Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2043363659', 'doi': 'https://doi.org/10.1111/j.1365-2672.2008.03941.x', 'title': 'Microbial nitrilases: versatile, spiral forming, industrial enzymes', 'display_name': 'Microbial nitrilases: versatile, spiral forming, industrial enzymes', 'publication_year': 2009, 'publication_date': '2009-03-01', 'ids': {'openalex': 'https://openalex.org/W2043363659', 'doi': 'https://doi.org/10.1111/j.1365-2672.2008.03941.x', 'mag': '2043363659', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19040702'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2672.2008.03941.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S39794811', 'display_name': 'Journal of Applied Microbiology', 'issn_l': '1364-5072', 'issn': ['1364-5072', '1365-2672'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1111/j.1365-2672.2008.03941.x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5009068714', 'display_name': 'R.N. Thuku', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157614274', 'display_name': 'University of Cape Town', 'ror': 'https://ror.org/03p74gp79', 'country_code': 'ZA', 'type': 'education', 'lineage': ['https://openalex.org/I157614274']}], 'countries': ['ZA'], 'is_corresponding': False, 'raw_author_name': 'R.N. Thuku', 'raw_affiliation_strings': ['Department of Molecular and Cell Biology, University of Cape Town, South Africa', 'Electron Microscope Unit, University of Cape Town, South Africa'], 'affiliations': [{'raw_affiliation_string': 'Electron Microscope Unit, University of Cape Town, South Africa', 'institution_ids': ['https://openalex.org/I157614274']}, {'raw_affiliation_string': 'Department of Molecular and Cell Biology, University of Cape Town, South Africa', 'institution_ids': ['https://openalex.org/I157614274']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091601322', 'display_name': 'Dean Brady', 'orcid': 'https://orcid.org/0000-0002-4815-1030'}, 'institutions': [], 'countries': ['ZA'], 'is_corresponding': False, 'raw_author_name': 'D. Brady', 'raw_affiliation_strings': ['CSIR Biosciences, Modderfontein, Johannesburg, South Africa'], 'affiliations': [{'raw_affiliation_string': 'CSIR Biosciences, Modderfontein, Johannesburg, South Africa', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050624028', 'display_name': 'Michael J. Benedik', 'orcid': 'https://orcid.org/0000-0002-7435-0092'}, 'institutions': [{'id': 'https://openalex.org/I91045830', 'display_name': 'Texas A&M University', 'ror': 'https://ror.org/01f5ytq51', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I91045830']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M.J. Benedik', 'raw_affiliation_strings': ['Department of Biology, Texas A&M University, College Station, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, Texas A&M University, College Station, TX, USA', 'institution_ids': ['https://openalex.org/I91045830']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5040998270', 'display_name': 'B.T. Sewell', 'orcid': 'https://orcid.org/0000-0002-6701-2394'}, 'institutions': [{'id': 'https://openalex.org/I157614274', 'display_name': 'University of Cape Town', 'ror': 'https://ror.org/03p74gp79', 'country_code': 'ZA', 'type': 'education', 'lineage': ['https://openalex.org/I157614274']}], 'countries': ['ZA'], 'is_corresponding': False, 'raw_author_name': 'B.T. Sewell', 'raw_affiliation_strings': ['Electron Microscope Unit, University of Cape Town, South Africa', 'Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa'], 'affiliations': [{'raw_affiliation_string': 'Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa', 'institution_ids': ['https://openalex.org/I157614274']}, {'raw_affiliation_string': 'Electron Microscope Unit, University of Cape Town, South Africa', 'institution_ids': ['https://openalex.org/I157614274']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2623, 'currency': 'GBP', 'value_usd': 3217, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.867, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 142, 'citation_normalized_percentile': {'value': 0.999984, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '106', 'issue': '3', 