Publication Information

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'https://openalex.org/W2490482741', 'https://openalex.org/W2429060612', 'https://openalex.org/W2207864787', 'https://openalex.org/W2079054804'], 'abstract_inverted_index': {'Human': [0, 186, 372], 'neutrophils': [1, 60, 88, 187, 246, 274, 373, 532, 552, 571, 808, 1186, 1215, 2333, 2958, 3101, 3208, 3320, 3696, 3873], 'normally': [2, 188, 1394, 2199], 'have': [3, 45, 189, 231, 374, 729, 1195, 1310, 1333, 2626, 2945, 4189], 'a': [4, 39, 190, 225, 375, 536, 952, 1086, 1161, 1226, 1393, 1399, 1707, 1726, 1820, 1849, 2026, 2521, 2761, 2868, 3251, 3272, 3369, 4048, 4217], 'very': [5, 191, 376], 'short': [6, 192, 377, 2027, 2200], 'half-life': [7, 193, 378, 1025, 2028, 2201], 'and': [8, 61, 92, 100, 117, 136, 194, 247, 278, 286, 303, 322, 387, 508, 520, 562, 629, 646, 668, 811, 819, 932, 948, 962, 969, 1036, 1044, 1100, 1110, 1115, 1200, 1208, 1216, 1273, 1328, 1354, 1401, 1410, 1456, 1466, 1502, 1530, 1618, 1629, 1721, 1795, 1836, 1898, 1906, 1957, 2018, 2062, 2221, 2376, 2635, 2718, 2735, 2857, 3093, 3114, 3139, 3189, 3314, 3327, 3387, 3401, 3405, 3446, 3496, 3500, 3551, 3593, 3703, 3707, 3764, 3839, 3909, 3956, 4000, 4030, 4173, 4199, 4211], 'die': [9, 195], 'by': [10, 77, 95, 125, 196, 263, 281, 311, 576, 699, 977, 1296, 1342, 1386, 1543, 1626, 1741, 1845, 2293, 2323, 2342, 2364, 2371, 2383, 2485, 2513, 2563, 2707, 2714, 2728, 2747, 2811, 2862, 3130, 3153, 3183, 3191, 3221, 3259, 3316, 3644, 3664, 3719, 3786, 4137, 4183], 'apoptosis.': [11, 65, 137, 197, 251, 323, 704, 1307, 1331, 1371, 2303, 2534, 3388, 3835, 4202], 'Cytokines': [12, 198], 'such': [13, 199, 642, 1184], 'as': [14, 200, 643, 767, 1185, 1624, 1646, 1743, 1914, 2321, 2362, 2401, 2592, 2888, 3615, 3673, 3709, 3784], 'granulocyte-macrophage': [15, 201, 820, 829, 860], 'colony-stimulating': [16, 202, 821, 830, 861], 'factor': [17, 203, 822], '(GM-CSF)': [18, 204, 823], 'can': [19, 205, 624, 1204, 1219, 1383, 2631, 2806], 'delay': [20, 206, 528, 702, 2956, 3806], 'this': [21, 207, 1105, 2138, 2291, 2939, 3831], 'apoptosis': [22, 94, 118, 169, 208, 280, 304, 355, 394, 517, 530, 550, 722, 734, 887, 1737, 1774, 2063, 2388, 2497, 2955, 3716, 3756, 3855], 'via': [23, 174, 183, 209, 360, 369, 1348, 2042, 2210, 2817, 3549], 'increases': [24, 210, 1338, 2684, 2821], 'in': [25, 164, 177, 211, 350, 363, 379, 546, 626, 718, 727, 1213, 1225, 1271, 1281, 1366, 1388, 1404, 1593, 1648, 1745, 1797, 1826, 1838, 1864, 2064, 2089, 2102, 2108, 2152, 2163, 2169, 2178, 2312, 2347, 2541, 2679, 2685, 2724, 2732, 2760, 2764, 2782, 2787, 2824, 2830, 2837, 2914, 2925, 2948, 2957, 3099, 3203, 3225, 3229, 3274, 3280, 3323, 3345, 3398, 3436, 3486, 3513, 3517, 3534, 3541, 3587, 3603, 3617, 3699, 3752, 3759, 3773, 3799, 3856, 3872, 3899, 4036, 4058, 4062, 4077, 4090, 4196, 4201, 4208], 'the': [26, 35, 50, 54, 79, 110, 126, 139, 144, 165, 178, 184, 212, 221, 236, 240, 265, 296, 312, 325, 330, 351, 364, 370, 380, 502, 557, 566, 633, 671, 683, 696, 711, 762, 929, 941, 978, 1024, 1027, 1041, 1083, 1223, 1294, 1376, 1389, 1503, 1649, 1814, 1827, 1966, 2007, 2035, 2043, 2057, 2073, 2109, 2120, 2124, 2147, 2170, 2195, 2198, 2211, 2215, 2227, 2288, 2316, 2348, 2357, 2384, 2469, 2483, 2488, 2494, 2542, 2682, 2733, 2751, 2788, 2792, 2818, 2831, 2838, 2883, 2934, 2950, 3230, 3235, 3293, 3324, 3399, 3406, 3425, 3434, 3437, 3449, 3453, 3475, 3483, 3492, 3510, 3518, 3524, 3562, 3604, 3618, 3700, 3760, 3774, 3780, 3815, 3848, 3878, 3900, 3912, 3957, 4001, 4051, 4078, 4091, 4106, 4113, 4193, 4209], 'cellular': [27, 213, 739, 2058, 2135, 2228, 2637, 2702, 2765, 3416], 'levels': [28, 214, 740, 1210, 1275, 1283, 1303, 1317, 1327, 1341, 2059, 2082, 2087, 2136, 2153, 2171, 2229, 2289, 2639, 2687, 2703, 2742, 2766, 2810, 2859, 2881, 3152, 3161, 3174, 3309, 3341, 3417, 3467, 3640, 3655], 'of': [29, 34, 49, 56, 81, 85, 105, 122, 167, 180, 215, 220, 235, 242, 267, 271, 291, 308, 353, 366, 516, 529, 539, 551, 560, 569, 670, 688, 713, 741, 761, 775, 805, 814, 928, 1026, 1108, 1182, 1193, 1211, 1222, 1314, 1322, 1346, 1357, 1363, 1392, 1532, 1704, 1710, 1734, 1773, 1816, 1998, 2000, 2012, 2050, 2060, 2075, 2083, 2096, 2111, 2123, 2132, 2137, 2154, 2172, 2202, 2206, 2214, 2230, 2287, 2290, 2318, 2330, 2345, 2350, 2356, 2386, 2465, 2471, 2482, 2487, 2496, 2498, 2504, 2515, 2529, 2547, 2584, 2619, 2623, 2681, 2691, 2704, 2737, 2743, 2753, 2767, 2770, 2790, 2794, 2815, 2833, 2842, 2849, 2878, 2890, 2895, 2952, 3088, 3112, 3120, 3122, 3127, 3136, 3162, 3175, 3197, 3232, 3253, 3269, 3283, 3310, 3330, 3335, 3351, 3371, 3383, 3403, 3411, 3418, 3424, 3433, 3439, 3451, 3455, 3477, 3494, 3520, 3527, 3564, 3568, 3576, 3606, 3622, 3659, 3668, 3688, 3705, 3714, 3739, 3754, 3762, 3771, 3776, 3779, 3818, 3851, 3880, 3904, 4083, 4097, 4133, 4167, 4181, 4185, 4213], 'Mcl-1,': [30, 216], 'an': [31, 217, 724, 758, 768, 925], 'anti-apoptotic': [32, 218, 759], 'protein': [33, 219, 760, 834, 842, 865, 873, 955, 1029, 1165, 1207, 1282, 1302, 1315, 1340, 2036, 2117, 2125, 2292, 2379, 2809, 3396, 3435, 3466, 3569, 3577, 3800], 'Bcl-2': [36, 222, 763, 930, 947, 1099, 1111], 'family': [37, 223, 764, 931, 945, 958], 'with': [38, 224, 1094, 1098, 1279, 1598, 1614, 1718, 1770, 1895, 1980, 2086, 2146, 2306, 2730, 3207, 3288, 3368, 3392, 3413, 3464, 3498, 3682, 3897, 4105, 4206, 4216], 'rapid': [40, 226, 1170, 2121, 2208, 2762, 3431], 'turnover': [41, 58, 135, 182, 