Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2042511497', 'doi': 'https://doi.org/10.1371/journal.pone.0118826', 'title': 'Targeted Inhibitory Effect of Lenti-SM22alpha-p27-EGFP Recombinant Lentiviral Vectors on Proliferation of Vascular Smooth Muscle Cells without Compromising Re-Endothelialization in a Rat Carotid Artery Balloon Injury Model', 'display_name': 'Targeted Inhibitory Effect of Lenti-SM22alpha-p27-EGFP Recombinant Lentiviral Vectors on Proliferation of Vascular Smooth Muscle Cells without Compromising Re-Endothelialization in a Rat Carotid Artery Balloon Injury Model', 'publication_year': 2015, 'publication_date': '2015-03-11', 'ids': {'openalex': 'https://openalex.org/W2042511497', 'doi': 'https://doi.org/10.1371/journal.pone.0118826', 'mag': '2042511497', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25760326', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4356572'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0118826', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0118826&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0118826&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103841916', 'display_name': 'Liang Jing', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Liang Jing', 'raw_affiliation_strings': ['Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100344693', 'display_name': 'Wenlong Wang', 'orcid': 'https://orcid.org/0000-0001-8355-3863'}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Wenlong Wang', 'raw_affiliation_strings': ['Department of Cardiovascular Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024070925', 'display_name': 'Shuangshuang Zhang', 'orcid': 'https://orcid.org/0000-0002-9374-2198'}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Shuangshuang Zhang', 'raw_affiliation_strings': ['Department of Cardiovascular Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100656337', 'display_name': 'Minjie Xie', 'orcid': 'https://orcid.org/0000-0001-7317-3066'}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Minjie Xie', 'raw_affiliation_strings': ['Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069692734', 'display_name': 'Dai‐Shi Tian', 'orcid': 'https://orcid.org/0000-0002-7627-0811'}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Daishi Tian', 'raw_affiliation_strings': ['Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079414919', 'display_name': 'Xiang Luo', 'orcid': 'https://orcid.org/0000-0001-9233-5788'}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Xiang Luo', 'raw_affiliation_strings': ['Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014137444', 'display_name': 'Dao Wen Wang', 'orcid': 'https://orcid.org/0000-0002-9774-3980'}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Daowen Wang', 'raw_affiliation_strings': ['Department of Cardiovascular Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100705133', 'display_name': 'Qin Ning', 'orcid': 'https://orcid.org/0000-0002-2027-9593'}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Qin Ning', 'raw_affiliation_strings': ['Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046767109', 'display_name': 'Junlin Lu', 'orcid': 'https://orcid.org/0000-0002-3438-0297'}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Jiagao Lü', 'raw_affiliation_strings': ['Department of Cardiovascular Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiovascular Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100391941', 'display_name': 'Wei Wang', 'orcid': 'https://orcid.org/0000-0002-3422-0402'}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Wei Wang', 'raw_affiliation_strings': ['Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5103841916', 'https://openalex.org/A5100344693', 'https://openalex.org/A5024070925', 'https://openalex.org/A5100656337', 'https://openalex.org/A5069692734', 'https://openalex.org/A5079414919', 'https://openalex.org/A5014137444', 'https://openalex.org/A5100705133', 'https://openalex.org/A5046767109', 'https://openalex.org/A5100391941'], 'corresponding_institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344', 'https://openalex.org/I47720641', 'https://openalex.org/I4210160344', 'https://openalex.org/I47720641', 'https://openalex.org/I4210160344', 'https://openalex.org/I47720641', 'https://openalex.org/I4210160344', 'https://openalex.org/I47720641', 'https://openalex.org/I4210160344', 'https://openalex.org/I47720641', 'https://openalex.org/I4210160344', 'https://openalex.org/I47720641', 'https://openalex.org/I4210160344', 'https://openalex.org/I47720641', 'https://openalex.org/I4210160344', 'https://openalex.org/I47720641', 'https://openalex.org/I4210160344', 'https://openalex.org/I47720641', 'https://openalex.org/I4210160344'], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 0.305, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 5, 'citation_normalized_percentile': {'value': 0.660632, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 