Title: NTP-CERHR Expert Panel report on the reproductive and developmental toxicity of acrylamide
Abstract: Birth Defects Research Part B: Developmental and Reproductive ToxicologyVolume 74, Issue 1 p. 17-113 Review Article NTP-CERHR Expert Panel report on the reproductive and developmental toxicity of acrylamide† ‡ Jeanne Manson, Jeanne Manson University of Pennsylvania, Philadelphia, PennsylvaniaSearch for more papers by this authorMichael J. Brabec, Michael J. Brabec Eastern Michigan University, Ypsilanti, MichiganSearch for more papers by this authorJudy Buelke-Sam, Judy Buelke-Sam Toxicology Services, Greenfield, IndianaSearch for more papers by this authorGary P. Carlson, Gary P. Carlson Purdue University, West Lafayette, IndianaSearch for more papers by this authorRobert E. Chapin, Robert E. Chapin Pfizer, Inc., Groton, ConnecticutSearch for more papers by this authorJohn B. Favor, John B. Favor GSF-National Research Center for Environment and Health, Neuherberg, GermanySearch for more papers by this authorLawrence J. Fischer, Lawrence J. Fischer Michigan State University, Lansing, MichiganSearch for more papers by this authorDale Hattis, Dale Hattis Clark University, Worcester, MassachusettsSearch for more papers by this authorPeter S.J. Lees, Peter S.J. Lees Johns Hopkins University, Baltimore, MarylandSearch for more papers by this authorSally Perreault-Darney, Sally Perreault-Darney U.S. Environmental Protection Agency (EPA), Research Triangle Park, North CarolinaSearch for more papers by this authorJoe Rutledge, Joe Rutledge Children's Hospital, Seattle, WashingtonSearch for more papers by this authorThomas J. Smith, Thomas J. Smith Harvard School of Public Health, Boston, MassachusettsSearch for more papers by this authorRaymond R. Tice, Raymond R. Tice Integrated Laboratory Systems, Inc., Research Triangle Park, North CarolinaSearch for more papers by this authorPeter Working, Peter Working Cell Genesys, Inc., South San Francisco, CaliforniaSearch for more papers by this author Jeanne Manson, Jeanne Manson University of Pennsylvania, Philadelphia, PennsylvaniaSearch for more papers by this authorMichael J. Brabec, Michael J. Brabec Eastern Michigan University, Ypsilanti, MichiganSearch for more papers by this authorJudy Buelke-Sam, Judy Buelke-Sam Toxicology Services, Greenfield, IndianaSearch for more papers by this authorGary P. Carlson, Gary P. Carlson Purdue University, West Lafayette, IndianaSearch for more papers by this authorRobert E. Chapin, Robert E. Chapin Pfizer, Inc., Groton, ConnecticutSearch for more papers by this authorJohn B. Favor, John B. Favor GSF-National Research Center for Environment and Health, Neuherberg, GermanySearch for more papers by this authorLawrence J. Fischer, Lawrence J. Fischer Michigan State University, Lansing, MichiganSearch for more papers by this authorDale Hattis, Dale Hattis Clark University, Worcester, MassachusettsSearch for more papers by this authorPeter S.J. Lees, Peter S.J. Lees Johns Hopkins University, Baltimore, MarylandSearch for more papers by this authorSally Perreault-Darney, Sally Perreault-Darney U.S. Environmental Protection Agency (EPA), Research Triangle Park, North CarolinaSearch for more papers by this authorJoe Rutledge, Joe Rutledge Children's Hospital, Seattle, WashingtonSearch for more papers by this authorThomas J. Smith, Thomas J. Smith Harvard School of Public Health, Boston, MassachusettsSearch for more papers by this authorRaymond R. Tice, Raymond R. Tice Integrated Laboratory Systems, Inc., Research Triangle Park, North CarolinaSearch for more papers by this authorPeter Working, Peter Working Cell