227, 244, 321, 368, 976, 1316, 1347, 1364, 1390, 2122, 2209, 2296, 2512, 2719, 2773, 2816, 3432, 3454, 3525, 3557, 3879, 3892, 3945, 4061], 'rate.': [42, 228, 2720], 'Here': [43, 229], 'we': [44, 230, 1309, 2282, 2694], 'shown': [46, 232, 731, 1197, 1311, 1335, 2022, 2572, 2628, 2917, 3729], 'that': [47, 161, 233, 347, 732, 937, 972, 1090, 1166, 1187, 1198, 1217, 1312, 1336, 1379, 1397, 2023, 2156, 2182, 2197, 2217, 2629, 2803, 2918, 2937, 3216, 3532], 'inhibition': [48, 234, 1321, 2049, 2481, 2514, 2690], 'proteasome': [51, 237, 979, 1323, 2051, 2148, 2484, 2516, 2530, 2692, 3460, 3809, 4002], '(a)': [52, 238], 'decreases': [53, 239], 'rate': [55, 80, 166, 179, 241, 266, 352, 365, 515, 1345, 1362, 1391, 2297, 2495, 2774, 2814, 3526, 3558], 'Mcl-1': [57, 82, 90, 115, 123, 134, 153, 181, 243, 268, 276, 301, 309, 320, 339, 367, 742, 806, 815, 923, 1109, 1158, 1301, 1326, 1339, 1358, 1418, 1937, 2016, 2024, 2061, 2084, 2097, 2155, 2203, 2231, 2511, 2624, 2686, 2705, 2744, 2768, 2795, 2808, 2822, 2858, 2880, 2915, 2923, 3276, 3385, 3419, 3456, 3487, 3514, 3528, 3542, 3556, 3588, 3639, 3654, 3891, 3944, 4041, 4060, 4072, 4134, 4171, 4197], 'within': [59, 245, 622, 807, 1318, 2029, 2034, 2190, 3117], '(b)': [62, 248], 'significantly': [63, 131, 249, 317, 2158, 2390, 2467, 2492, 3805], 'delays': [64, 250, 2532], 'This': [66, 252, 527, 1766, 3195], 'led': [67, 253, 1290], 'us': [68, 254, 1291], 'to': [69, 87, 255, 273, 383, 510, 533, 541, 637, 681, 686, 694, 710, 1032, 1169, 1178, 1190, 1292, 1305, 1586, 1715, 1738, 1908, 1995, 2113, 2392, 2474, 2696, 2778, 2851, 2932, 3150, 3265, 3333, 3353, 3374, 3379, 3394, 3422, 3531, 3863, 3870, 3953, 4039, 4177], 'determine': [70, 256, 2697, 2933, 3266, 3864, 4178], 'whether': [71, 257, 2048, 2285, 2698, 3267, 3865, 4179], 'GM-CSF': [72, 86, 258, 272, 1199, 1218, 1286, 1298, 1337, 1473, 1634, 2133, 2466, 2552, 2604, 2620, 2630, 2699, 2791, 2804, 2843, 2912, 2919, 2953, 3108, 3187, 3246, 3289, 3331, 3381, 3404, 3544, 3610, 3683, 3708, 3763, 3802, 3819, 3852, 3905, 4098, 4214], 'could': [73, 259, 707, 1299, 2700, 3803, 4188], 'enhance': [74, 260], 'neutrophil': [75, 168, 261, 354, 620, 703, 721, 733, 1330, 1370, 1381, 2001, 2218, 2302, 2526, 2533, 3755, 3854], 'survival': [76, 262, 621, 1164, 1181, 1382, 2222], 'altering': [78, 264, 2294, 2715], 'turnover.': [83, 269, 1171, 3473, 4042, 4073], 'Addition': [84, 270], 'enhanced': [89, 275, 3384], 'stability': [91, 116, 154, 277, 302, 340, 2717, 2793, 2823, 2924, 3386, 3539, 3585, 4198], 'delayed': [93, 279, 519, 1306, 1329], 'signaling': [96, 172, 282, 358, 1349, 2935, 2943, 3256, 3372, 3382, 3766], 'pathways': [97, 107, 283, 293, 1350, 2936, 3257], 'requiring': [98, 284, 1351], 'PI3K/Akt': [99, 285], 'p44/42': [101, 287, 1486, 1940], 'Erk/Mek,': [102, 288], 'because': [103, 289, 390, 2031, 2205, 2769], 'inhibitors': [104, 290, 3373, 4003, 4187], 'these': [106, 156, 292, 342, 1269, 2179, 2183, 2307, 2783, 3270, 3521, 3765, 3857, 3947, 4045], 'completely': [108, 294, 3508, 3846], 'abrogated': [109, 295, 3509, 3847], 'GM-CSF-mediated': [111, 297, 3511, 3584, 4194], 'effect': [112, 151, 298, 337, 2055, 2300, 2523, 3481, 3817, 3829, 3833, 3876, 3889, 3942, 4191], 'on': [113, 152, 299, 338, 565, 738, 1970, 1989, 2015, 2056, 2226, 2301, 2524, 2621, 2954, 3482, 3555, 3830, 3834, 3853, 3877, 3890, 3943, 4170, 4192], 'both': [114, 133, 300, 319, 817, 1103, 1206], 'delay.': [119, 305], 'Conversely,': [120, 306], 'induction': [121, 307, 770], 'hyperphosphorylation': [124, 310, 4180], 'phosphatase': [127, 313, 1429, 1664, 1884, 4186], 'inhibitor,': [128, 141, 147, 314, 327, 333], 'okadaic': [129, 315, 1657], 'acid,': [130, 316, 1427, 1658], 'accelerated': [132, 318, 1360, 1369], 'Neither': [138, 324], 'calpain': [140, 326, 3914, 4107], 'carbobenzoxy-valinyl-phenylalaninal,': [142, 328], 'nor': [143, 329, 4056], 'pan': [145, 331, 3883, 4114], 'caspase': [146, 332, 3884, 4115], 'benzyloxycarbonyl-VAD-fluoromethylketone,': [148, 334], 'had': [149, 335, 2053, 2079, 2298, 2520, 3420, 3479, 3827, 3874, 3887, 3940], 'any': [150, 336, 2054, 2076, 2299, 2351, 3268, 3875, 4190], 'under': [155, 341, 3946], 'conditions.': [157, 343, 3949], 'These': [158, 344, 1172, 1288, 1372, 2192, 2799, 3248], 'observations': [159, 345, 1289, 4046], 'indicate': [160, 346, 2802, 4047], 'profound': [162, 348], 'changes': [163, 176, 349, 362, 564, 1270, 1280, 1387, 2168, 3168, 3540, 3751], 'following': [170, 356, 1285, 1641, 3107, 3245, 3543], 'cytokine': [171, 357], 'occur': [173, 359], 'dynamic': [175, 361, 1402], 'proteasome.': [185, 371, 2044], 'circulation': [381], '(estimated': [382], 'be': [384, 1033, 1384, 1739, 2779], 'between': [385, 1034], '12': [386], '18': [388], 'h)': [389], 'they': [391, 521], 'constitutively': [392], 'undergo': [393], '(1Akgul': [395, 2959], 'A.C.': [396, 2960], 'Moulding': [397, 455, 890, 1007, 1550, 2234, 2961], 'D.A.': [398, 456, 744, 891, 1008, 1048, 1231, 1551, 1748, 1917, 2235, 2252, 2424, 2641, 2962], 'Edwards': [399, 439, 749, 1011, 1055, 1238, 1254, 1558, 1574, 1757, 1920, 2257, 2410, 2431, 2648, 2664, 2963], 'S.W.': [400, 440, 454, 649, 666, 750, 889, 1012, 1056, 1239, 1255, 1559, 1575, 1758, 1921, 2233, 2258, 2411, 2432, 2649, 2665, 2964], 'FEBS': [401, 1013, 2965], 'Lett.': [402, 1014, 2966], '2001;': [403, 1060, 1243, 2653, 2967, 2986, 3008, 3048, 3079], '487:': [404, 2968], '318-322Crossref': [405, 2969], 'PubMed': [406, 432, 448, 