81, 'max': 82}, 'biblio': {'volume': '10', 'issue': '3', 'first_page': 'e0118826', 'last_page': 'e0118826'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9944, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9944, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10193', 'display_name': 'Clinical Studies on Coronary Stents and Revascularization', 'score': 0.9815, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10816', 'display_name': 'Diagnosis and Treatment of Carotid Artery Disease', 'score': 0.978, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neointima', 'display_name': 'Neointima', 'score': 0.86381805}, {'id': 'https://openalex.org/keywords/intimal-hyperplasia', 'display_name': 'Intimal hyperplasia', 'score': 0.7347109}, {'id': 'https://openalex.org/keywords/stenting', 'display_name': 'Stenting', 'score': 0.504406}, {'id': 'https://openalex.org/keywords/neointimal-hyperplasia', 'display_name': 'Neointimal hyperplasia', 'score': 0.49626976}], 'concepts': [{'id': 'https://openalex.org/C2777339539', 'wikidata': 'https://www.wikidata.org/wiki/Q6993039', 'display_name': 'Neointima', 'level': 4, 'score': 0.86381805}, {'id': 'https://openalex.org/C2779395532', 'wikidata': 'https://www.wikidata.org/wiki/Q7916469', 'display_name': 'Vascular smooth muscle', 'level': 3, 'score': 0.79793286}, {'id': 'https://openalex.org/C2778283817', 'wikidata': 'https://www.wikidata.org/wiki/Q6590597', 'display_name': 'Restenosis', 'level': 3, 'score': 0.76681006}, {'id': 'https://openalex.org/C2779751240', 'wikidata': 'https://www.wikidata.org/wiki/Q16909635', 'display_name': 'Intimal hyperplasia', 'level': 3, 'score': 0.7347109}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.54816926}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.49843526}, {'id': 'https://openalex.org/C2778095995', 'wikidata': 'https://www.wikidata.org/wiki/Q17147174', 'display_name': 'Neointimal hyperplasia', 'level': 4, 'score': 0.49626976}, {'id': 'https://openalex.org/C32470452', 'wikidata': 'https://www.wikidata.org/wiki/Q2298489', 'display_name': 'Viral vector', 'level': 4, 'score': 0.4853236}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.47102365}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.44639266}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.38997138}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3697877}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.3611511}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34992334}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.29582793}, {'id': 'https://openalex.org/C2778583881', 'wikidata': 'https://www.wikidata.org/wiki/Q1325542', 'display_name': 'Stent', 'level': 2, 'score': 0.26052982}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.1948219}, {'id': 'https://openalex.org/C2992686903', 'wikidata': 'https://www.wikidata.org/wiki/Q208453', 'display_name': 'Smooth muscle', 'level': 2, 'score': 0.11374146}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002339', 'descriptor_name': 'Carotid Arteries', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D050760', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p27', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008840', 'descriptor_name': 'Microfilament Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D032389', 'descriptor_name': 'Myocytes, Smooth Muscle', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D021721', 'descriptor_name': 'Balloon Occlusion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002339', 'descriptor_name': 'Carotid Arteries', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050760', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p27', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D050760', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p27', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D059585', 'descriptor_name': 'G1 Phase Cell Cycle Checkpoints', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016086', 'descriptor_name': 'Lentivirus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016086', 'descriptor_name': 'Lentivirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008840', 'descriptor_name': 'Microfilament Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D032389', 'descriptor_name': 'Myocytes, Smooth Muscle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058426', 'descriptor_name': 'Neointima', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058426', 'descriptor_name': 'Neointima', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066253', 'descriptor_name': 'Vascular Remodeling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014945', 'descriptor_name': 'Wound Healing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0118826', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0118826&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/2a461d46c40e437ead14d81b3164f3a4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4356572', 'pdf_url': 'https://europepmc.org/articles/pmc4356572?