Keeney': [805, 3342, 4313], 'Chang': [807, 3344, 4315], 'G.J.': [808, 3345, 4316], 'Linn': [809, 920, 948, 1190, 3346, 4317], 'Chem.': [813, 837, 928, 960, 1202, 1476, 3350, 4321, 4345], '1993;': [814, 2475, 3351, 4322], '268:': [815, 3352, 4323], '21293-21300Abstract': [816, 3353, 4324], '10Fujiwara': [823, 4331], 'Y.': [824, 1875, 1879, 4332, 4750], 'Kondo': [829, 1876, 4337], '274:': [839, 4347], '20027-20033Abstract': [840, 4348], '(154)': [848, 4356], 'precise': [852], 'role': [853], 'understood': [861], 'because': [862, 2818, 2979, 3143, 3236, 3943], 'reaction': [865], 'recapitulated': [868], 'its': [872], 'absence': [873, 1173], '(11Aboussekhra': [874], 'Biggerstaff': [876], 'Shivji': [878], 'M.K.': [879], 'Vilpo': [880], 'J.A.': [881], 'Moncollin': [882], 'Podust': [884], 'V.N.': [885], 'Protic': [886], 'Hubscher': [888], 'Egly': [890], '1995;': [895], '80:': [896], '859-868Abstract': [897], '(760)': [903], 'Scholar),': [905, 1489, 1519, 1734, 4507, 4764], 'although': [906], 'inclusion': [907], 'stimulate': [911, 3725, 3781, 4518], '2–17-fold': [913], '(12Wakasugi': [914], 'Shimizu': [916], 'Morioka': [918, 946, 1188], 'H.': [919, 947, 1189, 1374, 1921, 2013, 4890], 'Nikaido': [922, 954, 1196, 1540, 1723, 2957], 'O.': [923, 955, 1197, 1541, 1724, 2958], 'Matsunaga': [924, 956, 1198, 1719, 2953], '276:': [930, 1478], '15434-15440Abstract': [931], '(83)': [939, 4552], '13Wakasugi': [942], 'Kawashima': [944, 1186], 'Sancar': [950, 1192], 'Mori': [952, 1194], '277:': [962, 1204], '1637-1640Abstract': [963, 1205], '(191)': [971, 1213], 'dimer': [976], 'photoproduct': [983, 1336, 2505, 2911], 'phosphate-buffered': [984], 'saline': [985], 'One': [997, 3136, 3913], 'caveat': [998, 3137, 3914], 'substrates': [1009, 4783], 'were': [1010, 1642, 1659, 1691, 1752, 1807, 1835, 1979, 2029, 2040, 2059, 2094, 2118, 2129, 2134, 2161, 2187, 2196, 2224, 2249, 2278, 2302, 2379, 2389, 2431, 2661, 3255, 3274, 3530, 3565, 3579, 3818, 4058], 'bound': [1012, 1317, 3078, 3163, 4208], 'nucleosomes': [1014, 2739], 'folded': [1016], 'higher': [1018, 3317, 4464], 'order': [1019], 'chromatin': [1020, 1046, 1057, 4632], 'structures': [1021, 1098], 'as': [1022, 1041, 1180, 1776, 2198, 2591, 2777, 3195, 3257, 3272, 3292, 3297, 3488, 3927, 4000, 4042, 4466, 4637], 'would': [1023, 3305, 4654, 4773], 'an': [1027, 1286, 1421, 1844, 1850, 2402, 2523, 2891, 3501, 4905, 4911], 'intact': [1028], 'nucleus': [1029, 1116], 'had': [1031, 2347, 2608, 2890, 3242, 4080], 'sustained': [1032], 'damage.': [1034], 'Regulation': [1035], 'many': [1037, 1282, 3258], 'processes,': [1039], 'such': [1040, 1179, 4636], 'transcription': [1042, 4641], 'replication,': [1044], 'involves': [1045], 'remodeling;': [1047], 'it': [1048, 3522, 3560], 'now': [1050, 4005], 'clear': [1051, 2658], 'remodeling': [1058, 4633], 'access': [1060, 4798], 'damaged': [1061], 'nucleotides': [1062], '(14Meijer': [1063], 'Smerdon': [1065, 2711], 'M.J.': [1066, 1234, 2690, 2712], 'Bioessays.': [1067], '21:': [1069, 1555], '596-603Crossref': [1070], '(55)': [1073], '15Thoma': [1076], 'EMBO': [1078, 1381, 1552, 1928, 2726], '18:': [1081], '6585-6598Crossref': [1082], 'Binding': [1086, 3706], 'performed': [1088, 1775, 2916], 'necessary': [1092], 'fully': [1094], 'understand': [1095], 'how': [1096], 'affecting': [1101], 'Use': [1104], 'UV': [1108, 1135, 1270, 1294, 1335, 1391, 1426, 1438, 1522, 