Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2043217730', 'doi': 'https://doi.org/10.1007/s00018-011-0884-2', 'title': 'Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation', 'display_name': 'Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation', 'publication_year': 2011, 'publication_date': '2011-12-01', 'ids': {'openalex': 'https://openalex.org/W2043217730', 'doi': 'https://doi.org/10.1007/s00018-011-0884-2', 'mag': '2043217730', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22130515', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3314179'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00018-011-0884-2', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007%2Fs00018-011-0884-2.pdf', 'source': {'id': 'https://openalex.org/S60362788', 'display_name': 'Cellular and Molecular Life Sciences', 'issn_l': '1420-682X', 'issn': ['1420-682X', '1420-9071'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://link.springer.com/content/pdf/10.1007%2Fs00018-011-0884-2.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5055797658', 'display_name': 'Reena Singh', 'orcid': 'https://orcid.org/0000-0001-8860-8800'}, 'institutions': [{'id': 'https://openalex.org/I34809795', 'display_name': 'Medizinische Hochschule Hannover', 'ror': 'https://ror.org/00f2yqf98', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I34809795']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Reena Singh', 'raw_affiliation_strings': ['Institut für Molekularbiologie, Medizinische Hochschule Hannover'], 'affiliations': [{'raw_affiliation_string': 'Institut für Molekularbiologie, Medizinische Hochschule Hannover', 'institution_ids': ['https://openalex.org/I34809795']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004768958', 'display_name': 'Willem M.H. Hoogaars', 'orcid': 'https://orcid.org/0000-0001-6061-2576'}, 'institutions': [{'id': 'https://openalex.org/I887064364', 'display_name': 'University of Amsterdam', 'ror': 'https://ror.org/04dkp9463', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I887064364']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Willem M. Hoogaars', 'raw_affiliation_strings': ['University of Amsterdam#N#'], 'affiliations': [{'raw_affiliation_string': 'University of Amsterdam#N#', 'institution_ids': ['https://openalex.org/I887064364']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073843586', 'display_name': 'Phil Barnett', 'orcid': 'https://orcid.org/0000-0001-7420-6106'}, 'institutions': [{'id': 'https://openalex.org/I887064364', 'display_name': 'University of Amsterdam', 'ror': 'https://ror.org/04dkp9463', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I887064364']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Phil Barnett', 'raw_affiliation_strings': ['University of Amsterdam#N#'], 'affiliations': [{'raw_affiliation_string': 'University of Amsterdam#N#', 'institution_ids': ['https://openalex.org/I887064364']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036420589', 'display_name': 'Thomas Grieskamp', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I34809795', 'display_name': 'Medizinische Hochschule Hannover', 'ror': 'https://ror.org/00f2yqf98', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I34809795']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Thomas Grieskamp', 'raw_affiliation_strings': ['Institut für Molekularbiologie, Medizinische Hochschule Hannover'], 'affiliations': [{'raw_affiliation_string': 'Institut für Molekularbiologie, Medizinische Hochschule Hannover', 'institution_ids': ['https://openalex.org/I34809795']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103574362', 'display_name': 'M. Sameer Rana', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I887064364', 'display_name': 'University of Amsterdam', 'ror': 'https://ror.org/04dkp9463', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I887064364']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'M. Sameer Rana', 'raw_affiliation_strings': ['University of Amsterdam#N#'], 'affiliations': [{'raw_affiliation_string': 'University of Amsterdam#N#', 'institution_ids': ['https://openalex.org/I887064364']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002498747', 'display_name': 'Henk P.J. Buermans', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Henk Buermans', 'raw_affiliation_strings': ['LEIDEN UNIVERSITY (MEDICAL CENTER)'], 'affiliations': [{'raw_affiliation_string': 'LEIDEN UNIVERSITY (MEDICAL CENTER)', 'institution_ids': ['https://openalex.org/I2800006345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040494071', 'display_name': 'Henner F. Farin', 'orcid': 'https://orcid.org/0000-0003-1558-5366'}, 'institutions': [{'id': 'https://openalex.org/I34809795', 'display_name': 'Medizinische Hochschule Hannover', 'ror': 'https://ror.org/00f2yqf98', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I34809795']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Henner F. Farin', 'raw_affiliation_strings': ['Institut für