Genesys, Inc., South San Francisco, CaliforniaSearch for more papers by this author First published: 23 February 2005 https://doi.org/10.1002/bdrb.20030Citations: 40 † This article is a US Government work and, as such, is in the public domain in the United States of America. With the Support of CERHR Staff: NTP/NIEHS, Michael Shelby, Ph.D. (Director, CERHR), Christopher Portier, Ph.D. (Associate Director, National Toxicology Program); Sciences International, Inc., Anthony R. Scialli, M.D. (Principal Scientist), Annette Iannucci, M.S. (Toxicologist), Gloria Jahnke, D.V.M. (Toxicologist). ‡ Correspondence to: Michael D. Shelby, PhD, NIEHS, EC-32, PO Box 12233, Research Triangle Park, NC 27709. E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat 6.0 References Abramsson-Zetterberg L. 2003. The dose-response relationship at very low doses of acrylamide is linear in the flow cytometer-based mouse micronucleus assay. Mutat Res 535: 215–222. ACGIH. 2001. Acrylamide. TA:ACGIH documentation of the threshold limit values and biological exposure indices PG 3(7). ACGIH. 2003. Acrylamide. Documentation of the threshold limit values and biological exposure indices:12 Adler ID. 1990. Clastogenic effects of acrylamide in different germ-cell stages of male mice. Banbury Report 34: 115–131. Adler ID, Reitmeir P, Schmoller R, Schriever-Schwemmer G. 1994. Dose response for heritable translocations induced by acrylamide in spermatids of mice. Mutat Res 309: 285–291. Adler ID, Baumgartner A, Gonda H, Friedman MA, Skerhut M. 2000. 1-Aminobenzotriazole inhibits acrylamide-induced dominant lethal effects in spermatids of male mice. Mutagenesis 15: 133–136. Agrawal AK, Squibb RE. 1981. Effects of acrylamide given during gestation on dopamine receptor binding in rat pups. Toxicol Lett 7: 233–238. Albert Einstein College of Medicine. 1980. A fetal toxicity study of acrylamide in rats. Wayne, NJ. Report nr Epa/Ots; Doc ♯878211680; NTIS/OTS0206055. Anzenbacher P, Anzenbacherova E. 2001. Cytochromes P450 and metabolism of xenobiotics. Cell Mol Life Sci 58: 737–747. Backer LC, Dearfield KL, Erexson GL, Campbell JA, Westbrook-Collins B, Allen JW. 1989. The effects of acrylamide on mouse germ-line and somatic cell chromosomes. Environ Mol Mutagen 13: 218–226. Barber DS, Hunt JR, Ehrich MF, Lehning EJ, LoPachin RM. 2001. Metabolism, toxicokinetics and hemoglobin adduct formation in rats following subacute and subchronic acrylamide dosing. Neurotoxicology 22: 341–353. Bergmark E, Calleman CJ, Costa LG. 1991. Formation of hemoglobin adducts of acrylamide and its epoxide metabolite glycidamide in the rat. Toxicol Appl Pharmacol 111: 352–363. Besaratinia A, Pfeifer GP. 2003. Weak yet distinct mutagenicity of acrylamide in mammalian cells. J Natl Cancer Inst 95: 889–896. Bio/Dynamics Inc. 1979. A fetal toxicity study of acrylamide in rats. EPA/OTS; Doc ♯878211679; NTIS/OTS0206055. Bishop JB, Morris RW, Seely JC, Hughes LA, Cain KT, Generoso WM. 1997. Alterations in the reproductive patterns of female mice exposed to xenobiotics. Fundam Appl Toxicol 40: 191–204. Bjørge C, Brunborg G, Wiger R, Holme JA, Scholz T, Dybing E, Soderlund EJ. 1996. A comparative study of chemically induced DNA damage in isolated human and rat testicular cells. Reprod Toxicol 10: 509–519. Burek JD, Albee RR, Beyer JE, Bell TJ, Carreon RM, Morden DC, Wade CE, Hermann EA, Gorzinski SJ. 1980. Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery. J Environ Pathol Toxicol 4: 157–182. Calleman CJ. 1996. The metabolism and pharmacokinetics of acrylamide: implications for mechanisms of toxicity and human risk estimation. Drug Metab Rev 28: 527–590. Chapin RE, Fail PA, George JD, Grizzle TB, Heindel JJ, Harry GJ, Collins BJ, Teague J. 1995. The reproductive and neural toxicities of acrylamide and three analogues in Swiss mice, evaluated using the continuous breeding protocol. Fundam Appl Toxicol 27: 9–24. Chemfinder. 