467, 495, 598, 613, 660, 755, 799, 902, 1000, 1018, 1077, 1124, 1135, 1263, 1565, 1580, 1763, 1783, 1928, 2246, 2263, 2418, 2437, 2458, 2673, 2970, 3011, 3037, 3051, 3082, 3935, 3974, 3995, 4025], 'Scopus': [407, 433, 449, 468, 496, 599, 614, 661, 800, 903, 1001, 1019, 1078, 1125, 1264, 1566, 1784, 1929, 2247, 2419, 2438, 2459, 2674, 2971, 3012, 3038, 3052, 3083, 3936, 3975, 3996, 4026], '(400)': [408, 2972], 'Google': [409, 435, 451, 470, 498, 601, 616, 663, 678, 756, 802, 905, 921, 1003, 1021, 1063, 1080, 1127, 1136, 1156, 1246, 1266, 1568, 1581, 1764, 1786, 1931, 2249, 2264, 2280, 2421, 2440, 2461, 2656, 2676, 2973, 3014, 3040, 3054, 3085, 3938, 3977, 3998, 4028], 'Scholar,': [410, 436, 452, 471, 602, 664, 906, 1004, 1064, 1128, 1137, 1247, 1569, 2250, 2265, 2422, 2441, 2657, 2974, 2989, 3015, 3041, 3055, 3978], '2Ward': [411], 'I.': [412, 414, 418, 481, 2978], 'Dransfield': [413, 480, 2977], 'Chilvers': [415], 'E.R.': [416], 'Haslett': [417, 588, 605, 2450, 2979], 'Rossi': [419, 2981], 'A.G.': [420, 1573, 2982], 'Trends': [421], 'Pharmacol.': [422], 'Sci.': [423, 444, 491, 792, 993, 1259, 1778, 2669], '1999;': [424, 1132, 1925], '20:': [425], '503-509Abstract': [426], 'Full': [427, 429, 595, 657, 3971], 'Text': [428, 430, 596, 658, 3972], 'PDF': [431, 597, 659, 3973], '(162)': [434], '3Akgul': [437], 'C.': [438, 473, 589, 606, 1006, 1050, 1233, 1249, 2451, 2643, 2659, 2980, 2995, 3918], 'Cell.': [441, 1256, 2666], 'Mol.': [442, 1257, 2667], 'Life': [443, 1258, 2668], '2003;': [445, 464, 899, 1562, 2243], '60:': [446], '2402-2408Crossref': [447], '(69)': [450], '4Edwards': [453], 'Derouet': [457, 892, 1051, 1234, 2236, 2644], 'M.': [458, 479, 893, 1052, 1147, 1235, 2237, 2645, 3001, 3920, 3926], 'Moots': [459, 894, 1554, 2238], 'R.J.': [460, 895, 1555, 2239], 'Chem.': [461, 896, 2240, 2985], 'Immunol.': [462, 590, 652, 897, 1561, 2241, 3007, 3033, 3078], 'Allergy.': [463, 898, 2242], '83:': [465, 900, 1781, 2244], '204-224Crossref': [466, 901, 2245], '(37)': [469, 904, 2248], '5Haslett': [472], 'Savill': [474, 2444], 'J.S.': [475], 'Whyte': [476], 'M.K.': [477], 'Stern': [478], 'Meagher': [482, 2446], 'L.C.': [483, 2447], 'Philos.': [484], 'Trans.': [485], 'R.': [486, 1143, 3025, 3067, 3069], 'Soc.': [487], 'Lond.': [488], 'B.': [489, 3059], 'Biol.': [490, 609, 917, 1059, 1073, 1242, 1924, 2276, 2454, 2652, 2984], '1994;': [492, 1153], '345:': [493], '327-333Crossref': [494], '(208)': [497], 'Scholar).': [499, 617, 679, 803, 922, 1022, 1081, 1157, 1267, 1582, 1932, 2462, 2677, 3086], 'However,': [500, 618, 1268, 2678, 3160, 3234, 3950], 'if': [501, 632], 'cells': [503, 581, 634, 778, 1183, 1319, 1590, 1722, 1829, 1860, 2030, 2092, 2337, 2358, 2473, 3671, 3781, 3796, 3894], 'are': [504, 635, 809, 1112, 1116, 1188, 2573, 2899, 3349, 3692, 3730, 4142], 'recruited': [505], 'into': [506], 'tissues': [507, 623], 'exposed': [509, 1972], 'proinflammatory': [511, 1202], 'cytokines,': [512], 'then': [513, 554, 2283, 2561, 2930, 3148, 3642, 3861, 4175], 'their': [514, 544, 639, 3377, 4037], 'is': [518, 553, 692, 735, 924, 951, 1030, 1159, 1167, 2128, 2204, 2223, 3589], 'survive': [522, 534], 'for': [523, 535, 556, 574, 716, 975, 1375, 1892, 2040, 2069, 2105, 2143, 2315, 2538, 3143, 3308, 3376, 3598, 4050, 4087], 'much': [524, 953], 'longer': [525], 'periods.': [526], 'allows': [531], 'sufficient': [537], 'period': [538], 'time': [540, 2740, 2847, 2886, 3294, 3426, 4157], 'efficiently': [542], 'perform': [543], 'function': [545, 2052, 2517, 2531, 3810, 3871], 'host': [547], 'defense.': [548], 'Subsequent': [549], 'necessary': [555, 2931, 3264, 3862], 'successful': [558], 'resolution': [559, 687], 'inflammation,': [561], 'molecular': [563, 697, 935], 'cell': [567, 1042, 1405, 2219], 'surface': [568], 'apoptotic': [570, 2319, 2336, 2360, 2472, 2585, 3783], 'target': [572, 973, 2038], 'them': [573], 'phagocytosis': [575], 'tissue': [577, 630], 'macrophages': [578], 'or': [579, 2174, 2327, 2370, 2545, 2555, 2568, 2840, 3097, 3300, 3572, 3600, 3620, 3635, 3725, 3790, 3902, 4069, 4081, 4094, 4128], 'endothelial': [580], '(6Savill': [582], 'J.': [583, 604, 915, 1057, 1071, 1151, 1240, 1560, 1776, 1922, 2274, 2413, 2445, 2452, 2650, 2983, 3006, 3032, 3047, 3077, 4019], 'Fadok': [584], 'V.': [585, 3045], 'Henson': [586], 'P.': [587, 786, 987], 'Today.': [591, 653], '1993;': [592, 796, 997], '14:': [593], '131-136Abstract': [594], '(981)': [600], '7Savill': [603], 'Semin.': [607], 'Cell': [608, 1072, 1497, 3990], '1995;': [610, 1074, 3968], '6:': [611], '385-393Crossref': [612], '(178)': [615], 'extended': [619], 'result': [625], 'persistent': [627], 'inflammation': [628, 690], 'damage': [631], 'stimulated': [636], 'secrete': [638], 'cytotoxic': [640], 'molecules,': [641], 'reactive': [644], 'oxidants': [645], 'proteases': [647], '(8Edwards': [648], 'Hallett': [650], 'M.B.': [651], '1997;': [654, 2455, 3932], '18:': [655], '320-324Abstract': [656], '(303)': [662], '9Edwards': [665], 'Biochemistry': [667], 'Physiology': [669], 'Neutrophil.': [672], 'Cambridge': [673], 'University': [674], 'Press,': [675], 'New': [676], 'York1994Crossref': [677], 'Therefore,': [680], 'understand': [682], 'processes': [684, 1295, 3868], 'leading': [685, 1304], 'acute': [689, 1191], 'it': [691, 939, 974, 1091, 1175, 2039, 2928, 3262], 'important': [693], 'identify': [695], 'mechanisms': [698], 'which': [700, 719, 1102, 1297], 'cytokines': [701, 