1575, 1634, 2036, 2115, 3045, 4817], 'irradiation': [1109, 1136, 1392, 3046, 3437, 4063, 4818], 'technique': [1110, 1145], 'whereby': [1111, 4777], 'parts': [1113], 'irradiated': [1118, 1159, 2041, 2162, 3074, 3154, 3219, 3382, 3425, 3479, 3825, 3863, 4021, 4584], 'micropore': [1121, 2925], 'polycarbonate': [1122, 2147, 2926, 3027], 'filter': [1123, 2148, 2165, 2927, 3028, 3059], 'powerful': [1126], 'tool': [1127], 'analyzing': [1129], 'localization': [1131, 3124, 3364], 'We': [1139, 1598, 2548, 3039, 3774, 3962, 4186], 'others': [1141], 'demonstrate': [1147, 3049], 'bind': [1152], 'rapidly': [1153, 4815], 'areas': [1155, 4017], 'both': [1165, 1764, 2315, 2464, 2907, 3079, 3789, 3821, 3995, 4210, 4477], 'occur': [1170, 2675, 4622], 'other': [1175, 1283, 4631], 'important': [1176, 4906], 'factors,': [1178], 'XPA': [1181, 1857], 'p53': [1183, 3068, 4476], '(13Wakasugi': [1184], '16Fitch': [1216], 'M.E.': [1217, 1780, 3084, 3794, 4824], 'Cross': [1218, 1781, 3085, 3795, 4825], 'I.V.': [1219, 1782, 3086, 3796, 4826], 'Carcinogenesis.': [1222, 3089, 3799], '2003;': [1223, 1796, 3090, 3800, 4547, 4752, 4840, 4895], '24:': [1224, 3091, 3801], '843-850Crossref': [1225, 3092, 3802], '(67)': [1228, 3095, 3805], '17Volker': [1231], 'Mone': [1233], 'Karmakar': [1235], 'P.': [1236, 1664], 'Schul': [1240], 'W.': [1241, 1243, 1528, 4880], 'Vermeulen': [1242, 4879], 'Driel': [1247], '8:': [1257], '213-224Abstract': [1258], '(660)': [1266], 'Although': [1269, 4703], 'solely': [1274, 2507], 'organisms': [1284], 'possess': [1285], 'alternative': [1287], 'individual': [1293, 1412, 1454, 1631, 2865], 'use': [1298, 1324], 'single': [1300, 2033], 'enzymes': [1301, 1323], 'called': [1302], 'photolyases': [1303, 4195], '(18Sancar': [1304], 'G.B.': [1305], 'Mut.': [1306], '1990;': [1308], '236:': [1309], '147-160Crossref': [1310], '(159)': [1313], 'Once': [1316], 'specifically': [1318, 4587], 'lesion,': [1321], 'energy': [1325, 2576], 'visible': [1328], 'spectrum': [1329], 'reverse': [1333], 'without': [1337, 2066], 'any': [1338, 2501, 4074, 4691], 'incision': [1339], 'religation': [1341], 'event,': [1342], 'process': [1344, 1592], 'termed': [1345], 'photoreactivation.': [1346], 'Photolyases': [1347, 1440], 'specific': [1348, 1619, 2527, 2598, 2940, 3233, 3262, 4193], 'described': [1358, 1778], 'bacteria,': [1360], 'lower': [1361, 3361], 'eukaryotes,': [1362], 'plants,': [1363], 'even': [1365], 'marsupials': [1366], '(19Yasui': [1367, 1914], 'Yasuhira': [1371, 1918], 'Yajima': [1373, 1920], 'Kobayashi': [1375, 1922], 'Takao': [1377, 1924], 'Oikawa': [1379, 1926], '1994;': [1383, 1930], '6143-6151Crossref': [1385, 1932], '(181)': [1388, 1935], 'induces': [1393], 'substantially': [1394], 'more': [1395, 2623, 2635, 2665, 2684, 2773, 3690, 3748], 'yet': [1399, 4664], 'repair,': [1401], 'consequence': [1403], 'having': [1405], 'unrepaired': [1406], 'lesions,': [1407], 'unclear.': [1417], 'Therefore,': [1418], 'generation': [1419], 'experimental': [1422], 'system': [1423], 'defined': [1425], 'great': [1430, 1596], 'interest': [1431], 'understanding': [1433, 4919], 'physiologic': [1435], 'response': [1436, 1492, 1573], 'irradiation.': [1439, 1635], 'recently': [1442, 4724], 'systems': [1447], 'address': [1449, 1617], 'contribution': [1451], 'mutagenic': [1458], 'effects': [1459], 'UV-B': [1461], '(20You': [1462], 'Y.H.': [1463], 'Lee': [1464], 