2003. Acrylamide. Available at: http://chemfinder.cambridgesoft.com/result.asp. Collins JJ, Swaen GM, Marsh GM, Utidjian HM, Caporossi JC, Lucas LJ. 1989. Mortality patterns among workers exposed to acrylamide. J Occup Med 31: 614–617. Collins BW, Howard DR, Allen JW. 1992. Kinetochore-staining of spermatid micronuclei: studies of mice treated with X-radiation or acrylamide. Mutat Res 281: 287–294. Cosmetic Ingredient Review. 2003. Amended report of the Cosmetic Ingredient Review Expert Panel: safety assessment of polyacrylamide. Washington, DC. Costa LG, Deng H, Gregotti C, Manzo L, Faustman EM, Bergmark E, Calleman CJ. 1992. Comparative studies on the neuro- and reproductive toxicity of acrylamide and its epoxide metabolite glycidamide in the rat. Neurotoxicology 13: 219–224. Damjanov I, Friedman MA. 1998. Mesotheliomas of tunica vaginalis testis of Fischer 344 (F344) rats treated with acrylamide: a light and electron microscopy study. In Vivo 12: 495–502. Dearfield KL, Douglas GR, Ehling UH, Moore MM, Sega GA, Brusick DJ. 1995. Acrylamide: a review of its genotoxicity and an assessment of heritable genetic risk. Mutat Res 330: 71–99. DiNovi M, Howard D. 2004. The updated exposure assessment for acrylamide. Available at http://www.jifsan.umd.edu/acrylamide2004.htm. FDA/CFSAN. Dixit R, Husain R, Mukhtar H, Seth PK. 1981. Acrylamide induced inhibition of hepatic glutathione-S-transferase activity in rats. Toxicol Lett 7: 207–210. Dobrzynska M, Lenarczyk M, Gajewski AK. 1990. Induction of dominant lethal mutations by combined X-ray-acrylamide treatment in male mice. Mutat Res 232: 209–215. Dobrzynska MM, Gajewski AK. 2000. Induction of micronuclei in bone marrow and sperm head abnormalities after combined exposure of mice to low doses of X-rays and acrylamide. Teratog Carcinog Mutagen 20: 133–140. Edwards PM. 1976. The insensitivity of the developing rat foetus to the toxic effects of acrylamide. Chem Biol Interact 12: 13–18. Ehling UH, Neuhäuser-Klaus A. 1992. Reevaluation of the induction of specific-locus mutations in spermatogonia of the mouse by acrylamide. Mutat Res 283: 185–191. EPA. 1994. Chemical summary for acrylamide. Office of Pollution Prevention and Toxics. Report nr EPA 749-F-94-005a. EPA. 2000. TRI calculation results. EPA. 2001. IRIS acrylamide file. EPA. 2002a. Consumer factsheet on: acrylamide. EPA. 2002b. National primary drinking water regulations: treatment techniques for acrylamide and epichlorohydrin. Report nr 40CFR141.111. European_Commision. 2002. Opinion of the scientific committee on food on new findings regarding the presence of acrylamide in food (http://europa.eu.int/comm/food/fs/sc/scf/out131_en.pdf). Brussels, Belgium. European-Union. 2002. European Union risk assessment report: acrylamide. Institute for Health and Consumer Protection. FAO/WHO. 2002. Health implications of acrylamide in food (http://www.who.int/fsf/Acrylamide/Acrylamide_index.htm). Geneva, Switzerland. FDA. 2003a. Acrylamide: questions & answers. center for food safety and applied nutrition. FDA. 2003b. FDA draft action plan for acrylamide in food - February 24, 2003 update. Center for Food Safety and Applied Nutrition, Office of Plant & Dairy Foods & Beverages. FDA. 2004a. Exploratory data on acrylamide in food. Available at http://www.cfsan.fda.gov/∼dms/acrydata.htmllast. FDA CFSAN/Office of Plant & Dairy Foods. FDA. 2004b. Exploratory data on