Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2042218175', 'doi': 'https://doi.org/10.1158/1535-7163.targ-13-b255', 'title': 'Abstract B255: Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.', 'display_name': 'Abstract B255: Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.', 'publication_year': 2013, 'publication_date': '2013-11-01', 'ids': {'openalex': 'https://openalex.org/W2042218175', 'doi': 'https://doi.org/10.1158/1535-7163.targ-13-b255', 'mag': '2042218175'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.targ-13-b255', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5053231562', 'display_name': 'Keiichiro Okuhira', 'orcid': 'https://orcid.org/0000-0002-0127-9571'}, 'institutions': [{'id': 'https://openalex.org/I4210151964', 'display_name': 'National Institute of Health Sciences', 'ror': 'https://ror.org/04s629c33', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I1333985979', 'https://openalex.org/I4210151964']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Keiichiro Okuhira', 'raw_affiliation_strings': ['National Institute of Health Sciences, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Health Sciences, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210151964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019548450', 'display_name': 'Yosuke Demizu', 'orcid': 'https://orcid.org/0000-0001-7521-4861'}, 'institutions': [{'id': 'https://openalex.org/I4210151964', 'display_name': 'National Institute of Health Sciences', 'ror': 'https://ror.org/04s629c33', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I1333985979', 'https://openalex.org/I4210151964']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yosuke Demizu', 'raw_affiliation_strings': ['National Institute of Health Sciences, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Health Sciences, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210151964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054830184', 'display_name': 'Takayuki Hattori', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210151964', 'display_name': 'National Institute of Health Sciences', 'ror': 'https://ror.org/04s629c33', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I1333985979', 'https://openalex.org/I4210151964']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takayuki Hattori', 'raw_affiliation_strings': ['National Institute of Health Sciences, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Health Sciences, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210151964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055913661', 'display_name': 'Nobumichi Ohoka', 'orcid': 'https://orcid.org/0000-0002-0533-0610'}, 'institutions': [{'id': 'https://openalex.org/I4210151964', 'display_name': 'National Institute of Health Sciences', 'ror': 'https://ror.org/04s629c33', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I1333985979', 'https://openalex.org/I4210151964']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Nobumichi Ohoka', 'raw_affiliation_strings': ['National Institute of Health Sciences, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Health Sciences, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210151964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001523978', 'display_name': 'Norihito Shibata', 'orcid': 'https://orcid.org/0000-0001-5792-8510'}, 'institutions': [{'id': 'https://openalex.org/I4210151964', 'display_name': 'National Institute of Health Sciences', 'ror': 'https://ror.org/04s629c33', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I1333985979', 'https://openalex.org/I4210151964']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Norihito Shibata', 'raw_affiliation_strings': ['National Institute of Health Sciences, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Health Sciences, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210151964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069671627', 'display_name': 'Tomoko Nishimaki‐Mogami', 'orcid': 'https://orcid.org/0000-0003-0194-2377'}, 'institutions': [{'id': 'https://openalex.org/I4210151964', 'display_name': 'National Institute of Health Sciences', 'ror': 'https://ror.org/04s629c33', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I1333985979', 'https://openalex.org/I4210151964']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tomoko Nishimaki-Mogami', 'raw_affiliation_strings': ['National Institute of Health Sciences, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Health Sciences, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210151964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113606918', 