Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2042939195', 'doi': 'https://doi.org/10.1182/blood-2006-09-044776', 'title': 'A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA', 'display_name': 'A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA', 'publication_year': 2007, 'publication_date': '2007-09-15', 'ids': {'openalex': 'https://openalex.org/W2042939195', 'doi': 'https://doi.org/10.1182/blood-2006-09-044776', 'mag': '2042939195', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17548579', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1976374'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1182/blood-2006-09-044776', 'pdf_url': 'https://ashpublications.org/blood/article-pdf/110/6/1970/1481894/zh801807001970.pdf', 'source': {'id': 'https://openalex.org/S200071133', 'display_name': 'Blood', 'issn_l': '0006-4971', 'issn': ['0006-4971', '1528-0020'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://ashpublications.org/blood/article-pdf/110/6/1970/1481894/zh801807001970.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080940457', 'display_name': 'Stanimir S. Ivanov', 'orcid': 'https://orcid.org/0000-0002-3294-7595'}, 'institutions': [{'id': 'https://openalex.org/I27804330', 'display_name': 'Brown University', 'ror': 'https://ror.org/05gq02987', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27804330']}, {'id': 'https://openalex.org/I196272386', 'display_name': 'Providence College', 'ror': 'https://ror.org/00rxpqe74', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196272386']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stanimir Ivanov', 'raw_affiliation_strings': ['Department of Molecular Microbiology and Immunology, Brown University, Providence, RI;'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Microbiology and Immunology, Brown University, Providence, RI;', 'institution_ids': ['https://openalex.org/I27804330', 'https://openalex.org/I196272386']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065964858', 'display_name': 'Ana‐Maria Dragoi', 'orcid': 'https://orcid.org/0000-0001-9841-6802'}, 'institutions': [{'id': 'https://openalex.org/I27804330', 'display_name': 'Brown University', 'ror': 'https://ror.org/05gq02987', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27804330']}, {'id': 'https://openalex.org/I196272386', 'display_name': 'Providence College', 'ror': 'https://ror.org/00rxpqe74', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196272386']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ana-Maria Dragoi', 'raw_affiliation_strings': ['Department of Molecular Microbiology and Immunology, Brown University, Providence, RI;'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Microbiology and Immunology, Brown University, Providence, RI;', 'institution_ids': ['https://openalex.org/I27804330', 'https://openalex.org/I196272386']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100327957', 'display_name': 'Xin Wang', 'orcid': 'https://orcid.org/0000-0002-5122-2418'}, 'institutions': [{'id': 'https://openalex.org/I27804330', 'display_name': 'Brown University', 'ror': 'https://ror.org/05gq02987', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27804330']}, {'id': 'https://openalex.org/I196272386', 'display_name': 'Providence College', 'ror': 'https://ror.org/00rxpqe74', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196272386']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xin Wang', 'raw_affiliation_strings': ['Department of Molecular Microbiology and Immunology, Brown University, Providence, RI;'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Microbiology and Immunology, Brown University, Providence, RI;', 'institution_ids': ['https://openalex.org/I27804330', 'https://openalex.org/I196272386']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005445530', 'display_name': 'Corrado Dallacosta', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I292310028', 'display_name': 'San Raffaele University of Rome', 'ror': 'https://ror.org/02rwycx38', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I292310028']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Corrado Dallacosta', 'raw_affiliation_strings': ['San Raffaele Scientific Institute, Milano, Italy;'], 'affiliations': [{'raw_affiliation_string': 'San Raffaele Scientific Institute, Milano, Italy;', 'institution_ids': ['https://openalex.org/I292310028']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077952115', 'display_name': 'Jennifer Louten', 'orcid': 'https://orcid.org/0000-0002-4568-187X'}, 'institutions': [{'id': 'https://openalex.org/I27804330', 'display_name': 'Brown University', 'ror': 'https://ror.org/05gq02987', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27804330']}, {'id': 'https://openalex.org/I196272386', 'display_name': 'Providence College', 'ror': 'https://ror.org/00rxpqe74', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196272386']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jennifer Louten', 'raw_affiliation_strings': ['Department of Molecular Microbiology and Immunology, Brown University, Providence, RI;'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Microbiology and Immunology, Brown University, Providence, RI;', 'institution_ids': ['https://openalex.org/I27804330', 'https://openalex.org/I196272386']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002901056', 'display_name': 'Giovanna Musco', 'orcid': 'https://orcid.org/0000-0002-0469-2994'}, 