Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2041215841', 'doi': 'https://doi.org/10.7326/0003-4819-115-8-585', 'title': '<i>Enterobacter</i> Bacteremia: Clinical Features and Emergence of Antibiotic Resistance during Therapy', 'display_name': '<i>Enterobacter</i> Bacteremia: Clinical Features and Emergence of Antibiotic Resistance during Therapy', 'publication_year': 1991, 'publication_date': '1991-10-15', 'ids': {'openalex': 'https://openalex.org/W2041215841', 'doi': 'https://doi.org/10.7326/0003-4819-115-8-585', 'mag': '2041215841', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1892329'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-115-8-585', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5012661788', 'display_name': 'Joseph W. Chow', 'orcid': 'https://orcid.org/0000-0002-5934-5877'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joseph W. Chow', 'raw_affiliation_strings': ['University of Pittsburgh'], 'affiliations': [{'raw_affiliation_string': 'University of Pittsburgh', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102829136', 'display_name': 'Michael J. Fine', 'orcid': 'https://orcid.org/0000-0003-3470-9846'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Michael J. Fine', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027247104', 'display_name': 'David M. Shlaes', 'orcid': 'https://orcid.org/0000-0001-9226-7199'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'David M. Shlaes', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061510230', 'display_name': 'John P. Quinn', 'orcid': 'https://orcid.org/0000-0003-3551-7803'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'John P. Quinn', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032938040', 'display_name': 'David C. Hooper', 'orcid': 'https://orcid.org/0000-0002-1444-9939'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'David C. Hooper', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109153339', 'display_name': 'Michaekl P. Johnson', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Michaekl P. Johnson', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005823003', 'display_name': 'Reuben Ramphal', 'orcid': 'https://orcid.org/0000-0002-9087-1816'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Reuben Ramphal', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112491885', 'display_name': 'Marilyn M. Wagener', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Marilyn M. Wagener', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056637698', 'display_name': 'D Miyashiro', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Deborah K. Miyashiro', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5113655339', 'display_name': 'Victor L. Yu', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Victor L. Yu', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 11.584, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 884, 'citation_normalized_percentile': {'value': 0.99683, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '115', 'issue': '8', 'first_page': '585', 'last_page': '590'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10147', 'display_name': 'Antibiotic Resistance in Bacteria', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10147', 'display_name': 'Antibiotic Resistance in Bacteria', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13849', 'display_name': 'Enterobacteriaceae and Cronobacter Research', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1310', 'display_name': 'Endocrinology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11316', 'display_name': 'Mycobacterium research and diagnosis', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bacteremia', 'display_name': 'Bacteremia', 'score': 0.7992455}], 'concepts': [{'id': 'https://openalex.org/C2778983983', 'wikidata': 'https://www.wikidata.org/wiki/Q134281', 'display_name': 'Enterobacter', 'level': 4, 'score': 0.8635009}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8031524}, {'id': 'https://openalex.org/C2779443120', 'wikidata': 'https://www.wikidata.org/wiki/Q650912', 'display_name': 'Bacteremia', 'level': 3, 'score': 0.7992455}, {'id': 'https://openalex.org/C64778159', 'wikidata': 'https://www.wikidata.org/wiki/Q271021', 'display_name': 'Cephalosporin', 'level': 3, 'score': 0.7743497}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.63624537}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.54543847}, {'id': 'https://openalex.org/C94665300', 'wikidata': 'https://www.wikidata.org/wiki/Q63391344', 'display_name': 'Antibiotic resistance', 'level': 3, 'score': 0.4865064}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.41372234}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 0.3442021}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.09263173}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004754', 'descriptor_name': 'Enterobacter', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D004756', 'descriptor_name': 'Enterobacteriaceae Infections', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000617', 'descriptor_name': 'Aminoglycosides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000704', 'descriptor_name': 'Analysis of Variance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002511', 'descriptor_name': 'Cephalosporins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002511', 'descriptor_name': 'Cephalosporins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004352', 'descriptor_name': 'Drug Resistance, Microbial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004754', 'descriptor_name': 'Enterobacter', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004756', 'descriptor_name': 'Enterobacteriaceae Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004756', 'descriptor_name': 'Enterobacteriaceae Infections', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015999', 'descriptor_name': 