Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2040405249', 'doi': 'https://doi.org/10.1002/biot.200500049', 'title': '<i>Arenicola marina</i> extracellular hemoglobin: a new promising blood substitute', 'display_name': '<i>Arenicola marina</i> extracellular hemoglobin: a new promising blood substitute', 'publication_year': 2006, 'publication_date': '2006-02-22', 'ids': {'openalex': 'https://openalex.org/W2040405249', 'doi': 'https://doi.org/10.1002/biot.200500049', 'mag': '2040405249', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16897713'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/biot.200500049', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S31411064', 'display_name': 'Biotechnology Journal', 'issn_l': '1860-6768', 'issn': ['1860-6768', '1860-7314'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008580929', 'display_name': 'M Rousselot', 'orcid': 'https://orcid.org/0000-0001-9004-1620'}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I2802436875', 'display_name': 'Station Biologique de Roscoff', 'ror': 'https://ror.org/03s0pzj56', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I2802436875', 'https://openalex.org/I39804081', 'https://openalex.org/I4210107625']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Morgane Rousselot', 'raw_affiliation_strings': ['Equipe Ecophysiologie: Adaptation et Evolution Moléculaires, UPMC – CNRS UMR 7144, Station biologique, Roscoff, France'], 'affiliations': [{'raw_affiliation_string': 'Equipe Ecophysiologie: Adaptation et Evolution Moléculaires, UPMC – CNRS UMR 7144, Station biologique, Roscoff, France', 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I2802436875']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046667159', 'display_name': 'Eric Delpy', 'orcid': 'https://orcid.org/0000-0001-8056-3652'}, 'institutions': [{'id': 'https://openalex.org/I4210159878', 'display_name': 'Structure Fédérative de Recherche en Biologie et Santé de Rennes', 'ror': 'https://ror.org/05cx7ek10', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210159878', 'https://openalex.org/I56067802']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Eric Delpy', 'raw_affiliation_strings': ['BIOTRIAL, Preclinical Pharmacology Unit, Rennes, France'], 'affiliations': [{'raw_affiliation_string': 'BIOTRIAL, Preclinical Pharmacology Unit, Rennes, France', 'institution_ids': ['https://openalex.org/I4210159878']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113860245', 'display_name': 'Christophe Drieu La Rochelle', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210159878', 'display_name': 'Structure Fédérative de Recherche en Biologie et Santé de Rennes', 'ror': 'https://ror.org/05cx7ek10', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210159878', 'https://openalex.org/I56067802']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Christophe Drieu La Rochelle', 'raw_affiliation_strings': ['BIOTRIAL, Preclinical Pharmacology Unit, Rennes, France'], 'affiliations': [{'raw_affiliation_string': 'BIOTRIAL, Preclinical Pharmacology Unit, Rennes, France', 'institution_ids': ['https://openalex.org/I4210159878']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072778963', 'display_name': 'Vincent Lagente', 'orcid': 'https://orcid.org/0000-0003-4920-009X'}, 'institutions': [{'id': 'https://openalex.org/I56067802', 'display_name': 'Université de Rennes', 'ror': 'https://ror.org/015m7wh34', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I56067802']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Vincent Lagente', 'raw_affiliation_strings': ['INSERM U620, Laboratoire de pharmacodynamie et de pharmacologie moléculaire, Faculté des sciences pharmaceutiques et biologiques, Université de Rennes 1, Rennes, France'], 'affiliations': [{'raw_affiliation_string': 'INSERM U620, Laboratoire de pharmacodynamie et de pharmacologie moléculaire, Faculté des sciences pharmaceutiques et biologiques, Université de Rennes 1, Rennes, France', 'institution_ids': ['https://openalex.org/I56067802', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028001713', 'display_name': 'Ralph Pirow', 'orcid': 'https://orcid.org/0000-0003-0513-1045'}, 'institutions': [{'id': 'https://openalex.org/I22465464', 'display_name': 'University of Münster', 'ror': 'https://ror.org/00pd74e08', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I22465464']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ralph