Abstract: The report by Caro et al in this issue of The Lancet, of a decreased ratio of cerebrospinal fluid (CSF) leptin to serum leptin with obesity, expands the horizon of our understanding of this fascinating new molecule. The authors argue that “leptin resistance” may result from slower entry of leptin into the brain because of increased peripheral binding. But here we are getting ahead of the story. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistanceOur data suggest that leptin enters the brain by a saturable transport system. The capacity of leptin transport is lower in obese individuals, and may provide a mechanism for leptin resistance. Full-Text PDF
Publication Year: 1996
Publication Date: 1996-07-01
Language: en
Type: letter
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 54
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