'D.H.': [1465], 'Yoon': [1466], 'Nakajima': [1468, 1542, 1982], 'Yasui': [1470, 1509, 1544], 'Pfeifer': [1472], 'G.P.': [1473, 1508], '44688-44694Abstract': [1479], '(240)': [1487], 'apoptotic': [1491], 'HeLa': [1494], 'UV-C': [1497, 2047, 2056, 2170, 2564, 3023, 3436], '(21Chigancas': [1498], 'Miyaji': [1500], 'E.N.': [1501], 'Muotri': [1502], 'A.R.': [1503], 'de': [1504, 1537], 'Fatima': [1505], 'J.J.': [1506], 'Amarante-Mendes': [1507], 'Menck': [1511], 'C.F.': [1512], 'Cancer': [1513], '60:': [1516], '2458-2463PubMed': [1517], 'resistance': [1523], 'whole': [1525, 4061], 'animals': [1526], '(22Schul': [1527], 'Jans': [1529], 'Rijksen': [1531], 'Y.M.A.': [1532], 'Klemann': [1533], 'K.H.M.': [1534], 'A.P.M.': [1536], 'Wit': [1538], 'J.H.J.': [1547, 4892], 'Horst': [1550, 4883], 'G.T.J.': [1551, 4884], '4719Crossref': [1556], '(84)': [1559, 1801, 4845], 'These': [1562, 4056], 'all': [1565, 2986], 'suggested': [1566], 'cellular': [1572], 'attributable': [1577], 'CPDs.': [1579, 3402, 4131, 4589, 4810], 'Understanding': [1580], 'mechanism': [1582, 3902, 4599, 4718, 4776], 'versus': [1587, 3284], 'therefore': [1594, 3963, 4517], 'importance.': [1597], 'NER-deficient': [1601], 'XP-A': [1602, 1851, 2457, 2533, 2880, 3413, 4189], 'heterologous': [1609], 'CPD-specific': [1610, 3111], 'photolyase': [1611, 1615, 1832, 1893, 1905, 1944, 2439, 2449, 2513, 2531, 2744, 2825, 2848, 3247, 3939, 4114], '6–4PP-specific': [1614, 3186], 'roles': [1620], 'after': [1633, 2339, 2366, 2806, 2837, 3225, 3435, 3472, 3857, 4482, 4816], 'Antibodies—For': [1636], 'immunoblots,': [1637], 'rabbit': [1638, 1735, 2009], 'polyclonal': [1639, 1736], 'anti-photolyase': [1640, 1737], 'antibodies': [1641, 1658, 1688, 1738, 1751, 2277, 2346, 2595, 2942], '1:2000': [1645], 'horseradish': [1647], 'peroxidase-conjugated': [1648], 'donkey': [1649], 'anti-rabbit': [1650], '1:5000': [1652], '(Pierce)': [1653], 'chemiluminescent': [1655], 'detection': [1656, 1771, 2899, 4699], '(anti-photolyase': [1657], 'gifts': [1660], 'Dr.': [1662], 'Andre': [1663], 'Eker,': [1666], 'Erasmus': [1667], 'University,': [1668, 1710], 'Rotterdam,': [1669], 'Netherlands).': [1671], '50': [1672], 'μg': [1673], 'loaded': [1677], 'on': [1678, 2121, 2200, 2221, 2745, 4559], '12%': [1680], 'SDS-PAGE': [1681], 'analysis': [1683], 'photolyases.': [1686], 'Primary': [1687, 2274], 'immunofluorescence': [1690, 2904], 'mouse': [1692, 1698, 1742, 2331, 2345], 'monoclonal': [1693, 1699, 2594, 2941], 'anti-CPD': [1694], '1:1500': [1696], '(TDM2),': [1697], 'anti-6–4PP': [1700], '1:400': [1702], '(64M-2)': [1703], '(gifts': [1704], 'Toshio': [1706], 'Mori,': [1707], 'Nara': [1708], 'Medical': [1709], 'Nara,': [1711], 'Japan)': [1712], '(23Mori': [1713, 2947], 'Nakane': [1715, 2949], 'Hattori': [1717, 2951], 'Ihara': [1721, 2955], 'Photochem.': [1725, 2959], 'Photobiol.': [1726, 2960], '54:': [1728, 2962], '225-232Crossref': [1729, 2963], '(395)': [1732, 2966], '1:500,': [1740], 'anti-V5': [1743], 'fluorescein': [1744, 2361], 'isothiocyanate': [1745], 'conjugated': [1746], '1:500': [1748, 1767], '(Invitrogen).': [1749], 'Secondary': [1750], 'Alexa': [1753, 1759], 'Fluor': [1754, 1760], '594': [1755], 'goat': [1756, 1762], 'anti-mouse': [1757], '488': [1761], 'anti-rabbit,': [1763], '(Molecular': [1768], 'Probes).': [1769], 'Immunoslotblot': [1770], 'previously': [1777, 3041, 3776, 