Publication Information

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'https://openalex.org/W2032514624', 'https://openalex.org/W2022247016'], 'abstract_inverted_index': {'Binding': [0, 239], 'of': [1, 14, 16, 48, 82, 96, 117, 126, 149, 180, 190, 203, 213, 240, 253, 255, 287, 321, 335, 356, 365, 388, 419, 429, 442, 452, 490, 493, 499, 502, 559, 729, 763, 778, 782, 833, 837, 908, 911, 927, 998, 1157, 1165, 1269, 1277, 1284, 1344, 1349, 1375, 1445, 1473, 1489, 1527, 1577, 1627, 1633, 1642, 1649, 1653, 1666, 1722, 1739, 1783, 1895, 1900, 1927, 1929, 1936, 1945, 2030, 2068, 2106, 2200, 2235, 2288, 2298, 2313, 2357, 2361, 2403, 2610, 2700, 2710, 2769, 2799, 2809, 2813, 2829, 2835, 2845, 2850, 2862, 2869, 2937, 2943, 2948, 2967, 2973, 2986, 3015, 3022, 3070, 3083, 3135, 3195, 3231, 3408, 3413, 3420, 3424, 3430, 3436, 3471, 3478, 3514, 3525, 3565, 3577, 3585, 3612, 3618, 3627, 3646, 3721, 3727, 3735, 3773, 3783, 3828, 3848, 3871, 3884, 3903, 3916, 3920, 3935, 3960, 4004, 4044, 4272, 4286, 4345, 4354, 4438, 4461, 4465, 4470, 4477, 4487, 4497, 4505, 4517, 4524, 4531, 4601, 4673, 4683, 4694, 4792, 4907, 4951, 4978, 5087, 5106, 5122, 5132, 5147, 5151, 5212, 5217, 5223, 5245, 5251, 5257, 5277, 5330, 5343, 5362, 5395, 5477, 5495, 5564, 5722, 5734, 5766, 5840], 'tumor': [2, 241, 786, 841, 1458], 'necrosis': [3, 242, 787, 842, 1459], 'factor-α': [4, 243, 1460], '(TNFα)': [5, 244], 'to': [6, 42, 50, 67, 98, 132, 144, 167, 194, 205, 245, 281, 289, 306, 337, 371, 383, 406, 433, 444, 541, 759, 919, 1000, 1148, 1203, 1341, 1366, 1368, 1382, 1467, 1486, 1531, 1565, 1735, 1910, 2128, 2138, 2348, 2369, 2385, 2426, 2502, 2513, 2771, 2792, 2880, 2952, 2962, 3026, 3056, 3062, 3073, 3086, 3092, 3129, 3132, 3235, 3267, 3297, 3320, 3357, 3382, 3401, 3503, 3517, 3575, 3614, 3723, 3737, 3749, 3756, 3780, 3834, 3880, 3886, 3901, 3930, 3956, 3985, 4001, 4016, 4025, 4338, 4350, 4396, 4433, 4452, 4501, 4512, 4521, 4617, 4657, 4675, 4689, 4739, 4782, 4794, 4808, 4818, 4938, 4955, 5032, 5051, 5095, 5144, 5157, 5236, 5247, 5265, 5282, 5345, 5364, 5444, 5472, 5481, 5548, 5575, 5606, 5624, 5724, 5740, 5779, 5788, 5806], 'its': [7, 170, 246, 409, 1937, 3087, 4466, 4944, 5283, 5346, 5351, 5571], 'receptor,': [8, 247, 3861], 'TNF-R1,': [9, 118, 248, 357, 790, 845, 2746, 3758, 3999, 4441, 5125, 5803], 'results': [10, 249, 2760, 2840, 3742], 'in': [11, 32, 40, 53, 84, 110, 130, 164, 250, 271, 279, 292, 323, 349, 369, 403, 549, 681, 704, 732, 930, 1266, 1287, 1336, 1452, 1615, 1662, 