'display_name': 'Haruhiro Okuda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210151964', 'display_name': 'National Institute of Health Sciences', 'ror': 'https://ror.org/04s629c33', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I1333985979', 'https://openalex.org/I4210151964']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Haruhiro Okuda', 'raw_affiliation_strings': ['National Institute of Health Sciences, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Health Sciences, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210151964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110302940', 'display_name': 'Masaaki Kurihara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210151964', 'display_name': 'National Institute of Health Sciences', 'ror': 'https://ror.org/04s629c33', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I1333985979', 'https://openalex.org/I4210151964']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masaaki Kurihara', 'raw_affiliation_strings': ['National Institute of Health Sciences, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Health Sciences, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210151964']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5082394662', 'display_name': 'Mikihiko Naito', 'orcid': 'https://orcid.org/0000-0003-0451-1337'}, 'institutions': [{'id': 'https://openalex.org/I4210151964', 'display_name': 'National Institute of Health Sciences', 'ror': 'https://ror.org/04s629c33', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I1333985979', 'https://openalex.org/I4210151964']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Mikihiko Naito', 'raw_affiliation_strings': ['National Institute of Health Sciences, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Health Sciences, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210151964']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 65}, 'biblio': {'volume': '12', 'issue': '11_Supplement', 'first_page': 'B255', 'last_page': 'B255'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9756, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9756, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 0.9668, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11559', 'display_name': 'Retinoids in leukemia and cellular processes', 'score': 0.9616, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/protein-degradation', 'display_name': 'Protein Degradation', 'score': 0.5508221}, {'id': 'https://openalex.org/keywords/estrogen-receptor-alpha', 'display_name': 'Estrogen receptor alpha', 'score': 0.54681}], 'concepts': [{'id': 'https://openalex.org/C84606932', 'wikidata': 'https://www.wikidata.org/wiki/Q416496', 'display_name': 'Estrogen receptor', 'level': 4, 'score': 0.7036805}, {'id': 'https://openalex.org/C2777176818', 'wikidata': 'https://www.wikidata.org/wiki/Q412178', 'display_name': 'Tamoxifen', 'level': 4, 'score': 0.68467164}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.6435562}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.63259405}, {'id': 'https://openalex.org/C134459356', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin ligase', 'level': 4, 'score': 0.55928344}, {'id': 'https://openalex.org/C2992195973', 'wikidata': 'https://www.wikidata.org/wiki/Q33123', 'display_name': 'Protein degradation', 'level': 2, 'score': 0.5508221}, {'id': 'https://openalex.org/C172313692', 'wikidata': 'https://www.wikidata.org/wiki/Q14902310', 'display_name': 'Estrogen receptor alpha', 'level': 5, 'score': 0.54681}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.48015112}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.47915143}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.44196206}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4348864}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.36452395}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.32471704}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.30551237}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09796548}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.targ-13-b255', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.86, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W94091198', 'https://openalex.org/W4378834194', 'https://openalex.org/W3195663446', 'https://openalex.org/W3110810129', 'https://openalex.org/W2102368462', 'https://openalex.org/W2054919679', 'https://openalex.org/W2043590168', 'https://openalex.org/W2040788846', 'https://openalex.org/W2007249806', 'https://openalex.org/W1970861248'], 