Title: Fullerene–Oligonucleotide Conjugates: Photoinduced Sequence‐Specific DNA Cleavage
Abstract: Angewandte Chemie International Edition in EnglishVolume 33, Issue 23-24 p. 2462-2465 Communication Fullerene–Oligonucleotide Conjugates: Photoinduced Sequence-Specific DNA Cleavage† Dr. Alexandre S. Boutorine, Dr. Alexandre S. Boutorine Laboratoire de Biophysique, INSERM U201, CNRS UA 481 Muséum National d'Histoire Naturelle 43 Rue Cuvier, F-75005 Paris (France) Telefax: Int. code + (1)40793705Search for more papers by this authorDr. Masashi Takasugi, Dr. Masashi Takasugi Laboratoire de Biophysique, INSERM U201, CNRS UA 481 Muséum National d'Histoire Naturelle 43 Rue Cuvier, F-75005 Paris (France) Telefax: Int. code + (1)40793705Search for more papers by this authorProf. Claude Hélène, Corresponding Author Prof. Claude Hélène Laboratoire de Biophysique, INSERM U201, CNRS UA 481 Muséum National d'Histoire Naturelle 43 Rue Cuvier, F-75005 Paris (France) Telefax: Int. code + (1)40793705Laboratoire de Biophysique, INSERM U201, CNRS UA 481 Muséum National d'Histoire Naturelle 43 Rue Cuvier, F-75005 Paris (France) Telefax: Int. code + (1)40793705Search for more papers by this authorDr. Hidetoshi Tokuyama, Dr. Hidetoshi Tokuyama Department of Chemistry, Tokyo Institute of Technology O-Okayama, Meguro-Ku, Tokyo 152 (Japan)Search for more papers by this authorHiroyuki Isobe, Hiroyuki Isobe Department of Chemistry, Tokyo Institute of Technology O-Okayama, Meguro-Ku, Tokyo 152 (Japan)Search for more papers by this authorProf. Eiichi Nakamura, Prof. Eiichi Nakamura Department of Chemistry, Tokyo Institute of Technology O-Okayama, Meguro-Ku, Tokyo 152 (Japan)Search for more papers by this author Dr. Alexandre S. Boutorine, Dr. Alexandre S. Boutorine Laboratoire de Biophysique, INSERM U201, CNRS UA 481 Muséum National d'Histoire Naturelle 43 Rue Cuvier, F-75005 Paris (France) Telefax: Int. code + (1)40793705Search for more papers by this authorDr. Masashi Takasugi, Dr. Masashi Takasugi Laboratoire de Biophysique, INSERM U201, CNRS UA 481 Muséum National d'Histoire Naturelle 43 Rue Cuvier, F-75005 Paris (France) Telefax: Int. code + (1)40793705Search for more papers by this authorProf. Claude Hélène, Corresponding Author Prof. Claude Hélène Laboratoire de Biophysique, INSERM U201, CNRS UA 481 Muséum National d'Histoire Naturelle 43 Rue Cuvier, F-75005 Paris (France) Telefax: Int. code + (1)40793705Laboratoire de Biophysique, INSERM U201, CNRS UA 481 Muséum National d'Histoire Naturelle 43 Rue Cuvier, F-75005 Paris (France) Telefax: Int. code + (1)40793705Search for more papers by this authorDr. Hidetoshi Tokuyama, Dr. Hidetoshi Tokuyama Department of Chemistry, Tokyo Institute of Technology O-Okayama, Meguro-Ku, Tokyo 152 (Japan)Search for more papers by this authorHiroyuki Isobe, Hiroyuki Isobe Department of Chemistry, Tokyo Institute of Technology O-Okayama, Meguro-Ku, Tokyo 152 (Japan)Search for more papers by this authorProf. Eiichi Nakamura, Prof. Eiichi Nakamura Department of Chemistry, Tokyo Institute of Technology O-Okayama, Meguro-Ku, Tokyo 152 (Japan)Search for more papers by this author First published: January 3, 1995 https://doi.org/10.1002/anie.199424621Citations: 188 † E. N. thanks the Japanese Ministry of Education, Science, and Culture for financial support (Grant-in-Aid for Scientific Research on Priority Area no. 06240217). H. T. thanks the Japan Society for the Promotion of Science for a postdoctoral fellowship. The Agence Nationale de Recherche sur le SIDA (ANRS) is acknowledged for a research fellowship to A. B. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract The guanine-specific cleavage of oligonucleotides is achieved with the conjugate 1, which contains a fullerene tethered to a tetradecadeoxyribonucleotide Nu(pNu)n. This conjugate was able to form a duplex with a complementary oligonucleotide, and triplexes with appropriate double-stranded oligonucleotides. Irradiation of the complexes leads to site-specfic cleavage of the target sequences—probably through the action of singlet oxygen. Citing Literature Volume33, Issue23-24January 3, 1995Pages 2462-2465 This article also appears in:Fullerenes RelatedInformation
Publication Year: 1995
Publication Date: 1995-01-03
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 231
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