Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2042095676', 'doi': 'https://doi.org/10.1016/s0005-2728(99)00030-4', 'title': 'Roles of nitric oxide in brain hypoxia-ischemia', 'display_name': 'Roles of nitric oxide in brain hypoxia-ischemia', 'publication_year': 1999, 'publication_date': '1999-05-01', 'ids': {'openalex': 'https://openalex.org/W2042095676', 'doi': 'https://doi.org/10.1016/s0005-2728(99)00030-4', 'mag': '2042095676', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10320673'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0005-2728(99)00030-4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210237460', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Bioenergetics', 'issn_l': '0005-2728', 'issn': ['0005-2728', '1879-2650'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1016/s0005-2728(99)00030-4', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058571857', 'display_name': 'Juan P. Bolaños', 'orcid': 'https://orcid.org/0000-0002-3949-6862'}, 'institutions': [{'id': 'https://openalex.org/I184999862', 'display_name': 'Universidad de Salamanca', 'ror': 'https://ror.org/02f40zc51', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I184999862']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Juan P Bolaños', 'raw_affiliation_strings': ['Departamento de Bioquı́mica y Biologı́a Molecular, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Bioquı́mica y Biologı́a Molecular, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain', 'institution_ids': ['https://openalex.org/I184999862']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5050991733', 'display_name': 'Ángeles Almeida', 'orcid': 'https://orcid.org/0000-0003-0485-8904'}, 'institutions': [{'id': 'https://openalex.org/I184999862', 'display_name': 'Universidad de Salamanca', 'ror': 'https://ror.org/02f40zc51', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I184999862']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Angeles Almeida', 'raw_affiliation_strings': ['Departamento de Bioquı́mica y Biologı́a Molecular, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Bioquı́mica y Biologı́a Molecular, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain', 'institution_ids': ['https://openalex.org/I184999862']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5058571857'], 'corresponding_institution_ids': ['https://openalex.org/I184999862'], 'apc_list': {'value': 4220, 'currency': 'USD', 'value_usd': 4220, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.087, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 307, 'citation_normalized_percentile': {'value': 0.998572, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '1411', 'issue': '2-3', 'first_page': '415', 'last_page': '436'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10155', 'display_name': 'Role of Nitric Oxide in Health and Disease', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10155', 'display_name': 'Role of Nitric Oxide in Health and Disease', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Dynamics and Reactive Oxygen Species Regulation', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12381', 'display_name': 'Electron Spin Resonance in Biomolecular Studies', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1304', 'display_name': 'Biophysics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hypoxia', 'display_name': 'Hypoxia (environmental)', 'score': 0.5608747}, {'id': 'https://openalex.org/keywords/nitric-oxide', 'display_name': 'Nitric Oxide', 'score': 0.462445}, {'id': 'https://openalex.org/keywords/brain-ischemia', 'display_name': 'Brain ischemia', 'score': 0.45560426}, {'id': 'https://openalex.org/keywords/endothelial-nos', 'display_name': 'Endothelial NOS', 'score': 0.4521395}], 'concepts': [{'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.8471086}, {'id': 'https://openalex.org/C25498285', 'wikidata': 'https://www.wikidata.org/wiki/Q1981368', 'display_name': 'Neuroprotection', 'level': 2, 'score': 0.7730521}, {'id': 'https://openalex.org/C2778326061', 'wikidata': 'https://www.wikidata.org/wiki/Q1761022', 