1203], 'Such': [705], 'information': [706], 'perhaps': [708], 'lead': [709], 'development': [712], 'new': [714], 'therapies': [715], 'diseases': [717], 'impaired': [720], 'plays': [723, 1398], 'underlying': [725], 'role': [726, 1403, 3273, 4049], 'pathology.We': [728], 'previously': [730, 1196, 2405, 2627], 'critically': [736, 2224], 'dependent': [737, 2225], '(10Moulding': [743], 'Quayle': [745, 2253, 2425], 'J.A.': [746, 2254, 2426, 3021], 'Hart': [747, 1918, 2255, 2408, 2429], 'C.A.': [748, 1919, 2256, 2409, 2430], 'Blood.': [751, 1576, 1759, 2259], '1998;': [752, 2260, 3992], '92:': [753, 2261, 2416], '2495-2502Crossref': [754, 2262], 'Scholar),': [757, 2281], 'first': [765, 1377], 'identified': [766], 'early': [769], 'gene': [771, 1224], 'expressed': [772], 'during': [773], 'differentiation': [774], 'ML-1': [776], 'myeloid': [777], '(11Kozopas': [779, 980], 'K.M.': [780, 981, 1068, 3043], 'Yang': [781, 982], 'T.': [782, 983, 1066, 2993, 3984, 4010, 4014], 'Buchan': [783, 984], 'H.L.': [784, 985], 'Zhou': [785, 986, 2996], 'Craig': [787, 988, 1069], 'R.W.': [788, 989, 1070, 1119], 'Proc.': [789, 990], 'Natl.': [790, 991], 'Acad.': [791, 992], 'U.': [793, 994], 'S.': [794, 995, 1139, 1141, 3005, 3076, 4006, 4016], 'A.': [795, 912, 996, 2271, 2449, 3029, 3982, 4018], '90:': [797, 998], '3516-3520Crossref': [798, 999], '(873)': [801, 1002], 'Levels': [804, 2017, 2095, 2894, 3087, 3135, 3687, 4132], 'cytokine-regulated,': [810], 'antisense': [812], 'disruption': [813], 'accelerates': [816], 'constitutive': [818], '1The': [824], 'abbreviations': [825, 856], 'used': [826, 857, 1935, 1952], 'are:': [827, 858], 'GM-CSF,': [828, 859, 2754, 3452], 'factor;': [831, 862], 'MAPK,': [832, 863, 1944, 3092], 'mitogen-activated': [833, 841, 864, 872], 'kinase;': [835, 839, 846, 866, 870, 877], 'Erk,': [836, 867, 3312], 'extracellular': [837, 868], 'signal-regulated': [838, 844, 869, 875], 'Mek,': [840, 871], 'kinase/extracellular': [843, 874], 'kinase': [845, 876, 1353, 3255, 3570, 3578], 'Z-VAD-fmk,': [847, 878, 1697], 'benzyloxycarbonyl-VAD-fluoromethyl': [848, 879], 'ketone;': [849, 880], 'FITC,': [850, 881], 'fluorescein': [851, 882], 'isothiocyanate;': [852, 883], 'PI3K,': [853, 884], 'phosphatidylinositol': [854, 885], '3-kinase.1The': [855], '3-kinase.-regulated': [886], '(4Edwards': [888, 2232], '12Leuenroth': [907, 2266], 'S.J.': [908, 2267], 'Grutkoski': [909, 2268], 'P.S.': [910, 2269], 'Ayala': [911, 2270], 'Simms': [913, 2272], 'H.H.': [914, 2273], 'Leukocyte': [916, 1058, 1241, 1923, 2275, 2453, 2651], '2000;': [918, 1015, 1260, 1760, 2277, 2670, 3034], '68:': [919, 2278], '158-166PubMed': [920, 2279], 'unusual': [926], 'member': [927], 'has': [933, 2021, 2025, 2402], 'some': [934], 'properties': [936, 1173], 'distinguish': [938], 'from': [940, 1415, 1423, 1459, 1471, 1475, 1482, 1496, 1508, 1515, 1522, 1536, 1540, 1793, 3210, 4153], 'other': [942, 957, 970, 1201, 1771, 3866], 'well': [943, 1769], 'characterized': [944], 'members,': [946], 'Bcl-X.': [949], 'It': [950], 'larger': [954], 'than': [956, 2160], 'members': [959], '(40/42': [960], 'kDa),': [961], 'its': [963, 1344, 1361, 2207, 2295, 2716, 2771, 2813], 'N-terminal': [964], 'region': [965], 'contains': [966], 'PEST': [967, 2032], 'sequences': [968, 2033], 'motifs': [971], '13Akgul': [1005], 'White': [1009, 1053, 1236, 1252, 1556, 1753, 2646, 2662], 'M.R.': [1010, 1054, 1237, 1253, 1557, 1754, 2647, 2663], '478:': [1016], '72-76Crossref': [1017], '(83)': [1020], 'Indeed,': [1023], 'mature': [1028], 'estimated': [1031, 2777], '2': [1035, 3409, 3601, 3657], '3': [1037, 2070, 2106, 2144, 3118, 4088], 'h,': [1038, 2853], 'depending': [1039], 'upon': [1040], 'type': [1043], 'culture': [1045, 1794, 3224], 'conditions': [1046], '(14Moulding': [1047, 1230, 2640], 'Akgul': [1049, 1232, 2642], '70:': [1061, 1244, 2654], '783-792PubMed': [1062, 1245, 2655], '15Yang': [1065], 'Kozopas': [1067], '128:': [1075], '1173-1184Crossref': [1076], '(270)': [1079], 'Further,': [1082], 'molecule': [1084, 1396], 'lacks': [1085], 'BH4': [1087], 'domain,': [1088], 'indicating': [1089, 2119, 2181, 3430, 3471], 'must': [1092], 'interact': [1093], 'different': [1095, 3211], 'proteins': [1096, 2186, 4182], 'compared': [1097, 1278, 2085, 3681], 'Bcl-X,': [1101], 'contain': [1104], 'motif.': [1106], 'Transcription': [1107], 'independently': [1113], 'regulated': [1114], 'tissue-specific': [1117], '(16Craig': [1118], 'Leukemia.': [1120], '2002;': [1121], '16:': [1122], '444-454Crossref': [1123], '(255)': [1126], '17Johnson': [1129], 'A.L.': [1130], 'Endocrinology.': [1131], '140:': [1133], '5465-5468Crossref': [1134], '18Krajewski': [1138], 'Bodrug': [1140], 'Gascoyne': [1142], 'Berean': [1144], 'K.': [1145, 2991, 3063, 3980, 4008, 4012], 'Krajewska': [1146], 'Reed': [1148], 'J.C.': [1149], 'Am.': [1150], 'Pathol.': [1152], '145:': [1154], '515-525PubMed': [1155], 'thus': [1160], 'rapidly': [1162, 1862, 3105], 'induced': [1163], 'subject': [1168, 1189], 'make': [1174], 'ideally': [1176], 'suited': [1177], 'dynamically': [1179], 'regulate': [1180, 1300], 'regulation': [1192], 'function.We': [1194], 'up-regulate': [1205], 'mRNA': [1209, 1274, 2638], 'mcl-1': [1212], 'human': [1214, 1463, 1601, 2065, 2926], 'stimulate': [1220, 2632], 'transcription': [1221, 1272, 2634], 'luciferase': [1227], 'reporter': [1228], 'assay': [1229], '19Akgul': [1248, 2658], 'Turner': [1250, 2660], 'P.C.': [1251, 