acrylamide in food. FY 2003 total diet study results. Available at http://www.cfsan.fda.gov/∼dms/acrydat2.html. FDA CFSAN/Office of Plant &Dairy Foods. Fennell TR, MacNeela JP, Morris RW, Watson M, Thompson CL, Bell DA. 2000. Hemoglobin adducts from acrylonitrile and ethylene oxide in cigarette smokers: effects of glutathione S-transferase T1-null and M1-null genotypes. Cancer Epidemiol Biomarkers Prev 9: 705–712. Field EA, Price CJ, Sleet RB, Marr MC, Schwetz BA, Morrissey RE. 1990. Developmental toxicity evaluation of acrylamide in rats and mice. Fundam Appl Toxicol 14: 502–512. Friedman MA, Dulak LH, Stedham MA. 1995. A lifetime oncogenicity study in rats with acrylamide. Fundam Appl Toxicol 27: 95–105. Friedman MA, Tyl RW, Marr MC, Myers CB, Gerling FS, Ross WP. 1999. Effects of lactational administration of acrylamide on rat dams and offspring. Reprod Toxicol 13: 511–520. Friedman M. 2003. Chemistry, biochemistry, and safety of acrylamide. A review. J Agric Food Chem 51: 4504–4526. Fullerton PM, Barnes JM. 1966. Peripheral neuropathy in rats produced by acrylamide. Br J Ind Med 23: 210–221. Gassner P, Adler ID. 1995. Analysis of chemically induced spindle aberrations in male mouse germ cells: comparison of differential and immunofluorescent staining procedures. Mutagenesis 10: 243–252. Gassner P, Adler ID. 1996. Induction of hypoploidy and cell cycle delay by acrylamide in somatic and germinal cells of male mice. Mutat Res 367: 195–202. Generoso WM, Sega GA, Lockhart AM, Hughes LA, Cain KT, Cacheiro NLA, Shelby MD. 1996. Dominant lethal mutations, heritable translocations, and unscheduled DNA synthesis induced in male mouse germ cells by glycidamide, a metabolite of acrylamide. Mutat Res 3: 175–183. Gutierrez-Espeleta GA, Hughes LA, Piegorsch WW, Shelby MD, Generoso WM. 1992. Acrylamide: dermal exposure produces genetic damage in male mouse germ cells. Fundam Appl Toxicol 18: 189–192. Hagmar L, Tornqvist M, Nordander C, Rosen I, Bruze M, Kautiainen A, Magnusson AL, Malmberg B, Aprea P, Granath F, Axmon A. 2001. Health effects of occupational exposure to acrylamide using hemoglobin adducts as biomarkers of internal dose. Scand J Work Environ Health 27: 219–226. Hashimoto K, Sakamoto J, Tanii H. 1981. Neurotoxicity of acrylamide and related compounds and their effects on male gonads in mice. Arch Toxicol 47: 179–189. Hayes JD, Pulford DJ. 1995. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 30: 445–600. He FS, Zhang SL, Wang HL, Li G, Zhang ZM, Li FL, Dong XM, Hu FR. 1989. Neurological and electroneuromyographic assessment of the adverse effects of acrylamide on occupationally exposed workers. Scand J Work Environ Health 15: 125–129. Hines RN, McCarver DG. 2002. The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes. J Pharmacol Exp Ther 300: 355–360. Holland N, Ahlborn T, Turteltaub K, Markee C, Moore D 2nd, Wyrobek AJ, Smith MT. 1999. Acrylamide causes preimplantation abnormalities in embryos and induces chromatin-adducts in male germ cells of mice. Reprod Toxicol 13: 167–178. HSDB. 2003. Acrylamide. Husain R, Dixit R, Das M, Seth PK. 1987. Neurotoxicity of acrylamide in developing rat brain: changes in the levels of brain biogenic amines and activities of monoamine oxidase and acetylcholine esterase. Ind Health 25: 19–28. IARC. 1994. Acrylamide. TA:IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans PG:60. Igisu H, Goto I, Kawamura Y, Kato M, Izumi K. 1975. Acrylamide encephaloneuropathy due to well water pollution. J Neurol Neurosurg Psychiatry 38: 581–584. Ikeda GJ, Miller E, Sapienza PP, Michel TC, King MT, Turner VA, Blumenthal H, Jackson WE 3rd, Levin S. 1983. Distribution