Inhibition of Activator Protein-1, NF-κB, and MAPKs and Induction of Phase 2 Detoxifying Enzyme Activity by Chlorogenic Acid

Name: Work Video:
Duration: 3 min 30 s
Rentian Feng; Yongju Lu; Linda Bowman; Yong Qian; Vincent Castranova; Min Ding
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4000, 4048, 4072, 4133, 4154, 4236, 4303], 'human': [19, 62, 260, 303, 540, 2590, 2937, 4118], 'diet.': [20, 261], 'The': [21, 67, 186, 262, 308, 427, 929, 980, 1505, 2104, 2422, 2522, 2589, 2617, 2661, 2716, 2781, 2806, 2830, 2860, 2944, 2992, 3016, 3026, 3109, 3156, 3356, 3534, 3594, 3616, 3745, 3825, 3941, 3959, 4019, 4109, 4146], 'antioxidant': [22, 180, 230, 263, 421, 471, 678, 1526, 2645, 4060, 4079], 'and': [23, 105, 126, 154, 214, 232, 238, 264, 346, 367, 395, 455, 473, 479, 499, 542, 780, 844, 938, 941, 994, 1018, 1024, 1142, 1156, 1257, 1299, 1370, 1463, 1519, 1536, 1623, 1718, 1756, 1866, 1926, 1986, 1992, 2044, 2058, 2157, 2242, 2274, 2290, 2304, 2314, 2321, 2339, 2355, 2378, 2409, 2433, 2494, 2530, 2585, 2607, 2682, 2689, 2722, 2739, 2793, 2818, 2958, 3012, 3170, 3194, 3217, 3224, 3291, 3351, 3387, 3396, 3450, 3477, 3490, 3530, 3543, 3672, 3680, 3696, 3743, 3776, 3794, 3841, 3869, 3878, 4035, 4054, 4138, 4219, 4293, 4318, 4336, 4347], 'anticarcinogenic': [24, 265], 'properties': [25, 266, 602, 2226], 'chlorogenic': [27, 45, 55, 76, 96, 115, 162, 206, 221, 268, 286, 296, 317, 337, 356, 403, 447, 462, 619, 2228, 2235, 2261, 2269, 2302, 2648, 2813, 2931, 3010, 3049, 3129, 3349, 3409, 3448, 3571, 3741, 3964, 4063, 4075, 4093, 4112, 4141, 4181, 4202, 4311, 4330, 4355, 4390, 4410], 'have': [29, 270, 947, 1263, 1406, 4029, 4223], 'been': [30, 271, 544, 835, 949, 1264, 1292, 1407, 2948, 4030], 'established': [31, 272], 'animal': [33, 274, 555, 2221], 'studies.': [34, 275], 'However,': [35, 276, 595], 'little': [36, 277, 4184], 'known': [38, 279, 693, 1627, 4031, 4424], 'about': [39, 280], 'molecular': [41, 282, 597, 697, 1469], 'mechanisms': [42, 283, 598, 610, 1466, 2306], 'through': [43, 225, 284, 466], 'which': [44, 285, 2487, 2684], 'inhibits': [47, 288], 'carcinogenesis.': [48, 289, 4304], 'In': [49, 290, 2629, 4040], 'this': [50, 291, 2704], 'study,': [51, 292], 'we': [52, 293, 2230, 2263, 4057], 'found': [53, 294, 906, 1734], 'that': [54, 75, 161, 205, 216, 295, 316, 402, 446, 457, 485, 765, 1010, 1022, 1294, 2035, 2116, 2453, 2710, 3847, 4082, 4092, 4201, 4225, 4294, 4400, 4425], 'inhibited': [57, 298, 4333], 'proliferation': [59, 300, 2238, 2935, 3030, 4115, 4171, 4188, 4402], 'A549': [61, 302, 2939, 4173], 'cancer': [63, 304, 498, 558, 913, 1460, 1990, 2224, 2240, 2592, 2938, 4120], 'cells': [64, 86, 94, 305, 327, 335, 914, 937, 946, 2241, 2618, 2634, 2744, 2807, 2831, 2940, 2993, 3017, 3060, 3110, 3180, 3341, 3444, 3577, 3595, 3617, 3647, 3677, 3704, 3735, 3746, 3930, 3960, 4153, 4174, 4191, 4238, 4328, 4405], 'vitro.': [66, 307], 'results': [68, 200, 309, 441, 2296, 2861], 'soft': [71, 312, 3063], 'agar': [72, 313, 3064, 3139, 3148], 'assay': [73, 314, 2424, 2665, 2845, 2946, 3065, 3231, 3982, 4398], 'indicated': [74, 160, 315, 401, 2034, 4399], 'suppressed': [78, 319, 4177, 4363], '12-O-tetradecanoylphorbol-13-acetate': [79, 320, 2340], '(TPA)-induced': [80, 321], 'neoplastic': [81, 322, 775, 1300, 2243, 4234], 'transformation': [82, 323, 1155, 1301, 1417, 2244, 3054, 4235], 'JB6': [84, 93, 325, 334, 1416, 2250, 2523, 2531, 2734, 2942, 3058, 3443, 3576, 3703, 3929, 4190, 4237, 4393, 4404], 'P+': [85, 326, 3059], 'a': [88, 329, 1000, 1006, 1019, 1455, 1510, 1731, 2455, 2497, 2556, 2625, 2653, 2686, 2708, 2764, 2775, 2855, 3161, 3501, 3683, 3900, 4117, 4166, 4322, 4340, 4350, 4414, 4430], 'dose-dependent': [89, 330], 'manner.': [90, 331], 'Pretreatment': [91, 332, 4326], 'blocked': [98, 339, 1304], 'UVB-': [99, 340], 'or': [100, 341, 658, 757, 1089, 2396, 2436, 2450, 2555, 2729, 2804, 2811, 2825, 2867, 2941, 3008, 3123, 3739, 3857, 4216, 4228, 4315, 4359, 4366, 4377], 'TPA-induced': [101, 342, 3052, 4334, 4357], 'transactivation': [102, 343, 2289, 2320], 'AP-1': [104, 345, 627, 756, 832, 983, 1297, 2728, 2803, 2866, 4051, 4218, 4227, 4317, 4335, 4358, 4376], 'NF-κB': [106, 347, 688, 758, 904, 934, 1075, 2437, 2730, 2868, 4220, 4229, 4319, 4337, 4360, 4378], 'over': [107, 348, 3143, 3417, 4086, 4339], 'same': [109, 350, 3242, 4088, 4194], 'dose': [110, 351, 4195], 'range.': [111, 352], 'At': [112, 353, 4165, 4349], 'low': [113, 354], 'concentrations,': [114, 355], 'decreased': [117, 358], 'phosphorylation': [119, 360, 1015, 3190, 3238], 'c-Jun': [121, 362, 647], 'NH2-terminal': [122, 363, 648], 'kinases,': [123, 364], 'p38': [124, 365, 995, 1927, 3195, 3218, 3225], 'kinase,': [125, 366], 'MAPK': [127, 239, 368, 480, 640, 1007, 1144, 1258, 2275, 2411], 'kinase': [128, 369, 652, 653, 1008, 1021, 1083, 1087, 1915, 1923, 3196, 3226], '4': [129, 370, 654, 3636], 'induced': [130, 371, 1296, 1871, 2245, 2277], 'by': [131, 372, 986, 1085, 1305, 1728, 1872, 2049, 2113, 2246, 2278, 2476, 2847, 2911, 3353, 3408, 3488, 3538, 3603, 3785, 3863, 4364, 4409], 'UVB/12-O-tetradecanoylphorbol-13-acetate,': [132, 373], 'yet': [133, 374], 'higher': [134, 375, 2159], 'doses': [135, 376], 'were': [136, 377, 2119, 2342, 2360, 2380, 2414, 2572, 2619, 2635, 2718, 2737, 2758, 2768, 2808, 2832, 2997, 3018, 3114, 3158, 3174, 3181, 3197, 3233, 3293, 3342, 3445, 3486, 3498, 3583, 3596, 3618, 3640, 3648, 3678, 3705, 3736, 3747, 3783, 3795, 3830, 3848, 3861, 3931, 