2661], '57:': [1261, 2671], '684-691Crossref': [1262, 2672], '(95)': [1265, 2675], 'were': [1276, 1414, 1458, 1470, 1495, 1507, 1534, 1591, 1620, 1643, 1723, 1791, 1830, 1855, 1861, 1912, 1953, 1963, 2004, 2098, 2157, 2176, 2187, 2310, 2536, 2722, 2745, 2828, 2855, 2860, 3095, 3141, 3286, 3306, 3321, 3342, 3365, 3390, 3468, 3559, 3596, 3641, 3697, 3757, 3782, 3797, 3895, 4075, 4102, 4135, 4204], 'small': [1277], 'seen': [1284, 3202, 3238, 3244], 'treatment.': [1287, 3247], 're-examine': [1293], 'Here,': [1308], 'manipulation': [1313, 2286], '(by': [1320], 'function)': [1324], 'stabilized': [1325], 'We': [1332, 2045], 'also': [1334, 1644, 2491, 2501, 2900, 3343, 3693, 4103], 'decreasing': [1343, 2812], 'phosphatidylinositol-3': [1352], 'ERK/MEK.': [1355], 'Hyperphosphorylation': [1356], 'greatly': [1359, 2080, 2921], 'and,': [1365], 'parallel,': [1367], 'considerably': [1368], 'data': [1373, 2876, 3504, 3741, 3843], 'show,': [1374], 'time,': [1378], 'cytokine-mediated': [1380], 'controlled': [1385, 2938], 'labile': [1395], 'critical': [1400], 'survival.EXPERIMENTAL': [1406], 'PROCEDURESMaterials—RPMI': [1407], '1640': [1408, 1595], 'medium': [1409, 1596], 'fetal': [1411], 'calf': [1412], 'serum': [1413, 1604], 'Invitrogen.': [1416], 'Anti-human': [1417], 'monoclonal': [1419], 'antibody': [1420], '(13656E)': [1421], 'was': [1422, 1474, 1481, 1514, 1521, 1610, 1635, 1712, 1978, 1993, 2381, 2389, 2560, 2796, 2929, 3200, 3242, 3263, 3457, 3462, 3529, 3613, 3717, 3811, 3820, 3860], 'BD': [1424], 'PharMingen.': [1425], 'Okadaic': [1426], 'cypermethrin,': [1428, 1661], 'inhibitor': [1430, 1665, 1885, 2149, 2489, 3567, 3575, 3825, 3885, 3915, 4108, 4116], 'mixture': [1431, 1666], 'set': [1432, 1886], 'II': [1433, 1887], '(imidazole,': [1434], 'sodium': [1435, 1437, 1439, 1441], 'fluoride,': [1436], 'molybdate,': [1438], 'orthovanadate,': [1440], 'tartrate': [1442], 'dihydrate),': [1443], 'MG-132,': [1444, 1654, 3465], 'PD98059,': [1445], 'SB202190,': [1446, 1674], 'H-89,': [1447, 1680], 'GF203109X,': [1448, 1686], 'wortmannin,': [1449, 1677], 'ALLN': [1450, 3951, 4121], '(N-acetyl-luecinylleucinyl-norleucinal),': [1451], 'MDL': [1452], '28170': [1453], '(carbobenzoxy-valinyl-phenylalaninal),': [1454], 'lactacystin,': [1455, 1700], 'Z-VAD-fmk': [1457, 4117], 'Calbiochem.': [1460], 'Cycloheximide,': [1461], 'pooled': [1462, 1600], 'AB': [1464, 1603], 'serum,': [1465], 'sheep': [1467], 'anti-mouse': [1468], 'IgG': [1469, 1501, 1513, 1956], 'Sigma-Aldrich.': [1472], 'Roche': [1476], 'Applied': [1477], 'Science.': [1478], 'FITC-annexin': [1479, 2564, 3721], 'V': [1480, 1799, 1840, 2325, 2366, 2565, 3722, 3788], 'BIOSOURCE': [1483], 'Int.': [1484], 'Anti-phospho': [1485], 'Thr202/Tyr204': [1487], '(ERK1/2),': [1488], 'anti-phospho': [1489, 1492, 1939, 1942, 1945], 'p38-MAPK': [1490, 3128, 3164, 3177, 3217, 3337, 3340, 3478, 3824], 'Thr180/Tyr182,': [1491], 'Akt': [1493, 3094, 3115, 3140, 3315], 'Ser463': [1494], 'Signaling.': [1498], 'Donkey': [1499, 1511], 'anti-rabbit': [1500, 1955], 'ECL': [1504, 1967], 'detection': [1505], 'kit': [1506], 'Amersham': [1509], 'Biosciences.': [1510], 'anti-goat': [1512, 1959], 'Santa': [1516], 'Cruz': [1517], 'Biotechnology': [1518], 'Inc.': [1519], 'Polymorphprep': [1520, 1547], 'Robbins': [1523], 'Scientific': [1524], '(Europe)': [1525], 'Ltd.,': [1526], 'Solihull,': [1527], 'UK.Isolation,': [1528], 'Purification,': [1529], 'Incubation': [1531], 'Neutrophils—Neutrophils': [1533], 'isolated': [1535, 2091, 2165, 2332, 3209, 3670], 'heparinized': [1537], 'venous': [1538], 'blood': [1539], 'healthy': [1541], 'volunteers': [1542], 'one-step': [1544], 'centrifugation': [1545], 'through': [1546, 3591], '(20Fossati': [1548], 'G.': [1549], 'Spiller': [1552, 1751], 'D.G.': [1553, 1752], '170:': [1563], '1964-1972Crossref': [1564], '(250)': [1567], '21Gasmi': [1570], 'L.': [1571], 'McLennan': [1572], '1996;': [1577, 2415, 2434], '87:': [1578], '3442-3449Crossref': [1579], 'After': [1583, 1823, 3171, 3408, 3711, 3768], 'hypotonic': [1584], 'lysis': [1585], 'remove': [1587], 'contaminating': [1588], 'erythrocytes,': [1589], 'resuspended': [1592, 1796, 1837], 'RPMI': [1594, 1719], 'supplemented': [1597], '5%': [1599], 'male': [1602], 'at': [1605, 1611, 1637, 1819, 1832, 1900, 2587, 2739, 2885, 3239, 3292, 4156], '5': [1606, 1681, 1893, 3154, 3192], '×': [1607, 1834], '106/ml.': [1608], 'Culture': [1609], '37': [1612], '°C': [1613, 1902], 'gentle': [1615], 'agitation.': [1616], 'Purity': [1617], 'viability': [1619], 'routinely': [1621], 'above': [1622], '95%': [1623], 'assessed': [1625, 2322, 3785], 'May-Grünwald-Giemsa': [1627], 'staining': [1628, 1733], 'trypan': [1630], 'blue': [1631], 'exclusion,': [1632], 'respectively.': [1633], 'added': [1636, 2077, 3614], '50': [1638, 1655, 1672, 1698, 3625, 3629, 4119], 'ng/ml.': [1639], 'The': [1640, 1947, 2130, 2463, 3538, 3823, 3882], 'additions': [1642], 'made': [1645, 1713], 'indicated': [1647, 3215, 3296, 3616, 3740], 'text:': [1650], 'cycloheximide,': [1651, 2387, 3777], '10': [1652, 1684, 1824, 2601], 'μg/ml;': [1653], 'μm;': [1656, 1660, 1663, 1673, 1676, 1682, 1685, 1691, 1696, 1699], '1': [1659, 1662, 1675, 1695, 3633, 4111], 'II,': [1667], '1:100': [1668, 1821], 'dilution;': [1669], 'PD': [1670], '98059,': [1671], '20': [1678], 'nm,': [1679], 'LY294002,': [1683, 3503, 3842], '200': [1687, 1716], 'nm;': [1688], 'ALLN,': [1689], '100': [1690], 