Molekularbiologie, Medizinische Hochschule Hannover'], 'affiliations': [{'raw_affiliation_string': 'Institut für Molekularbiologie, Medizinische Hochschule Hannover', 'institution_ids': ['https://openalex.org/I34809795']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040922232', 'display_name': 'Marianne Petry', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I34809795', 'display_name': 'Medizinische Hochschule Hannover', 'ror': 'https://ror.org/00f2yqf98', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I34809795']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Marianne Petry', 'raw_affiliation_strings': ['Institut für Molekularbiologie, Medizinische Hochschule Hannover'], 'affiliations': [{'raw_affiliation_string': 'Institut für Molekularbiologie, Medizinische Hochschule Hannover', 'institution_ids': ['https://openalex.org/I34809795']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007919185', 'display_name': 'Todd R. Heallen', 'orcid': 'https://orcid.org/0000-0002-6003-8743'}, 'institutions': [{'id': 'https://openalex.org/I125029298', 'display_name': 'Texas A&M Health Science Center', 'ror': 'https://ror.org/01tx6pn92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I125029298', 'https://openalex.org/I91045830']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Todd Heallen', 'raw_affiliation_strings': ['Texas A&M Health Science Center: Institute of Biosciences and Technology'], 'affiliations': [{'raw_affiliation_string': 'Texas A&M Health Science Center: Institute of Biosciences and Technology', 'institution_ids': ['https://openalex.org/I125029298']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080982128', 'display_name': 'James F. Martin', 'orcid': 'https://orcid.org/0000-0002-7842-9857'}, 'institutions': [{'id': 'https://openalex.org/I125029298', 'display_name': 'Texas A&M Health Science Center', 'ror': 'https://ror.org/01tx6pn92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I125029298', 'https://openalex.org/I91045830']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James F. Martin', 'raw_affiliation_strings': ['Texas A&M Health Science Center: Institute of Biosciences and Technology'], 'affiliations': [{'raw_affiliation_string': 'Texas A&M Health Science Center: Institute of Biosciences and Technology', 'institution_ids': ['https://openalex.org/I125029298']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002005916', 'display_name': 'Antoon F.M. Moorman', 'orcid': 'https://orcid.org/0000-0003-1547-5087'}, 'institutions': [{'id': 'https://openalex.org/I887064364', 'display_name': 'University of Amsterdam', 'ror': 'https://ror.org/04dkp9463', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I887064364']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Antoon F. M. Moorman', 'raw_affiliation_strings': ['University of Amsterdam#N#'], 'affiliations': [{'raw_affiliation_string': 'University of Amsterdam#N#', 'institution_ids': ['https://openalex.org/I887064364']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021033668', 'display_name': 'Peter A.C. ’t Hoen', 'orcid': 'https://orcid.org/0000-0003-4450-3112'}, 'institutions': [{'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Peter A. C. ‘t Hoen', 'raw_affiliation_strings': ['LEIDEN UNIVERSITY (MEDICAL CENTER)'], 'affiliations': [{'raw_affiliation_string': 'LEIDEN UNIVERSITY (MEDICAL CENTER)', 'institution_ids': ['https://openalex.org/I2800006345']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075279504', 'display_name': 'Andreas Kispert', 'orcid': 'https://orcid.org/0000-0002-8154-0257'}, 'institutions': [{'id': 'https://openalex.org/I34809795', 'display_name': 'Medizinische Hochschule Hannover', 'ror': 'https://ror.org/00f2yqf98', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I34809795']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Andreas Kispert', 'raw_affiliation_strings': ['Institut für Molekularbiologie, Medizinische Hochschule Hannover'], 'affiliations': [{'raw_affiliation_string': 'Institut für Molekularbiologie, Medizinische Hochschule Hannover', 'institution_ids': ['https://openalex.org/I34809795']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024997012', 'display_name': 'Vincent M. Christoffels', 'orcid': 'https://orcid.org/0000-0003-4131-2636'}, 'institutions': [{'id': 'https://openalex.org/I887064364', 'display_name': 'University of Amsterdam', 'ror': 'https://ror.org/04dkp9463', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I887064364']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Vincent M. Christoffels', 'raw_affiliation_strings': ['University of Amsterdam#N#'], 'affiliations': [{'raw_affiliation_string': 'University of Amsterdam#N#', 'institution_ids': ['https://openalex.org/I887064364']}]}], 'countries_distinct_count': 3, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3290, 'currency': 'EUR', 'value_usd': 4290, 'provenance': 'doaj'}, 'apc_paid': {'value': 3290, 'currency': 'EUR', 'value_usd': 4290, 'provenance': 