1670, 1897, 1957, 2032, 2395, 2398, 2433, 2442, 2468, 2515, 2528, 2533, 2646, 2690, 2702, 2762, 2777, 2804, 2822, 2827, 2975, 2988, 3090, 3253, 3260, 3265, 3272, 3291, 3305, 3367, 3374, 3399, 3410, 3432, 3568, 3596, 3608, 3658, 3675, 3747, 3832, 3850, 3928, 3983, 4050, 4172, 4249, 4261, 4266, 4295, 4307, 4342, 4361, 4394, 4474, 4510, 4619, 4666, 5030, 5035, 5045, 5111, 5142, 5220, 5309, 5401, 5459, 5491, 5541, 5634, 5804], 'the': [12, 46, 75, 80, 94, 134, 145, 150, 201, 210, 251, 285, 314, 319, 333, 373, 384, 389, 440, 449, 500, 726, 735, 761, 882, 909, 1151, 1155, 1163, 1267, 1270, 1282, 1337, 1342, 1360, 1369, 1373, 1443, 1456, 1474, 1487, 1494, 1525, 1528, 1532, 1575, 1640, 1645, 1737, 1740, 1781, 1836, 1887, 1893, 1898, 1930, 2129, 2134, 2311, 2349, 2427, 2451, 2503, 2767, 2818, 2830, 2860, 2867, 2941, 2965, 3005, 3020, 3081, 3118, 3123, 3133, 3136, 3191, 3306, 3375, 3406, 3411, 3428, 3433, 3476, 3504, 3523, 3563, 3583, 3719, 3733, 3757, 3846, 3860, 3869, 3882, 3943, 4042, 4156, 4275, 4284, 4343, 4355, 4436, 4475, 4484, 4502, 4522, 4529, 4599, 4613, 4692, 4790, 4917, 4949, 4976, 5081, 5103, 5112, 5119, 5148, 5310, 5328, 5331, 5360, 5492, 5542, 5651, 5731, 5735, 5764, 5830], 'activation': [13, 121, 159, 212, 226, 252, 360, 398, 451, 465, 762, 1159, 1199, 1268, 1289, 1444, 1521, 1576, 1626, 1641, 1665, 1721, 1777, 1899, 1921, 2699, 2709, 2756, 2798, 2834, 2844, 2856, 2864, 2971, 2990, 2997, 3038, 3050, 3064, 3189, 3194, 3412, 3435, 3470, 3524, 3567, 3839, 3902, 3927, 3962, 3970, 3982, 4003, 4476, 4486, 4530, 4820, 4931, 5029, 5131, 5136, 5230, 5253, 5259, 5323, 5454, 5572, 5661, 5774], 'inhibitor': [15, 254, 777, 781, 832, 836, 1343], 'κB': [17, 256, 783, 838, 1345], 'kinase': [18, 23, 257, 262, 766, 1353, 2227, 2254, 2281, 4052], '(IKK)': [19, 258], 'and': [20, 30, 34, 61, 70, 138, 140, 169, 187, 208, 259, 269, 273, 300, 309, 377, 379, 408, 426, 447, 554, 701, 749, 924, 1089, 1371, 1447, 1491, 1571, 1629, 1638, 1647, 1668, 1845, 1914, 1916, 1919, 1934, 1942, 1970, 1990, 2002, 2028, 2048, 2072, 2084, 2110, 2145, 2191, 2225, 2251, 2295, 2321, 2337, 2353, 2375, 2390, 2448, 2471, 2523, 2556, 2592, 2606, 2628, 2654, 2754, 2852, 2955, 3018, 3079, 3122, 3130, 3162, 3190, 3193, 3233, 3241, 3243, 3263, 3303, 3378, 3393, 3403, 3422, 3480, 3508, 3520, 3527, 3581, 3588, 3640, 3697, 3703, 3731, 3740, 3752, 3761, 3785, 3796, 3867, 3874, 3889, 3894, 3918, 3925, 3950, 4023, 4288, 4453, 4463, 4526, 4533, 4615, 4622, 4742, 4797, 4920, 4940, 4958, 5002, 5089, 5108, 