Publication Information

{'id': 'https://openalex.org/W2043567648', 'doi': 'https://doi.org/10.7326/0003-4819-117-5-390', 'title': 'Trimethoprim-Sulfamethoxazole Compared with Vancomycin for the Treatment of <i>Staphylococcus aureus</i> Infection', 'display_name': 'Trimethoprim-Sulfamethoxazole Compared with Vancomycin for the Treatment of <i>Staphylococcus aureus</i> Infection', 'publication_year': 1992, 'publication_date': '1992-09-01', 'ids': {'openalex': 'https://openalex.org/W2043567648', 'doi': 'https://doi.org/10.7326/0003-4819-117-5-390', 'mag': '2043567648', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1503330'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-117-5-390', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5064026329', 'display_name': 'Norman Markowitz', 'orcid': 'https://orcid.org/0000-0001-6886-0400'}, 'institutions': [{'id': 'https://openalex.org/I2803043754', 'display_name': 'Henry Ford Hospital', 'ror': 'https://ror.org/0193sb042', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I154057602', 'https://openalex.org/I2803043754']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Norman Markowitz', 'raw_affiliation_strings': ['Division of Infectious Diseases, Henry Ford Hospital, Detroit, MI 48202.'], 'affiliations': [{'raw_affiliation_string': 'Division of Infectious Diseases, Henry Ford Hospital, Detroit, MI 48202.', 'institution_ids': ['https://openalex.org/I2803043754']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110321311', 'display_name': 'Edward Quinn', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Edward L. Quinn', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5043799859', 'display_name': 'Louis D. Saravolatz', 'orcid': 'https://orcid.org/0000-0002-7711-7915'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Louis D. Saravolatz', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.721, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 350, 'citation_normalized_percentile': {'value': 0.985751, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '117', 'issue': '5', 'first_page': '390', 'last_page': '398'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10195', 'display_name': 'Antimicrobial Resistance in Staphylococcus', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10195', 'display_name': 'Antimicrobial Resistance in Staphylococcus', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10150', 'display_name': 'Antifungal resistance and susceptibility', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11117', 'display_name': 'Drug-Induced Adverse Reactions', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bacteremia', 'display_name': 'Bacteremia', 'score': 0.6401505}, {'id': 'https://openalex.org/keywords/sulfamethoxazole', 'display_name': 'Sulfamethoxazole', 'score': 0.5980502}, {'id': 'https://openalex.org/keywords/trimethoprim', 'display_name': 'Trimethoprim', 'score': 0.56029236}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.92473066}, {'id': 'https://openalex.org/C2778980435', 'wikidata': 'https://www.wikidata.org/wiki/Q424027', 'display_name': 'Vancomycin', 'level': 4, 'score': 0.87624764}, {'id': 'https://openalex.org/C2779489039', 'wikidata': 'https://www.wikidata.org/wiki/Q188121', 'display_name': 'Staphylococcus aureus', 'level': 3, 'score': 0.68170357}, {'id': 'https://openalex.org/C2779443120', 'wikidata': 'https://www.wikidata.org/wiki/Q650912', 'display_name': 'Bacteremia', 'level': 3, 'score': 0.6401505}, {'id': 'https://openalex.org/C2779425571', 'wikidata': 'https://www.wikidata.org/wiki/Q415843', 'display_name': 'Sulfamethoxazole', 'level': 3, 'score': 0.5980502}, {'id': 'https://openalex.org/C2777052132', 'wikidata': 'https://www.wikidata.org/wiki/Q595158', 'display_name': 'Methicillin-resistant Staphylococcus aureus', 'level': 4, 'score': 0.5631652}, {'id': 'https://openalex.org/C2780728791', 'wikidata': 'https://www.wikidata.org/wiki/Q422665', 'display_name': 'Trimethoprim', 'level': 3, 'score': 0.56029236}, {'id': 'https://openalex.org/C2775872228', 'wikidata': 'https://www.wikidata.org/wiki/Q82504', 'display_name': 'Endocarditis', 'level': 2, 'score': 