3961, 4006, 4131, 4383], 'required': [137, 378, 4232], 'to': [138, 379, 546, 694, 837, 1150, 1409, 1628, 1639, 2123, 2166, 2468, 2485, 2707, 2713, 2760, 2786, 2798, 2821, 2926, 3116, 3235, 3518, 3866, 3891, 3956, 4032, 4386], 'inhibit': [139, 380, 1868, 1920, 4206], 'extracellular': [140, 381, 643], 'signal-regulated': [141, 382, 644], 'kinases.': [142, 383], 'also': [145, 386, 948, 1077, 1420, 1919, 2264], 'increased': [146, 387], 'enzymatic': [148, 389, 3557], 'activities': [149, 390, 2046, 3283], 'glutathione': [151, 392, 664, 1749], 'S-transferases': [152, 393], '(GST)': [153, 394, 1751], 'NAD(P)H:': [155, 396], 'quinone': [156, 397], 'oxidoreductase.': [157, 398], 'Further': [158, 399], 'studies': [159, 400, 4222], 'could': [164, 208, 405, 449], 'stimulate': [165, 406], 'nuclear': [167, 408, 3828], 'translocation': [168, 409], 'Nrf2': [170, 197, 411, 438, 1508, 1757, 2036, 2288, 2319, 2397, 3697, 3873], '(NF-E2-related': [171, 412], 'factor)': [172, 413], 'as': [173, 175, 414, 416, 773, 1266, 1309, 2281, 2283, 2724, 2864, 3039, 3066, 3200, 3296, 3413, 3509, 3563, 3707, 3907, 3984, 3991, 3998], 'well': [174, 415, 2282, 2762, 4423], 'subsequent': [176, 417], 'induction': [177, 418, 2041, 2191, 2286, 3407], 'GSTA1': [179, 420], 'response': [181, 422, 679, 1527], 'element': [182, 423, 1528], '(ARE)-mediated': [183, 424, 1529], 'GST': [184, 425, 1860, 1917, 2043, 2464, 2481, 3441, 3560, 3887], 'activity.': [185, 426, 2325, 4379], 'phosphatidylinositol': [187, 428], '3-kinase': [188, 429], 'pathway': [189, 430], 'might': [190, 431, 493], 'be': [191, 224, 432, 465, 625, 695, 838, 1078, 1151, 1303, 1410, 2691, 4033], 'involved': [192, 433, 767, 839], 'activation': [195, 436, 1865, 2276, 4230, 4361], 'translocation.': [198, 439], 'These': [199, 440, 4380], 'provide': [201, 442], 'first': [203, 444], 'evidence': [204, 445, 483], 'protect': [209, 450], 'against': [210, 451, 1641, 2204, 2394, 2720, 3211, 3222], 'environmental': [211, 452, 1633], 'carcinogen-induced': [212, 453], 'carcinogenesis': [213, 454, 552, 2205], 'suggest': [215, 456], 'chemopreventive': [218, 459, 700, 1269, 1306, 1461, 1991, 2053], 'effects': [219, 460, 1994, 2233, 2267, 2317, 4309, 4382], 'may': [223, 464, 1861, 1918, 4204], 'its': [226, 467, 600, 939], 'up-regulation': [227, 468], 'cellular': [229, 470], 'enzymes': [231, 472, 1535, 1625, 2110], 'suppression': [233, 474, 2702], 'ROS-mediated': [235, 476], 'NF-κB,': [236, 477, 1141, 1255, 2272], 'AP-1,': [237, 478, 632, 1140, 1256, 2273], 'activation.': [240, 481], 'Epidemiological': [482], 'demonstrates': [484], 'consumption': [486], 'healthy': [488], 'foods': [489], 'containing': [490, 2444, 2462, 2579, 2614, 2678, 3140, 3149, 3524, 3629, 3827, 3885, 3944], 'phytochemical': [491], 'compounds': [492], 'reduce': [494], 'incidence': [496, 549], 'chronic': [500], 'degenerative': [501], 'diseases': [502], '(1Tamimi': [503], 'R.M.': [504], 'Lagiou': [505], 'P.': [506, 707, 739, 804, 856, 888, 1317, 1332, 1476, 1661, 1764, 2139, 2177, 2545, 3074, 4244], 'Adami': [507], 'H.O.': [508], 'Trichopoulos': [509], 'D.': [510, 1884], 'J.': [511, 1059, 1111, 1117, 1119, 1172, 1225, 1603, 1669, 1673, 1772, 1776, 1840, 1941, 1951, 1964, 2023, 2892, 2967, 3264, 3324, 3724, 4278], 'Intern.': [512], 'Med.': [513, 971, 1581, 2097, 4284], '2002;': [514, 746, 811, 895, 921, 957, 972, 1339, 1693, 1796, 1831, 2009], '251:': [515], '286-300Crossref': [516], 'PubMed': [517, 590, 731, 749, 796, 814, 827, 880, 898, 924, 960, 975, 1040, 1070, 1105, 1135, 1183, 1206, 1285, 1342, 1365, 1396, 1442, 1500, 1570, 1590, 1614, 1651, 1677, 1696, 1780, 1799, 1851, 1975, 2101, 2152, 2184, 2214, 2517, 2903, 2974, 2987, 3104, 3275, 3313, 3333, 3434, 3924, 4268, 4288], 'Scopus': [518, 591, 732, 750, 797, 815, 828, 881, 899, 925, 961, 976, 1041, 1071, 1106, 1136, 1184, 1207, 1286, 1343, 1366, 1397, 1443, 1501, 1571, 1591, 1615, 1652, 1678, 1697, 1710, 1781, 1800, 1813, 1852, 1976, 2153, 2185, 2215, 2518, 2904, 2975, 2988, 3105, 3276, 3314, 3435, 3925, 4269, 4289], '(75)': [519], 'Google': [520, 572, 593, 715, 734, 752, 799, 817, 830, 864, 883, 901, 927, 963, 978, 1043, 1073, 1108, 1138, 1186, 1209, 1233, 1247, 1288, 1325, 1345, 1368, 1399, 1445, 1484, 1503, 1573, 1593, 1617, 1654, 1680, 1699, 1712, 1783, 1802, 1815, 1834, 1854, 1906, 1978, 2012, 2028, 2084, 2102, 2155, 2187, 2217, 2520, 2553, 2906, 2977, 2990, 3082, 3107, 3278, 3316, 3334, 3437, 3732, 3927, 4252, 4271, 4291], 'Scholar).': [521, 594, 753, 831, 902, 928, 979, 1074, 1139, 1248, 1289, 1400, 1446, 1504, 1618, 1713, 1855, 1907, 1979, 2029, 2103, 2188, 2218, 2521, 2907, 2991, 3108, 3279, 3335, 3438, 3733, 3928], 'diet': [541], 'has': [543, 834, 1291, 2947], 'reported': [545, 1293], 'decrease': [547], 'chemical': [551], 'several': [554], 'models': [556], '(2Huang': [559], 'M.T.': [560], 'Smart': [561], 'R.C.': [562], 'Wong': [563], 'C.Q.': [564], 'Conney': [565], 'A.H.': [566], 'Cancer': [567, 710, 859, 1320, 1479, 1705, 1808, 1829, 2007, 2079, 2548, 3077, 4107, 4247], 'Res.': [568, 711, 860, 1321, 1480, 1565, 1830, 2008, 2080, 2512, 2549, 3078, 3308, 3429, 3919, 4248], '1988;': [569], '48:': [570], '5941-5946PubMed': [571], 'Scholar,': [573, 716, 735, 800, 818, 865, 884, 964, 1044, 1109, 1187, 1210, 1234, 1485, 1574, 1594, 1655, 1681, 1700, 1784, 1803, 1816, 1835, 2013, 2085, 2978, 3083, 3317, 4253, 4272], '3Kasai': [574], 'H.': [575, 583, 1576, 1598, 1961, 2019], 'Fukada': [576], 'S.': [577, 581, 1201, 