5159, 5164, 5392, 5485, 5529, 5552, 5557, 5573, 5737, 5825, 5834], 'c-Jun': [21, 260, 764, 773, 828, 5811], 'N-terminal': [22, 261, 765, 774, 829, 5812], '(JNK)': [24, 263], 'pathways': [25, 264], 'that': [26, 39, 62, 129, 178, 188, 220, 235, 265, 278, 301, 368, 417, 427, 459, 474, 1439, 1625, 1639, 1835, 1907, 1917, 2696, 2739, 2766, 2842, 3048, 3316, 3390, 3621, 3746, 3845, 3992, 4077, 4083, 4170, 4255, 4301, 4398, 4446, 4677, 4733, 4814, 4929, 4941, 4948, 4972, 5044, 5083, 5228, 5273, 5316, 5338, 5356, 5439, 5452, 5467, 5629, 5658, 5726, 5763], 'are': [27, 266, 546, 555, 578, 702, 745, 1440, 1922, 3185, 3395, 3705, 3754, 3764, 3769, 4472, 4663, 4960, 5155, 5531], 'coordinately': [28, 267, 1636, 2858], 'regulated': [29, 268, 1637, 3003], 'important': [31, 270, 482, 5648], 'survival': [33, 272, 1005, 1384, 1672, 1727, 1741], 'death.': [35, 73, 274, 312, 1619], 'We': [36, 275, 1904, 3008, 3223, 3559, 4167, 4279, 4334, 5814], 'demonstrated': [37, 276, 758, 1624, 1834, 2694, 3315, 3779, 4509, 5272, 5315, 5400, 5451], 'previously': [38, 277, 2661, 2695], 'response': [41, 131, 280, 370, 3266, 3400, 3748, 3833, 3929, 3984, 4511, 5031, 5143], 'hydrogen': [43, 282, 1838], 'peroxide': [44, 283, 1839], '(H2O2),': [45, 284], 'ability': [47, 95, 286, 334, 2768, 3021, 3883, 4791], 'TNFα': [49, 288, 1462, 1980, 3025, 3044, 3268, 3298, 3362, 3383, 3474, 3607, 3662, 3684, 3736, 3885, 3986, 4028, 4536, 4793, 5145, 5344, 5363, 5456, 5468, 5727, 5776], 'activate': [51, 68, 99, 195, 206, 290, 307, 338, 434, 445, 1372, 2772, 3027, 3441, 3724, 3887, 4085, 4795, 4956, 5096, 5625], 'IKK': [52, 158, 207, 225, 291, 397, 446, 464, 1529, 1578, 1628, 1918, 2192, 2711, 2853, 3196, 3317, 3442, 3472, 3526, 3566, 3708, 3739, 3767, 3888, 3926, 3961, 4045, 4439, 4532, 4796, 4930, 4957, 5218, 5280, 5626], 'mouse': [54, 293, 1948], 'lung': [55, 89, 294, 328, 479, 935, 2011, 2703, 2747, 2976, 4356, 5402, 5842], 'epithelial': [56, 295, 936, 1952, 2704, 2977, 4357, 5403], 'cells': [57, 112, 165, 296, 351, 404, 937, 1953, 2510, 2614, 2705, 2779, 2824, 2978, 3034, 3262, 3278, 3569, 3659, 3676, 3852, 3937, 4262, 4267, 4309, 4358, 4404, 4787, 5047, 5404, 5460], '(C10)': [58, 297, 1954], 'was': [59, 65, 101, 122, 162, 173, 182, 192, 298, 304, 340, 361, 401, 412, 421, 431, 1955, 1981, 2005, 2060, 2097, 2114, 2195, 2230, 2283, 2367, 2497, 2595, 2658, 2757, 2774, 2801, 3239, 3246, 3372, 3573, 3629, 3878, 3973, 4799, 4803, 4934, 5115], 'inhibited': [60, 102, 299, 341], 'H2O2': [63, 97, 186, 