Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2040450077', 'doi': 'https://doi.org/10.1128/aac.37.5.1108', 'title': 'Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu)', 'display_name': 'Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu)', 'publication_year': 1993, 'publication_date': '1993-05-01', 'ids': {'openalex': 'https://openalex.org/W2040450077', 'doi': 'https://doi.org/10.1128/aac.37.5.1108', 'mag': '2040450077', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8517699', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/187911'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.37.5.1108', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc187911?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108138248', 'display_name': 'Steven R. Meshnick', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S R Meshnick', 'raw_affiliation_strings': ['Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor 48109.'], 'affiliations': [{'raw_affiliation_string': 'Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor 48109.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108086278', 'display_name': 'Y Z Yang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Y Z Yang', 'raw_affiliation_strings': ['Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor 48109.'], 'affiliations': [{'raw_affiliation_string': 'Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor 48109.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069983719', 'display_name': 'Vera Lúcia de Menezes Lima', 'orcid': 'https://orcid.org/0000-0003-2581-9218'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'V Lima', 'raw_affiliation_strings': ['Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor 48109.'], 'affiliations': [{'raw_affiliation_string': 'Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor 48109.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047162260', 'display_name': 'Frans A. Kuypers', 'orcid': 'https://orcid.org/0000-0003-0731-1007'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'F Kuypers', 'raw_affiliation_strings': ['Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor 48109.'], 'affiliations': [{'raw_affiliation_string': 'Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor 48109.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091720746', 'display_name': 'Sumalee Kamchonwongpaisan', 'orcid': 'https://orcid.org/0000-0002-4723-5232'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S Kamchonwongpaisan', 'raw_affiliation_strings': ['Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor 48109.'], 'affiliations': [{'raw_affiliation_string': 'Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor 48109.', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5060203261', 'display_name': 'Yongyuth Yuthavong', 'orcid': 'https://orcid.org/0000-0002-3582-8401'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Y Yuthavong', 'raw_affiliation_strings': ['Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor 48109.'], 'affiliations': [{'raw_affiliation_string': 'Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor 48109.', 'institution_ids': ['https://openalex.org/I27837315']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 24.52, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 316, 'citation_normalized_percentile': {'value': 0.999893, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '37', 'issue': '5', 'first_page': '1108', 'last_page': '1114'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10166', 'display_name': 'Mosquito-borne diseases and control', 'score': 0.9911, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Drug Discovery Methods', 'score': 0.9689, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hemin', 'display_name': 'Hemin', 'score': 0.7704089}, {'id': 'https://openalex.org/keywords/deferiprone', 'display_name': 'Deferiprone', 'score': 0.5552567}, {'id': 'https://openalex.org/keywords/artemisia-annua', 'display_name': 'Artemisia annua', 'score': 0.5082821}], 'concepts': [{'id': 'https://openalex.org/C2776120307', 'wikidata': 'https://www.wikidata.org/wiki/Q426921', 'display_name': 'Artemisinin', 'level': 4, 'score': 0.9825053}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.80210483}, {'id': 'https://openalex.org/C2776672577', 'wikidata': 'https://www.wikidata.org/wiki/Q419618', 'display_name': 'Deferoxamine', 'level': 2, 'score': 0.7851466}, {'id': 'https://openalex.org/C2777723881', 'wikidata': 'https://www.wikidata.org/wiki/Q107315604', 'display_name': 'Hemin', 'level': 4, 'score': 0.7704089}, {'id': 'https://openalex.org/C2776517179', 'wikidata': 'https://www.wikidata.org/wiki/Q749664', 'display_name': 'Deferiprone', 'level': 3, 'score': 0.5552567}, {'id': 'https://openalex.org/C2779691961', 'wikidata': 'https://www.wikidata.org/wiki/Q1308044', 'display_name': 'Artemisia annua', 'level': 5, 'score': 0.5082821}, {'id': 'https://openalex.org/C197404232', 'wikidata': 'https://www.wikidata.org/wiki/Q319827', 'display_name': 'Chelation', 'level': 2, 'score': 0.47331488}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.390882}, {'id': 'https://openalex.org/C2778371730', 'wikidata': 'https://www.wikidata.org/wiki/Q311383', 'display_name': 'Plasmodium falciparum', 'level': 3, 'score': 0.3406047}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.33532578}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3158852}, {'id': 'https://openalex.org/C2776217839', 'wikidata': 'https://www.wikidata.org/wiki/Q189621', 'display_name': 'Heme', 'level': 3, 'score': 0.30026525}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.17639655}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.07542196}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.07400957}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D037621', 'descriptor_name': 'Artemisinins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004365', 'descriptor_name': 'Drugs, Chinese Herbal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007501', 'descriptor_name': 'Iron', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012717', 'descriptor_name': 'Sesquiterpenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D004365', 