of 14C-labelled acrylamide and betaine in foetuses of rats, rabbits, beagle dogs and miniature pigs. Food Chem Toxicol 21: 49–58. Ikeda GJ, Miller E, Sapienza PP, Michel TC, King MT, Sager AO. 1985. Maternal-foetal distribution studies in late pregnancy II. Distribution of [1-14C] acrylamide in tissues of beagle dogs and miniature pigs. Food Chem Toxicol 23: 757–761. IPCS. 1985. Acrylamide environmental health criteria 49 (http://www.inchem.org/documents/ehc/ehc/ehc49.htm). IPCS. 1996. Poisons information monograph 652: Acrylamide (http://www.inchem.org/documents/pims/chemical/pim652.htm). JIFSAN/NCFST. 2002a. Exposure and biomarkers white paper. Acrylamide in food workshop: scientific issues, uncertainties, and research strategies. JIFSAN/NCFST. 2002b. Mechanisms of formation of acrylamide in food summary report. Acrylamide in food workshop: scientific issues, uncertainties, and research strategies. JIFSAN/NCFST. 2002c. Overview of acrylamide toxicity and metabolism. Acrylamide in food workshop: scientific issues, uncertainties, and research strategies. Johnson KA, Gorzinski SJ, Bodner KM, Campbell RA, Wolf CH, Friedman MA, Mast RW. 1986. Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol Appl Pharmacol 85: 154–168. Kaplan ML, Murphy SD. 1972. Effect of acrylamide on rotarod performance and sciatic nerve beta-glucuronidase activity of rats. Toxicol Appl Pharmacol 22: 259–268. Kirman CR, Gargas ML, Deskin R, Tonner-Navarro L, Andersen ME. 2003. A physiologically based pharmacokinetic model for acrylamide and its metabolite, glycidamide, in the rat. J Toxicol Environ Health A 66: 253–274. Ko MH, Chen WP, Lin-Shiau SY, Hsieh ST. 1999. Age-dependent acrylamide neurotoxicity in mice: morphology, physiology, and function. Exp Neurol 158: 37–46. Lähdetie J, Suutari A, Sjoblom T. 1994. The spermatid micronucleus test with the dissection technique detects the germ cell mutagenicity of acrylamide in rat meiotic cells. Mutat Res 309: 255–262. Mallinckrodt. 1987. Acrylamide material safety data sheet. Mallinckrodt Science Product Division. Marchetti F, Lowe X, Bishop J, Wyrobek AJ. 1997. Induction of chromosomal aberrations in mouse zygotes by acrylamide treatment of male germ cells and their correlation with dominant lethality and heritable translocations. Environ Mol Mutagen 30: 410–417. Marlowe C, Clark MJ, Mast RW, Friedman MA, Waddell WJ. 1986. The distribution of [14C]acrylamide in male and pregnant Swiss-Webster mice studied by whole-body autoradiography. Toxicol Appl Pharmacol 86: 457–465. Marsh GM, Lucas LJ, Youk AO, Schall LC. 1999. Mortality patterns among workers exposed to acrylamide: 1994 follow up. Occup Environ Med 56: 181–190. McCarver DG, Hines RN. 2002. The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms. J Pharmacol Exp Ther 300: 361–366. Miller MJ, Carter DE, Sipes IG. 1982. Pharmacokinetics of acrylamide in fisher-344 rats. Toxicol Appl Pharmacol 63: 36–44. Molak V. 1991. NIOH and NIOSH basis for an occupational health standard. Acrylamide: a review of the literature. Atlanta, Georgia: U.S. Department of Health and Human Services. Mucci LA, Dickman PW, Steineck G, Adami HO, Augustsson K. 2003. Dietary acrylamide and cancer of the large bowel, kidney, and bladder: absence of an association in a population-based study in Sweden. Br J Cancer 88: 84–89. Nagao T. 1994. Developmental abnormalities due to exposure of mouse paternal germ cells, preimplantation embryos, and organogenic embryos to acrylamide. Congenit Anom 34: 35–46. Neuh ä user-Klaus A, Schmahl W. 1989. Mutagenic and teratogenic effects of acrylamide in the mammalian spot test. Mutat Res 226: 157–162. NICNAS. 