1355, 1544, 1822, 1828, 1880, 2000, 2006, 2021, 2147, 2883, 3099, 3255], 'Yamaizumi': [578], 'Z.': [579, 720, 785, 869, 1050, 1094, 1115, 1125, 1127, 1195, 1274, 1431, 1489, 1890, 1894, 3085, 4257], 'Sugie': [580], 'Mori': [582], 'Food': [584], 'Chem.': [585, 1061, 1174, 1605, 1842, 1966, 2894, 3266, 3326], 'Toxicol.': [586, 745, 810, 894, 1228, 1338, 3727], '2000;': [587, 723, 788, 872, 1097, 1230, 1277, 1434, 1492, 1707, 1810, 1903, 3729, 4260, 4285], '38:': [588], '467-471Crossref': [589], '(190)': [592], 'for': [599, 618, 1013, 1268, 1458, 2039, 2201, 2795, 2815, 2950, 3023, 3036, 3167, 3189, 3481, 3573, 3588, 3613, 3658, 3771, 3779, 3791, 3820, 3838, 3966, 4143, 4159, 4233], 'anti-carcinogenic': [601], 'are': [603, 692, 766, 984, 1148, 1626, 1987, 2862, 3989], 'poorly': [604], 'understood.': [605], 'Thus,': [606, 1447, 1980, 2189], 'elucidation': [607], 'such': [609, 772, 1308], 'action': [612], 'essential': [614, 1522, 2038, 2353, 2577, 2752, 2791, 3154], 'before': [615], 'possibility': [617], 'application': [621], 'chemoprevention': [623, 2299], 'can': [624, 1076, 1302, 2690, 4095], 'considered.': [626], '1The': [628], 'abbreviations': [629], 'used': [630, 2925, 2949, 3234], 'are:': [631], 'activator': [633], 'protein-1;': [634], 'MAPK,': [635, 1005, 1017], 'mitogen-activated': [636], 'protein': [637, 3513], 'kinases;': [638], 'MAPKK,': [639], 'kinase;': [641, 645, 649], 'ERK,': [642], 'JNK,': [646, 3216], 'MKK4,': [650], 'MAP': [651], '(alternatively': [655], 'designated': [656], 'SEK1': [657], 'MEK4);': [659], 'NQO1,': [660], 'NAD(P)H:quinone': [661, 1753], 'oxidoreductase;': [662], 'GST,': [663, 3292], 'S-transferase;': [665], 'TPA,': [666], '12-O-tetradecanoylphorbol-13-acetate;': [667], 'ECIS,': [668], 'electric': [669], 'cell-substrate': [670], 'impedance': [671], 'sensing;': [672], 'ROS,': [673], 'reactive': [674, 4098], 'oxygen': [675, 4026, 4099], 'species;': [676], 'ARE,': [677, 1730], 'element;': [680], 'FBS,': [681, 2581], 'fetal': [682], 'bovine': [683, 2374, 3365, 3607, 3631], 'serum;': [684], 'PI,': [685], 'phosphatidylinositol.': [686], 'and/or': [687], 'signal': [689, 1145], 'transduction': [690, 1146], 'pathways': [691, 1147, 1929], 'important': [696, 4044, 4301], 'targets': [698, 1267], 'strategies': [701], '(4Li': [702, 851, 1312, 1471, 2540, 3069, 4239], 'J.J.': [703, 852, 1313, 1472, 2541, 3070, 4240], 'Westergaard': [704, 853, 1314, 1473, 2542, 3071, 4241], 'C.': [705, 854, 1189, 1315, 1474, 2076, 2543, 2881, 3072, 3253, 4242], 'Ghosh': [706, 855, 1316, 1475, 2544, 3073, 4243], 'Colburn': [708, 821, 857, 1192, 1318, 1477, 2546, 3075, 3092, 4245, 4279], 'N.H.': [709, 822, 858, 1319, 1478, 2547, 3076, 3093, 4246, 4280], '1997;': [712, 861, 1175, 1322, 1481, 1567, 1648, 2211, 2550, 3079, 4249], '57:': [713, 862, 1323, 1482, 2551, 3080, 4250], '3569-3576PubMed': [714, 863, 1324, 1483, 2552, 3081, 4251], '5Bode': [717, 866, 1486, 4254], 'A.M.': [718, 783, 867, 1092, 1272, 1429, 1487, 4255], 'Dong': [719, 784, 868, 1049, 1093, 1194, 1273, 1430, 1488, 1954, 4256], 'Lancet': [721, 786, 870, 1095, 1275, 1432, 1490, 4258], 'Oncol.': [722, 787, 871, 1096, 1229, 1276, 1433, 1491, 2024, 3728, 4259], '1:': [724, 789, 873, 1098, 1278, 1435, 1493, 4261], '181-188Abstract': [725, 790, 874, 1099, 1279, 1436, 1494, 4262], 'Full': [726, 728, 791, 793, 875, 877, 1037, 1065, 1067, 1100, 1102, 1178, 1180, 1280, 1282, 1437, 1439, 1495, 1497, 1585, 1587, 1609, 1611, 1846, 1848, 1970, 1972, 2898, 2900, 2971, 3270, 3272, 3330, 4263, 4265], 'Text': [727, 729, 792, 794, 876, 878, 1038, 1066, 1068, 1101, 1103, 1179, 1181, 1281, 1283, 1438, 1440, 1496, 1498, 1586, 1588, 1610, 1612, 1847, 1849, 1971, 1973, 2899, 2901, 2972, 3271, 3273, 3331, 4264, 4266], 'PDF': [730, 795, 879, 1039, 1069, 1104, 1182, 1284, 1441, 1499, 1589, 1613, 1850, 1974, 2902, 2973, 3274, 3332, 4267], '(127)': [733, 798, 882, 1107, 1287, 1444, 1502, 4270], '6Yang': [736, 801, 885], 'S.C.': [737, 802, 886, 1330], 'Maliakal': [738, 803, 887, 1331], 'Meng': [740, 805, 889, 1333], 'X.': [741, 806, 890, 1048, 1224, 1334, 1382, 2891, 3263, 3723], 'Annu.': [742, 807, 891, 1335], 'Rev.': [743, 808, 892, 919, 955, 968, 1336], 'Pharmacol.': [744, 809, 893, 1337, 1361], '42:': [747, 812, 896, 1340], '25-54Crossref': [748, 813, 897, 1341], '(846)': [751, 816, 900, 1344], 'Activation': [754], 'induces': [759], 'expression': [761, 1530, 1720, 2196], 'target': [763], 'genes': [764, 1538, 1723, 1740], 'many': [769, 911, 1742, 4038], 'disease': [770], 'processes,': [771], 'inflammation,': [774], 'transformation,': [776, 4053], 'tumor': [777, 842, 945, 1157, 1424, 2247, 2279, 2312, 4049, 4055, 4207], 'progression,': [778], 'metastasis,': [779], 'angiogenesis': [781], '(5Bode': [782, 1091, 1271, 1428], '7Bernstein': [819], 'L.R.': [820], 'Science.': [823, 2392], '1989;': [824], '244:': [825], '566-569Crossref': [826], '(206)': [829], 'activity': [833, 1298, 2300, 2801, 2851, 2869, 3558, 3976, 4080, 4338], 'shown': [836, 1408, 4071, 4224], 'promotion': [843, 1158, 1425, 2313], 'progression': [845], 'various': [847], 'types': [848], 'cancers': [850], 'Active': [903], 'nucleus': [909], 'different': [912, 2050, 3126], '(8Darnell': [915, 951], 'Jr.,': [916, 952, 1170, 2508, 3304, 3425, 3915], 'J.E.': [917, 953], 'Nat.': [918, 954, 1130], 'Cancer.': [920, 956, 1392], '2:': [922, 958, 1133], '740-749Crossref': [923, 959], '(961)': [926, 962], 'potential': [930], 'proapoptotic': [931], 'effect': [932, 