'display_name': 'Enos', 'level': 4, 'score': 0.7570097}, {'id': 'https://openalex.org/C541997718', 'wikidata': 'https://www.wikidata.org/wiki/Q188151', 'display_name': 'Ischemia', 'level': 2, 'score': 0.756692}, {'id': 'https://openalex.org/C2777622882', 'wikidata': 'https://www.wikidata.org/wiki/Q417619', 'display_name': 'Nitric oxide synthase', 'level': 3, 'score': 0.6324777}, {'id': 'https://openalex.org/C7836513', 'wikidata': 'https://www.wikidata.org/wiki/Q1641506', 'display_name': 'Hypoxia (environmental)', 'level': 3, 'score': 0.5608747}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.48124146}, {'id': 'https://openalex.org/C2778820722', 'wikidata': 'https://www.wikidata.org/wiki/Q4862390', 'display_name': 'Brain ischemia', 'level': 3, 'score': 0.45560426}, {'id': 'https://openalex.org/C2779698670', 'wikidata': 'https://www.wikidata.org/wiki/Q408853', 'display_name': 'Endothelial NOS', 'level': 5, 'score': 0.4521395}, {'id': 'https://openalex.org/C157767197', 'wikidata': 'https://www.wikidata.org/wiki/Q886843', 'display_name': 'Cerebral blood flow', 'level': 2, 'score': 0.4311009}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3670642}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.36082327}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3340667}, {'id': 'https://openalex.org/C540031477', 'wikidata': 'https://www.wikidata.org/wiki/Q629', 'display_name': 'Oxygen', 'level': 2, 'score': 0.098380715}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002545', 'descriptor_name': 'Brain Ischemia', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D002534', 'descriptor_name': 'Hypoxia, Brain', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002545', 'descriptor_name': 'Brain Ischemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018846', 'descriptor_name': 'Excitatory Amino Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018846', 'descriptor_name': 'Excitatory Amino Acids', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002534', 'descriptor_name': 'Hypoxia, Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009566', 'descriptor_name': 'Nitrates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009566', 'descriptor_name': 'Nitrates', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D052248', 'descriptor_name': 'Nitric Oxide Synthase Type I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052250', 'descriptor_name': 'Nitric Oxide Synthase Type III', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010500', 'descriptor_name': 'Perinatology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014664', 'descriptor_name': 'Vasodilation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0005-2728(99)00030-4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210237460', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Bioenergetics', 'issn_l': '0005-2728', 'issn': ['0005-2728', '1879-2650'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10320673', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0005-2728(99)00030-4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210237460', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Bioenergetics', 'issn_l': '0005-2728', 'issn': ['0005-2728', '1879-2650'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 276, 'referenced_works': ['https://openalex.org/W107648938', 'https://openalex.org/W1500094754', 'https://openalex.org/W1528505919', 'https://openalex.org/W1533966692', 'https://openalex.org/W1546521548', 'https://openalex.org/W1573644537', 'https://openalex.org/W1594710697', 'https://openalex.org/W1600981813', 'https://openalex.org/W1606988289', 'https://openalex.org/W1667686291', 'https://openalex.org/W1764308599', 'https://openalex.org/W1765591388', 'https://openalex.org/W1883672642', 'https://openalex.org/W1896045165', 'https://openalex.org/W1929009802', 'https://openalex.org/W1934555453', 'https://openalex.org/W1943296211', 'https://openalex.org/W1963608093', 'https://openalex.org/W1963874268', 'https://openalex.org/W1964621255', 'https://openalex.org/W1964796026', 'https://openalex.org/W1966163673', 