Pirow', 'raw_affiliation_strings': ['Institut für Zoophysiologie, Westfälische Wilhelms-Universität Münster, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institut für Zoophysiologie, Westfälische Wilhelms-Universität Münster, Germany', 'institution_ids': ['https://openalex.org/I22465464']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052330427', 'display_name': 'Jean‐François Rees', 'orcid': 'https://orcid.org/0000-0002-8171-6689'}, 'institutions': [{'id': 'https://openalex.org/I95674353', 'display_name': 'UCLouvain', 'ror': 'https://ror.org/02495e989', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I95674353']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Jean‐François Rees', 'raw_affiliation_strings': ['Laboratoire de Biologie cellulaire, Institut des Sciences de la Vie, Université catholique de Louvain, Louvain-la-Neuve, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Biologie cellulaire, Institut des Sciences de la Vie, Université catholique de Louvain, Louvain-la-Neuve, Belgium', 'institution_ids': ['https://openalex.org/I95674353']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005494837', 'display_name': 'Agnès Hagège', 'orcid': 'https://orcid.org/0000-0002-9246-929X'}, 'institutions': [{'id': 'https://openalex.org/I4210152404', 'display_name': 'Laboratoire COBRA', 'ror': 'https://ror.org/04e8pda19', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I4210105918', 'https://openalex.org/I4210128300', 'https://openalex.org/I4210152404', 'https://openalex.org/I62396329', 'https://openalex.org/I88814501']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Agnès Hagege', 'raw_affiliation_strings': ['Laboratoire de Chimie Analytique et Minérale, ECPM, Strasbourg, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Chimie Analytique et Minérale, ECPM, Strasbourg, France', 'institution_ids': ['https://openalex.org/I4210152404']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075676454', 'display_name': 'Dominique Le Guen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I2802436875', 'display_name': 'Station Biologique de Roscoff', 'ror': 'https://ror.org/03s0pzj56', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I2802436875', 'https://openalex.org/I39804081', 'https://openalex.org/I4210107625']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Dominique Le Guen', 'raw_affiliation_strings': ['Equipe Ecophysiologie: Adaptation et Evolution Moléculaires, UPMC – CNRS UMR 7144, Station biologique, Roscoff, France'], 'affiliations': [{'raw_affiliation_string': 'Equipe Ecophysiologie: Adaptation et Evolution Moléculaires, UPMC – CNRS UMR 7144, Station biologique, Roscoff, France', 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I2802436875']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061769218', 'display_name': 'Stéphane Hourdez', 'orcid': 'https://orcid.org/0000-0001-6418-3887'}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I2802436875', 'display_name': 'Station Biologique de Roscoff', 'ror': 'https://ror.org/03s0pzj56', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I2802436875', 'https://openalex.org/I39804081', 'https://openalex.org/I4210107625']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Stéphane Hourdez', 'raw_affiliation_strings': ['Equipe Ecophysiologie: Adaptation et Evolution Moléculaires, UPMC – CNRS UMR 7144, Station biologique, Roscoff, France'], 'affiliations': [{'raw_affiliation_string': 'Equipe Ecophysiologie: Adaptation et Evolution Moléculaires, UPMC – CNRS UMR 7144, Station biologique, Roscoff, France', 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I2802436875']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5040480966', 'display_name': 'Franck Zal', 'orcid': 'https://orcid.org/0000-0002-2872-6618'}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I2802436875', 'display_name': 'Station Biologique de Roscoff', 'ror': 'https://ror.org/03s0pzj56', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I2802436875', 'https://openalex.org/I39804081', 'https://openalex.org/I4210107625']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Franck Zal', 'raw_affiliation_strings': ['Equipe Ecophysiologie: Adaptation et Evolution Moléculaires, UPMC – CNRS UMR 7144, Station biologique, Roscoff, France'], 'affiliations': [{'raw_affiliation_string': 'Equipe Ecophysiologie: Adaptation et Evolution Moléculaires, UPMC – CNRS UMR 7144, Station biologique, Roscoff, France', 