'doaj'}, 'fwci': 4.092, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 123, 'citation_normalized_percentile': {'value': 0.909922, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '69', 'issue': '8', 'first_page': '1377', 'last_page': '1389'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11677', 'display_name': 'Molecular Mechanisms of Cardiac Development and Regeneration', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11677', 'display_name': 'Molecular Mechanisms of Cardiac Development and Regeneration', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10172', 'display_name': 'Management of Valvular Heart Disease', 'score': 0.9687, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11962', 'display_name': 'Molecular Mechanisms of Cardiac Remodeling and Repair', 'score': 0.9674, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/atrioventricular-valve', 'display_name': 'Atrioventricular valve', 'score': 0.860929}, {'id': 'https://openalex.org/keywords/atrioventricular-canal', 'display_name': 'Atrioventricular canal', 'score': 0.78782475}, {'id': 'https://openalex.org/keywords/atrioventricular-cushions', 'display_name': 'Atrioventricular cushions', 'score': 0.76869535}, {'id': 'https://openalex.org/keywords/heart-development', 'display_name': 'Heart development', 'score': 0.6740603}, {'id': 'https://openalex.org/keywords/t-box-genes', 'display_name': 'T-Box Genes', 'score': 0.504361}], 'concepts': [{'id': 'https://openalex.org/C2993958809', 'wikidata': 'https://www.wikidata.org/wiki/Q215620', 'display_name': 'Atrioventricular valve', 'level': 3, 'score': 0.860929}, {'id': 'https://openalex.org/C2781301203', 'wikidata': 'https://www.wikidata.org/wiki/Q4817568', 'display_name': 'Atrioventricular canal', 'level': 3, 'score': 0.78782475}, {'id': 'https://openalex.org/C129119232', 'wikidata': 'https://www.wikidata.org/wiki/Q2879939', 'display_name': 'Atrioventricular cushions', 'level': 3, 'score': 0.76869535}, {'id': 'https://openalex.org/C62425271', 'wikidata': 'https://www.wikidata.org/wiki/Q14819288', 'display_name': 'Heart development', 'level': 4, 'score': 0.6740603}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.5595571}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.45416433}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.41087264}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.40571982}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.40030995}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.34762168}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.32947072}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32846612}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.31316638}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.20357639}, {'id': 'https://openalex.org/C2778921608', 'wikidata': 'https://www.wikidata.org/wiki/Q2002035', 'display_name': 'Ventricle', 'level': 2, 'score': 0.2017406}, {'id': 'https://openalex.org/C145103041', 'wikidata': 'https://www.wikidata.org/wiki/Q1151519', 'display_name': 'Embryonic stem cell', 'level': 3, 'score': 0.088520736}, {'id': 'https://openalex.org/C2780074459', 'wikidata': 'https://www.wikidata.org/wiki/Q389735', 'display_name': 'Heart disease', 'level': 2, 'score': 0.07377207}], 'mesh': [{'descriptor_ui': 'D054089', 'descriptor_name': 'Endocardial Cushions', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': True}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020825', 'descriptor_name': 'T-Box Domain Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055396', 'descriptor_name': 'Bone Morphogenetic Protein 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D055396', 'descriptor_name': 'Bone Morphogenetic Protein 2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D055396', 'descriptor_name': 'Bone Morphogenetic Protein 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054089', 'descriptor_name': 'Endocardial Cushions', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D054089', 'descriptor_name': 'Endocardial Cushions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020825', 'descriptor_name': 'T-Box Domain Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020825', 'descriptor_name': 'T-Box Domain Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00018-011-0884-2', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007%2Fs00018-011-0884-2.pdf', 'source': {'id': 'https://openalex.org/S60362788', 'display_name': 'Cellular and Molecular Life Sciences', 'issn_l': '1420-682X', 'issn': ['1420-682X', '1420-9071'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3314179', 'pdf_url': 'https://europepmc.org/articles/pmc3314179?