'https://openalex.org/W1966322594', 'https://openalex.org/W1966648142', 'https://openalex.org/W1966664051', 'https://openalex.org/W1966895843', 'https://openalex.org/W1968551857', 'https://openalex.org/W1968735016', 'https://openalex.org/W1968962228', 'https://openalex.org/W1969530182', 'https://openalex.org/W1969869149', 'https://openalex.org/W1970259166', 'https://openalex.org/W1971141628', 'https://openalex.org/W1974892577', 'https://openalex.org/W1976541392', 'https://openalex.org/W1978348298', 'https://openalex.org/W1978643925', 'https://openalex.org/W1979302035', 'https://openalex.org/W1981729244', 'https://openalex.org/W1982135056', 'https://openalex.org/W1983718973', 'https://openalex.org/W1984616391', 'https://openalex.org/W1985221375', 'https://openalex.org/W1985846647', 'https://openalex.org/W1986100628', 'https://openalex.org/W1986830200', 'https://openalex.org/W1988726352', 'https://openalex.org/W1990798856', 'https://openalex.org/W1991268433', 'https://openalex.org/W1991329566', 'https://openalex.org/W1991619596', 'https://openalex.org/W1991830766', 'https://openalex.org/W1992184489', 'https://openalex.org/W1992729478', 'https://openalex.org/W1994333676', 'https://openalex.org/W1995379325', 'https://openalex.org/W1997075816', 'https://openalex.org/W1997451049', 'https://openalex.org/W1998104086', 'https://openalex.org/W1998516209', 'https://openalex.org/W1999316393', 'https://openalex.org/W2000142262', 'https://openalex.org/W2000798702', 'https://openalex.org/W2001096410', 'https://openalex.org/W2001561674', 'https://openalex.org/W2002099191', 'https://openalex.org/W2002526073', 'https://openalex.org/W2003292990', 'https://openalex.org/W2005371462', 'https://openalex.org/W2005706069', 'https://openalex.org/W2005730678', 'https://openalex.org/W2005813817', 'https://openalex.org/W2006835697', 'https://openalex.org/W2007085280', 'https://openalex.org/W2008354596', 'https://openalex.org/W2009037341', 'https://openalex.org/W2009926364', 'https://openalex.org/W2010548443', 'https://openalex.org/W2011564032', 'https://openalex.org/W2011955852', 'https://openalex.org/W2012864018', 'https://openalex.org/W2014546878', 'https://openalex.org/W2015076773', 'https://openalex.org/W2015463429', 'https://openalex.org/W2015591213', 'https://openalex.org/W2016597337', 'https://openalex.org/W2017195276', 'https://openalex.org/W2017546932', 'https://openalex.org/W2017626532', 'https://openalex.org/W2017642597', 'https://openalex.org/W2018082620', 'https://openalex.org/W2018622009', 'https://openalex.org/W2018968104', 'https://openalex.org/W2019610055', 'https://openalex.org/W2019838448', 'https://openalex.org/W2020569812', 'https://openalex.org/W2020622209', 'https://openalex.org/W2024556319', 'https://openalex.org/W2024773521', 'https://openalex.org/W2024862570', 'https://openalex.org/W2025680091', 'https://openalex.org/W2026021727', 'https://openalex.org/W2026797052', 'https://openalex.org/W2028162046', 'https://openalex.org/W2028345121', 'https://openalex.org/W2028676745', 'https://openalex.org/W2029288709', 'https://openalex.org/W2029706669', 'https://openalex.org/W2029898926', 'https://openalex.org/W2032173511', 'https://openalex.org/W2032478929', 'https://openalex.org/W2032928404', 'https://openalex.org/W2034507570', 'https://openalex.org/W2034614276', 'https://openalex.org/W2035750459', 'https://openalex.org/W2036564332', 'https://openalex.org/W2037085141', 'https://openalex.org/W2037404192', 'https://openalex.org/W2038369630', 'https://openalex.org/W2039189829', 'https://openalex.org/W2039674246', 'https://openalex.org/W2039881438', 'https://openalex.org/W2041273914', 'https://openalex.org/W2041573451', 'https://openalex.org/W2041795514', 'https://openalex.org/W2041944141', 'https://openalex.org/W2042160368', 'https://openalex.org/W2042358124', 'https://openalex.org/W2042681316', 'https://openalex.org/W2043968522', 'https://openalex.org/W2045281710', 'https://openalex.org/W2045623123', 'https://openalex.org/W2045942875', 'https://openalex.org/W2046709889', 'https://openalex.org/W2047362612', 'https://openalex.org/W2047761404', 