'carbobenzoxy-valinyl-phenylalaninal': [1692, 3916], '(MDL': [1693], '2810),': [1694], '40': [1701, 4126], 'μm.Morphological': [1702], 'Estimation': [1703], 'Apoptosis—Following': [1705], 'culture,': [1706, 1858], '20-μl': [1708], 'aliquot': [1709], 'suspension': [1711], 'up': [1714, 2850], 'μl': [1717], '1640,': [1720], 'cytocentrifuged': [1724], 'using': [1725, 1848, 1965, 2006], 'Shandon': [1727], 'Cytospin3': [1728], '(Runcorn,': [1729], 'Cheshire,': [1730], 'UK).': [1731], 'Romanowsky': [1732], 'cytospins': [1735, 2581], 'allowed': [1736], 'scored': [1740], 'morphology': [1742, 2372, 2569, 2586, 3726, 3791], 'described': [1744, 1915], 'Ref.': [1746], '22Moulding': [1747], 'Giles': [1749], 'R.V.': [1750], 'Tidd': [1755], 'D.M.': [1756], '96:': [1761], '1756-1763Crossref': [1762], 'Scholar.': [1765], 'method': [1767], 'correlates': [1768], 'markers': [1772], '(23Savill': [1775], 'Clin.': [1777], '(Lond.).': [1779], '1992;': [1780], '649-655Crossref': [1782], '(48)': [1785], 'Scholar).Annexin': [1787], 'V-FITC': [1788, 1818], 'Staining—Neutrophils': [1789], '(106)': [1790], 'removed': [1792, 2856], 'Annexin': [1798], 'binding': [1800, 1841, 2326, 2367, 2566, 3723, 3789], 'buffer': [1801, 1842, 1869], '(10': [1802, 1878, 2549, 2835, 3608, 4085], 'mm': [1803, 1808, 1811], 'Hepes,': [1804], 'pH': [1805], '7.4,': [1806], '140': [1807], 'NaCl,': [1809], '2.5': [1810], 'CaCl2),': [1812], 'before': [1813, 1843], 'addition': [1815, 2131, 2385, 2464, 3121, 3563], 'annexin': [1817, 1839, 2324, 2365, 3787], 'dilution.': [1822], 'min': [1825, 1894, 3119, 3132, 3146], 'dark,': [1828], 'pelleted': [1831], '400': [1833], 'g': [1835], 'analysis': [1844], 'flow': [1846, 1851], 'cytometry': [1847], 'Coulter-EpicsAltra': [1850], 'cytometer.': [1852], '10000': [1853], 'cells/sample': [1854], 'analyzed.Western': [1856], 'Analysis—Following': [1857], '106': [1859], 'lysed': [1863], 'boiling': [1865], 'reducing': [1866], 'SDS-PAGE': [1867, 1905], 'sample': [1868], 'containing': [1870], 'aprotinin': [1871], '(20': [1872, 1875], 'μg/ml),': [1873, 1876, 1879, 1883], 'leupeptin': [1874], 'pepstatin': [1877], 'phenylmethylsulfonyl': [1880], 'fluoride': [1881], '(400': [1882], '(1:100': [1888], 'dilution),': [1889], 'immediately': [1890], 'boiled': [1891], 'occasional': [1896], 'vortexing,': [1897], 'stored': [1899], '–80': [1901], 'until': [1903], 'use.': [1904], 'electrotransfer': [1907, 1992], 'polyvinylidene': [1909], 'difluoride': [1910], 'membranes': [1911, 1990], 'performed': [1913, 1979], '(24Moulding': [1916], '65:': [1926], '875-882Crossref': [1927], '(40)': [1930], 'Primary': [1933], 'antibodies': [1934, 1962], 'were:': [1936], '(13656E),': [1938], '(ERK),': [1941], 'p38': [1943, 3091], 'Akt.': [1946], 'horseradish': [1948], 'peroxidase-conjugated': [1949], 'secondary': [1950], 'antisera': [1951], 'donkey': [1954, 1958], 'IgG.': [1960], 'Bound': [1961], 'detected': [1964, 2088, 2162, 2861], 'system.': [1968], 'Densitometry': [1969], 'carefully': [1971], 'blots': [1973], '(to': [1974], 'avoid': [1975], 'film': [1976], 'saturation)': [1977], 'Image': [1981, 2612, 2903, 3358, 3744, 4160], '1.44': [1982], 'VDM': [1983], 'software': [1984], '(NIH).': [1985], 'Ponceau': [1986], 'S-stained': [1987], 'actin': [1988, 2175, 2896, 3689], 'after': [1991, 2590, 2689, 3156, 3186, 3561, 3656], 'measured': [1994, 2562, 3344, 3533, 3643, 3663, 3718], 'confirm': [1996, 2194, 3250], 'equivalence': [1997], 'loading': [1999], 'samples.Statistics—Data': [2002], 'sets': [2003], 'analyzed': [2005, 3307], 'paired': [2008], "Student's": [2009], 't': [2010], 'test.RESULTSEffects': [2011], 'Proteasome': [2013], 'Inhibition': [2014], 'Apoptosis—Previous': [2019], 'work': [2020], 'may': [2037], 'proteolysis': [2041], 'therefore': [2046, 3366], 'tested': [2047, 2284, 2311], 'neutrophils.': [2066, 2191, 2499, 2826], 'Neutrophils': [2067, 2304, 2535, 2721, 2827, 3285, 3595, 4074, 4203], 'incubated': [2068, 2104, 2305, 2537, 2829, 3287, 3322, 3391, 3597, 3698, 3896, 4076, 4104, 4205], 'h': [2071, 2107, 2145, 2344, 2540, 2589, 2781, 3155, 3185, 3193, 3223, 3241, 3410, 3602, 3658, 3713, 3770, 4089], '(in': [2072], 'absence': [2074, 2349, 2543, 2734, 2752, 2839, 3231, 3328, 3402, 3438, 3619, 3701, 3901, 4079, 4092, 4210], 'agents)': [2078], 'decreased': [2081, 2468, 2493, 3178, 3421], 'freshly': [2090, 2164, 2331, 3669], '(Fig.': [2093, 2368, 2373, 2518, 2775, 3102, 3133, 3158, 3169, 3443, 3792, 3906], '1).': [2094], 'depleted': [2099], 'even': [2100, 3228, 3821], 'further': [2101], 'cultures': [2103], 'presence': [2110, 2546, 2736, 2789, 2832, 2841, 3325, 3400, 3450, 3519, 3605, 3621, 3704, 3761, 3775, 3903, 4082, 4095, 4212], 'cycloheximide': [2112, 2548, 2599, 2731, 2834, 3393, 3414, 3607, 3685, 3706, 3898, 4084, 4207], 'block': [2114, 3395], 'de': [2115, 2709, 2725, 2756, 3440], 'novo': [2116, 2710, 2726, 2757, 3441], 'biosynthesis,': [2118, 3801], 'when': [2126, 3459, 3795, 3808, 3893], 'biosynthesis': [2127, 2380, 2711, 2727, 2758, 3397, 3442], 'inhibited.': [2129], 'maintained': [2134, 3142], 'protein,': [2139], 'but': [2140, 2341, 2712, 3104, 3147, 3179, 4053, 4066], 'remarkably,': [2141], 'incubation': [2142, 2346, 2591, 2729, 3412, 3660, 3772], 'MG-132': [2150, 2490, 2500, 2556, 2608, 3623, 4031, 4129], 'resulted': [2151, 2759], 'greater': [2159], 'those': [2161], 'cells.': [2166, 3347], 'No': [2167, 3553], 'Bax': [2173], 'observed': [2177, 2688, 3560, 3758], 