943, 2259, 3047, 4110, 4185, 4374], 'on': [935, 944, 2237, 2271, 2284, 2311, 2318, 2667, 2933, 3014, 3031, 3051, 3579, 3774, 3823, 3933, 4114, 4186, 4214, 4313, 4375, 4392], 'normal': [936], 'antiapoptotic': [940], 'cytoprotective': [942, 1722, 1993], 'reviewed': [950], '9Sonis': [965], 'S.T.': [966], 'Crit.': [967], 'Oral': [969], 'Biol.': [970, 1060, 1173, 1604, 1692, 1795, 1841, 1965, 2893, 3265, 3325, 4283], '13:': [973, 1245], '380-389Crossref': [974], '(176)': [977], 'components': [981], 'activated': [985, 1079], 'three': [987, 1003], 'distinct': [988], 'but': [989, 1419], 'parallel': [990], 'MAPKs:': [991], 'ERKs,': [992, 3192, 3215], 'JNKs,': [993, 3193], 'kinase.': [996, 3219], 'Each': [997], 'consists': [998], 'module': [1001], 'kinases:': [1004], '(MAPKK)': [1009], 'responsible': [1012], 'MAPKK': [1020, 1026, 1082], 'phosphorylates': [1023], 'activates': [1025], '(10Cano': [1027], 'E.': [1028, 1657, 1663, 1760, 1766], 'Mahadevan': [1029], 'L.C.': [1030], 'Trends': [1031, 1579], 'Biochem.': [1032, 1563, 1672, 1775, 2510, 3306, 3427, 3917], 'Sci.': [1033, 1199, 1902, 2145, 3097], '1995;': [1034, 1843, 2968], '20:': [1035], '117-122Abstract': [1036], '(1001)': [1042], '11Ding': [1045], 'M.': [1046, 1214, 1238, 1390, 1560, 1578, 1602, 1659, 1687, 1704, 1762, 1790, 1807, 1826, 2004, 2062, 2066, 2091, 2129, 2137, 2169, 2175, 2875, 3247, 3713], 'Shi': [1047, 1223, 1381, 2890, 3262, 3722], 'Chen': [1051, 1124], 'F.': [1052, 1212, 1596, 3711], 'Lu': [1053, 1215, 1377, 2876, 3248, 3714], 'Y.': [1054, 1113, 1216, 1378, 1550, 1562, 1953, 2877, 3249, 3715], 'Castranova': [1055, 1221, 1385, 2888, 3260, 3720], 'V.': [1056, 1058, 1220, 1222, 1351, 1386, 1388, 1888, 2887, 2889, 3259, 3261, 3719, 3721], 'Vallyathan': [1057, 1219, 1387, 2886, 3258, 3718], '1999;': [1062], '274:': [1063], '30611-30616Abstract': [1064], '(94)': [1072], 'at': [1080, 1467, 2621, 2693, 2771, 3403, 3492, 3504, 3548, 3553, 3591, 3635, 3787, 3834, 3843, 3936, 4015, 4192, 4413], 'level,': [1084], 'MAPK/ERK': [1086], '1': [1088, 2816, 3132, 3371, 3467, 3531, 3540, 3614, 3661, 3764, 3810, 3813], '3': [1090, 3574], '12Yang': [1110], 'Lin': [1112], 'Guo': [1114], 'Cheng': [1116], 'Huang': [1118, 2880, 3252], 'Deng': [1120], 'L.': [1121, 1837, 1882, 2879, 2885, 3251, 3257], 'Liao': [1122], 'W.': [1123], 'Liu': [1126], 'Su': [1128], 'B.': [1129], 'Immunol.': [1131], '2001;': [1132, 1362, 1967, 2025, 2081, 2098, 2149], '620-624Crossref': [1134], '(352)': [1137], 'associated': [1143, 1988, 4036], 'believed': [1149], 'crucial': [1152], 'cell': [1154, 1451, 2528, 2594, 2954, 3029, 3053, 3853, 4121, 4208], '(13Finco': [1159], 'T.S.': [1160, 1947], 'Westwick': [1161], 'J.K.': [1162], 'Norris': [1163], 'J.L.': [1164], 'Beg': [1165], 'A.A.': [1166], 'Der': [1167], 'C.J.': [1168, 1665, 1768, 2070], 'Baldwin': [1169], 'A.S.': [1171], '272:': [1176], '24113-24116Abstract': [1177], '(334)': [1185], '14Huang': [1188], 'Ma': [1190], 'W.Y.': [1191], 'N.': [1193, 1554], 'Proc.': [1196, 2142, 3094], 'Natl.': [1197, 2143, 3095], 'Acad.': [1198, 2144, 3096], 'U.': [1200, 2146, 3098], 'A.': [1202, 1876, 2148, 3100], '1998;': [1203], '95:': [1204], '156-161Crossref': [1205], '(187)': [1208], '15Chen': [1211], 'Ding': [1213, 1389, 3712], 'Leonard': [1217, 1379, 2882, 3254, 3716], 'S.S.': [1218, 1380, 3717], 'Environ.': [1226, 1645, 2208, 3725], 'Pathol.': [1227, 3726], '19:': [1231, 2026, 3730], '231-238PubMed': [1232, 3731], '16Gilmore': [1235], 'T.D.': [1236], 'Koedood': [1237], 'Piffat': [1239], 'K.A.': [1240], 'White': [1241], 'D.W.': [1242, 1353], 'Oncogene.': [1243], '1996;': [1244], '1367-1378PubMed': [1246], 'Because': [1249], 'critical': [1252], 'roles': [1253], 'signaling': [1259, 1870, 1928], 'carcinogenesis,': [1261], 'they': [1262, 3639], 'proposed': [1265], 'agents': [1270, 1405, 1462], 'It': [1290, 4421], 'agents,': [1307, 2054], 'pyrrolidine': [1310], 'dithiocarbamate': [1311], 'Scholar),': [1326, 1346, 1369], 'tea': [1327], '(6Yang': [1329], 'resveratrol': [1347], '(17Yu': [1348], 'R.': [1349, 1374, 1667, 1671, 1770, 1774], 'Hebbar': [1350], 'Kim': [1352, 1944, 1952, 1958], 'Mandlekar': [1354], 'Pezzuto': [1356], 'J.M.': [1357], 'Kong': [1358], 'A.N.': [1359], 'Mol.': [1360, 1580, 1690, 1793, 2096], '60:': [1363], '217-224Crossref': [1364], '(133)': [1367], 'blackberry': [1371], 'extract': [1372], '(18Feng': [1373], 'Bowman': [1375, 2878, 3250], 'L.L.': [1376], 'Jiang': [1383], 'B.H.': [1384], 'Nutr.': [1391], '2004;': [1393, 1582, 2895, 3267], '50:': [1394], '80-89Crossref': [1395], '(30)': [1398], 'Many': [1401], 'these': [1403, 1857, 2108, 4295], 'inhibitory': [1404, 2309, 4381], 'active': [1411], 'not': [1412, 4384, 4407], 'only': [1413], 'model': [1418, 1457, 2858, 2918], 'mouse': [1422, 1449, 2480, 2491, 2526, 3886], 'skin': [1423], 'vivo': [1427, 2048], 'epidermal': [1450, 2527], 'line,': [1452, 2595, 4122], 'JB6,': [1453], 'provides': [1454], 'validated': [1456], 'screening': [1459], 'elucidating': [1464], 'their': [1465, 2714], 'level': [1470], 'transcription': [1506, 4297], 'factor': [1507], 'member': [1511], 'basic': [1514], 'leucine': [1515], 'zipper': [1516], 'NF-E2': [1517], 'family': [1518], 'plays': [1520], 'an': [1521, 2198, 3659, 3872, 4300], 'role': [1523, 4045, 4302], 'phase': [1532, 1621, 1743, 2193, 2291, 2322, 3287], '2': [1533, 1622, 1744, 2194, 2292, 2323, 2582, 2740, 3168, 3288, 3839], 'detoxifying': [1534], 'stress-inducible': [1537], '(19Itoh': [1539], 