'institutions': [{'id': 'https://openalex.org/I292310028', 'display_name': 'San Raffaele University of Rome', 'ror': 'https://ror.org/02rwycx38', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I292310028']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giovanna Musco', 'raw_affiliation_strings': ['San Raffaele Scientific Institute, Milano, Italy;'], 'affiliations': [{'raw_affiliation_string': 'San Raffaele Scientific Institute, Milano, Italy;', 'institution_ids': ['https://openalex.org/I292310028']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058353178', 'display_name': 'Giovanni Sitia', 'orcid': 'https://orcid.org/0000-0003-1024-9128'}, 'institutions': [{'id': 'https://openalex.org/I292310028', 'display_name': 'San Raffaele University of Rome', 'ror': 'https://ror.org/02rwycx38', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I292310028']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giovanni Sitia', 'raw_affiliation_strings': ['San Raffaele Scientific Institute, Milano, Italy;'], 'affiliations': [{'raw_affiliation_string': 'San Raffaele Scientific Institute, Milano, Italy;', 'institution_ids': ['https://openalex.org/I292310028']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045104926', 'display_name': 'George Yap', 'orcid': 'https://orcid.org/0000-0003-4814-8445'}, 'institutions': [{'id': 'https://openalex.org/I27804330', 'display_name': 'Brown University', 'ror': 'https://ror.org/05gq02987', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27804330']}, {'id': 'https://openalex.org/I196272386', 'display_name': 'Providence College', 'ror': 'https://ror.org/00rxpqe74', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196272386']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'George S. Yap', 'raw_affiliation_strings': ['Department of Molecular Microbiology and Immunology, Brown University, Providence, RI;'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Microbiology and Immunology, Brown University, Providence, RI;', 'institution_ids': ['https://openalex.org/I27804330', 'https://openalex.org/I196272386']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031206065', 'display_name': 'Yinsheng Wan', 'orcid': 'https://orcid.org/0009-0004-9168-4125'}, 'institutions': [{'id': 'https://openalex.org/I196272386', 'display_name': 'Providence College', 'ror': 'https://ror.org/00rxpqe74', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196272386']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yinsheng Wan', 'raw_affiliation_strings': ['Department of Biology, Providence College, Providence, RI;'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, Providence College, Providence, RI;', 'institution_ids': ['https://openalex.org/I196272386']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082274877', 'display_name': 'Christine A. Biron', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27804330', 'display_name': 'Brown University', 'ror': 'https://ror.org/05gq02987', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27804330']}, {'id': 'https://openalex.org/I196272386', 'display_name': 'Providence College', 'ror': 'https://ror.org/00rxpqe74', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196272386']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christine A. Biron', 'raw_affiliation_strings': ['Department of Molecular Microbiology and Immunology, Brown University, Providence, RI;'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Microbiology and Immunology, Brown University, Providence, RI;', 'institution_ids': ['https://openalex.org/I27804330', 'https://openalex.org/I196272386']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017563247', 'display_name': 'Marco E. Bianchi', 'orcid': 'https://orcid.org/0000-0002-5329-6445'}, 'institutions': [{'id': 'https://openalex.org/I292310028', 'display_name': 'San Raffaele University of Rome', 'ror': 'https://ror.org/02rwycx38', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I292310028']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Marco E. Bianchi', 'raw_affiliation_strings': ['San Raffaele University, Faculty of Medicine, Milano, Italy;'], 'affiliations': [{'raw_affiliation_string': 'San Raffaele University, Faculty of Medicine, Milano, Italy;', 'institution_ids': ['https://openalex.org/I292310028']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100452906', 'display_name': 'Haichao Wang', 'orcid': 'https://orcid.org/0000-0002-0211-9000'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Haichao Wang', 'raw_affiliation_strings': ['Department of Emergency Medicine, North Shore-Long Island Jewish Research Institute, Manhasset, NY'], 'affiliations': [{'raw_affiliation_string': 'Department of Emergency Medicine, North Shore-Long Island Jewish Research Institute, Manhasset, NY', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5063682443', 'display_name': 'Weihua Chu', 'orcid': 'https://orcid.org/0000-0003-0055-2035'}, 'institutions': [{'id': 'https://openalex.org/I27804330', 'display_name': 'Brown University', 'ror': 'https://ror.org/05gq02987', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27804330']}, {'id': 'https://openalex.org/I196272386', 'display_name': 'Providence College', 'ror': 'https://ror.org/00rxpqe74', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I196272386']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wen-Ming Chu', 'raw_affiliation_strings': ['Department of Molecular Microbiology and