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314179', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22130515', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00018-011-0884-2', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007%2Fs00018-011-0884-2.pdf', 'source': {'id': 'https://openalex.org/S60362788', 'display_name': 'Cellular and Molecular Life Sciences', 'issn_l': '1420-682X', 'issn': ['1420-682X', '1420-9071'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.75, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 55, 'referenced_works': ['https://openalex.org/W1903925553', 'https://openalex.org/W1965159397', 'https://openalex.org/W1973431915', 'https://openalex.org/W1976530870', 'https://openalex.org/W1987509855', 'https://openalex.org/W1989084334', 'https://openalex.org/W2008555822', 'https://openalex.org/W2027264255', 'https://openalex.org/W2032756882', 'https://openalex.org/W2036145288', 'https://openalex.org/W2060418346', 'https://openalex.org/W2067835192', 'https://openalex.org/W2075011348', 'https://openalex.org/W2075581292', 'https://openalex.org/W2079018506', 'https://openalex.org/W2080666425', 'https://openalex.org/W2081098333', 'https://openalex.org/W2084844204', 'https://openalex.org/W2085221145', 'https://openalex.org/W2085315537', 'https://openalex.org/W2087694050', 'https://openalex.org/W2094047407', 'https://openalex.org/W2099750732', 'https://openalex.org/W2103757269', 'https://openalex.org/W2108819945', 'https://openalex.org/W2109730518', 'https://openalex.org/W2111336754', 'https://openalex.org/W2112723752', 'https://openalex.org/W2116293582', 'https://openalex.org/W2116461923', 'https://openalex.org/W2117276705', 'https://openalex.org/W2118069309', 'https://openalex.org/W2119632460', 'https://openalex.org/W2122598723', 'https://openalex.org/W2124478777', 'https://openalex.org/W2124668407', 'https://openalex.org/W2125026226', 'https://openalex.org/W2127375358', 'https://openalex.org/W2128466784', 'https://openalex.org/W2130207795', 'https://openalex.org/W2130907345', 'https://openalex.org/W2134208169', 'https://openalex.org/W2136309995', 'https://openalex.org/W2137342398', 'https://openalex.org/W2141804334', 'https://openalex.org/W2145606026', 'https://openalex.org/W2146184464', 'https://openalex.org/W2148428824', 'https://openalex.org/W2154617861', 'https://openalex.org/W2155539618', 'https://openalex.org/W2158304082', 'https://openalex.org/W2159459254', 'https://openalex.org/W2164511316', 'https://openalex.org/W2166252345', 'https://openalex.org/W2168881898'], 'related_works': ['https://openalex.org/W4390516824', 'https://openalex.org/W2480087820', 'https://openalex.org/W2414021103', 'https://openalex.org/W2274061632', 'https://openalex.org/W2157209959', 'https://openalex.org/W2043217730', 'https://openalex.org/W2021995517', 'https://openalex.org/W2001564124', 'https://openalex.org/W1562575759', 'https://openalex.org/W1484156340'], 'abstract_inverted_index': {'A': [0], 'key': [1], 'step': [2], 'in': [3, 60, 156], 'heart': [4, 157], 'development': [5, 9, 31, 132], 'is': [6], 'the': [7, 11, 15, 18, 27, 30, 33, 52, 66, 71, 96, 124, 134, 148], 'coordinated': [8], 'of': [10, 32, 73, 81, 113, 123, 133, 152], 'atrioventricular': [12, 34, 97, 120], 'canal': [13], '(AVC),': [14], 'constriction': [16], 'between': [17], 'atria': [19], 'and': [20, 24, 29, 43, 58, 78, 89, 94, 115, 126, 129, 150], 'ventricles': [21], 'that': [22, 36, 51, 84], 'electrically': [23], 'physically': [25], 'separates': [26], 'chambers,': [28], 'valves': [35, 125], 'ensure': [37], 'unidirectional': [38], 'blood': [39], 'flow.': [40], 'Using': [41], 'knock-out': [42], 'inducible': [44], 'overexpression': [45], 'mouse': [46], 'models,': [47], 'we': [48], 'provide': [49], 'evidence': [50], 'developmentally': [53], 'important': [54, 154], 'T-box': [55], 'factors': [56], 'Tbx2': [57, 114, 128], 'Tbx3,': [59], 'a': [61, 137, 145], 'functionally': [62], 'redundant': [63], 'manner,': [64], 'maintain': [65], 'AVC': [67], 'myocardium': [68], 'phenotype': [69, 99], 'during': [70], 'process': [72], 'chamber': [74, 91], 'differentiation.': [75], 'Expression': [76], 'profiling': [77], 'ChIP-sequencing': [79], 'analysis': [80], 'Tbx3': [82, 116, 130], 'revealed': [83], 'it': [85], 'directly': [86], 'interacts': [87], 'with': [88, 141], 'represses': [90], 'myocardial': [92], 'genes,': [93], 'induces': [95], 'pacemaker-like': [98], 'by': [100], 'activating': [101], 'relevant': [102], 'genes.': [103], 'Moreover,': [104], 'mutant': [105], 'mice': [106], 'lacking': [107], '3': [108], 'or': [109], '4': [110], 'functional': [111], 'alleles': [112], 'failed': [117], 'to': [118], 'form': [119], 'cushions,': [121], 'precursors': [122], 'septa.': [127], 'trigger': [131], 'cushions': [135], 'through': [136], 'regulatory': [138], 'feed-forward': [139], 'loop': [140], 'Bmp2,': [142], 'thus': [143], 'providing': [144], 'mechanism': [146], 'for': [147], 'co-localization': [149], 'coordination': [151], 'these': [153], 'processes': [155], 'development.': [158]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2043217730', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 16}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 12}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-09-01T01:24:14.025883', 'created_date': '2016-06-24'}