'first_page': '703', 'last_page': '727'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10404', 'display_name': 'Enzyme Immobilization Techniques', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10404', 'display_name': 'Enzyme Immobilization Techniques', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12770', 'display_name': 'Amino Acid Transport and Metabolism in Health and Disease', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11617', 'display_name': 'Microbial Enzymes and Biotechnological Applications', 'score': 0.9929, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nitrilase', 'display_name': 'Nitrilase', 'score': 0.97131604}, {'id': 'https://openalex.org/keywords/amidase', 'display_name': 'Amidase', 'score': 0.54230845}, {'id': 'https://openalex.org/keywords/amylases', 'display_name': 'Amylases', 'score': 0.500445}, {'id': 'https://openalex.org/keywords/enzyme-catalysis', 'display_name': 'Enzyme catalysis', 'score': 0.4285671}], 'concepts': [{'id': 'https://openalex.org/C2780296214', 'wikidata': 'https://www.wikidata.org/wiki/Q7041406', 'display_name': 'Nitrilase', 'level': 3, 'score': 0.97131604}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.6082964}, {'id': 'https://openalex.org/C65588867', 'wikidata': 'https://www.wikidata.org/wiki/Q24775735', 'display_name': 'Amidase', 'level': 3, 'score': 0.54230845}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4837094}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.47279543}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.45216548}, {'id': 'https://openalex.org/C41183919', 'wikidata': 'https://www.wikidata.org/wiki/Q423026', 'display_name': 'Active site', 'level': 3, 'score': 0.43033227}, {'id': 'https://openalex.org/C2779546866', 'wikidata': 'https://www.wikidata.org/wiki/Q531306', 'display_name': 'Dimer', 'level': 2, 'score': 0.4298774}, {'id': 'https://openalex.org/C69118441', 'wikidata': 'https://www.wikidata.org/wiki/Q2941663', 'display_name': 'Enzyme catalysis', 'level': 3, 'score': 0.4285671}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.42336023}, {'id': 'https://openalex.org/C9418097', 'wikidata': 'https://www.wikidata.org/wiki/Q440681', 'display_name': 'Directed evolution', 'level': 4, 'score': 0.4177154}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.33226472}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33006746}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.25123662}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.10578281}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000619', 'descriptor_name': 'Aminohydrolases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D015202', 'descriptor_name': 'Protein Engineering', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D012240', 'descriptor_name': 'Rhodococcus', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D000619', 'descriptor_name': 'Aminohydrolases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000619', 'descriptor_name': 'Aminohydrolases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D029721', 'descriptor_name': 'Drosophila Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029721', 'descriptor_name': 'Drosophila Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004331', 'descriptor_name': 'Drosophila melanogaster', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004331', 'descriptor_name': 'Drosophila melanogaster', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D004331', 'descriptor_name': 'Drosophila melanogaster', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015202', 'descriptor_name': 'Protein Engineering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012240', 'descriptor_name': 'Rhodococcus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2672.2008.03941.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S39794811', 'display_name': 'Journal of Applied Microbiology', 'issn_l': '1364-5072', 'issn': ['1364-5072', '1365-2672'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19040702', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2672.2008.03941.