204, 302, 336, 425, 443, 1908, 2687, 2697, 2770, 2999, 3023, 3042, 3052, 3067, 3227, 3300, 3417, 3438, 3572, 3605, 3634, 3679, 3713, 3722, 3835, 3849, 3939, 3972, 3979, 3993, 4019, 4078, 4695, 4734, 5138, 5232, 5274, 5317, 5339, 5463, 5551, 5602, 5616, 5630], 'alone': [64, 303], 'sufficient': [66, 193, 305, 432, 3879], 'JNK': [69, 86, 100, 120, 141, 196, 214, 229, 308, 325, 339, 359, 380, 435, 453, 468, 904, 999, 1158, 1198, 1446, 1520, 1630, 1650, 1667, 1723, 1776, 1901, 1911, 2194, 2226, 2689, 2701, 2741, 2755, 2773, 2800, 2836, 2846, 2851, 2863, 2883, 2957, 2968, 2989, 2996, 3037, 3049, 3063, 3188, 3352, 3370, 3394, 3414, 3730, 3838, 3904, 3924, 3969, 3981, 4058, 4086, 4248, 4257, 4447, 4607, 4802, 4966, 5135, 5162, 5225, 5229, 5252, 5453, 5660], 'induce': [71, 310, 5473], 'cell': [72, 311, 552, 561, 932, 1152, 1383, 1618, 4918, 5040, 5736, 5780], 'In': [74, 88, 313, 327, 1194, 1886, 2931, 3665, 4588, 4786, 4806, 5098], 'current': [76, 315], 'study,': [77, 316], 'we': [78, 317, 1833, 1890, 2993, 3348, 3862, 3911, 4442, 4942, 5270, 5313, 5449], 'investigated': [79, 318, 1451, 1892, 3225, 3561], 'involvement': [81, 320], 'TNF-R1': [83, 127, 322, 366, 1469, 1490, 1566, 1634, 1896, 1913, 2003, 2223, 2229, 2561, 2814, 2855, 2879, 2974, 2987, 3075, 3238, 3259, 3290, 3321, 3358, 3377, 3398, 3409, 3431, 3505, 3776, 3793, 3831, 4264, 4273, 4291, 4351, 4506, 5052, 5092, 5158, 5332, 5365, 5397, 5496, 5619, 5632, 5645, 5773], 'H2O2-induced': [85, 119, 324, 358, 2740, 2833, 2843, 3434, 3914, 4256, 4459, 5104, 5224, 5393, 5478, 5641], 'activation.': [87, 326, 1651, 4608, 4967], 'fibroblasts': [90, 105, 329, 344, 2012, 2748], 'from': [91, 106, 330, 345, 1976, 1983, 1995, 2007, 2015, 2054, 2101, 2197, 2232, 2241, 2422, 2751, 2789, 3274, 4916, 5566, 5638], 'TNF-R1-deficient': [92, 331], 'mice': [93, 332, 2019], 'compared': [103, 342, 2780, 3691, 4910], 'with': [104, 224, 343, 463, 1569, 1610, 1733, 2142, 2202, 2248, 2253, 2407, 2420, 2450, 2473, 2492, 2521, 2525, 2560, 2566, 2573, 2589, 2618, 2636, 2781, 2878, 2933, 3030, 3041, 3258, 3289, 3361, 3397, 3571, 3633, 3661, 3667, 3678, 3692, 3938, 3947, 3978, 4297, 4363, 4590, 4911, 5100, 5118, 5129, 5267, 5327, 5462], 'control': [107, 346, 3292], 'mice.': [108, 347], 'Additionally,': [109, 348, 1605, 1719, 2807], 'C10': [111, 350, 2823, 3851, 3936], 'expressing': [113, 352, 4268], 'a': [114, 232, 353, 471, 488, 497, 906, 925, 1275, 1465, 1925, 2098, 2293, 2330, 2378, 2408, 2474, 2489, 2602, 2619, 2655, 2691, 2810, 