Immunology, Brown University, Providence, RI;'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Microbiology and Immunology, Brown University, Providence, RI;', 'institution_ids': ['https://openalex.org/I27804330', 'https://openalex.org/I196272386']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5000, 'currency': 'USD', 'value_usd': 5000, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 23.183, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 439, 'citation_normalized_percentile': {'value': 0.999417, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '110', 'issue': '6', 'first_page': '1970', 'last_page': '1981'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11142', 'display_name': 'Biochemistry of Diabetic Complications', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11142', 'display_name': 'Biochemistry of Diabetic Complications', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10371', 'display_name': 'Innate Immune Recognition and Signaling Pathways', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma', 'score': 0.9808, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tlr9', 'display_name': 'TLR9', 'score': 0.8087725}, {'id': 'https://openalex.org/keywords/cpg-site', 'display_name': 'CpG site', 'score': 0.6616842}, {'id': 'https://openalex.org/keywords/hmgb1', 'display_name': 'HMGB1', 'score': 0.526637}, {'id': 'https://openalex.org/keywords/toll-like-receptor-9', 'display_name': 'Toll-Like Receptor 9', 'score': 0.42074043}], 'concepts': [{'id': 'https://openalex.org/C2779138994', 'wikidata': 'https://www.wikidata.org/wiki/Q15332550', 'display_name': 'TLR9', 'level': 5, 'score': 0.8087725}, {'id': 'https://openalex.org/C140173407', 'wikidata': 'https://www.wikidata.org/wiki/Q1138358', 'display_name': 'CpG site', 'level': 5, 'score': 0.6616842}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.47834942}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.44640374}, {'id': 'https://openalex.org/C2908999202', 'wikidata': 'https://www.wikidata.org/wiki/Q15332550', 'display_name': 'Toll-Like Receptor 9', 'level': 5, 'score': 0.42074043}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.39912003}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3703535}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.34415776}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.32746685}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.30240315}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.11183995}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D024243', 'descriptor_name': 'HMGB1 Protein', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D018664', 'descriptor_name': 'Interleukin-12', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009838', 'descriptor_name': 'Oligodeoxyribonucleotides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D051217', 'descriptor_name': 'Toll-Like Receptor 9', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D037281', 'descriptor_name': 'Calnexin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D037281', 'descriptor_name': 'Calnexin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018899', 'descriptor_name': 'CpG Islands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004797', 'descriptor_name': 'Enzyme-Linked Immunosorbent Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005434', 'descriptor_name': 'Flow Cytometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006056', 'descriptor_name': 'Golgi Apparatus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006056', 'descriptor_name': 'Golgi Apparatus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006056', 'descriptor_name': 'Golgi Apparatus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D024243', 'descriptor_name': 'HMGB1 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024243', 'descriptor_name': 'HMGB1 Protein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015151', 'descriptor_name': 'Immunoblotting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047468', 'descriptor_name': 'Immunoprecipitation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018664', 'descriptor_name': 'Interleukin-12', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D037241', 'descriptor_name': 'Mannose-Binding Lectins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D037241', 'descriptor_name': 'Mannose-Binding Lectins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052247', 'descriptor_name': 'Nitric Oxide Synthase Type II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052247', 'descriptor_name': 'Nitric Oxide Synthase Type II', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009838', 'descriptor_name': 'Oligodeoxyribonucleotides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022142', 'descriptor_name': 'Secretory Vesicles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022142', 'descriptor_name': 'Secretory Vesicles', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D022142', 'descriptor_name': 'Secretory Vesicles', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D051217', 'descriptor_name': 'Toll-Like Receptor 9', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051217', 'descriptor_name': 'Toll-Like Receptor 9', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1182/blood-2006-09-044776', 'pdf_url': 'https://ashpublications.org/blood/article-pdf/110/6/1970/1481894/zh801807001970.pdf', 'source': {'id': 'https://openalex.org/S200071133', 'display_name': 'Blood', 