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356572', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25760326', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0118826', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0118826&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.82, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W1890134050', 'https://openalex.org/W1963749523', 'https://openalex.org/W1967200131', 'https://openalex.org/W1976726006', 'https://openalex.org/W1980116041', 'https://openalex.org/W1983249576', 'https://openalex.org/W1985295233', 'https://openalex.org/W1989556574', 'https://openalex.org/W1996725005', 'https://openalex.org/W1998303192', 'https://openalex.org/W1999330214', 'https://openalex.org/W2006753991', 'https://openalex.org/W2009078871', 'https://openalex.org/W2011126296', 'https://openalex.org/W2014148022', 'https://openalex.org/W2015157609', 'https://openalex.org/W2027187758', 'https://openalex.org/W2028561646', 'https://openalex.org/W2030092320', 'https://openalex.org/W2040092124', 'https://openalex.org/W2042935847', 'https://openalex.org/W2045317411', 'https://openalex.org/W2053509650', 'https://openalex.org/W2060528472', 'https://openalex.org/W2066198185', 'https://openalex.org/W2079143453', 'https://openalex.org/W2079458151', 'https://openalex.org/W2080193771', 'https://openalex.org/W2083630382', 'https://openalex.org/W2086360593', 'https://openalex.org/W2087167049', 'https://openalex.org/W2088880246', 'https://openalex.org/W2090560187', 'https://openalex.org/W2092897714', 'https://openalex.org/W2104576349', 'https://openalex.org/W2115929132', 'https://openalex.org/W2116326813', 'https://openalex.org/W2121619780', 'https://openalex.org/W2125852108', 'https://openalex.org/W2150755435', 'https://openalex.org/W2151062204', 'https://openalex.org/W2163531798', 'https://openalex.org/W2170858457', 'https://openalex.org/W2171336746', 'https://openalex.org/W2288526040', 'https://openalex.org/W2317967370', 'https://openalex.org/W2336122316', 'https://openalex.org/W2340939962', 'https://openalex.org/W2422837789'], 'related_works': ['https://openalex.org/W335699998', 'https://openalex.org/W2531664817', 'https://openalex.org/W2419267623', 'https://openalex.org/W2392166704', 'https://openalex.org/W2389259733', 'https://openalex.org/W2360642739', 'https://openalex.org/W2115830214', 'https://openalex.org/W2090846657', 'https://openalex.org/W2036101787', 'https://openalex.org/W1995425925'], 'abstract_inverted_index': {'In-stent': [0], 'restenosis': [1, 106], 'remains': [2], 'a': [3, 25, 52, 95], 'serious': [4], 'problem': [5], 'after': [6, 110], 'the': [7, 46, 76, 114, 122, 130, 141], 'implantation': [8], 'of': [9, 34, 43, 59, 105, 116, 121, 135, 159], 'drug-eluting': [10], 'stents,': [11], 'which': [12, 28], 'is': [13], 'attributable': [14], 'to': [15, 23, 56, 146, 157], 'neointima': [16], 'formation': [17], 'and': [18, 101, 119, 149], 're-endothelialization.': [19], 'Here,': [20], 'we': [21], 'tried': [22], 'find': [24], 'new': [26], 'method': [27], 'aims': [29], 'at': [30, 75], 'selectively': [31, 150], 'inhibiting': [32], 'proliferation': [33, 40, 69, 85], 'vascular': [35], 'smooth': [36, 47, 131], 'muscle': [37, 132], 'cells': [38], '(VSMC)': [39], 'without': [41, 162], 'inhibition': [42, 104, 158], 're-endothelialization.We': [44], 'used': [45, 145], 'muscle-specific': [48], 'SM22alpha': [49, 142], 'promoter': [50, 143], 'in': [51, 63, 154], 'recombinant': [53, 137], 'lentiviral': [54, 81, 138], 'vector': [55, 82, 139], 'drive': [57], 'overexpression': [58], 'cell-cycle': [60], 'inhibitor,': [61], 'p27,': [62], 'VSMCs.': [64], 'p27': [65, 152], 'effectively': [66, 87, 147], 'inhibited': [67, 83], 'VSMC': [68, 84], 'mediated': [70], 'by': [71, 129], 'cell': [72], 'cycle': [73], 'arrest': [74], 'G0/G1': [77], 'checkpoint.': [78], 'The': [79], 'SM22alpha-p27': [80], 'more': [86], 'than': [88], 'paclitaxel.': [89], 'Rats': [90], 'infected': [91], 'with': [92], 'Lenti-SM22alpha-p27': [93], 'had': [94], 'significantly': [96], 'lower': [97], 'intima/media': [98], '(I/M)': [99], 'ratio': [100], 'also': [102], 'showed': [103], 'on': [107], 'day': [108], '28': [109], 'balloon': [111], 'injury.': [112], 'Moreover,': [113], 'repair': [115], 'injured': [117], 'endothelium,': [118], 're-endothelialization': [120], 'carotid': [123], 'artery': [124], 'wall,': [125], 'was': [126, 144], 'not': [127], 'affected': [128], 'cell-specific': [133], 'expression': [134], 'p27.A': [136], 'carrying': [140], 'infect': [148], 'overexpress': [151], 'protein': [153], 'VSMCs,': [155], 'leading': [156], 'intimal': [160], 'hyperplasia': [161], 'compromising': [163], 'endothelial': [164], 'repair.': [165]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2042511497', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-09-10T16:04:21.680172', 'created_date': '2016-06-24'}