3905], '(24Fitch': [1779, 4823], 'Turner': [1783, 4827], 'S.J.': [1784, 4828], 'Adimoolam': [1785, 4829], 'Lin': [1787, 4831], 'C.X.': [1788, 4832], 'Williams': [1789, 4833], 'K.G.': [1790, 4834], 'Repair': [1794, 2630, 4545, 4838], '(Amst.).': [1795, 4839], '819-826Crossref': [1798, 4842], 'Cell': [1804, 2427], 'Lines—All': [1805], 'maintained': [1808], "Dulbecco's": [1810, 2062], 'modified': [1811, 2063], "Eagle's": [1812, 2064], 'medium': [1813, 2065], 'supplemented': [1814], '10%': [1816], 'fetal': [1817, 2253], 'bovine': [1818, 2254, 2283], 'serum,': [1819], '2': [1820, 2190, 2239, 2648, 2977, 3008, 3033, 3226, 3433, 3470, 3834], 'mm': [1821], 'glutamine,': [1822], 'antibiotics,': [1823], '500': [1825], 'μg/ml': [1826, 2330], 'G418': [1827], '(for': [1828], 'maintenance': [1829], 'transgenic': [1831, 4052], 'genes)': [1833], 'incubated': [1836, 2060, 2250, 2290, 2349, 2371], '37': [1838, 2246], '°C': [1839], '5%': [1841], 'CO2.': [1842], 'XP12ROSV,': [1843], 'SV40-transformed': [1845], 'cell': [1846, 1898, 2034, 2429, 4035, 4044, 4062], 'line': [1847], 'derived': [1848, 1908, 1947], 'patient,': [1852], 'mutated': [1854], 'possesses': [1860], 'no': [1861, 3848, 4029], 'activity': [1863, 2742], '(25Satokata': [1864], 'I.': [1865, 4738], 'Tanaka': [1866, 4747], 'Miura': [1868], 'N.': [1869], 'Narita': [1870], 'Mimaki': [1872], 'Satoh': [1874], 'Okada': [1878], '1992;': [1882], '273:': [1883], '193-202Crossref': [1884], '(73)': [1887], 'For': [1890, 2113, 2138, 2869], 'expression': [1891, 2528], 'XP12ROSV': [1897], 'line,': [1899], 'cDNA': [1901, 1940, 1990, 2888], '(CPDphr)': [1907], 'rat': [1910, 2442], 'kangaroo': [1911, 2443], 'Potorous': [1912, 2444], 'tridactylis': [1913, 2445], 'Scholar)': [1937, 1978, 2498, 2735, 4554], '(6–4phr)': [1946], 'plant': [1949], 'Arabidopsis': [1950, 2451], 'thaliana': [1951], '(26Nakajima': [1952], 'Sugiyama': [1954], 'Hitomi': [1958], 'Otoshi': [1960], 'E.': [1961], 'Kim': [1962], 'S.T.': [1963], 'Jiang': [1964], 'C.Z.': [1965], 'Todo': [1966], 'Britt': [1968], 'A.B.': [1969], 'Yamamoto': [1970], 'Nucleic': [1972, 2694, 4858], 'Acids': [1973, 2695, 4859], '634-638Google': [1977], 'used.': [1980], '2S.': [1981], 'Yasui,': [1985], 'manuscript': [1986], 'preparation.': [1988], 'each': [1992, 2298, 2530, 2847, 2873], 'introduced': [1995], 'vector': [1998], 'pCY4B,': [1999], 'contains': [2001], 'cytomegalovirus': [2003], 'enhancer,': [2004], 'chicken': [2005], 'β-actin': [2006], 'promoter,': [2007], 'poly(A)': [2010], 'signal': [2011, 3296], '(27Niwa': [2012], 'Yamamura': [2014], 'Miyazaki': [2016], 'Gene.': [2018], '108:': [2020], '193-199Crossref': [2021], '(4667)': [2024], 'CPD-3': [2027, 2535, 2612, 2756, 2804, 3002, 3099, 3281, 3387, 3431, 3571], 'subcloned': [2031], 'dilution.': [2035], 'Irradiation—For': [2037], 'photoreactivation,': [2038, 3858], 'indicated': [2044, 2199, 2778, 2795], 'dose': [2045, 3052, 3072], 'using': [2048, 2141, 2401, 2456, 2593, 2917, 2939], 'germicidal': [2050, 2173], 'lamp': [2051, 2174], '(predominantly': [2052], '254': [2053], 'nm).': [2054], 'After': [2055, 2297], 'exposure,': [2057], 'phenol': [2067], 'red': [2068], 'exposed': [2070], 'photoreactivating': [2072, 3974], '360-nm': [2073], 'UV-A': [2074, 2193, 2579, 2589, 2617, 2651, 2768, 2810, 2971, 3036, 3837, 3975], 'bulbs': [2078, 2106], '(Sankyo': [2079], 'Denki,': [2080], 'F15T8BLB': [2081], '15W;': [2082], 