0.5170739}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.47088557}, {'id': 'https://openalex.org/C2780852908', 'wikidata': 'https://www.wikidata.org/wiki/Q127076', 'display_name': 'Vomiting', 'level': 2, 'score': 0.4106591}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.39147025}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.31558993}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.19192922}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D013203', 'descriptor_name': 'Staphylococcal Infections', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D015662', 'descriptor_name': 'Trimethoprim, Sulfamethoxazole Drug Combination', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D014640', 'descriptor_name': 'Vancomycin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001434', 'descriptor_name': 'Bacteriophage Typing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004311', 'descriptor_name': 'Double-Blind Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016106', 'descriptor_name': 'Methicillin Resistance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011446', 'descriptor_name': 'Prospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013203', 'descriptor_name': 'Staphylococcal Infections', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D013203', 'descriptor_name': 'Staphylococcal Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015819', 'descriptor_name': 'Substance Abuse, Intravenous', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D015819', 'descriptor_name': 'Substance Abuse, Intravenous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015662', 'descriptor_name': 'Trimethoprim, Sulfamethoxazole Drug Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015662', 'descriptor_name': 'Trimethoprim, Sulfamethoxazole Drug Combination', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D014640', 'descriptor_name': 'Vancomycin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014640', 'descriptor_name': 'Vancomycin', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-117-5-390', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1503330', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.87, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 57, 'referenced_works': ['https://openalex.org/W1746237620', 'https://openalex.org/W1896249406', 'https://openalex.org/W1975150477', 'https://openalex.org/W1976171548', 'https://openalex.org/W1981416226', 'https://openalex.org/W1991973686', 'https://openalex.org/W1992100516', 'https://openalex.org/W1996562609', 'https://openalex.org/W1996568372', 'https://openalex.org/W1999627552', 'https://openalex.org/W2020762005', 'https://openalex.org/W2021410956', 'https://openalex.org/W2024538746', 'https://openalex.org/W2025857485', 'https://openalex.org/W2028086568', 'https://openalex.org/W2029715279', 'https://openalex.org/W2033074810', 'https://openalex.org/W2033446763', 'https://openalex.org/W2033927279', 'https://openalex.org/W2036129782', 'https://openalex.org/W2039465130', 'https://openalex.org/W2042946732', 'https://openalex.org/W2043226051', 'https://openalex.org/W2044087791', 'https://openalex.org/W2044761912', 'https://openalex.org/W2048886316', 'https://openalex.org/W2048993021', 'https://openalex.org/W2049543496', 'https://openalex.org/W2050106966', 'https://openalex.org/W2057525476', 'https://openalex.org/W2058341549', 'https://openalex.org/W2062001308', 'https://openalex.org/W2082859998', 'https://openalex.org/W2084650440', 'https://openalex.org/W2095043796', 'https://openalex.org/W2095170227', 'https://openalex.org/W2108062164', 'https://openalex.org/W2122060628', 'https://openalex.org/W2124853229', 'https://openalex.org/W2126520713', 'https://openalex.org/W2126874955', 'https://openalex.org/W2129095360', 'https://openalex.org/W2129487827', 'https://openalex.org/W2147473727', 'https://openalex.org/W2151619842', 'https://openalex.org/W2159898484', 'https://openalex.org/W2159917073', 'https://openalex.org/W2315252930', 'https://openalex.org/W2320403432', 'https://openalex.org/W2331731062', 'https://openalex.org/W2410063558', 'https://openalex.org/W2410163860', 'https://openalex.org/W2412071606', 'https://openalex.org/W2427708043', 