2002. Acrylamide: priority existing chemical assessment report No. 23. 174 p. NIOSH. 2003a. Acrylamide: NIOSH Pocket Guide. NIOSH. 2003b. National Occupational Exposure Survey (1981–1983). NLM. 2001. Household Products Database: Polyacrylamide. NIH National Library of Medicine Specialized Information Services. NTP. 1993. Final report on the reproductive toxicity of acrylamide (ACRL) (CAS no. 79-06-1) in CD-1 Swiss mice. NTIS Technical Report. NTP. 2001. NTP chemical repository: acrylamide. NTP. 2002. Report on carcinogens, 10th Edition. U.S. Department of Health and Human Services, Public Health Service. OSHA. 2001. Air contaminants. 29 CFR 19101000. Pacchierotti F, Tiveron C, D'Archivio M, Bassani B, Cordelli E, Leter G, Spano M. 1994. Acrylamide-induced chromosomal damage in male mouse germ cells detected by cytogenetic analysis of one-cell zygotes. Mutat Res 309: 273–284. Pantusa VP, Stock TH, Morandi MT, Harrist RB, Afshar M. 2002. Inhalation exposures to acrylamide in biomedical laboratories. AIHA J (Fairfax, Va) 63: 468–473. Pelucchi C, Franceschi S, Levi F, Trichopoulos D, Bosetti C, Negri E, La Vecchia C. 2003. Fried potatoes and human cancer. Int J Cancer 105: 558–560. Russell LB, Hunsicker PR, Cacheiro NL, Generoso WM. 1991. Induction of specific-locus mutations in male germ cells of the mouse by acrylamide monomer. Mutat Res 262: 101–107. Russo A, Gabbani G, Simoncini B. 1994. Weak genotoxicity of acrylamide on premeiotic and somatic cells of the mouse. Mutat Res 309: 263–272. Rutledge JC, Generoso WM, Shourbaji A, Cain KT, Gans M, Oliva J. 1992. Developmental anomalies derived from exposure of zygotes and first-cleavage embryos to mutagens. Mutat Res 296: 167–177. Sakamoto J, Hashimoto K. 1986. Reproductive toxicity of acrylamide and related compounds in mice--effects on fertility and sperm morphology. Arch Toxicol 59: 201–205. Sakamoto J, Kurosaka Y, Hashimoto K. 1988. Histological changes of acrylamide-induced testicular lesions in mice. Exp Mol Pathol 48: 324–334. Schettgen T, Broding HC, Angerer J, Drexler H. 2002. Hemoglobin adducts of ethylene oxide, propylene oxide, acrylonitrile and acrylamide-biomarkers in occupational and environmental medicine. Toxicol Lett 134: 65–70. Schettgen T, Weiss T, Drexler H, Angerer J. 2003. A first approach to estimate the internal exposure to acrylamide in smoking and non-smoking adults from Germany. Int J Hyg Environ Health 206: 9–14. Schettgen T, Kutting B, Hornig M, Beckmann MW, Weiss T, Drexler H, Angerer J. 2004. Trans-placental exposure of neonates to acrylamide-a pilot study. Int Arch Occup Environ Health 77: 213–216. Schmid TE, Xu W, Adler ID. 1999. Detection of aneuploidy by multicolor FISH in mouse sperm after in vivo treatment with acrylamide, colchicine, diazepam or thiabendazole. Mutagenensis 14: 173–179. Sega GA, Alcota RPV, Tancongco CP, Brimer PA. 1989. Acrylamide binding to the DNA and protamine of spermiogenic stages in the mouse and its relationship to genetic damage. Mutat Res 216: 221–230. Sega GA, Generoso EE. 1990. Measurement of DNA breakage in specific germ-cell stages of male mice exposed to acrylamide, using an alkaline-elution procedure. Mutat Res 242: 79–87. Sega GA, Generoso EE, Brimer PA. 1990. Acrylamide exposure induces a delayed unscheduled DNA synthesis in germ cells of male mice that is correlated with the temporal pattern of adduct formation in testis DNA. Environ Mol Mutagen 16: 137–142. Sega GA. 1991. Adducts in sperm protamine and DNA vs. mutation frequency. Prog Clin Biol Res 372: 521–530. Shelby MD, Cain KT, Hughes LA, Braden PW, Generoso WM. 1986. Dominant lethal effects of acrylamide in male mice. Mutat