'https://openalex.org/W2047843548', 'https://openalex.org/W2049619207', 'https://openalex.org/W2050342402', 'https://openalex.org/W2050854460', 'https://openalex.org/W2051031104', 'https://openalex.org/W2051045520', 'https://openalex.org/W2051235004', 'https://openalex.org/W2051894873', 'https://openalex.org/W2052816407', 'https://openalex.org/W2054036917', 'https://openalex.org/W2054712846', 'https://openalex.org/W2055178683', 'https://openalex.org/W2055524735', 'https://openalex.org/W2055952684', 'https://openalex.org/W2057643090', 'https://openalex.org/W2058137293', 'https://openalex.org/W2058586534', 'https://openalex.org/W2058676829', 'https://openalex.org/W2058821788', 'https://openalex.org/W2059192931', 'https://openalex.org/W2059368708', 'https://openalex.org/W2059379142', 'https://openalex.org/W2059640915', 'https://openalex.org/W2059770569', 'https://openalex.org/W2059799186', 'https://openalex.org/W2060243949', 'https://openalex.org/W2060791535', 'https://openalex.org/W2060948802', 'https://openalex.org/W2060980402', 'https://openalex.org/W2061274901', 'https://openalex.org/W2062232335', 'https://openalex.org/W2062384458', 'https://openalex.org/W2063097303', 'https://openalex.org/W2063257313', 'https://openalex.org/W2064255459', 'https://openalex.org/W2065083920', 'https://openalex.org/W2065872100', 'https://openalex.org/W2065949088', 'https://openalex.org/W2066168019', 'https://openalex.org/W2067051297', 'https://openalex.org/W2067147937', 'https://openalex.org/W2067637414', 'https://openalex.org/W2068869692', 'https://openalex.org/W2070009716', 'https://openalex.org/W2071233035', 'https://openalex.org/W2071365883', 'https://openalex.org/W2071553665', 'https://openalex.org/W2073048205', 'https://openalex.org/W2073167767', 'https://openalex.org/W2073363889', 'https://openalex.org/W2074036818', 'https://openalex.org/W2074187719', 'https://openalex.org/W2074490016', 'https://openalex.org/W2074683731', 'https://openalex.org/W2075380902', 'https://openalex.org/W2075431372', 'https://openalex.org/W2075472794', 'https://openalex.org/W2075862266', 'https://openalex.org/W2077166140', 'https://openalex.org/W2078833131', 'https://openalex.org/W2079274182', 'https://openalex.org/W2079910315', 'https://openalex.org/W2082011784', 'https://openalex.org/W2082707311', 'https://openalex.org/W2082964670', 'https://openalex.org/W2083783803', 'https://openalex.org/W2084086773', 'https://openalex.org/W2084560433', 'https://openalex.org/W2085106588', 'https://openalex.org/W2086288645', 'https://openalex.org/W2086938866', 'https://openalex.org/W2087421641', 'https://openalex.org/W2088195616', 'https://openalex.org/W2088609449', 'https://openalex.org/W2088831200', 'https://openalex.org/W2088985332', 'https://openalex.org/W2091565864', 'https://openalex.org/W2092386374', 'https://openalex.org/W2093033612', 'https://openalex.org/W2093283930', 'https://openalex.org/W2093962216', 'https://openalex.org/W2093980002', 'https://openalex.org/W2094216072', 'https://openalex.org/W2094667477', 'https://openalex.org/W2095212152', 'https://openalex.org/W2095472033', 'https://openalex.org/W2099649534', 'https://openalex.org/W2100358219', 'https://openalex.org/W2101220293', 'https://openalex.org/W2106795247', 'https://openalex.org/W2112950347', 'https://openalex.org/W2117104323', 'https://openalex.org/W2123632844', 'https://openalex.org/W2131011042', 'https://openalex.org/W2131347780', 'https://openalex.org/W2132895844', 'https://openalex.org/W2136370254', 'https://openalex.org/W2136590470', 'https://openalex.org/W2140936548', 'https://openalex.org/W2142554393', 'https://openalex.org/W2144663935', 'https://openalex.org/W2153889396', 'https://openalex.org/W2156825937', 'https://openalex.org/W2157982135', 'https://openalex.org/W2163029180', 'https://openalex.org/W2164996701', 'https://openalex.org/W2166342281', 'https://openalex.org/W2170351884', 'https://openalex.org/W2179702494', 'https://openalex.org/W2185220614', 'https://openalex.org/W2185299052', 'https://openalex.org/W2261115509', 'https://openalex.org/W2285668203', 'https://openalex.org/W2287622621', 