'K.': [1540, 1548, 1556, 1685, 1788, 1878, 1937, 2064, 2089, 2135, 2173], 'Chiba': [1541], 'T.': [1542, 1546, 1552, 2017], 'Takahashi': [1543], 'Ishii': [1545], 'Igarashi': [1547], 'Katoh': [1549], 'Oyake': [1551], 'Hayashi': [1553], 'Satoh': [1555], 'Hatayama': [1557], 'I.': [1558, 2965, 2980], 'Yamamoto': [1559, 1577, 1601, 1686, 1789, 1825, 2003, 2065, 2090, 2136, 2174], 'Nabeshima': [1561], 'Biophys.': [1564, 2511, 2966, 3307, 3428, 3918], 'Commun.': [1566, 2513, 3309, 3430, 3920], '236:': [1568], '313-322Crossref': [1569], '(3226)': [1572], '20Motohashi': [1575], '10:': [1583], '549-557Abstract': [1584], '(1397)': [1592], '21Katsuoka': [1595], 'Motohashi': [1597], 'Engel': [1599], 'J.D.': [1600, 1702, 1805, 2078], '2005;': [1606], '280:': [1607], '4483-4490Abstract': [1608], '(88)': [1616], 'Inducers': [1619], 'antioxidative': [1624], 'enhance': [1629], 'detoxication': [1631], 'carcinogens': [1634, 2167], 'animals,': [1636], 'often': [1637], 'leading': [1638], 'protection': [1640, 2203], 'neoplasia': [1642], '(22Kensler': [1643, 2206], 'T.W.': [1644, 1689, 1792, 1824, 2002, 2095, 2141, 2179, 2207, 2506, 3302, 3423, 3913], 'Health': [1646, 2209], 'Perspect.': [1647, 2210], '105:': [1649, 2212], '965-970Crossref': [1650, 2213], '(240)': [1653, 2216], '23Balogun': [1656], 'Hoque': [1658, 1761], 'Gong': [1660, 1763], 'Killeen': [1662, 1765], 'Green': [1664, 1767], 'Foresti': [1666, 1769], 'Alam': [1668, 1771], 'Motterlini': [1670, 1773], '2003;': [1674, 1777, 2181, 2514, 3310, 3431, 3921], '371:': [1675, 1778], '887-895Crossref': [1676, 1779], '(904)': [1679, 1782], '24Kwak': [1682, 1785], 'M.K.': [1683, 1786, 2087, 2131, 2504, 3300, 3421, 3911], 'Itoh': [1684, 1787, 2063, 2088, 2134, 2172], 'Kensler': [1688, 1791, 1823, 2001, 2094, 2140, 2178, 2505, 3301, 3422, 3912], 'Cell.': [1691, 1794], '22:': [1694, 1797], '2883-2892Crossref': [1695, 1798], '(475)': [1698, 1801], '25Hayes': [1701, 1804], 'McMahon': [1703, 1806], 'Lett.': [1706, 1809], '174:': [1708, 1811], '103-113Crossref': [1709, 1812], '(306)': [1711, 1814], 'Regulation': [1714], 'both': [1716, 4429], 'basal': [1717, 2800, 3136], 'inducible': [1719], 'mediated': [1725], 'part': [1727], 'cis-acting': [1732], 'sequence': [1733, 2461, 3884], '5′-flanking': [1737], 'region': [1738], 'encoding': [1741], 'enzymes,': [1745, 3289], 'including': [1746, 2055], 'heme': [1747], 'oxygenase-1,': [1748], 'S-transferase': [1750], 'A1,': [1752], 'oxidoreductase': [1754], '(NQO1),': [1755], 'itself': [1758], '(23Balogun': [1759], '26Thimmulappa': [1817], 'R.K.': [1818, 1996], 'Mai': [1819, 1997], 'K.H.': [1820, 1998], 'Srisuma': [1821, 1999], 'Biswal': [1827, 2005], '62:': [1832, 2010], '5196-5203PubMed': [1833, 2011], '27Favreau': [1836], 'Pickett': [1838], 'C.B.': [1839], '270:': [1844], '24468-24474Abstract': [1845], '(152)': [1853], 'Among': [1856], 'defensive': [1858], 'systems,': [1859], 'block': [1862], 'JNK-induced': [1863], 'Jun': [1864], 'subsequently': [1867], 'mitogenic': [1869], 'oncogenic': [1873], 'Ras-p21': [1874], '(28Villafania': [1875], 'Anwar': [1877], 'Amar': [1879], 'Chie': [1881], 'Way': [1883], 'Chung': [1885], 'D.L.': [1886], 'Adler': [1887], 'Ronai': [1889], 'Brandt-Rauf': [1891], 'P.W.': [1892], 'Yamaizumii': [1893], 'Kung': [1895], 'H.F.': [1896], 'Pincus': [1897], 'M.R.': [1898, 4276], 'Ann.': [1899], 'Clin.': [1900], 'Lab.': [1901], '30:': [1904], '57-64PubMed': [1905], 'As': [1908, 4070], 'endogenous': [1910], 'inhibitor': [1911], 'apoptosis': [1913, 1921], 'signal-regulating': [1914, 1922], '1,': [1916, 4074], '1-activated': [1924], 'JNK': [1925], '(29Cho': [1930], 'S.G.': [1931, 1959], 'Lee': [1932, 1956], 'Y.H.': [1933], 'Park': [1934, 1940], 'H.S.': [1935], 'Ryoo': [1936], 'Kang': [1938], 'K.W.': [1939], 'Eom': [1942], 'S.J.': [1943], 'M.J.': [1945, 1957, 3087, 3321], 'Chang': [1946], 'Choi': [1948, 1962], 'S.Y.': [1949], 'Shim': [1950], 'M.S.': [1955], 'Ichijo': [1960], 'E.J.': [1963], '276:': [1968], '12749-12755Abstract': [1969], '(347)': [1977], 'GSTs': [1981], 'display': [1982], 'broad': [1983], 'substrate': [1984], 'specificity': [1985], '(26Thimmulappa': [1995], '30Yoshitani': [2014], 'S.I.': [2015], 'Tanaka': [2016], 'Kohno': [2018], 'Takashima': [2020], 'Int.': [2022], '929-939PubMed': [2027], 'Studies': [2030], 'nrf2-disrupted': [2032], 'mice': [2033, 2118], 'was': [2037, 2347, 2370, 2388, 2398, 2426, 2474, 2488, 2597, 2650, 2783, 2852, 2924, 3034, 3055, 3391, 3401, 3411, 3516, 3536, 3551, 3561, 3897, 3954, 3977, 4013, 4124, 4157, 4175, 4362, 4406], 'NQO1': [2045, 3290, 3338, 3406], 'classes': [2051], 'dithiole-thiones,': [2056], 'isothiocyanates,': [2057], 'phenolic': [2059], 'antioxidants': [2060], '(31MacMahon': [2061], 'Chanas': [2067], 'S.A.': [2068], 'Henderson': [2069], 'McLellan': [2071], 'L.I.': [2072], 'Wolf': [2073], 'C.R.': [2074, 2963, 2982], 'Cavin': [2075], 'Hayes': [2077], '61:': [2082], '3299-3307PubMed': [2083], '32Kwak': [2086], 'Sutter': [2092], 'T.R.': [2093], '7:': [2099], '135-145Crossref': [2100], 'likely': [2105], 'importance': [2106], 'protective': [2109], 'highlighted': [2112], 'recent': [2114], 'observations': [2115], 'nrf2-null': [2117], 'considerably': [2120], 'more': [2121], 'sensitive': [2122], 'tumorigenicity': [2125], 'benzo[a]pyrene': [2127], '(33Ramos-Gomez': [2128], 'Kwak': [2130], 'Dolan': [2132, 2170], 'P.M.': [2133, 2171], 'Talalay': [2138, 2176], '98:': [2150], '3410-3415Crossref': [2151], '(995)': [2154], 