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I2802436875']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 8, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4330, 'currency': 'USD', 'value_usd': 4330, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.761, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 121, 'citation_normalized_percentile': {'value': 0.999848, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '1', 'issue': '3', 'first_page': '333', 'last_page': '345'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12094', 'display_name': 'Hemoglobin structure and function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12094', 'display_name': 'Hemoglobin structure and function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11848', 'display_name': 'Heme Oxygenase-1 and Carbon Monoxide', 'score': 0.9896, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12286', 'display_name': 'Erythrocyte Function and Pathophysiology', 'score': 0.9796, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/blood-substitute', 'display_name': 'Blood substitute', 'score': 0.4571533}], 'concepts': [{'id': 'https://openalex.org/C2778917026', 'wikidata': 'https://www.wikidata.org/wiki/Q43041', 'display_name': 'Hemoglobin', 'level': 2, 'score': 0.7431003}, {'id': 'https://openalex.org/C28406088', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Extracellular', 'level': 2, 'score': 0.6204965}, {'id': 'https://openalex.org/C2778337571', 'wikidata': 'https://www.wikidata.org/wiki/Q831050', 'display_name': 'Blood substitute', 'level': 3, 'score': 0.4571533}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.41069973}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3974667}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3675655}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.22566584}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.16166231}], 'mesh': [{'descriptor_ui': 'D000845', 'descriptor_name': 'Annelida', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001802', 'descriptor_name': 'Blood Substitutes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D001802', 'descriptor_name': 'Blood Substitutes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006454', 'descriptor_name': 'Hemoglobins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006454', 'descriptor_name': 'Hemoglobins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000845', 'descriptor_name': 'Annelida', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001802', 'descriptor_name': 'Blood Substitutes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001802', 'descriptor_name': 'Blood Substitutes', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D045604', 'descriptor_name': 'Extracellular Fluid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045604', 'descriptor_name': 'Extracellular Fluid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D045604', 'descriptor_name': 'Extracellular Fluid', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006454', 'descriptor_name': 'Hemoglobins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006454', 'descriptor_name': 'Hemoglobins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006454', 'descriptor_name': 'Hemoglobins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008811', 'descriptor_name': 'Mice, Inbred DBA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/biot.200500049', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S31411064', 'display_name': 'Biotechnology Journal', 'issn_l': '1860-6768', 'issn': ['1860-6768', '1860-7314'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16897713', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.88}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W1526270399', 'https://openalex.org/W1583810029', 'https://openalex.org/W1676063974', 'https://openalex.org/W1785721426', 'https://openalex.org/W1964651116', 'https://openalex.org/W1967169588', 'https://openalex.org/W1981764830', 'https://openalex.org/W1983415172', 'https://openalex.org/W1984788347', 'https://openalex.org/W1993991805', 'https://openalex.org/W2001320781', 'https://openalex.org/W2005828038', 'https://openalex.org/W2007393053', 'https://openalex.org/W2008503480', 'https://openalex.org/W2012361581', 'https://openalex.org/W2016086080', 'https://openalex.org/W2016466336', 'https://openalex.org/W2019499716', 'https://openalex.org/W2024130943', 