2944, 2984, 3011, 3158, 3511, 3609, 3622, 3715, 3788, 3957, 3995, 4061, 4080, 4250, 4269, 4480, 4515, 4620, 4681, 5084, 5213, 5255, 5635, 5789], 'mutant': [115, 354], 'form': [116, 355, 2812, 3510, 5216], 'also': [123, 362, 547, 1263, 1669, 1725, 2802, 2825, 3001, 3054, 3228, 3287, 3354, 3899, 4280, 4449, 4664, 4737, 5116, 5234, 5260, 5319], 'inhibited.': [124, 363], 'Immunoprecipitation': [125, 364, 2352], 'revealed': [128, 367, 3620], 'H2O2,': [133, 168, 372, 407, 2992, 3402, 3750, 4171, 4594, 5770], 'adapter': [135, 374], 'proteins,': [136, 375], 'TRADD': [137, 376, 1570, 1606, 1989, 3156, 3232, 3242, 3256, 3280, 3751, 3784, 4289], 'TRAF2,': [139, 378, 798, 853, 1988, 3392, 3586, 3786, 4789], 'were': [142, 381, 1993, 2013, 2087, 2126, 2175, 2189, 2245, 2308, 2319, 2327, 2335, 2342, 2383, 2392, 2405, 2418, 2435, 2461, 2511, 2531, 2558, 2579, 2585, 2615, 2634, 2644, 2749, 3282, 3601, 3672, 4014, 4335], 'recruited': [143, 382, 1564, 3128, 3319, 3356, 3755, 4451, 5156], 'receptor.': [146, 385], 'However,': [147, 386, 5435, 5538], 'expression': [148, 179, 387, 418, 1738, 2364, 2942, 3690, 4400, 4953, 4973, 5150], 'adaptor': [151, 390, 1495, 1931, 2362, 3084, 4302, 4348, 4498, 5482, 5558], 'protein': [152, 391, 913, 1561, 2201, 2218, 2236, 2363, 2575, 4499, 5483, 5559], 'RIP,': [153, 392, 805, 860, 1933, 3587, 4999], 'which': [154, 393, 739, 915, 1612, 1731, 2816, 2876, 3184, 3763, 4160, 4471, 4519, 5154, 5601], 'is': [155, 394, 480, 905, 916, 1334, 1356, 1517, 1563, 1572, 1613, 1635, 1660, 1774, 1778, 2743, 2857, 3053, 3076, 3127, 3318, 4079, 4258, 4454, 4672, 4731, 4927, 4970, 5093, 5139, 5233, 5275, 5336, 5437, 5457, 5469, 5609, 5620, 5655, 5721, 5761], 'essential': [156, 395, 1518, 1573, 3765, 4473], 'for': [157, 200, 209, 396, 439, 448, 484, 580, 1442, 1519, 1574, 2184, 2214, 2304, 2359, 2439, 2454, 2465, 2482, 2563, 2581, 2640, 3160, 3187, 3635, 3680, 3707, 3718, 3766, 3790, 3940, 4020, 4029, 4041, 4283, 4483, 4965, 5534, 5650, 5793, 5828, 5837], 'by': [160, 185, 215, 399, 424, 454, 738, 922, 1351, 1902, 2025, 2062, 2074, 2089, 2116, 2177, 2310, 2339, 2499, 2598, 2745, 2969, 2991, 2998, 3004, 3051, 3059, 3065, 3248, 3415, 3473, 3590, 3604, 3712, 3856, 3963, 3971, 4159, 4365, 4492, 4535, 4669, 4932, 5137, 5231, 5240, 5325, 5455, 5536, 5550, 5600, 5775, 5798], 'TNFα,': [161, 400, 785, 840, 2963], 'decreased': [163, 402, 2776, 3283, 3304, 3674, 4260], 'exposed': [166, 405, 2127, 4015], 'chaperone': [171, 410, 4467], 'Hsp90': [172, 411, 1991, 3425, 