'experiments,': [2180], 'latter': [2184, 3522], 'two': [2185], 'relatively': [2188], 'stable': [2189], 'experiments': [2193, 2314, 2800, 3206, 3214, 3249], 'idea': [2196], 'proteasome.In': [2212], 'view': [2213, 2680], 'proposal': [2216], 'death': [2220], '10Moulding': [2251], 'same': [2308], 'agents': [2309], 'parallel': [2313, 2522], 'appearance': [2317, 2583], 'features': [2320, 2361], 'morphology.': [2328], 'Cultures': [2329], 'contained': [2334], 'no': [2335, 2596, 3480, 3888, 3941], '(data': [2338, 2506, 3580], 'not': [2339, 2507, 2706, 3505, 3581, 3844, 4054, 4067], 'shown),': [2340, 3506], '8': [2343, 2539, 2588, 3712, 3769], 'exogenous': [2352], 'agents,': [2353], 'over': [2354, 2393], '40%': [2355], 'exhibited': [2359], 'determined': [2363, 2746, 4136], '2A)': [2369], '2,': [2374], 'B': [2375], 'C).': [2377], 'When': [2378], 'blocked': [2382, 2723, 3463, 3798], 'increased': [2391, 2922, 3106, 3181, 3469], '75%': [2394], '(±10%,': [2395], 'n': [2396, 2477, 2576, 3675, 3733, 4145], '=': [2397, 2478, 2577, 3676, 3734, 4146], '5,': [2398, 3444], 'p': [2399, 3679, 3737], '<0.01)': [2400, 4152], 'been': [2403, 2946], 'reported': [2404], '(25Stringer': [2406], 'R.E.': [2407, 2428], 'Brit.': [2412], 'Haematol.': [2414], '169-175Crossref': [2417], '(64)': [2420], '26Moulding': [2423], 'Stringer': [2427], 'Biologicals.': [2433], '24:': [2435], '301-306Crossref': [2436], '(12)': [2439], '27Whyte': [2442], 'M.K.B.': [2443], 'Lee': [2448, 3965], '62:': [2456], '195-202Crossref': [2457], '(65)': [2460], 'number': [2470, 3252], '15%': [2475], '(±8%,': [2476], '5);': [2479], 'importantly,': [2480], 'use': [2486, 4184], 'prevented': [2502], 'activation': [2503, 3111, 3126, 3199, 3237, 3282], 'caspase-3': [2505], 'shown).': [2508], 'Thus,': [2509, 3516], 'preventing': [2510], '1)': [2519], 'delaying': [2525], 'apoptosis.Fig.': [2527], '2Inhibition': [2528], '(C)': [2544], 'μg/ml,': [2550], 'CHX),': [2551], '(50': [2553, 2557, 2605, 2609, 2844, 3290, 3611, 4099, 4130], 'ng/ml),': [2554], 'μm).': [2558, 4131], 'Apoptosis': [2559], '(A)': [2567, 3299, 4093], '(B).': [2570], 'Values': [2571, 3728, 4140], 'mean': [2574, 2875, 3652, 3731], '(±S.D.),': [2575, 3732], '5.': [2578, 3677, 3735], 'C,': [2579, 3319, 3695], 'representative': [2580, 2869, 3648], 'showing': [2582], 'follows:': [2593], '(i)': [2594], 'control,': [2595], 'additions;': [2597], '(ii)': [2598], '(CHX,': [2600], 'μg/ml);': [2602], '(iii)': [2603], 'ng/ml);': [2606, 3291], '(iv)': [2607], 'μm).View': [2610], 'Large': [2611, 2902, 3357, 3743, 4159], 'Figure': [2613, 2904, 3359, 3745, 4161], 'ViewerDownload': [2614, 2905, 3360, 3746, 4162], 'Hi-res': [2615, 2906, 3361, 3747, 4163], 'image': [2616, 2907, 3362, 3748, 4164], 'Download': [2617, 2908, 3363, 3749, 4165], '(PPT)Effects': [2618, 4166], 'Rates': [2622], 'Turnover—We': [2625, 4174], 'MCL-1': [2633], 'increase': [2636, 2701, 2807, 3485, 3512, 3586, 4195], 'striking': [2683], 'function,': [2693], 'decided': [2695], 'increasing': [2708], 'instead': [2713], 'GM-CSF;': [2738, 3260], 'intervals,': [2741], 'Western': [2748, 2863, 2870, 3317, 3645, 3649, 4138], 'blotting.': [2749, 2864, 3318, 3646, 4139], 'In': [2750, 2785, 3448, 3489, 3836], 'blocking': [2755, 3491], 'decrease': [2763, 4200], 'high': [2772], '3),': [2776], '∼2': [2780, 3184], 'experiments.': [2784, 2893], 'contrast,': [2786, 3490, 3837], 'dramatically': [2797], 'increased.': [2798], 'clearly': [2801], 'treatment': [2805, 2920, 3188], 'proteasome.Fig.': [2819], '3GM-CSF': [2820], 'cycloheximide-treated': [2825, 3858], 'μg/ml)': [2836, 4086], 'ng/ml).': [2845, 4100], 'At': [2846], 'periods': [2848], '4': [2852], 'samples': [2854, 3305], 'Upper': [2865], 'panel': [2866, 2873, 3370], 'shows': [2867, 2874], 'blot;': [2871], 'lower': [2872], '(±S.D.)': [2877], 'relative': [2879, 3653], '(taking': [2882], 'signal': [2884], '0': [2887, 3427, 3599], '100%)': [2889], 'five': [2891, 3354], 'separate': [2892, 3205, 3355], '(Western': [2897], 'blot)': [2898], 'shown.View': [2901], '(PPT)Signaling': [2909], 'Pathways': [2910], 'Regulating': [2911], 'Changes': [2913], 'Levels—Having': [2916], 'neutrophils,': [2927], 'phenomenon.': [2940], 'Several': [2941], 'intracellular': [2942], 'systems': [2944], 'implicated': [2947], 'mediating': [2949], 'effects': [2951, 3554, 3850], '28Martin': [2975], 'M.C.': [2976], '17:': [2987], '17Google': [2988], '29Suzuki': [2990], 'Hasegawa': [2992], 'Sakamoto': [2994], 'Y.M.': [2997], 'Hato': [2998], 'F.': [2999, 3061], 'Hino': [3000], 'Tatsumi': [3002], 'N.': [3003], 'Kitagawa': [3004], '166:': [3009, 3080], '1185-1192Crossref': [3010], '(51)': [3013], '30Klein': [3016], 'J.B.': [3017], 'Rane': [3018], 'M.J.': [3019], 'Scherzer': [3020], 'Coxon': [3022], 'P.Y.': [3023], 'Kettritz': [3024], 'Mathiesen': [3026], 'J.M.': [3027, 3988], 'Buridi': [3028], 'McLeish': [3030], 'K.R.': [3031], '164:': [3035], '4286-4291Crossref': [3036], '(246)': [3039], '31Schubert': [3042], 'Duronio': [3044], 'Biochem.': [3046], '356:': [3049], '473-480Crossref': [3050], '(67)': [3053], '32Epling-Burnette': [3056], 'P.K.': [3057], 'Zhong': [3058], 'Bai': [3060], 'Jiang': [3062], 'Bailey': [3064], 'R.D.': [3065], 'Garcia': [3066], 'Jove': [3068], 'Djeu': [3070], 'J.Y.': [3071], 'Loughran': [3072], 'Jr.,': [3073], 'T.P.': [3074], 'Wei': [3075], '7486-7495Crossref': [3081], '(169)': [3084], 'activated': [3089, 3137, 3163, 3176, 3220, 3258, 3311, 