'https://openalex.org/W2435645454', 'https://openalex.org/W2461857387', 'https://openalex.org/W4255683429'], 'related_works': ['https://openalex.org/W4235798964', 'https://openalex.org/W3195257122', 'https://openalex.org/W2622183983', 'https://openalex.org/W2418198648', 'https://openalex.org/W2402324785', 'https://openalex.org/W2153696005', 'https://openalex.org/W2136162208', 'https://openalex.org/W2085109512', 'https://openalex.org/W2077515515', 'https://openalex.org/W1593737715'], 'abstract_inverted_index': {'Objective:': [0], 'To': [1], 'compare': [2], 'trimethoprim-sulfamethoxazole': [3], '(TMP-SMZ)': [4], 'and': [5, 9, 31, 43, 47, 52, 57, 66, 68, 81, 91, 106, 121, 140, 163, 185, 190, 196, 211, 234], 'vancomycin': [6, 119, 167, 186, 214, 267], 'regarding': [7], 'efficacy': [8, 86, 221, 233], 'safety': [10, 235], 'in': [11, 84, 115, 122, 134, 142, 160, 166, 219, 232, 250, 268], 'the': [12, 85, 199, 220], 'therapy': [13], 'of': [14, 64, 102, 108, 117, 124, 155, 208, 213, 271], 'serious': [15], 'Staphylococcus': [16], 'aureus': [17, 39, 79, 97, 104, 150], 'infections.': [18, 244], 'Design:': [19], 'Randomized,': [20], 'double-blind': [21], 'comparative': [22], 'trial.': [23], 'Setting:': [24], 'A': [25], 'tertiary-care': [26], 'hospital.': [27], 'Patients:': [28], 'One': [29], 'hundred': [30], 'one': [32], 'intravenous': [33, 73, 200, 238], 'drug': [34, 74, 239], 'users': [35, 240], 'hospitalized': [36, 172], 'with': [37, 136, 144, 194, 204, 252], 'S.': [38, 78, 96, 103, 149], 'infection.': [40, 273], 'Measurements:': [41], 'Cure': [42], 'failure': [44], 'rates;': [45], 'blood': [46], 'wound': [48], 'cultures;': [49], 'minimum': [50], 'inhibitory': [51, 56], 'bactericidal': [53, 58], 'concentrations;': [54], 'serum': [55], 'titers;': [59], 'temperature;': [60], 'leukocyte': [61], 'count;': [62], 'durations': [63], 'treatment': [65, 247], 'hospitalization;': [67], 'toxicity.': [69], 'Results:': [70], 'Of': [71], '228': [72], 'users,': [75], '101': [76], 'had': [77], 'infection': [80, 145, 254], 'were': [82, 110, 113, 180, 192], 'included': [83], 'analysis': [87], '(43': [88], 'received': [89, 93], 'TMP-SMZ': [90, 126, 161, 183, 195, 209, 231, 259], '58': [92, 118], 'vancomycin).': [94], 'Methicillin-resistant': [95], '(MRSA)': [98], 'accounted': [99], 'for': [100, 173, 182], '47%': [101], 'isolates,': [105], '65%': [107], 'patients': [109, 135, 251], 'bacteremic.': [111], 'Infections': [112], 'cured': [114], '57': [116], 'recipients': [120, 127, 162, 210, 215], '37': [123], '43': [125], '(P': [128, 223], '<': [129], '0.02).': [130], 'Failure': [131], 'occurred': [132, 249], 'mostly': [133], 'tricuspid': [137], 'valve': [138], 'endocarditis': [139], 'only': [141], 'those': [143], 'caused': [146], 'by': [147], 'methicillin-sensitive': [148], '(MSSA).': [151], 'The': [152], 'mean': [153], 'duration': [154], 'bacteremia': [156], 'was': [157, 202], '6.7': [158], 'days': [159, 165], '4.3': [164], 'recipients.': [168], 'Among': [169], '222': [170], 'subjects': [171], 'at': [174, 198, 255], 'least': [175], '24': [176], 'hours,': [177], 'toxicity': [178], 'rates': [179], 'similar': [181], '(23%)': [184], '(20%)': [187], 'recipients;': [188], 'nausea': [189], 'vomiting': [191], 'associated': [193, 203], 'inflammation': [197], 'site': [201], 'vancomycin.': [205], 'Forty-four': [206], 'percent': [207], '29%': [212], 'experienced': [216], 'side': [217], 'effects': [218], 'cohort': [222], '>': [224], '0.05).': [225], 'Conclusions:': [226], 'Vancomycin': [227], 'is': [228], 'superior': [229], 'to': [230, 266], 'when': [236], 'treating': [237], 'who': [241], 'have': [242], 'staphylococcal': [243], 'However,': [245], 'all': [246], 'failures': [248], 'MSSA': [253], 'any': [256], 'site.': [257], 'Therefore,': [258], 'may': [260], 'be': [261], 'considered': [262], 'as': [263], 'an': [264], 'alternative': [265], 'selected': [269], 'cases': [270], 'MRSA': [272]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2043567648', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 17}, {'year': 2014, 'cited_by_count': 16}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2025-01-18T02:27:09.503639', 'created_date': '2016-06-24'}