'PGC': [2083], 'Scientific)': [2084], 'above.': [2086], 'To': [2087], 'block': [2088, 2271, 2351], 'shorter': [2089], 'wavelengths,': [2090], 'black': [2092], 'lights': [2093], 'filtered': [2095], 'one': [2097, 2586, 2668, 4692], '5-mm': [2098], 'borosilicate': [2099], 'glass': [2100, 2122], 'plate.': [2101], 'distance': [2103], '∼15': [2111], 'cm.': [2112], 'local': [2114, 3044], 'irradiation,': [2116, 2126, 2143], 'grown': [2119, 2197], 'overnight': [2120], 'coverslips.': [2123], 'Prior': [2124], 'media': [2128], 'aspirated,': [2130], 'washed': [2135, 2206, 2225, 2303], 'PBS.': [2137], 'every': [2139], 'experiment': [2140, 3993], '3-μm': [2145, 3026, 3058], 'isopore': [2146], '(Millipore)': [2149], 'presoaked': [2150], 'PBS': [2152], 'placed': [2154], '200': [2167, 3021, 3054, 3827], 'J/m2': [2168, 2562, 3022, 3055, 3828], 'calibrated': [2175], 'deliver': [2177], '10': [2178, 2219], 'J/m2/s.': [2179], 'membrane': [2181], 'removed,': [2183], 'photoreactivated': [2188, 3832], 'h': [2191, 2649, 2978, 3034, 3227, 3434, 3471, 3835], 'under': [2192, 2970], 'blacklight.': [2194], 'Immunofluorescence—Cells': [2195], 'coverslips': [2201], '35-mm': [2204], 'dish,': [2205], 'PBS,': [2208, 2229], 'then': [2209, 2231, 2566, 2901, 3030, 3831], 'fixed': [2210], '2%': [2212], 'formaldehyde': [2213], '0.2%': [2215], 'Triton': [2216, 2260], 'X-100/PBS': [2217], 'min': [2220, 2244, 2266, 2293, 2308, 2338, 2374], 'ice.': [2222], 'Cells': [2223, 2248], 'three': [2226, 2304], 'times': [2227, 2305, 2572], 'denatured': [2235], 'incubation': [2237], 'n': [2240], 'HCl': [2241], '5': [2243, 2307, 2329], '°C.': [2247], '20%': [2252], 'serum': [2255, 2284], 'washing': [2257, 2287, 2310], 'buffer': [2258, 2288], '(0.1%': [2259], 'X-100': [2261], 'PBS)': [2263], '30': [2265, 2337], 'room': [2268, 2295, 2376], 'temperature': [2269], 'nonspecific': [2272], 'binding.': [2273], 'secondary': [2276], 'made': [2279], '1%': [2282], 'albumin': [2285], '45': [2292, 2373], 'temperature.': [2296, 2377], 'antibody': [2299, 2363], 'step,': [2300], 'buffer.': [2311], 'When': [2312, 4459], 'staining': [2313, 4040], 'V5': [2321, 2358, 2893], 'epitope-tagged': [2322], 'proteins,': [2323], 'second': [2325], 'blocking': [2326], 'IgG': [2332, 2368], '(Sigma)': [2333], 'added': [2335, 2365], 'goat-anti': [2344], 'non-specific': [2352], 'interactions': [2353], 'between': [2354, 2822, 3714, 4661], 'them': [2355], 'antibody.': [2359], 'Anti-V5': [2360], 'isothiocyanate-conjugated': [2362], 'Coverslips': [2378], 'mounted': [2380], 'VectaShield': [2382], '4,6-diamidino-2-phenylindole': [2384], '(DAPI;': [2385], 'Vector': [2386], 'Laboratories).': [2387], 'Images': [2388], 'captured': [2390], 'Nikon': [2393], 'Eclipse': [2394], 'E800': [2395], 'microscope': [2396], '(with': [2397], '×60': [2398], 'oil': [2399], 'objective)': [2400], 'RT': [2403, 2412], 'Slider': [2404], 'CCD': [2405], 'camera': [2406], '(Spot': [2407, 2415], 'Diagnostic),': [2408, 2416], 'analyzed': [2409], 'Spot': [2411], '3.0': [2413], 'software': [2414], 'adjusted': [2419], 'Adobe': [2421], 'PhotoShop': [2422], '6.0.': [2423], 'Characterization': [2424], 'Photolyase-expressing': [2426], 'Lines—XP-A': [2428], 'lines': [2430], 'established': [2432, 2843], 'thaliana.': [2452], 'advantage': [2454], 'completely': [2459], 'deficient': [2460, 3742], '(28Lommel': [2468], 