Publication Information

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'https://openalex.org/W2015249181', 'https://openalex.org/W1893746691', 'https://openalex.org/W175181557'], 'abstract_inverted_index': {'To': [0, 231], 'provide': [1, 232], 'new': [2, 233], 'insights': [3, 234], 'into': [4, 235], 'the': [5, 8, 46, 50, 56, 62, 65, 68, 72, 81, 85, 115, 123, 141, 145, 152, 181, 196, 200, 214, 236, 239, 277, 281, 287, 293, 296, 299, 303, 312, 316, 346, 354, 372, 376, 383, 412, 427, 431, 445], 'regions': [6, 237], 'of': [7, 20, 45, 64, 74, 84, 126, 144, 156, 199, 238, 251, 276, 295, 305, 315, 357, 375, 387, 430], 'human': [9, 22, 240, 253], 'A1': [10, 23, 26, 241, 254, 257], 'adenosine': [11, 27, 242, 258], 'receptor': [12, 130, 149, 201, 243, 361, 380, 432], '(A1AR)': [13, 244], 'involved': [14, 245], 'in': [15, 228, 246, 459], 'ligand': [16, 153, 207, 224, 247, 384, 438, 455], 'binding,': [17, 248], 'a': [18, 249], 'series': [19, 250], 'chimeric': [21, 252], 'and': [24, 55, 89, 104, 159, 220, 223, 255, 286, 320, 335, 390, 451, 454], 'rat': [25, 256], 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304], 'transmembrane': [75, 306], '(TM)': [76, 307], '1': [77, 308], 'was': [78, 92, 98, 102, 192, 309, 323, 329, 333, 423], 'replaced': [79, 310], 'by': [80, 311], 'corresponding': [82, 313], '(A1TM1/A1),': [87, 318], '[3H]CGS-21680': [88, 100, 319, 331], '[3H]CCPA': [90, 112, 321, 343], 'binding': [91, 101, 107, 154, 191, 222, 322, 332, 338, 385, 422, 453], 'detectable.': [93, 324], 'an': [95, 326], 'A1TM1-2/A1': [96, 327], 'construct': [97, 117, 328, 348], 'studied,': [99, 330], 'lost': [103, 334], '[3H]': [105, 336], 'DPCPX': [106, 337], 'appeared.': [108, 339], 'Saturation': [109, 134, 340, 365], 'revealed': [113, 139, 344, 370], 'that': [114, 140, 178, 195, 213, 345, 371, 409, 426, 444], 'A1TM1/A1': [116, 347], 'had': [118, 349], 'low': [119, 350], 'affinity.': [120, 150, 351, 381], 'However,': [121, 352], 'with': [122, 353], 'subsequent': [124, 355], 'addition': [125, 356], 'TMs': [128, 142, 229, 359, 373, 460], '2-4': [129, 360], 'affinity': [131, 362], 'improved': [132, 363], 'markedly.': [133, 364], '[3H]DPCPX': [137, 368], 'also': [138, 369], '1-4': [143, 374], 'conferred': [147, 378], 'wild-type': [148, 379], 'properties': [155, 386], 'A1TM1-4/A1,': [157, 388], 'A1TM1-6/A1,': [158, 389], 'wild': [160, 391], 'type': [161, 392], 'constructs': [163, 394], 'directly': [165, 396], 'compared,': [166, 397], 'no': [167, 190, 398, 421], 'differences': [168, 399], 'found': [170, 401], '10': [172, 403], 'different': [173, 404], 'compounds.': [174, 405], 'truncated': [176, 407], 'A1ARs': [177, 408], 'extended': [179, 410], 'shortly': [185, 416], 'after': [186, 417], 'TM4': [187, 418], 'examined,': [189, 420], 'detectable': [193, 424], 'suggesting': [194, 425], 'half': [198, 429], 'alone': [202, 433], 'is': [203, 434], 'not': [204, 435], 'sufficient': [205, 436], 'for': [206, 217, 437, 448], 'binding.': [208, 439], 'Collectively,': [209, 440], 'these': [210, 441], 'data': [211, 442], 'suggest': [212, 443], 'important': [215, 446], 'determinants': [216, 447], 'specificity': [225, 456], 'are': [226, 457], 'present': [227, 458], '1-4.': [230, 461]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2041366274', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-14T16:53:35.000804', 'created_date': '2016-06-24'}