'Multivariate Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011446', 'descriptor_name': 'Prospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D018805', 'descriptor_name': 'Sepsis', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-115-8-585', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1892329', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.89, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1570631062', 'https://openalex.org/W1833207062', 'https://openalex.org/W1964378214', 'https://openalex.org/W1970416250', 'https://openalex.org/W1972533883', 'https://openalex.org/W1973138645', 'https://openalex.org/W19776871', 'https://openalex.org/W1996630432', 'https://openalex.org/W2002178722', 'https://openalex.org/W2006185255', 'https://openalex.org/W2008210401', 'https://openalex.org/W2013140724', 'https://openalex.org/W2013375402', 'https://openalex.org/W2014655100', 'https://openalex.org/W2017533148', 'https://openalex.org/W2020459071', 'https://openalex.org/W2023723290', 'https://openalex.org/W2025801951', 'https://openalex.org/W2033146625', 'https://openalex.org/W2054981389', 'https://openalex.org/W2068285861', 'https://openalex.org/W2079766929', 'https://openalex.org/W2082872467', 'https://openalex.org/W2086342344', 'https://openalex.org/W2091354107', 'https://openalex.org/W2096341421', 'https://openalex.org/W2099608737', 'https://openalex.org/W2101557576', 'https://openalex.org/W2129650566', 'https://openalex.org/W2159747966', 'https://openalex.org/W2161847483', 'https://openalex.org/W2161870065', 'https://openalex.org/W2312394100', 'https://openalex.org/W2312481240', 'https://openalex.org/W2323169997', 'https://openalex.org/W2323702900', 'https://openalex.org/W2412001344', 'https://openalex.org/W2414772529', 'https://openalex.org/W2419391513', 'https://openalex.org/W2441585266', 'https://openalex.org/W4210921275'], 'related_works': ['https://openalex.org/W4320037900', 'https://openalex.org/W4297123388', 'https://openalex.org/W4226193097', 'https://openalex.org/W2955020749', 'https://openalex.org/W2507683919', 'https://openalex.org/W2161847483', 'https://openalex.org/W2125863771', 'https://openalex.org/W2076505260', 'https://openalex.org/W2029063045', 'https://openalex.org/W1975996448'], 'abstract_inverted_index': {'▪Objectives:': [0], 'To': [1], 'study': [2, 34], 'the': [3, 10, 16, 21, 134, 212], 'effect': [4], 'of': [5, 14, 23, 35, 61, 75, 86, 106, 112, 122, 129, 146, 152, 159, 166, 173, 182, 187, 197, 207, 214, 248], 'previously': [6], 'administered': [7], 'antibiotics': [8, 113], 'on': [9], 'antibiotic': [11, 24, 78], 'susceptibility': [12], 'profile': [13], 'Enterobacter,': [15], 'factors': [17], 'affecting': [18], 'mortality,': [19], 'and': [20, 51, 80], 'emergence': [22, 74, 181], 'resistance': [25, 76, 167, 183], 'during': [26, 77], 'therapy': [27, 79, 171, 246], 'for': [28, 228], 'Enterobacter': [29, 39, 97, 131, 156, 217, 229, 232], 'bacteremia.': [30, 40, 230], '▪Design:': [31], 'Prospective,': [32], 'observational': [33], 'consecutive': [36], 'patients': [37, 64], 'with': [38, 95, 140], '▪Setting:': [41], 'Three': [42], 'university': [43], 'tertiary': [44], 'care': [45], 'centers,': [46], 'one': [47], 'major': [48], 'university-affiliated': [49, 53], 'hospital,': [50], 'two': [52, 69], 'Veterans': [54], 'Affairs': [55], 'medical': [56], 'centers.': [57], '▪Patients:': [58], 'A': [59], 'total': [60], '129': [62], 'adult': [63], 'were': [65, 73], 'studied.': [66], '▪Measurements:': [67], 'The': [68], 'main': [70], 'end': [71], 'points': [72], 'death.': [81], '▪Main': [82], 'Results:': [83], 'Previous': [84], 'administration': [85, 111], 'third-generation': [87, 119, 169, 208, 244], 'cephalosporins': [88, 209], 'was': [89, 110, 138, 150], 'more': [90, 154, 177], 'likely': [91], 'to': [92, 168, 184, 242], 'be': [93, 240], 'associated': [94, 139], 'multiresistant': [96, 130, 216], 'isolates': [98], 'in': [99, 133, 220, 224], 'an': [100], 'initial,': [101], 'positive': [102], 'blood': [103, 136], 'culture': [104, 137], '(22': [105], '32,': [107], '69%)': [108], 'than': [109, 149, 179], 'that': [114], 'did': [115, 180], 'not': [116], 'include': [117], 'a': [118, 141, 153, 225], 'cephalosporin': [120, 170, 245], '(14': [121, 158], '71,': [123], '20%;': [124], 'P': [125, 162, 190, 199], '<': [126], '0.001).': [127], 'Isolation': [128], 'sp.': [132, 157], 'initial': [135], 'higher': [142], 'mortality': [143, 227], 'rate': [144], '(12': [145], '37,': [147], '32%)': [148], 'isolation': [151], 'sensitive': [155], '92,': [160], '15%;': [161], '=': [163, 191, 200], '0.03).': [164], 'Emergence': [165], '(6': [172], '31,': [174], '19%)': [175], 'occurred': [176], 'often': [178], 'aminoglycoside': [185], '(1': [186], '89,': [188], '0.01%;': [189], '0.001)': [192], 'or': [193], 'other': [194], 'beta-lactam': [195], '(0': [196], '50;': [198], '0.002)': [201], 'therapy.': [202], '▪Conclusions:': [203], 'More': [204], 'judicious': [205], 'use': [206], 'may': [210, 222, 239], 'decrease': [211], 'incidence': [213], 'nosocomial': [215], 'spp.,': [218], 'which': [219], 'turn': [221], 'result': [223], 'lower': [226], 'When': [231], 'organisms': [233], 'are': [234], 'isolated': [235], 'from': [236], 'blood,': [237], 'it': [238], 'prudent': [241], 'avoid': [243], 'regardless': [247], 'in-vitro': [249], 'susceptibility.': [250]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2041215841', 'counts_by_year': [{'year': 2024, 'cited_by_count': 22}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 20}, {'year': 2021, 'cited_by_count': 20}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 21}, {'year': 2018, 'cited_by_count': 26}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 19}, {'year': 2015, 'cited_by_count': 26}, {'year': 2014, 'cited_by_count': 29}, {'year': 2013, 'cited_by_count': 26}, {'year': 2012, 'cited_by_count': 24}], 'updated_date': '2024-12-30T13:44:48.530729', 'created_date': '2016-06-24'}