'L.': [2469], '970-976Crossref': [2477], '(49)': [2480], '29Mitchell': [2483], 'D.L.': [2484], 'Haipek': [2485], 'C.A.': [2486], 'Clarkson': [2487], '1985;': [2491], '143:': [2492], '109-112Crossref': [2493], '(246)': [2496], 'removal': [2502], 'occurs': [2506], 'action': [2510, 3957, 4110], 'Fig.': [2520, 3007, 3198, 3415, 3491, 3808, 3845, 3941, 3984, 4002], '1A': [2521], 'immunoblot': [2524], 'demonstrating': [2525], 'cells;': [2534], 'photolyase,': [2540, 3112, 3187], 'photolyase.': [2547, 3585, 3961], 'examined': [2549, 3133, 3210, 3498, 3885], 'kinetics': [2551], 'photoreactivation': [2553, 2582], 'first': [2555, 3682, 4593], 'irradiating': [2556], 'photolyase-expressing': [2558, 2879, 2993, 3003, 3369, 3412, 4144, 4153], '20': [2561], 'exposing': [2567], 'varying': [2571], 'reactivating': [2575, 3037], 'light.': [2580, 3038], 'Substantial': [2581], 'observed': [2584, 3127, 3204, 3365, 3384, 3450, 3713, 3777, 3879, 3906, 4379], 'hour': [2587], 'treatment': [2590, 2618, 2652, 2811], 'measured': [2592], '(Fig.': [2600, 2653, 3005, 3121, 3252, 3874], '1B).': [2601, 2654, 3006, 3253], 'By': [2602], 'hours,': [2604], '∼83%': [2605], 'photoreversed': [2610], 'cells.': [2613, 3414], 'Increasing': [2614], 'lengths': [2615], 'cause': [2621, 3174], 'significantly': [2622], 'reversal': [2624], '(data': [2627], 'shown).': [2629], 'efficient': [2636, 3691], '98%': [2642], 'reversed': [2646], 'following': [2647], 'why': [2659, 3734], 'so': [2663, 2681, 4372], 'efficiently,': [2666], 'typically': [2674], 'outside': [2676], 'chromatinized': [2678], 'regions': [2679], 'accessible': [2685], 'enzyme': [2688], '(30Smerdon': [2689], 'Conconi': [2691], 'Prog.': [2693], '62:': [2700], '227-255Crossref': [2701], '(119)': [2704], 'Previous': [2707], 'work': [2708], '(31Kosmoski': [2709], 'J.V.': [2710], '38:': [2715], '9485-9494Crossref': [2716], '(48)': [2719], '32Schieferstein': [2722], 'Thoma': [2724], '17:': [2729], '306Crossref': [2730], '(45)': [2733], 'demonstrated': [2737, 3500, 3558, 3599], 'inhibit': [2740], 'CPDs,': [2746, 3194, 3747, 4025, 4712, 4785], 'residual': [2750, 3170, 3401, 3576, 4075], 'seen': [2752, 3489, 3543, 3856, 4014], 'UV-A-treated': [2755], 'reside': [2759], 'within': [2760], 'nucleosomal': [2761], 'structures.': [2762], 'Exposure': [2763], 'induce': [2772], 'lack': [2781, 3548], 'change': [2783], 'band': [2786], 'intensities': [2787], 'vector-only': [2790], 'expressing': [2791, 4050], 'time': [2796, 3250, 4693], 'points.': [2797], 'Notably,': [2798], 'diminished': [2801], 'hours': [2808], '∼30%': [2813], 'original': [2815], 'levels,': [2816, 4465], 'possibly': [2817, 4786], 'some': [2820, 4612, 4659], 'cross-reactivity': [2821], '6–4PP.': [2828, 4219], 'Localization': [2829], 'Damage': [2836], 'Photoreactivation': [2838, 2969], '6–4PPs—Having': [2842], 'clone,': [2849], 'utilized': [2851], 'determine': [2855, 3933], 'properties': [2858, 4202, 4369], 'study': [2871, 4471], 'protein,': [2874], 'transiently': [2876], 'transfected': [2877, 3819, 3970, 4162], 'additional': [2892], 'epitope': [2894], 'tag': [2895], 'aid': [2897], 'indirect': [2903, 3545], 'visualize': [2906], 'interest.': [2913], 'Irradiation': [2914], 'introduction': [2920], 'colocalization': [2929, 3201, 3263, 3378, 3443, 3505, 3700, 4136, 4375], 'nuclear': [2931], 'carried': [2974], 'out': [2975], 'sufficient': [2982], 'remove': [2984, 3839], 'nearly': [2985], 