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S39794811', 'display_name': 'Journal of Applied Microbiology', 'issn_l': '1364-5072', 'issn': ['1364-5072', '1365-2672'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'score': 0.44, 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 130, 'referenced_works': ['https://openalex.org/W1488981269', 'https://openalex.org/W149288948', 'https://openalex.org/W151694266', 'https://openalex.org/W1518854024', 'https://openalex.org/W1534441969', 'https://openalex.org/W1543464656', 'https://openalex.org/W1565674158', 'https://openalex.org/W1568415320', 'https://openalex.org/W1611764007', 'https://openalex.org/W1628108294', 'https://openalex.org/W1799573947', 'https://openalex.org/W1809713791', 'https://openalex.org/W1839073584', 'https://openalex.org/W1875710860', 'https://openalex.org/W1963808031', 'https://openalex.org/W1965794026', 'https://openalex.org/W1967100912', 'https://openalex.org/W1967779445', 'https://openalex.org/W1974804581', 'https://openalex.org/W1974988585', 'https://openalex.org/W1979670502', 'https://openalex.org/W1980675771', 'https://openalex.org/W1982477994', 'https://openalex.org/W1984904626', 'https://openalex.org/W1995473468', 'https://openalex.org/W1997938835', 'https://openalex.org/W1997954108', 'https://openalex.org/W2000761825', 'https://openalex.org/W2002348014', 'https://openalex.org/W2002604337', 'https://openalex.org/W2004407451', 'https://openalex.org/W2006102365', 'https://openalex.org/W2007125645', 'https://openalex.org/W2008807736', 'https://openalex.org/W2010450283', 'https://openalex.org/W2010490059', 'https://openalex.org/W2010618393', 'https://openalex.org/W2010856921', 'https://openalex.org/W2011659166', 'https://openalex.org/W2013776698', 'https://openalex.org/W2015117091', 'https://openalex.org/W2016886117', 'https://openalex.org/W2018712093', 'https://openalex.org/W2019073875', 'https://openalex.org/W2019819550', 'https://openalex.org/W2021179083', 'https://openalex.org/W2024565527', 'https://openalex.org/W2024914551', 'https://openalex.org/W2027659663', 'https://openalex.org/W2030396327', 'https://openalex.org/W2034210188', 'https://openalex.org/W2035533304', 'https://openalex.org/W2036161713', 'https://openalex.org/W2039098799', 'https://openalex.org/W2042381751', 'https://openalex.org/W2042776954', 'https://openalex.org/W2042896521', 'https://openalex.org/W2044067896', 'https://openalex.org/W2045603561', 'https://openalex.org/W2048668787', 'https://openalex.org/W2049125285', 'https://openalex.org/W2049354519', 'https://openalex.org/W2049887020', 'https://openalex.org/W2052895657', 'https://openalex.org/W2054630885', 'https://openalex.org/W2055931897', 'https://openalex.org/W2057747260', 'https://openalex.org/W2062577702', 'https://openalex.org/W2068982922', 'https://openalex.org/W2072261180', 'https://openalex.org/W2073895688', 'https://openalex.org/W2076143264', 'https://openalex.org/W2076338063', 'https://openalex.org/W2079115124', 'https://openalex.org/W2082119052', 'https://openalex.org/W2083839522', 'https://openalex.org/W2084563059', 'https://openalex.org/W2087730171', 'https://openalex.org/W2094694540', 'https://openalex.org/W2094703583', 'https://openalex.org/W2095070246', 'https://openalex.org/W2099996913', 'https://openalex.org/W2101559772', 'https://openalex.org/W2103326934', 'https://openalex.org/W2104488128', 'https://openalex.org/W2105112909', 'https://openalex.org/W2107516137', 'https://openalex.org/W2110282379', 'https://openalex.org/W2111007325', 'https://openalex.org/W2112712659', 'https://openalex.org/W2121261256', 'https://openalex.org/W2122084702', 'https://openalex.org/W2122726565', 'https://openalex.org/W2125147988', 'https://openalex.org/W2130137859', 'https://openalex.org/W2132629607', 'https://openalex.org/W2140534808', 'https://openalex.org/W2141212142', 'https://openalex.org/W2142209403', 'https://openalex.org/W2142529984', 'https://openalex.org/W2143340210', 'https://openalex.org/W2144055074', 'https://openalex.org/W2144483796', 'https://openalex.org/W2147059525', 'https://openalex.org/W2147203026', 'https://openalex.org/W2148080293', 'https://openalex.org/W2149810880', 'https://openalex.org/W2156590646', 'https://openalex.org/W2157904754', 'https://openalex.org/W2158215039', 