'Scholar)': [2156, 2554, 4292], 'form': [2158], 'levels': [2160], 'DNA': [2162, 2460, 3883, 3949], 'adducts': [2163], 'following': [2164, 3969], 'exposure': [2165], '(34Ramos-Gomez': [2168], 'Carcinogenesis.': [2180], '24:': [2182], '461-467Crossref': [2183], '(159)': [2186], 'gene': [2195, 4324], 'effective': [2199], 'strategy': [2200], 'achieving': [2202], 'Given': [2219], 'data': [2222], 'suggesting': [2223], 'prevention': [2225], 'tested': [2231, 4307], 'promoter': [2248, 2447, 2483], 'cells.': [2251, 2943], 'To': [2252], 'elucidate': [2253], 'mechanism': [2255], 'anti-tumorigenic': [2258], 'investigated': [2265, 3056], 'promotors': [2280], 'enzyme': [2293, 2324], 'activities.': [2294], 'Our': [2295], 'demonstrate': [2297], 'possible': [2298], 'characterize': [2305], 'actions': [2310], 'inductive': [2316], 'Materials—Chlorogenic': [2326], '1-chloro-2,4-dinitrobenzene,': [2328, 3542], '3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium': [2329, 3385, 3399], 'bromide,': [2330, 3386], 'NADP,': [2331, 3377], 'FAD,': [2332, 3370], 'menadione,': [2333], 'glucose': [2334, 3373], '6-phosphate,': [2335, 3374], 'yeast': [2336], 'glucose-6-phosphate': [2337, 3381], 'dehydrogenase,': [2338, 3382], '(TPA)': [2341], 'purchased': [2343, 2381, 2415], 'from': [2344, 2349, 2362, 2371, 2382, 2389, 2400, 2416, 2428, 2470, 2478, 2490, 2562, 2599, 3702, 3850, 3893], 'Sigma.': [2345], 'LY294002': [2346], 'obtained': [2348, 2361, 2399, 2427, 2598], 'Calbiochem.': [2350], "Eagle's": [2351, 2358, 2575, 2612, 2750, 2789, 3005, 3152], 'minimal': [2352, 2576, 2751, 2790, 3153], 'medium': [2354, 2359, 2369, 2578, 2613, 2677, 2753, 2782, 2792, 3006, 3137, 3953], "Dulbecco's": [2356, 2610, 3003], 'modified': [2357, 2611, 3004], 'Whittaker': [2363], 'Biosciences': [2364], '(Walkersville,': [2365], 'MD).': [2366], 'Opti-MEM': [2367, 3951], 'I': [2368, 3952], 'Invitrogen.': [2372, 2383], 'Fetal': [2373], 'serum': [2375, 3366, 3608, 3632], '(FBS),': [2376], 'gentamicin,': [2377], 'l-glutamine': [2379], 'Fugene': [2384], '6': [2385], 'Transfection': [2386, 3875], 'reagent': [2387, 4068], 'Roche': [2390], 'Applied': [2391], 'Antibody': [2393], 'MKK4': [2395], 'Santa': [2401], 'Cruz': [2402, 3656], 'Biotechnology,': [2403], 'Inc.': [2404], '(Santa': [2405, 3655], 'Cruz,': [2406], 'CA).': [2407], 'Phospho-SEK1/MKK4': [2408], 'PhosphoPlus': [2410], 'antibody': [2412, 3624, 3654], 'kits': [2413, 3232], 'Cell': [2417, 2434, 2908], 'Signaling': [2418], 'Technology': [2419], '(Beverley,': [2420], 'MA).': [2421], 'luciferase': [2423, 2438, 2456, 2498, 2844, 3901, 3981], 'kit': [2425, 2846, 3983], 'Promega': [2429], '(Madison,': [2430], 'WI).': [2431], 'Plasmids': [2432, 3877], 'Culture—AP-1': [2435], 'reporter': [2439, 2457, 2499, 2538, 2558, 3902, 4323], 'plasmid': [2440, 2539, 2559, 3948], 'construct': [2443], 'collagenase': [2446], 'bearing': [2448], 'AP-1-': [2449], 'NF-κB-binding': [2451], 'sites': [2452, 3213], 'drives': [2454], 'gene.': [2458], 'A': [2459, 3752, 4346], 'A1': [2465, 2482, 3888], 'ARE': [2466, 3889], '(-833': [2467, 3890], '-533': [2469, 3892], 'start': [2472, 3895], 'codon)': [2473, 3896], 'prepared': [2475, 3487, 3706], 'PCR': [2477], '(-1094': [2484], '-10),': [2486], 'isolated': [2489], 'brain': [2492], 'cDNA': [2493], 'inserted': [2495, 3898], 'into': [2496, 3393, 3899], 'vector': [2500, 3904], '(ARE-TATA': [2501, 3905], 'Luc+)': [2502, 3906], '(35Kwak': [2503, 3299, 3420, 3910], 'Casero': [2507, 3303, 3424, 3914], 'R.A.': [2509, 3305, 3426, 3916], '305:': [2515, 3311, 3432, 3922], '662-670Crossref': [2516, 3312, 3433, 3923], '(73)': [2519, 3315, 3436, 3926], 'promotion-sensitive': [2524], '(P+)': [2525], 'line': [2529], 'cells,': [2532, 4394], 'stably': [2533], 'transfected': [2534], 'either': [2536, 3851, 4226], 'AP-1-luciferase': [2537], 'NF-κB-luciferase': [2557], '(a': [2560], 'gift': [2561], 'Dr.': [2563], 'Chuanshu': [2564], 'Huang,': [2565], 'New': [2566], 'York': [2567], 'University': [2568], 'School': [2569], 'Medicine),': [2571], 'cultured': [2573, 2608], '5%': [2580, 2626, 2756, 2779, 3164, 3606], 'mm': [2583, 3360, 3372, 3463, 3468, 3471, 3474, 3526, 3532, 3541, 3754, 3759, 3762, 3765, 3768, 3801, 3811, 3814, 3817], 'l-glutamine,': [2584], '50': [2586, 3388], 'μg/ml': [2587], 'gentamicin.': [2588], 'lung': [2591, 4119], 'epithelial': [2593], 'A549,': [2596, 4123], 'American': [2601], 'Type': [2602], 'Culture': [2603], 'Collection': [2604], '(Manassas,': [2605], 'VA)': [2606], '10%': [2615], 'FBS.': [2616], 'grown': [2620, 3343, 3578, 4132], '37': [2622, 2772, 3162], '°C': [2623, 2773, 3494], 'CO2': [2627, 3165], 'atmosphere.': [2628], 'all': [2630], 'experiments,': [2631], 'exponentially': [2632], 'growing': [2633], 'used.': [2636], 'Assay': [2637, 2726, 2910], 'Antioxidant': [2640, 4021], 'Capacity': [2641, 4022], 'Acid—The': [2644], 'capacity': [2646, 4061], 'determined': [2651, 4007, 4125], 'using': [2652, 2854, 3061, 3208, 3240, 3507, 3682, 3979, 4008, 4065, 4126, 4321], '2,2′-azio-diethylbenzthiazoline': [2654, 2673], 'sulfonate': [2655], 'test': [2656], 'set': [2657, 4014], '(Randox': [2658], 'Laboratories': [2659], 'Ltd.).': [2660], 'principle': [2662], 'depends': [2666], 'production': [2668, 2706], 'radical': [2671], 'cation': [2672], 'sulfonate+': [2674], 'incubation': [2676], 'substrates': [2680], '(H2O2': [2681], 'peroxidase),': [2683], 'blue-green': [2687], 'color': [2688, 2705], 'detected': [2692, 3870], '600': [2694], 'nm.': [2695, 