'representative': [3010, 3419, 3812, 3988], 'images': [3011], 'subjected': [3031], 'assay': [3047], 'able': [3061, 3532, 4363, 4510], 'activate': [3063], 'tumor': [3065], 'suppressor': [3066], '(16Fitch': [3083, 3793], 'where': [3101, 3847, 4568], 'removed': [3108, 3244, 3517, 3581], 'clearly': [3114, 3888, 4705], 'contain': [3119, 3866, 4024], '2A).': [3122], 'This': [3123, 3200, 3304, 3586, 3679, 3876, 3887, 4523, 4590, 4772], 'pattern': [3125, 3178, 3202, 3264, 3406, 3877, 4041], '100': [3129, 3881], '105': [3131], 'visually': [3134, 3211], '(95.2%).': [3135], 'finding': [3140], 'small': [3146], 'number': [3147], 'photolyase-resistant': [3149], 'remaining': [3151, 3528, 4157, 4159, 4803], 'sites,': [3155, 4567, 4585], 'definitively': [3159], 'if': [3161, 3168], 'seen.': [3179], '2B.': [3199], '88': [3206], '112': [3208], '(78.5%).': [3212], 'reactivation': [3229, 3439, 3473], 'appears': [3230], 'vast': [3238], 'point': [3251], 'There': [3254, 4610], 'there': [3273, 4027, 4657], '(78.5': [3283], '95.2%),': [3285], 'strong': [3293, 4226], 'consistent': [3307, 3592], 'findings': [3312], 'percentage': [3362, 3376], 'suggests': [3372, 4683], 'high': [3375], 'indeed': [3390], 'due': [3391, 4122], 'recognizing': [3394, 3463], '2C': [3416], 'image': [3420, 3813], 'UV-A.': [3441], '99': [3452], '108': [3454], '(91.7%),': [3456], 'proficient': [3461], 'contrast,': [3469, 4222], 'colocalize': [3477], '2D.': [3492], 'Only': [3493], '9': [3494], '110': [3496], '(8.2%)': [3499], 'appreciable': [3502], 'amount': [3503, 4686], 'CPD-containing': [3509, 3708], 'sites.': [3510, 3520, 4382], 'Thus': [3521], 'inferred': [3525], 'recruit': [3535, 4512], 'enough': [3536, 4696], 'immunofluorescence.': [3546], 'recognized': [3566], 'data': [3589, 4137, 4147, 4236], 'again': [3591, 4069], 'demonstration': [3685, 4594], '(78.5%': [3698], 'positive': [3699], 'verses': [3701], '8.2%).': [3702], 'Activates': [3704], 'Sites—The': [3709], 'different': [3710], 'patterns': [3712], 'led': [3718], 'hypothesis': [3721], 'vivo,': [3731], 'thereby': [3732, 4796], 'explaining': [3733], 'mutant': [3737], 'predominantly': [3741], '(4Hwang': [3751, 4405, 4485], '3': [3809], 'p48,': [3824], 'UV-C,': [3829], 'comparison': [3843], '2D': [3846], 'detectable': [3849], 'strongly': [3860], 'colocalized': [3861], '3A).': [3875], '115': [3883], '(87.0%).': [3886], 'demonstrates': [3889, 4449], 'stimulates': [3892, 4603], 'provides': [3900], 'enhancement': [3907], 'p48.': [3912, 4055], 'our': [3916, 4470, 4701], 'transfection': [3917, 3992], 'conditions': [3922, 3930], 'photoreversal': [3929], 'efficiency': [3935], '1': [3942], 'ectopic': [3947], 'potentially': [3952], 'could': [3953], 'interfere': [3954], 'stained': [3965, 4006], 'after2hof': [3973], 'presence': [3978], 'XPC.': [3983, 4010, 4206], '3B': [3985], 'transgenes': [3999], '3A,': [4003], 'localizing': [4015], 'presumably': [4020], 'discernable': [4030], 'XPC-expressing': [4034], 'background': [4039], 'below': [4045], 'it,': [4046], 'results': [4057, 4118], 'verified': [4059], '(20': [4065], 'J/m2,': [4066], '2-h': [4067], 'photoreactivation);': [4068], 'observe': [4073, 4120, 4671], 'alone': [4085], 'combination': [4088], 'transgenes.': [4096], 'conclusion,': [4098], 'do': [4100, 4714], 'believe': [4102], 'interferes': [4107], 'activating': [4125], 'Table': [4132], 'I': [4133], 'summarizes': [4134], 