3481, 3507, 3515, 3580, 3589, 3619, 3628, 3652, 3704, 3921, 3951, 5109], 'cleaved.': [174, 413], 'Furthermore,': [175, 414, 3271, 5561], 'data': [176, 218, 415, 457, 3698, 3990], 'demonstrating': [177, 416, 4300, 4435, 5043, 5227], 'TRAF2': [181, 191, 420, 430, 1516, 1915, 2630, 3161, 3234, 3244, 3286, 3599, 3728, 3753, 3829, 3857, 3866, 3876, 3897, 4287, 4602, 4815, 4933, 4952, 5033, 5049, 5090, 5123, 5576], 'not': [183, 422, 3440, 3602, 3649, 3656, 3687, 3699, 4164, 4490, 4597, 5038, 5140, 5610], 'affected': [184, 423, 3603], 'overexpression': [189, 428, 2808, 3877, 3898, 4816, 5034, 5211], 'provide': [197, 436, 4443, 4479], 'an': [198, 437, 481, 556, 2203, 2238, 2953, 3825, 4030, 5221, 5597], 'explanation': [199, 438, 3717, 4482, 5599], 'inability': [202, 441, 3720], 'selective': [211, 450, 4485], 'H2O2.': [216, 455, 1903, 3270, 3364, 3385, 3416, 4493, 4670, 5537], 'Our': [217, 456, 5784], 'demonstrate': [219, 458, 1905, 2738, 2765, 2841, 3745, 4168, 5355], 'oxidative': [221, 460], 'stress': [222, 461], 'interferes': [223, 462], 'while': [227, 466, 2706, 3840, 4006], 'promoting': [228, 467, 1671, 5807], 'signaling,': [230, 469], 'creating': [231, 470], 'signaling': [233, 472, 731, 743, 1167, 1437, 1728, 2742, 3996, 4081, 5333, 5605, 5642, 5801], 'imbalance': [234, 473, 3997, 5643], 'may': [236, 475, 3836, 4736, 4914, 5545, 5646], 'favor': [237, 476], 'apoptosis.': [238, 477], 'The': [478, 996, 1436, 1478, 1985, 2280, 2759, 3469, 3771, 4054, 4458, 4905, 5475, 5640], 'target': [483], 'oxidant': [485, 1837, 5767], 'injury': [486], 'as': [487, 496, 742, 879, 881, 1160, 1162, 1464, 1522, 1524, 1658, 1924, 2147, 2292, 2660, 2874, 4060, 4936, 5126, 5128, 5254, 5448, 5498], 'consequence': [489], 'direct': [491, 5800], 'inhalation': [492], 'oxidants': [494, 503, 539, 740, 923, 1261, 5739, 5794], 'or': [495, 2017, 2193, 2206, 2290, 2365, 2631, 2832, 3024, 3043, 3269, 3276, 3299, 3363, 3384, 3443, 3606, 4036, 4046, 4265, 4402, 4947, 5348, 5782], 'result': [498, 1926, 5256], 'production': [501, 4735], 'during': [504], 'inflammation': [505], '(1Janssen': [506, 938, 1848], 'Y.M.': [507, 521, 708, 887, 939, 959, 1849, 1869, 2157, 2263, 2670, 2719, 3452, 4094, 4137, 5292], 'Matalon': [508, 940, 1850], 'S.': [509, 599, 609, 632, 642, 941, 1243, 1851, 4187, 4856, 5410, 5418, 5703], 'Mossman': [510, 942, 1852, 4140], 'B.T.': [511, 943, 1853, 4141], 'Am.': [512, 944, 1854, 4142, 5421], 'J.': [513, 585, 622, 671, 945, 960, 980, 1098, 1214, 1235, 1244, 1295, 1321, 1500, 