'https://openalex.org/W2326282712', 'https://openalex.org/W2338001129', 'https://openalex.org/W2409430195', 'https://openalex.org/W2409804882', 'https://openalex.org/W2410056392', 'https://openalex.org/W2413312669', 'https://openalex.org/W2413846594', 'https://openalex.org/W2415432740', 'https://openalex.org/W2416193238', 'https://openalex.org/W2416873272', 'https://openalex.org/W2417139078', 'https://openalex.org/W2418090875', 'https://openalex.org/W2418929586', 'https://openalex.org/W2418950152', 'https://openalex.org/W2439911457', 'https://openalex.org/W266349836', 'https://openalex.org/W26913945', 'https://openalex.org/W314368845', 'https://openalex.org/W3152061996', 'https://openalex.org/W3195820525', 'https://openalex.org/W394197928', 'https://openalex.org/W4211096425', 'https://openalex.org/W4236599054', 'https://openalex.org/W4298311268', 'https://openalex.org/W44031278', 'https://openalex.org/W51366274'], 'related_works': ['https://openalex.org/W3030505798', 'https://openalex.org/W3026529892', 'https://openalex.org/W2284947444', 'https://openalex.org/W2249728733', 'https://openalex.org/W2139541900', 'https://openalex.org/W2126050374', 'https://openalex.org/W2074042972', 'https://openalex.org/W2066360730', 'https://openalex.org/W2019650760', 'https://openalex.org/W2008305232'], 'abstract_inverted_index': {'A': [0], 'large': [1], 'body': [2], 'of': [3, 25, 35, 47, 55, 70, 81, 92, 110, 116, 136, 153, 157, 183], 'evidence': [4], 'has': [5], 'appeared': [6], 'over': [7], 'the': [8, 22, 26, 33, 45, 67, 90, 93, 107, 134, 181, 195], 'last': [9], '6': [10], 'years': [11], 'suggesting': [12], 'that': [13, 151], 'nitric': [14, 36, 56, 71], 'oxide': [15, 37, 57, 72], 'biosynthesis': [16], 'is': [17, 64, 112, 118, 145, 172], 'a': [18, 79, 173], 'key': [19], 'factor': [20], 'in': [21, 38, 73, 122], 'pathophysiological': [23], 'response': [24, 176], 'brain': [27, 74, 161, 197], 'to': [28, 194], 'hypoxia-ischemia.': [29], 'Whilst': [30], 'studies': [31], 'on': [32], 'influence': [34], 'this': [39], 'phenomenon': [40], 'initially': [41], 'offered': [42], 'conflicting': [43], 'conclusions,': [44], 'use': [46], 'better': [48], 'biochemical': [49], 'tools,': [50], 'such': [51], 'as': [52], 'selective': [53, 108, 114, 143], 'inhibition': [54, 109, 115, 144], 'synthase': [58], '(NOS)': [59], 'isoforms': [60], 'or': [61, 127, 155], 'transgenic': [62], 'animals,': [63], 'progressively': [65], 'clarifying': [66], 'precise': [68], 'role': [69], 'ischemia.': [75], 'Brain': [76], 'ischemia': [77, 126], 'triggers': [78], 'cascade': [80], 'events,': [82], 'possibly': [83, 163], 'mediated': [84], 'by': [85, 164], 'excitatory': [86], 'amino': [87], 'acids,': [88], 'yielding': [89], 'activation': [91, 152, 179], 'Ca2+-dependent': [94], 'NOS': [95, 99, 103, 139], 'isoforms,': [96], 'i.e.': [97], 'neuronal': [98], '(nNOS)': [100], 'and': [101, 141, 167, 189], 'endothelial': [102], '(eNOS).': [104], 'However,': [105, 170], 'whereas': [106], 'nNOS': [111, 154], 'neuroprotective,': [113], 'eNOS': [117, 178], 'neurotoxic.': [119], 'Furthermore,': [120], 'mainly': [121], 'glial': [123], 'cells,': [124], 'delayed': [125], 'reperfusion': [128], 'after': [129], 'an': [130], 'ischemic': [131, 160], 'episode': [132], 'induces': [133], 'expression': [135], 'Ca2+-independent': [137], 'inducible': [138], '(iNOS),': [140], 'its': [142], 'neuroprotective.': [146], 'In': [147], 'conclusion,': [148], 'it': [149], 'appears': [150], 'induction': [156], 'iNOS': [158], 'mediates': [159, 187], 'damage,': [162], 'mitochondrial': [165], 'dysfunction': [166], 'energy': [168], 'depletion.': [169], 'there': [171], 'simultaneous': [174], 'compensatory': [175], 'through': [177], 'within': [180], 'endothelium': [182], 'blood': [184, 192], 'vessels,': [185], 'which': [186], 'vasodilation': [188], 'hence': [190], 'increases': [191], 'flow': [193], 'damaged': [196], 'area.': [198]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2042095676', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 18}], 'updated_date': '2024-09-10T12:26:03.112551', 'created_date': '2016-06-24'}