'abstract_inverted_index': {'Abstract': [0], 'Breast': [1], 'cancer': [2, 8, 206, 326], 'is': [3, 36, 73, 124, 138, 147], 'the': [4, 14, 41, 70, 92, 136, 156, 160, 164, 171, 211, 214, 243, 248, 276, 332], 'leading': [5], 'cause': [6], 'of': [7, 13, 88, 115, 130, 170, 193, 199, 235, 270, 278, 310, 317, 331], 'death': [9, 230, 246, 323], 'in': [10, 32, 53, 96, 159, 202, 247, 324], 'women.': [11], 'Most': [12], 'primary': [15, 42], 'breast': [16, 33, 43, 205, 280, 325], 'cancers': [17], 'express': [18], 'estrogen': [19, 31, 71, 318], 'receptor': [20], 'α': [21], '(ERα)': [22], 'and': [23, 56, 108, 135, 155, 167, 195, 237, 262, 320, 338], 'they': [24], 'show': [25], 'estrogen-dependent': [26, 197, 204], 'proliferation.': [27], 'Since': [28], 'tamoxifen': [29, 46, 176], 'antagonizes': [30], 'cancers,': [34], 'it': [35], 'widely': [37], 'used': [38], 'to': [39, 68, 74, 85, 149, 186], 'treat': [40], 'cancers.': [44, 281], 'However,': [45], 'also': [47], 'shows': [48], 'a': [49, 62, 81, 121, 125, 139, 142, 151, 178, 233, 267, 273], 'partial': [50], 'agonistic': [51], 'activity': [52], 'different': [54, 117], 'tissues': [55], 'cellular': [57, 128], 'context,': [58], 'which': [59, 103], 'sometimes': [60], 'causes': [61], 'detrimental': [63], 'effect.': [64], 'An': [65], 'alternative': [66], 'strategy': [67], 'kill': [69], 'signaling': [72], 'downregulate': [75], 'ERα': [76, 188, 194, 212, 258], 'protein.': [77, 144, 173, 189], 'We': [78], 'have': [79], 'developed': [80, 183], 'protein': [82, 101, 132, 158], 'knockdown': [83, 187], 'system': [84, 94], 'induce': [86, 315], 'degradation': [87, 169, 192, 316], 'target': [89, 143, 157, 172], 'proteins': [90], 'via': [91], 'ubiquitin-proteasome': [93], '(UPS)': [95], 'cells.': [97, 208, 251, 327], 'The': [98], 'molecules': [99, 313], 'for': [100, 127, 141, 180, 275], 'knockdown,': [102], 'we': [104, 182], 'named': [105], 'SNIPER': [106, 146, 185], '(Specific': [107], 'Non-genetic': [109], 'IAP-dependent': [110], 'Protein': [111], 'ERaser),': [112], 'are': [113], 'composed': [114], 'two': [116], 'ligands': [118], 'connected': [119], 'by': [120, 232], 'linker;': [122], 'one': [123], 'ligand': [126, 140, 179], 'inhibitor': [129], 'apoptosis': [131], '1': [133], '(cIAP1)': [134], 'other': [137], 'Accordingly,': [145], 'expected': [148], 'crosslink': [150], 'ubiquitin': [152], 'ligase': [153], 'cIAP1': [154], 'cells,': [161], 'thereby': [162], 'inducing': [163], 'cIAP1-mediated': [165], 'ubiquitylation': [166], 'proteasomal': [168], 'By': [174], 'using': [175], 'as': [177, 272], 'ERα,': [181], 'novel': [184], 'SNIPER(ER)': [190, 226, 256, 271], 'induced': [191], 'inhibited': [196], 'expression': [198], 'pS2': [200], 'gene': [201], 'an': [203], 'MCF-7': [207, 216, 250], 'Intriguingly,': [209], 'after': [210], 'degradation,': [213, 259], 'SNIPER(ER)-treated': [215, 249], 'cells': [217], 'undergo': [218], 'rapid': [219], 'cell': [220, 229, 245, 264, 322], 'death.': [221], 'Detailed': [222], 'analysis': [223], 'indicated': [224], 'that': [225, 255, 314], 'caused': [227], 'necrotic': [228, 244, 263, 321], 'accompanied': [231], 'release': [234], 'HMGB1,': [236], 'reactive': [238], 'oxygen': [239], 'species': [240], '(ROS)': [241], 'mediate': [242], 'These': [252], 'results': [253], 'indicate': [254], 'induces': [257], 'ROS': [260], 'production': [261], 'death,': [265], 'implying': [266], 'therapeutic': [268], 'potential': [269], 'lead': [274], 'treatment': [277], 'ERα-positive': [279], 'Citation': [282, 289], 'Information:': [283], 'Mol': [284, 349], 'Cancer': [285, 339, 350], 'Ther': [286, 351], '2013;12(11': [287, 352], 'Suppl):B255.': [288], 'Format:': [290], 'Keiichiro': [291], 'Okuhira,': [292], 'Yosuke': [293], 'Demizu,': [294], 'Takayuki': [295], 'Hattori,': [296], 'Nobumichi': [297], 'Ohoka,': [298], 'Norihito': [299], 'Shibata,': [300], 'Tomoko': [301], 'Nishimaki-Mogami,': [302], 'Haruhiro': [303], 'Okuda,': [304], 'Masaaki': [305], 'Kurihara,': [306], 'Mikihiko': [307], 'Naito.': [308], 'Development': [309], 'hybrid': [311], 'small': [312], 'receptor-alpha': [319], '[abstract].': [328], 'In:': [329], 'Proceedings': [330], 'AACR-NCI-EORTC': [333], 'International': [334], 'Conference:': [335], 'Molecular': [336], 'Targets': [337], 'Therapeutics;': [340], '2013': [341], 'Oct': [342], '19-23;': [343], 'Boston,': [344], 'MA.': [345], 'Philadelphia': [346], '(PA):': [347], 'AACR;': [348], 'Suppl):Abstract': [353], 'nr': [354], 'B255.': [355]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2042218175', 'counts_by_year': [], 'updated_date': '2024-12-08T12:46:13.941704', 'created_date': '2016-06-24'}