Hemin: An Inhibitor of Erythroid Cell Ribonuclease

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Duration: 3 min 30 s
Description: Hemin, in concentrations which stimulate protein synthesis and stabilize polyribosomes in reticulocytes, is a potent inhibitor of ribonuclease activity in the erythroid cell. This may offer a partial explanation for the way in which hemin acts to accelerate globin synthesis and thus synchronize the synthesis of hemin and globin in the maturing erythroid cell.
Edward R. Burka
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