'https://openalex.org/W2163689020', 'https://openalex.org/W2164221066', 'https://openalex.org/W2166696244', 'https://openalex.org/W2167557732', 'https://openalex.org/W2253125605', 'https://openalex.org/W2281934661', 'https://openalex.org/W2290407983', 'https://openalex.org/W2320435523', 'https://openalex.org/W2466464310', 'https://openalex.org/W2527569512', 'https://openalex.org/W255996521', 'https://openalex.org/W2815110135', 'https://openalex.org/W2894600334', 'https://openalex.org/W2975422843', 'https://openalex.org/W4233791598', 'https://openalex.org/W4252113450', 'https://openalex.org/W4285719527', 'https://openalex.org/W4298265300', 'https://openalex.org/W65962201', 'https://openalex.org/W90650271'], 'related_works': ['https://openalex.org/W2961040150', 'https://openalex.org/W2949163464', 'https://openalex.org/W2393000914', 'https://openalex.org/W2104383711', 'https://openalex.org/W2094222926', 'https://openalex.org/W2052895657', 'https://openalex.org/W2039731543', 'https://openalex.org/W2030474642', 'https://openalex.org/W2027659663', 'https://openalex.org/W1988644775'], 'abstract_inverted_index': {'The': [0, 29, 92], 'nitrilases': [1], 'are': [2, 14, 79, 154], 'enzymes': [3, 94], 'that': [4, 202], 'convert': [5], 'nitriles': [6], 'to': [7, 150, 205], 'the': [8, 70, 83, 114, 121, 124, 129, 138, 158, 176, 186], 'corresponding': [9], 'acid': [10], 'and': [11, 22, 27, 44, 56, 62, 75, 89, 105, 128, 175, 193, 199], 'ammonia.': [12], 'They': [13], 'members': [15], 'of': [16, 72, 85, 123, 133, 140, 160, 178, 185, 191], 'a': [17, 35, 40, 161], 'superfamily,': [18], 'which': [19, 167], 'includes': [20], 'amidases': [21], 'occur': [23], 'in': [24, 82, 120, 189, 195], 'both': [25], 'prokaryotes': [26], 'eukaryotes.': [28], 'superfamily': [30, 93], 'is': [31], 'characterized': [32], 'by': [33, 145, 157], 'having': [34], 'homodimeric': [36], 'building': [37], 'block': [38], 'with': [39], 'αββα–αββα': [41], 'sandwich': [42], 'fold': [43], 'an': [45, 183], 'active': [46], 'site': [47], 'containing': [48], 'four': [49], 'positionally': [50], 'conserved': [51], 'residues:': [52], 'cys,': [53], 'glu,': [54], 'glu': [55], 'lys.': [57], 'Their': [58], 'high': [59, 162], 'chemical': [60], 'specificity': [61], 'frequent': [63], 'enantioselectivity': [64, 174], 'makes': [65], 'them': [66], 'attractive': [67], 'biocatalysts': [68], 'for': [69], 'production': [71], 'fine': [73], 'chemicals': [74], 'pharmaceutical': [76], 'intermediates.': [77], 'Nitrilases': [78], 'also': [80], 'used': [81], 'treatment': [84], 'toxic': [86], 'industrial': [87], 'effluent': [88], 'cyanide': [90], 'remediation.': [91], 'have': [95, 113], 'been': [96], 'visualized': [97], 'as': [98], 'dimers,': [99], 'tetramers,': [100], 'hexamers,': [101], 'octamers,': [102, 125], 'tetradecamers,': [103, 126], 'octadecamers': [104, 127], 'variable': [106], 'length': [107], 'helices,': [108, 130], 'but': [109], 'all': [110], 'nitrilase': [111, 165], 'oligomers': [112], 'same': [115], 'basic': [116], 'dimer': [117], 'interface.': [118], 'Moreover,': [119], 'case': [122], 'common': [131], 'principles': [132], 'subunit': [134], 'association': [135], 'apply.': [136], 'While': [137], 'range': [139], 'industrially': [141], 'interesting': [142], 'reactions': [143], 'catalysed': [144], 'this': [146, 196], 'enzyme': [147, 197], 'class': [148, 198], 'continues': [149], 'increase,': [151], 'research': [152], 'efforts': [153], 'still': [155], 'hampered': [156], 'lack': [159], 'resolution': [163], 'microbial': [164], 'structure': [166, 192], 'can': [168], 'provide': [169], 'insights': [170, 201], 'into': [171], 'their': [172], 'specificity,': [173], 'mechanism': [177], 'catalysis.': [179], 'This': [180], 'review': [181], 'provides': [182], 'overview': [184], 'current': [187], 'progress': [188], 'elucidation': [190], 'function': [194], 'emphasizes': [200], 'may': [203], 'lead': [204], 'further': [206], 'biotechnological': [207], 'applications.': [208]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2043363659', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 13}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-09-11T13:57:34.367028', 'created_date': '2016-06-24'}