1701, 1814, 1855, 1870, 2158, 2264, 2671, 2720, 2913, 3141, 3453, 3530, 3543, 4095, 4120, 4143, 4195, 4215, 4236, 4318, 4384, 4559, 4572, 4626, 4639, 4713, 4749, 4762, 4872, 5192, 5293, 5383, 5422, 5674, 5695, 5704], 'Physiol.': [514, 946, 1856], '1997;': [515, 672, 947, 1857, 4858], '273:': [516, 948, 1858], 'L789-L796PubMed': [517, 949, 1859], 'Google': [518, 536, 575, 617, 650, 678, 699, 723, 902, 950, 974, 994, 1020, 1042, 1062, 1087, 1118, 1145, 1192, 1228, 1258, 1302, 1328, 1394, 1414, 1434, 1513, 1558, 1603, 1694, 1717, 1767, 1807, 1830, 1860, 1884, 2172, 2278, 2685, 2734, 2906, 2929, 3113, 3154, 3182, 3221, 3346, 3467, 3501, 3557, 3822, 4109, 4134, 4154, 4205, 4224, 4245, 4332, 4391, 4429, 4556, 4586, 4653, 4727, 4776, 4839, 4864, 4886, 4903, 4997, 5024, 5078, 5185, 5208, 5307, 5390, 5433, 5527, 5594, 5688, 5718, 5758], 'Scholar,': [519, 618, 651, 951, 975, 1021, 1043, 1063, 1119, 1229, 1303, 1395, 1415, 1695, 1808, 1861, 2907, 4110, 4135, 4206, 4225, 4557, 4840, 4865, 4887, 5186, 5689], '2Janssen-Heininger': [520], 'Poynter': [522, 709, 888], 'M.E.': [523, 710, 889], 'Baeuerle': [524, 711, 890, 2092], 'P.A.': [525, 712, 891, 4210], 'Free': [526, 713, 892], 'Radic.': [527, 714, 893], 'Biol.': [528, 568, 692, 715, 894, 961, 981, 1138, 1215, 1245, 1422, 1710, 1823, 1871, 2159, 2265, 2672, 2721, 2922, 3454, 3544, 4096, 4121, 4147, 4319, 4573, 4640, 4714, 4763, 4827, 4873, 5201, 5294, 5426, 5587, 5675, 5705], 'Med.': [529, 716, 895, 4238], '2000;': [530, 717, 896, 983, 1009, 1112, 1547, 1592, 3210, 3335, 3546, 3811, 4418, 4575, 4642, 4765, 5067, 5588], '28:': [531, 718, 897], '1317-1327Crossref': [532, 719, 898], 'PubMed': [533, 572, 614, 647, 675, 696, 720, 899, 971, 991, 1017, 1039, 1059, 1084, 1115, 1142, 1189, 1225, 1255, 1299, 1325, 1391, 1411, 1431, 1510, 1555, 1600, 1691, 1714, 1764, 1804, 1827, 1881, 2169, 2275, 2682, 2731, 2903, 2926, 3110, 3151, 3179, 3218, 3343, 3464, 3498, 3554, 3819, 4106, 4131, 4151, 4202, 4221, 4242, 4329, 4388, 4426, 4553, 4583, 4650, 4724, 4773, 4836, 4861, 4883, 4900, 4994, 5021, 5075, 5182, 5205, 5304, 5387, 5430, 5524, 5591, 5685, 5715, 5755], 'Scopus': [534, 573, 615, 648, 676, 697, 721, 900, 972, 992, 1018, 1040, 1060, 1085, 1116, 1143, 1190, 1226, 1256, 1300, 1326, 1392, 1412, 1432, 1511, 1556, 1601, 1692, 1715, 1765, 1805, 1828, 1882, 2170, 2276, 2683, 2732, 2904, 2927, 3111, 3152, 3180, 3219, 3344, 3465, 3499, 3555, 3820, 4107, 4132, 4152, 4203, 4222, 4243, 4330, 4389, 4427, 4554, 4584, 4651, 4725, 