'descriptor_name': 'Drugs, Chinese Herbal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004907', 'descriptor_name': 'Erythrocyte Deformability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004907', 'descriptor_name': 'Erythrocyte Deformability', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005609', 'descriptor_name': 'Free Radicals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005609', 'descriptor_name': 'Free Radicals', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007501', 'descriptor_name': 'Iron', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007502', 'descriptor_name': 'Iron Chelating Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007502', 'descriptor_name': 'Iron Chelating Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D016778', 'descriptor_name': 'Malaria, Falciparum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016778', 'descriptor_name': 'Malaria, Falciparum', 'qualifier_ui': 'Q000469', 'qualifier_name': 'parasitology', 'is_major_topic': False}, {'descriptor_ui': 'D016778', 'descriptor_name': 'Malaria, Falciparum', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D012717', 'descriptor_name': 'Sesquiterpenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012717', 'descriptor_name': 'Sesquiterpenes', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D012717', 'descriptor_name': 'Sesquiterpenes', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.37.5.1108', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc187911', 'pdf_url': 'https://europepmc.org/articles/pmc187911?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC187911', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8517699', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc187911', 'pdf_url': 'https://europepmc.org/articles/pmc187911?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'score': 0.49, 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W126016206', 'https://openalex.org/W128213231', 'https://openalex.org/W1496019889', 'https://openalex.org/W1498914016', 'https://openalex.org/W1504596371', 'https://openalex.org/W1573704697', 'https://openalex.org/W160096264', 'https://openalex.org/W1604383285', 'https://openalex.org/W1968616621', 'https://openalex.org/W1978281757', 'https://openalex.org/W1980473859', 'https://openalex.org/W1983479470', 'https://openalex.org/W1986315454', 'https://openalex.org/W1995192949', 'https://openalex.org/W2007927375', 'https://openalex.org/W2009062454', 'https://openalex.org/W2012316678', 'https://openalex.org/W2025765364', 'https://openalex.org/W2034409947', 'https://openalex.org/W2041510906', 'https://openalex.org/W2052664734', 'https://openalex.org/W2054059522', 'https://openalex.org/W2061230633', 'https://openalex.org/W2070339172', 'https://openalex.org/W2070457129', 'https://openalex.org/W2089288068', 'https://openalex.org/W2090081368', 'https://openalex.org/W2090632234', 'https://openalex.org/W2092597744', 'https://openalex.org/W2098184601', 'https://openalex.org/W2105668259', 'https://openalex.org/W2108672965', 'https://openalex.org/W2112191861', 'https://openalex.org/W2128635872', 'https://openalex.org/W2130563538', 'https://openalex.org/W2148053140', 'https://openalex.org/W2238873502', 'https://openalex.org/W2284821231', 'https://openalex.org/W2299522784', 'https://openalex.org/W2395818450', 'https://openalex.org/W2398785798', 'https://openalex.org/W2407931396', 'https://openalex.org/W2410223094', 'https://openalex.org/W2411088972', 'https://openalex.org/W2427517169', 'https://openalex.org/W2764540609', 'https://openalex.org/W307882207', 'https://openalex.org/W4240007818', 'https://openalex.org/W4245175744', 'https://openalex.org/W4253301322', 'https://openalex.org/W4290170744', 'https://openalex.org/W4293247451'], 'related_works': ['https://openalex.org/W3149344166', 'https://openalex.org/W3149303686', 'https://openalex.org/W3140940931', 'https://openalex.org/W3025705671', 'https://openalex.org/W2886721652', 'https://openalex.org/W2393195802', 'https://openalex.org/W2228665180', 'https://openalex.org/W2077381490', 'https://openalex.org/W2039894471', 'https://openalex.org/W2037209505'], 'abstract_inverted_index': {'Artemisinin': [0], 'is': [1, 21, 39, 60, 126], 'an': [2, 17, 64], 'important': [3], 'new': [4], 'antimalarial': [5, 14], 'agent': [6], 'containing': [7], 'a': [8, 70, 111], 'bridged': [9], 'endoperoxide.': [10], 'The': [11, 81], 'in': [12, 37, 55, 72, 128], 'vitro': [13], 'activity': [15, 106], 'of': [16, 35, 47, 75, 79, 83, 96, 107, 131], 'artemisinin': [18, 36, 48, 84, 100, 108, 125], 'derivative,': [19], 'arteether,': [20], 'antagonized': [22, 40], 'by': [23, 41, 63, 119], 'two': [24], 'iron': [25, 65, 68], 'chelators,': [26], 'pyridoxal': [27], 'benzoylhydrazone': [28], 'and': [29, 49, 57, 77, 85, 109], '1,2-dimethyl-3-hydroxypyrid-4-one.': [30], 'Similarly,': [31], 'the': [32, 73, 94, 104, 129], 'acute': [33], 'toxicity': [34, 78], 'mice': [38], 'another': [42], 'chelator,': [43], 'deferoxamine-hydroxyethylstarch.': [44], 'A': [45], 'combination': [46, 82], 'hemin': [50, 86], 'oxidizes': [51], 'erythrocyte': [52, 89], 'membrane': [53], 'thiols': [54], 'vitro,': [56], 'this': [58], 'oxidation': [59], 'also': [61, 87], 'inhibited': [62], 'chelator.': [66], 'Thus,': [67], 'plays': [69], 'role': [71], 'mechanisms': [74], 'action': [76], 'artemisinin.': [80], 'decreases': [88], 'deformability.': [90], 'Iron': [91], 'probably': [92], 'catalyzes': [93], 'generation': [95], 'free': [97, 113], 'radicals': [98], 'from': [99], 'since': [101, 110], 'alpha-tocopherol': [102], 'antagonizes': [103], 'thiol-oxidizing': [105], 'spin-trapped': [112], 'radical': [114], 'signal': [115], 'can': [116], 'be': [117], 'seen': [118], 'electron': [120], 'paramagnetic': [121], 'resonance': [122], 'only': [123], 'when': [124], 'incubated': [127], 'presence': [130], 'iron.': [132]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2040450077', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 12}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 15}], 'updated_date': '2024-12-08T22:16:11.093946', 'created_date': '2016-06-24'}