3405, 3555], 'Antioxidants': [2696], 'sample': [2699, 3186], 'cause': [2700], 'degree': [2709], 'proportional': [2712], 'concentrations.': [2715], 'assays': [2717], 'calibrated': [2719], 'standards': [2721], 'expressed': [2723, 3412, 3562], 'μmol/liter.': [2725], 'Activity—Confluent': [2731], 'monolayers': [2732], 'stable': [2735], 'transfectants': [2736], 'trypsinized,': [2738], '×': [2741, 2995, 3112, 3789, 3836], '104': [2742], 'viable': [2743], 'suspended': [2745, 2998, 3748], '0.5': [2747, 3470, 3473, 3767, 3816, 3945], 'ml': [2748, 3133, 3145], 'supplemented': [2754], 'FBS': [2757, 2788, 3142, 3151], 'seeded': [2759, 3013], 'each': [2761, 3957], '48-well': [2765], 'plate.': [2766], 'Plates': [2767], 'incubated': [2769, 3446, 3619, 3649], 'overnight': [2770, 3634], 'humidified': [2776], 'atmosphere': [2777], 'CO2.': [2780], 'then': [2784, 2819, 3451, 3597, 3777], 'switched': [2785], '0.1%': [2787], 'culture': [2794], '24': [2796], 'h': [2797, 2817, 3038, 3662, 3968], 'minimize': [2799], 'NF-κB.': [2805], 'pretreated': [2809], 'without': [2812, 3009, 3740], 'exposed': [2820, 3115], 'TPA': [2822, 3117], '(20': [2823, 3118, 3800], 'ng/ml)': [2824, 3119], 'UVB': [2826, 4426], '(4': [2827], 'kJ/m2)': [2828], 'irradiation.': [2829], 'extracted': [2833, 3182, 3849], '100': [2835, 3525], 'μl': [2836, 3001, 3455, 3520], '1×': [2838, 3184], 'lysis': [2839, 3457], 'buffer': [2840, 3458, 3751, 3798], 'provided': [2841, 3228], 'manufacturer.': [2849], 'Luciferase': [2850, 3881, 3975], 'measured': [2853, 3294, 3402, 3552, 3978, 4058], 'Monolight': [2856], 'luminometer,': [2857], '3010.': [2859], 'presented': [2863, 3990], 'relative': [2865], 'compared': [2870], 'untreated': [2872], 'controls': [2873], '(36Ding': [2874, 3246], 'Wang': [2884, 3256], '279:': [2896, 3268], '10670-10676Abstract': [2897, 3269], '(55)': [2905, 3277], 'Proliferation': [2909, 4105], 'Electric': [2912], 'Cell-Substrate': [2913], 'Impedance': [2914], 'Sensing': [2915], '(ECIS)—The': [2916], 'ECIS': [2917, 2945, 4128, 4147, 4397], '1600R': [2919], '(Applied': [2920], 'BioPhysics,': [2921], 'Troy,': [2922], 'NY)': [2923], 'measure': [2927], 'influence': [2929], 'continuous': [2951], 'measurement': [2952], 'micromotion,': [2955], 'attachment,': [2956], 'spreading,': [2957], 'growth': [2959], '(37Lo': [2960], 'C.M.': [2961], 'Keese': [2962, 2981], 'Giaever': [2964], '69:': [2969], '2800-2807Abstract': [2970], '(244)': [2976], '38Giaever': [2979], 'Nature.': [2983], '1993;': [2984], '366:': [2985], '591-592Crossref': [2986], '(667)': [2989], '(1': [2994, 3111], '104)': [2996, 3113], '400': [3000], 'electrodes.': [3015], 'equilibrated': [3019], 'incubator': [3022, 3166], '15': [3024], 'min.': [3025, 3483], 'rate': [3027], 'microelectrode': [3033], 'monitored': [3035, 4158], '72': [3037, 4144], 'real-time': [3040], 'changes': [3041], 'resistance.': [3043], 'Anchorage-independent': [3044], 'Transformation': [3045], 'Assay—The': [3046, 3179, 3282], 'described': [3067, 3201, 3297, 3708, 3908, 3985], 'previously': [3068, 3298, 3709, 3909], '39Dong': [3084], 'Birrer': [3086], 'Watts': [3088], 'R.G.': [3089], 'Matrisian': [3090], 'L.M.': [3091], '1994;': [3101], '91:': [3102], '609-613Crossref': [3103], '(370)': [3106], 'presence': [3122], 'absence': [3124], 'concentrations': [3127], '0.33%': [3135], 'Eagle': [3138], '15%': [3141, 3150], '3.5': [3144], '0.5%': [3147, 3630], 'medium.': [3155], 'cultures': [3157], 'maintained': [3159], '°C,': [3163, 3506], 'weeks,': [3169], 'anchorage-independent': [3172], 'colonies': [3173], 'counted.': [3175], 'Protein': [3176], 'Kinase': [3177], 'Phosphorylation': [3178], 'SDS': [3185], 'buffer.': [3187], 'Immunoblots': [3188], 'carried': [3198], 'out': [3199], 'protocol': [3204], 'manufacturer,': [3207], 'phosphospecific': [3209], 'antibodies': [3210, 3221], 'phosphorylated': [3212], 'Nonphosphospecific': [3220], 'ERKs': [3223], 'proteins': [3227, 3829], 'normalize': [3236], 'assay,': [3239, 3339, 3442], 'transferred': [3243, 3865], 'membrane': [3244], 'blot': [3245], 'Enzyme': [3280], 'Activity': [3281], 'typical': [3286], 'spectrophotometrically': [3295], '40Habig': [3318], 'W.H.': [3319], 'Pabst': [3320], 'Jakoby': [3322], 'W.B.': [3323], '1974;': [3327], '249:': [3328], '7130-7139Abstract': [3329], 'For': [3336, 3439], '96-well': [3345], 'plates,': [3346], 'treated': [3347, 3416, 3737, 3962, 4139], 'lysed': [3352, 3452], '0.8%': [3354], 'digitonin.': [3355], 'reaction': [3357, 3522, 3535], 'solution': [3358], '(25': [3359], 'Tris-HCl': [3361], '(pH': [3362, 3528, 3756, 3803], '7.4),': [3363], '0.06%': [3364], 'albumin,': [3367], '5': [3368, 3549], 'μm': [3369, 3376, 3384, 3389, 4354, 4418], '30': [3375, 3482, 3589, 3821, 4365], '300': [3378], 'units': [3379], '725': [3383], 'menadione)': [3390], 'added': [3392, 3517, 3955], 'wells,': [3395, 4156], 'reduced': [3398], 'bromide': [3400], '610': [3404], 'ratios': [3414], 'vehicle': [3418], 'control': [3419], 'total': [3440], '200': [3454], '(0.25': [3459], 'm': [3460, 3808], 'sucrose,': [3461], '10': [3462, 3758, 3772, 3780], 'Tris-HCl,': [3464], 'pH': [3465], '7.5,': [3466], 'EDTA,': [3469, 3763, 3812], 'dithiothreitol,': [3472, 3766, 3815], 'phenylmethylsulfonyl': [3475, 3769, 3818], 'fluoride,': [3476], '1%': [3478], 'Triton': [3479], 'X-100)': [3480], 'Cytosolic': [3484, 3512], 'fractions': [3485], 'centrifugation': [3489, 3786, 3833], 'stored': [3491, 3842], '-70': [3493, 3844], 'until': [3495], 