'issn_l': '0006-4971', 'issn': ['0006-4971', '1528-0020'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976374', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1976374', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17548579', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1182/blood-2006-09-044776', 'pdf_url': 'https://ashpublications.org/blood/article-pdf/110/6/1970/1481894/zh801807001970.pdf', 'source': {'id': 'https://openalex.org/S200071133', 'display_name': 'Blood', 'issn_l': '0006-4971', 'issn': ['0006-4971', '1528-0020'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 60, 'referenced_works': ['https://openalex.org/W1478898356', 'https://openalex.org/W1514540900', 'https://openalex.org/W1536488163', 'https://openalex.org/W1547938117', 'https://openalex.org/W1560571961', 'https://openalex.org/W1562998360', 'https://openalex.org/W1589670817', 'https://openalex.org/W1596740642', 'https://openalex.org/W1639966555', 'https://openalex.org/W1655860314', 'https://openalex.org/W1656835564', 'https://openalex.org/W1895687559', 'https://openalex.org/W1952140144', 'https://openalex.org/W1962709364', 'https://openalex.org/W1967055803', 'https://openalex.org/W1973590054', 'https://openalex.org/W1983199037', 'https://openalex.org/W1992082488', 'https://openalex.org/W1997565255', 'https://openalex.org/W2004266769', 'https://openalex.org/W2009101696', 'https://openalex.org/W2016232550', 'https://openalex.org/W2017638885', 'https://openalex.org/W2018629826', 'https://openalex.org/W2018653121', 'https://openalex.org/W2021736304', 'https://openalex.org/W2027850046', 'https://openalex.org/W2029068688', 'https://openalex.org/W2035950274', 'https://openalex.org/W2045571454', 'https://openalex.org/W2047366876', 'https://openalex.org/W2050488981', 'https://openalex.org/W2061163173', 'https://openalex.org/W2066833587', 'https://openalex.org/W2069981713', 'https://openalex.org/W2079112084', 'https://openalex.org/W2082013812', 'https://openalex.org/W2084081368', 'https://openalex.org/W2085166735', 'https://openalex.org/W2087867048', 'https://openalex.org/W2093508027', 'https://openalex.org/W2094746130', 'https://openalex.org/W2096726255', 'https://openalex.org/W2101363646', 'https://openalex.org/W2101760818', 'https://openalex.org/W2103924560', 'https://openalex.org/W2114741192', 'https://openalex.org/W2116415854', 'https://openalex.org/W2123651838', 'https://openalex.org/W2130775443', 'https://openalex.org/W2131748081', 'https://openalex.org/W2135131688', 'https://openalex.org/W2147426561', 'https://openalex.org/W2158827553', 'https://openalex.org/W2161167739', 'https://openalex.org/W2162076795', 'https://openalex.org/W2163917183', 'https://openalex.org/W2164714222', 'https://openalex.org/W2171258458', 'https://openalex.org/W4211044652'], 'related_works': ['https://openalex.org/W580083713', 'https://openalex.org/W2997668962', 'https://openalex.org/W2579951821', 'https://openalex.org/W2374198738', 'https://openalex.org/W2314264549', 'https://openalex.org/W2159021562', 'https://openalex.org/W2148845369', 'https://openalex.org/W2129961630', 'https://openalex.org/W2070364388', 'https://openalex.org/W1482856546'], 'abstract_inverted_index': {'CpG-DNA': [0, 21], 'or': [1], 'its': [2, 76], 'synthetic': [3], 'analog': [4], 'CpG-ODN': [5, 57], 'activates': [6], 'innate': [7], 'immunity': [8], 'through': [9], 'Toll-like': [10], 'receptor': [11], '9': [12], '(TLR9).': [13], 'However,': [14, 106], 'the': [15, 40, 71, 97, 119], 'mechanism': [16], 'of': [17, 73, 83, 90, 108, 127], 'TLR9': [18, 38], 'activation': [19], 'by': [20, 115], 'remains': [22], 'elusive.': [23], 'Here': [24], 'we': [25], 'have': [26], 'identified': [27], 'HMGB1': [28, 33, 69, 91, 111, 122], 'as': [29], 'a': [30, 80, 94], 'CpG-ODN-binding': [31], 'protein.': [32], 'interacts': [34], 'and': [35, 46, 60, 86, 101, 125, 130], 'preassociates': [36], 'with': [37], 'in': [39, 53, 66, 96, 124], 'endoplasmic': [41], 'reticulum-Golgi': [42], 'intermediate': [43], 'compartment': [44], '(ERGIC),': [45], 'hastens': [47], "TLR9's": [48], 'redistribution': [49], 'to': [50, 55, 63, 75, 79, 93, 104, 134], 'early': [51], 'endosomes': [52], 'response': [54, 103], 'CpG-ODN.': [56, 105], 'stimulates': [58], 'macrophages': [59], 'dendritic': [61], 'cells': [62, 129], 'secrete': [64], 'HMGB1;': [65], 'turn,': [67], 'extracellular': [68, 116], 'accelerates': [70], 'delivery': [72], 'CpG-ODNs': [74], 'receptor,': [77], 'leading': [78], 'TLR9-dependent': [81], 'augmentation': [82], 'IL-6,': [84, 98], 'IL-12,': [85, 99], 'TNFalpha': [87], 'secretion.': [88], 'Loss': [89], 'leads': [92], 'defect': [95], 'TNFalpha,': [100], 'iNOS': [102], 'lack': [107], 'intracellular': [109], 'TLR9-associated': [110], 'can': [112], 'be': [113], 'compensated': [114], 'HMGB1.': [117], 'Thus,': [118], 'DNA-binding': [120], 'protein': [121], 'shuttles': [123], 'out': [126], 'immune': [128], 'regulates': [131], 'inflammatory': [132], 'responses': [133], 'CpG-DNA.': [135]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2042939195', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 20}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 21}, {'year': 2017, 'cited_by_count': 20}, {'year': 2016, 'cited_by_count': 26}, {'year': 2015, 'cited_by_count': 34}, {'year': 2014, 'cited_by_count': 39}, {'year': 2013, 'cited_by_count': 36}, {'year': 2012, 'cited_by_count': 31}], 'updated_date': '2024-09-09T11:11:41.167957', 'created_date': '2016-06-24'}