'cells.Table': [4145], 'IColocalization': [4146], 'cellsCell': [4154], 'lineTransfected': [4155], 'cDNAPercent': [4156], 'CPDsPercent': [4158], '6-4PPsNo.': [4160], 'countedNo.': [4164], 'colocalizationPercentCPD-3DDB21730105100ap48': [4168], 'colocalization.95.2CPD-3XPC173010899bXPC': [4169], 'colocalization.91.76-4DDB298211288ap48': [4170], 'colocalization.78.66-4XPC9821109bXPC': [4171], 'colocalization.8.26-4XPC': [4172], '+': [4173], 'DDB2982115100bXPC': [4174], 'colocalization.87.0a': [4175], 'colocalization.b': [4177], 'colocalization.': [4179], 'Open': [4180], 'table': [4181], 'new': [4184, 4913], 'tab': [4185], 'define': [4197], 'types,': [4212], 'slight': [4215], 'preference': [4216, 4228], 'showed': [4223], 'very': [4225], 'CPD.': [4234], 'Our': [4235], 'corroborate': [4237], 'preferences': [4246], 'Overexpression': [4359], 'dramatically': [4365], 'alter': [4366], 'significant': [4374, 4672], 'CPD-only-containing': [4381], 'Loss': [4383], 'causes': [4389], 'decrease': [4391], 'greatly': [4399], 'affect': [4400, 4578], 'ability': [4429], 'readily': [4433], 'correlates': [4441], 'phenotype': [4444], 'present': [4462], 'overexpression': [4468], 'upregulation': [4474], 'basal': [4479], 'levels': [4480], 'explains': [4525], 'recent': [4526], 'observations': [4527], 'Wang': [4529], 'et': [4530], 'al.': [4531], '(33Wang': [4532], 'Q.': [4533, 4535], 'Zhu': [4534], 'Wani': [4536, 4538, 4542], 'M.A.': [4537], 'Chen': [4540], '(Amst).': [4546], '483-499Crossref': [4549], 'describing': [4555], 'p53-dependent': [4557, 4575], 'effect': [4558], 'TFIIH': [4564], 'they': [4569], 'speculated': [4570], 'regulation': [4572, 4900], 'processes': [4634], 'occur,': [4635], 'those': [4638], 'related': [4639], 'replication.': [4644], 'suggest': [4655, 4774], 'two,': [4663], 'fact': [4666], 'allow': [4698, 4797], 'technique.': [4702], 'enhances': [4706], 'know': [4716], 'stimulation.': [4721], 'interact': [4728], 'COP9': [4731], 'signalosome': [4732], '(34Groisman': [4733], 'Polanowska': [4735], 'Kuraoka': [4737], 'Sawada': [4739], 'Saijo': [4741], 'Drapkin': [4743], 'Kisselev': [4745], 'A.F.': [4746], 'Nakatani': [4749], '113:': [4753], '357-367Abstract': [4754], '(602)': [4762], 'complex': [4766], 'ubiquitin': [4769, 4780, 4902], 'ligase': [4770], 'activity.': [4771], 'mediates': [4779], 'ligation': [4781], 'around': [4784], 'including': [4787], 'histones,': [4788], 'nucleosome': [4793], 'unfolding': [4794], 'components': [4804], 'machinery': [4808], 'itself': [4813], 'degraded': [4814], 'via': [4819], 'ubiquitin-mediated': [4821], 'proteasome': [4822, 4876], '35Rapic-Otrin': [4848], 'McLenigan': [4850], 'M.P.': [4851], 'Bisi': [4852], 'D.C.': [4853], 'Gonzalez': [4854], '30:': [4862], '2588-2598Crossref': [4863], '(143)': [4866], 'Scholar);': [4868], 'stability': [4870], 'regulated': [4873], '(36Ng': [4877], 'J.M.Y.': [4878], 'Bergink': [4885], 'Vrieling': [4889], '260003Google': [4897], 'Clearly,': [4899], 'pathways': [4903], 'feature': [4907], 'exciting': [4912], 'avenue': [4914], 'explore': [4916], 'NER.': [4921]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2043776245', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 12}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 15}], 'updated_date': '2025-01-10T21:51:37.811796', 'created_date': '2016-06-24'}
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