'https://openalex.org/W2029605073', 'https://openalex.org/W2032115021', 'https://openalex.org/W2032226735', 'https://openalex.org/W2032760539', 'https://openalex.org/W2034906784', 'https://openalex.org/W2040223458', 'https://openalex.org/W2044086635', 'https://openalex.org/W2046439509', 'https://openalex.org/W2050905302', 'https://openalex.org/W2054597788', 'https://openalex.org/W2061458010', 'https://openalex.org/W2070288609', 'https://openalex.org/W2073087806', 'https://openalex.org/W2076128870', 'https://openalex.org/W2080564334', 'https://openalex.org/W2089772493', 'https://openalex.org/W2094751995', 'https://openalex.org/W2095115132', 'https://openalex.org/W2102349872', 'https://openalex.org/W2111897470', 'https://openalex.org/W2116044709', 'https://openalex.org/W2117246901', 'https://openalex.org/W2118593308', 'https://openalex.org/W2120182098', 'https://openalex.org/W2126588926', 'https://openalex.org/W2130434014', 'https://openalex.org/W2132867842', 'https://openalex.org/W2162551249', 'https://openalex.org/W2169952241', 'https://openalex.org/W2170990246', 'https://openalex.org/W2212354373', 'https://openalex.org/W2411323646', 'https://openalex.org/W2469602754', 'https://openalex.org/W2833720673', 'https://openalex.org/W2979171911', 'https://openalex.org/W829757908', 'https://openalex.org/W83672633'], 'related_works': ['https://openalex.org/W2433134232', 'https://openalex.org/W2420319755', 'https://openalex.org/W2413913006', 'https://openalex.org/W2111973626', 'https://openalex.org/W2100768082', 'https://openalex.org/W2070520551', 'https://openalex.org/W2049280769', 'https://openalex.org/W2002430609', 'https://openalex.org/W1993335366', 'https://openalex.org/W1602555061'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'need': [2], 'to': [3, 47, 111, 160, 176], 'develop': [4], 'a': [5, 42, 74, 85], 'blood': [6, 28, 48, 75, 89], 'substitute': [7], 'is': [8, 108, 166], 'now': [9], 'urgent': [10], 'because': [11], 'of': [12, 70, 97, 130, 138, 152], 'the': [13, 21, 68, 91, 98, 122, 128, 178], 'increasing': [14], 'concern': [15], 'over': [16], "Europe's": [17], 'BSE': [18], 'outbreak': [19], 'and': [20, 44, 65, 82, 117, 155], 'worldwide': [22], 'HIV/AIDS': [23], 'epidemic,': [24], 'which': [25], 'have': [26, 59, 78, 83], 'cut': [27], 'supplies.': [29], 'Extracellular': [30], 'soluble': [31], 'hemoglobin': [32, 72, 96, 165], 'has': [33, 52], 'long': [34], 'been': [35], 'studied': [36], 'for': [37, 140, 156], 'its': [38, 115, 134], 'possible': [39], 'use': [40], 'as': [41, 73], 'safe': [43], 'effective': [45], 'alternative': [46], 'transfusion,': [49], 'but': [50], 'this': [51], 'met': [53], 'with': [54, 127, 146], 'little': [55], 'success.': [56], 'Clinical': [57], 'trials': [58], 'revealed': [60], 'undesirable': [61], 'side': [62, 123], 'effects–oxidative': [63], 'damage': [64], 'vasoconstriction–that': [66], 'hamper': [67], 'application': [69], 'cellfree': [71], 'substitute.': [76], 'We': [77], 'addressed': [79], 'these': [80], 'problems': [81], 'found': [84], 'new': [86], 'promising': [87], 'extracellular': [88, 94, 131], 'substitute:': [90], 'natural': [92, 164], 'giant': [93], 'polymeric': [95], 'polychaete': [99], 'annelid': [100], 'Arenicola': [101], 'marina.': [102], 'Here': [103], 'we': [104], 'show': [105], 'that': [106], 'it': [107], 'less': [109], 'likely': [110], 'cause': [112], 'immunogenic': [113], 'response;': [114], 'functional': [116], 'structural': [118], 'properties': [119, 136], 'should': [120], 'prevent': [121], 'effects': [124], 'often': [125, 144], 'associated': [126, 145], 'administration': [129], 'hemoglobin.': [132], 'Moreover,': [133, 162], 'intrinsic': [135], 'are': [137], 'interest': [139], 'other': [141], 'therapeutic': [142], 'applications': [143], 'hemorrhagic': [147], 'shock': [148, 154], '(ischemia': [149], 'reperfusion,': [150], 'treatment': [151], 'septic': [153], 'organ': [157], 'preservation': [158], 'prior': [159], 'transplantation).': [161], 'using': [163], 'particularly': [167], 'useful': [168], 'since': [169], 'recombinant': [170], 'DNA': [171], 'techniques': [172], 'could': [173], 'be': [174], 'used': [175], 'express': [177], 'protein': [179], 'in': [180], 'large': [181], 'quantities.': [182]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2040405249', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 12}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-11T21:06:55.812762', 'created_date': '2016-06-24'}