'use.': [3496], 'Assays': [3497], 'conducted': [3499], 'thermostated': [3502], 'compartment': [3503], '25': [3505], '1-chloro-2,4-dinitrobenzene': [3508], 'substrate.': [3511], '(45': [3514], 'μg)': [3515, 3856, 3860], '800': [3519], 'mixture': [3523], 'KH2PO4': [3527], '6.5)': [3529], 'glutathione.': [3533], 'initiated': [3537], 'adding': [3539], 'formation': [3545], 'thioether': [3547], 'min': [3550, 3590, 3773, 3822, 3840], '340': [3554], 'Total': [3556, 4020], 'nmol/min/mg': [3564], 'protein.': [3565], 'Immunocytochemistry': [3566], 'Nrf2—After': [3568], 'treatment': [3569], 'h,': [3575], 'Lab-TEK': [3580], 'chamber': [3581], 'slides': [3582], 'fixed': [3584], '100%': [3586], 'methanol': [3587], 'room': [3592], 'temperature.': [3593], 'washed': [3598, 3641, 3679], 'phosphate-buffered': [3600, 3611, 3627], 'saline': [3601, 3612, 3628], 'followed': [3602], 'blocking': [3604], 'albumin': [3609, 3633], 'h.': [3615, 4145], 'polyclonal': [3621], 'rabbit': [3622], 'anti-Nrf2': [3623], '(1:100)': [3625], '°C.': [3637, 3845], 'After': [3638], 'four': [3642], 'times': [3643], 'PBS,': [3645], 'fluorescein': [3651], 'isothiocyanate-conjugated': [3652], 'secondary': [3653], 'Biotechnology)': [3657], 'additional': [3660], 'dark.': [3665], 'Counterstaining': [3666], '4′,6-diamidino-2-phenylindole': [3668], 'verified': [3669], 'location': [3671], 'integrity': [3673], 'nuclei.': [3675], 'Stained': [3676], 'examined': [3681], 'laser-scanning': [3684], 'confocal': [3685], 'microscope,': [3686], 'Zeiss': [3687], 'LSM': [3688], '510': [3689], '(Thornwood,': [3690], 'NY).': [3691], 'Preparation': [3692], 'Nuclear': [3694, 3698], 'Extracts': [3695], 'Translocation': [3699], 'Assay—Nuclear': [3700], 'extracts': [3701], '(15Chen': [3710], 'Briefly,': [3734], 'harvested.': [3744], 'hypotonic': [3750], '(10': [3753], 'HEPES': [3755, 3802], '7.6),': [3757, 3804], 'KCl,': [3760], '0.1': [3761], 'fluoride)': [3770, 3819], 'ice': [3775], 'vortexed': [3778], 's.': [3781], 'Nuclei': [3782], 'pelleted': [3784], '12,000': [3788, 3835], 'g': [3790, 3837], '20': [3792], 's': [3793], 'resuspended': [3796], 'C': [3799], '25%': [3805], 'glycerol,': [3806], '0.4': [3807], 'NaCl,': [3809], 'ice.': [3824], 'supernatants': [3826], 'collected': [3831], 'after': [3832], 'Proteins': [3846], 'whole': [3852], 'lysate': [3854], '(30': [3855, 3859], 'nuclei': [3858], 'separated': [3862], 'SDS-PAGE,': [3864], 'nitrocellulose': [3867], 'membranes,': [3868], 'antibody.': [3874], 'Measurement': [3879], 'Activity—A': [3882], 'pGL3-Basic': [3903], 'plated': [3932], '24-well': [3934], 'plates': [3935], 'density': [3937], '50–60%': [3939], 'confluence.': [3940], 'transfection': [3942, 3971], 'complex': [3943], 'μg': [3946], 'well.': [3958], '18': [3967], 'transient': [3970], 'ARE-TATA': [3973], 'Luc+.': [3974], 'above.': [3986], 'Statistical': [3987], 'Analysis—Data': [3988], 'means': [3992], '±': [3993], 'S.E.': [3994], 'n': [3996], 'experiments/samples': [3997], 'noted': [3999], 'figure': [4002], 'legends.': [4003], 'Significant': [4004], 'differences': [4005], "Student's": [4009], 't': [4010], 'test.': [4011], 'Significance': [4012], 'p': [4016], '≤': [4017], '0.05.': [4018], 'Acid—Reactive': [4025], 'species': [4027], '(ROS)': [4028], 'mutagenic': [4034], 'diseases.': [4039], 'light': [4041], 'ROS': [4047], 'promoter-induced': [4050], 'activation,': [4052], 'promotion,': [4056], 'Randox': [4067], 'set.': [4069], 'Fig.': [4073], 'displayed': [4077], 'stronger': [4078], 'than': [4081], 'ascorbic': [4084], 'concentration': [4089, 4167, 4342, 4351, 4415], 'range,': [4090], 'indicating': [4091, 4149], 'effectively': [4096], 'scavenge': [4097], 'radicals.': [4100], 'Acid': [4102, 4213], 'Inhibits': [4103], 'Cells—': [4108], 'assay.': [4129, 4325], 'Cells': [4130], 'electrode': [4135], 'array': [4136], 'wells': [4137], 'resistance,': [4148], 'number': [4151], 'duration': [4161], 'experiment.': [4164], '80': [4169, 4417], 'μm,': [4170], 'significantly': [4176], '(Fig.': [4178, 4196, 4344, 4419], '2A).': [4179], 'Interestingly,': [4180], 'had': [4183, 4372], '2B).': [4197, 4420], 'This': [4198], 'result': [4199], 'suggests': [4200], 'preferentially': [4205], 'growth.': [4209], 'Effects': [4210], 'TPA-': [4215, 4314], 'UVB-induced': [4217, 4316], 'Activation—Previous': [4221], '41Hsu': [4273], 'T.C.': [4274], 'Young': [4275], 'Cmarik': [4277], 'Free': [4281], 'Radic.': [4282], '28:': [4286], '1338-1348Crossref': [4287], '(251)': [4290], 'two': [4296], 'factors': [4298], 'play': [4299], 'We': [4305], 'thus': [4306], 'activity,': [4320], 'markedly': [4332], 'similar': [4341], 'range': [4343], '3,': [4345], 'B).': [4348], '40': [4353], '42%,': [4367], 'respectively.': [4368], 'alone': [4371], 'no': [4373], 'due': [4385], 'cytotoxicity': [4388], 'since': [4395], 'affected': [4408], 'even': [4412], 'irradiation': [4427], 'acts': [4428]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2041269288', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 17}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 28}, {'year': 2018, 'cited_by_count': 26}, {'year': 2017, 'cited_by_count': 26}, {'year': 2016, 'cited_by_count': 24}, {'year': 2015, 'cited_by_count': 21}, {'year': 2014, 'cited_by_count': 31}, {'year': 2013, 'cited_by_count': 28}, {'year': 2012, 'cited_by_count': 26}], 'updated_date': '2025-01-11T00:26:18.518401', 'created_date': '2016-06-24'}
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