Res 173: 35–40. Shelby MD, Cain KT, Cornett CV, Generoso WM. 1987. Acrylamide: induction of heritable translocation in male mice. Environ Mutagen 9: 363–368. Shiraishi Y. 1978. Chromosome aberrations induced by monomeric acrylamide in bone marrow and germ cells of mice. Mutat Res 57: 313–324. Smith MK, Zenick H, Preston RJ, George EL, Lon RE. 1986. Dominant lethal effects of subchronic acrylamide administration in the male long-evans rat. Mutat Res 173: 273–277. Smith CJ, Perfetti TA, Rumple MA, Rodgman A, Doolittle DJ. 2000. "IARC group 2A carcinogens" reported in cigarette mainstream smoke. Food Chem Toxicol 38: 371–383. Sobel W, Bond GG, Parsons TW, Brenner FE. 1986. Acrylamide cohort mortality study. Br J Ind Med 43: 785–788. Sorgel F, Weissenbacher R, Kinzig-Schippers M, Hofmann A, Illauer M, Skott A, Landersdorfer C. 2002. Acrylamide: increased concentrations in homemade food and first evidence of its variable absorption from food, variable metabolism and placental and breast milk transfer in humans. Chemotherapy 48: 267–274. Sublet VH, Zenick H, Smith MK. 1989. Factors associated with reduced fertility and implantation rates in females mated to acrylamide-treated rats. Toxicology 55: 53–67. Sumner SC, Fennell TR, Moore TA, Chanas B, Gonzalez F, Ghanayem BI. 1999. Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice. Chem Res Toxicol 12: 1110–1116. Sumner SC, Williams CC, Snyder RW, Krol WL, Asgharian B, Fennell TR. 2003. Acrylamide: a comparison of metabolism and hemoglobin adducts in rodents following dermal, intraperitoneal, oral, or inhalation exposure. Toxicol Sci 75: 260–270. Suzuki K, Pfaff LD. 1973. Acrylamide neuropathy in rats. An electron microscopic study of degeneration and regeneration. Acta Neuropathol (Berl) 24: 197–213. Titenko-Holland N, Ahlborn T, Lowe X, Shang N, Smith MT, Wyrobek AJ. 1998. Micronuclei and developmental abnormalities in 4-day mouse embryos after paternal treatment with acrylamide. Environ Mol Mutagen 31: 206–217. Tyl RW, Friedman MA, Losco PE, Fisher LC, Johnson KA, Strother DE, Wolf CH. 2000a. Rat two-generation reproduction and dominant lethal study of acrylamide in drinking water. Reprod Toxicol 14: 385–401. Tyl RW, Marr MC, Myers CB, Ross WP, Friedman MA. 2000b. Relationship between acrylamide reproductive and neurotoxicity in male rats. Reprod Toxicol 14: 147–157. Walden R, Squibb RE, Schiller CM. 1981. Effects of prenatal and lactational exposure to acrylamide on the development of intestinal enzymes in the rat. Toxicol Appl Pharmacol 58: 363–369. Walum E, Flint OP. 1993. Selective effects of acrylamide, metylene bisacrylamide, and haloperidol on neuronal development in rat embryo midbrain micromass cultures. In Vitro Toxicology, A Journal of Molecular and Cellular Toxicology 6: 125–134. Wise LD, Gordon LR, Soper KA, Duchai DM, Morrissey RE. 1995. Developmental neurotoxicity evaluation of acrylamide in Sprague-Dawley rats. Neurotoxicol Teratol 17: 189–198. Working PK, Bentley KS, Hurtt ME, Mohr KL. 1987. Comparison of the dominant lethal effects of acrylonitrile and acrylamide in male Fischer 344 rats. Mutagenesis 2: 215–220. Xiao Y, Tates AD. 1994. Increased frequencies of micronuclei in early spermatids of rats following exposure of young primary spermatocytes to acrylamide. Mutat Res 309: 245–253. Zenick H, Hope E, Smith MK. 1986. Reproductive toxicity associated with acrylamide treatment in male and female rats. J Toxicol Environ Health 17: 457–472. Citing Literature Volume74, Issue1February 2005Pages 17-113 ReferencesRelatedInformation
Publication Year: 2005
Publication Date: 2005-01-01
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