3336], 'Erk1/2,': [3090], 'low': [3096], 'undetectable': [3098], 'resting': [3100], '4)': [3103], 'exposure.': [3109], 'Maximal': [3110], 'Erk1/2': [3113, 3138], 'occurred': [3116, 3129], 'cytokine,': [3123], 'whereas': [3124], 'maximal': [3125], '7': [3131], '4A).': [3134], 'about': [3144], '30': [3145], 'declined': [3149], 'basal': [3151], 'stimulation': [3157], '4B).': [3159], 'showed': [3165, 4033], 'more': [3166], 'complex': [3167], '4C).': [3170], 'initial': [3172], 'stimulation,': [3173], 'transiently': [3180], 'again': [3182, 3190, 3429], 'poststimulation.': [3194], 'pattern': [3196], 'transient': [3198, 3236, 3281], 'consistently': [3201], 'seven': [3204], 'donors.': [3212], 'Control': [3213], 'became': [3218], 'slowly': [3219], '4–5': [3222], 'untreated': [3226], 'cells,': [3227], 'GM-CSF.': [3233], '2–3': [3240], 'only': [3243], 'putative': [3254], 'hence': [3261], 'played': [3271], 'regulating': [3275, 4059], 'stability.Fig.': [3277], '4GM-CSF': [3278], 'results': [3279], 'MAPKs.': [3284], 'intervals': [3295], '(short': [3297], 'term': [3298, 3302], 'long': [3301], '(B,': [3303], 'C),': [3304], 'p38-MAPK,': [3313], '(+)': [3326], '(–)': [3329], 'prior': [3332], 'measurement': [3334], 'levels.': [3338], 'Total': [3339], 'GM-CSF-treated': [3346], 'Results': [3348], 'typical': [3350], 'three': [3352], 'experiments.View': [3356], '(PPT)Neutrophils': [3364], 'treated': [3367, 3536], 'test': [3375], 'ability': [3378, 4038], 'affect': [3380], 'Cells': [3389, 4101], 'inhibitors.': [3407, 3767], 'alone,': [3415], '∼40%': [3423], 'levels,': [3428], 'A': [3445, 3908], 'B).': [3447, 3910], 'slowed;': [3458], 'activity': [3461, 3476], 'further,': [3470], 'negligible': [3472], 'Blocking': [3474], 'GM-CSF-dependent': [3484], 'stability.': [3488, 3515], 'activities': [3493], 'Erk/Mek': [3495, 3550, 3592], 'PI3K': [3497], 'PD98059': [3499, 3627, 3838], 'wortmannin': [3501, 3636, 3840], '(or': [3502, 3841], 'respectively,': [3507], 'inhibitors,': [3523], 'identical': [3530], 'cycloheximide-only': [3535], 'cultures.': [3537], 'exposure': [3545], 'require': [3546], 'signals': [3547], 'generated': [3548], 'PI3K/Akt.': [3552, 3594], 'H89': [3565], '(an': [3566, 3574], 'A)': [3571], 'GF203109X': [3573], 'C)': [3579], 'shown).Fig.': [3582], '5The': [3583], 'signaled': [3590], 'μg/ml).': [3609], 'ng/ml)': [3612], '(MG,': [3624], 'μm),': [3626, 3630, 3634, 4112, 4120, 4123, 4127], '(PD,': [3628], 'SB202190': [3631, 3826], '(SB,': [3632], '(Wort,': [3637], '20nm).': [3638], 'A,': [3647], 'blot.': [3650], 'B,': [3651], '(±': [3661], 'S.D.)': [3662], 'densitometry': [3665], '(the': [3666], 'value': [3667], 'taken': [3672], '100%),': [3674], '*,': [3678, 3736, 4148], '<0.02': [3680, 3738], 'plus': [3684], 'alone.': [3686], '(Ponceau-stained': [3690], 'filter)': [3691], 'shown.': [3694], '(Control)': [3702], 'indicated.': [3710], 'incubation,': [3715], 'either': [3720], '(□)': [3724], '().': [3727], 'sets.View': [3742], '(PPT)Parallel': [3750], 'rates': [3753], '∼80%': [3778], '5C).': [3793], 'Even': [3794], 'still': [3804], 'apoptosis;': [3807], 'inhibited': [3812], '(with': [3813], 'MG-132),': [3814], 'protective': [3816, 3849], 'greater.': [3822], 'little': [3828], 'GM-CSF-regulated': [3832], 'shown)': [3845], 'cells.It': [3859], 'proteolytic': [3867], 'known': [3869], 'Mcl-1.': [3881], 'Z-FAD-fmk': [3886], '6,': [3907], 'Similarly,': [3911], 'cell-permeable': [3913], '(33Fukiage': [3917], 'Azuma': [3919], 'Nakamura': [3921, 3925], 'Y.': [3922, 3924], 'Tamada': [3923], 'Shearer': [3927], 'T.R.': [3928], 'Biochim.': [3929], 'Biophys.': [3930], 'Acta.': [3931], '1361:': [3933], '304-312Crossref': [3934], '(75)': [3937], 'Scholar)': [3939, 3999, 4029], 'experimental': [3948], '(known': [3952], 'inhibit': [3954], 'calpains': [3955, 4055], 'proteasome)': [3958], '(34Murray': [3959], 'E.J.': [3960], 'Tram': [3961], 'K.K.': [3962], 'Murray': [3963], 'S.S.': [3964], 'D.B.': [3966], 'Metabolism.': [3967], '44:': [3969, 4023], '141-144Abstract': [3970], '(8)': [3976], '35Zen': [3979], 'Karsan': [3981], 'Eunson': [3983], 'Yee': [3985], 'E.': [3986], 'Harlan': [3987], 'Exp.': [3989], 'Res.': [3991], '243:': [3993], '425-433Crossref': [3994], '(31)': [3997], 'lactacystin': [4004, 4124], '(36Omura': [4005], 'Matsuzaki': [4007], 'Fujimoto': [4009], 'Kosuge': [4011], 'Fuzuya': [4013], 'Fujita': [4015], 'Nakagawa': [4017], 'Antibiot.': [4020], '(Tokyo).': [4021], '1991;': [4022], '117-118Crossref': [4024], '(298)': [4027], 'all': [4032], 'remarkable': [4034], 'similarities': [4035], 'prevent': [4040], 'Taken': [4043], 'together,': [4044], 'proteasome,': [4052, 4065], 'caspases,': [4057], 'neutrophils.Fig.': [4063], '6The': [4064], 'caspases': [4068], 'calpains,': [4070], 'regulates': [4071], '(0h)': [4080], '(B)': [4096], 'MDL28170': [4109], '(Cal,': [4110], '(Cas,': [4118], '(100': [4122], '(Lact,': [4125], 'presented': [4141], 'means': [4143], '(±S.D.,': [4144], '4).': [4147], 'significant': [4149], 'difference': [4150], '(p': [4151], 'control': [4154], 'values': [4155], '0.View': [4158], 'Protein': [4168], 'Phosphorylation': [4169], 'Stability': [4172], 'sought': [4176], 'together': [4215]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2043069574', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 21}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 17}], 'updated_date': '2025-01-19T03:25:17.167742', 'created_date': '2016-06-24'}