4774, 4837, 4862, 4884, 4901, 4995, 5022, 5076, 5183, 5206, 5305, 5388, 5431, 5525, 5592, 5686, 5716, 5756], '(604)': [535, 722, 901], 'Scholar).': [537, 576, 724, 903, 995, 1193, 1259, 1329, 1435, 1559, 1604, 1718, 1768, 1831, 1885, 2173, 2279, 2686, 2735, 2930, 3114, 3155, 3222, 3468, 3558, 3823, 4333, 4430, 4587, 4654, 4728, 4904, 5209, 5434, 5719, 5759], 'Although': [538, 1260, 3965, 4072, 5269], 'contribute': [540, 4738], 'tissue': [542], 'damage,': [543], 'these': [544, 2934, 3668, 3967, 4661, 5101, 5440], 'species': [545, 3626], 'formed': [548], 'virtually': [550], 'every': [551], 'type': [553, 1950, 2783, 3865, 4919], 'integral': [557], 'part': [558], 'normal': [560], 'function': [562, 5633], '(3Finkel': [563], 'T.': [564, 669, 1239, 5406, 5699], 'Curr.': [565], 'Opin.': [566], 'Cell': [567, 691, 1137, 1421, 1709, 1822, 1940, 2921, 4145, 4826, 5200, 5424, 5586], '2003;': [569, 693, 1076, 1181, 1322, 1756, 4321, 4385, 5384], '15:': [570], '247-254Crossref': [571], '(1212)': [574], 'Oxidants': [577, 755], 'required': [579, 1441, 3186, 3706, 4964, 5094], 'proliferation': [581], '(4Arbiser': [582], 'J.L.': [583], 'Petros': [584, 633], 'Klafter': [586], 'R.': [587, 630, 655, 5508], 'Govindajaran': [588], 'B.': [589, 1678, 1791, 2890, 5009], 'McLaughlin': [590], 'E.R.': [591, 4702], 'Brown': [592], 'L.F.': [593], 'Cohen': [594, 4316], 'C.': [595, 1092, 5512], 'Moses': [596], 'M.': [597, 663, 1031, 1241, 1293, 1305, 1311, 1317, 1386, 1419, 1543, 1588, 1684, 1797, 2896, 3165, 3206, 3331, 3807, 4313, 4315, 4368, 4374, 4380, 4414, 4824, 4850, 4867, 4869, 4889, 4983, 5015, 5063, 5367, 5373, 5379, 5414, 5701], 'Kilroy': [598], 'Arnold': [600], 'R.S.': [601, 620], 'Lambeth': [602, 635], 'J.D.': [603, 636], 'Proc.': [604, 637, 4851], 'Natl.': [605, 638, 4852], 'Acad.': [606, 639, 4853], 'Sci.': [607, 640, 4854], 'U.': [608, 641, 4855], 'A.': [610, 643, 1102, 1123, 1535, 1537, 1580, 1582, 1686, 1707, 1799, 1820, 2898, 2919, 3198, 3200, 3323, 3325, 3532, 3534, 3799, 3801, 4193, 4227, 4406, 4408, 4561, 4563, 4628, 4630, 4751, 4753, 4857, 5055, 5057, 5198, 5504], '2002;': [611, 1056, 1139, 1247, 1711, 1824, 2923, 3490, 4199, 4545, 5202, 5707, 5752], '99:': [612], '715-720Crossref': [613], '(400)': [616], '5Arnold': [619], 'Shi': [621, 4705], 'Murad': [623], 'E.': [624], 'Whalen': [625], 'A.M.': [626, 657], 'Sun': [627], 'C.Q.': [628], 'Polavarapu': [629], 'Parthasarathy': [631], 'J.A.': [634, 1065, 1170, 1208, 1745, 4114, 5668], '2001;': [644, 963, 1217, 1423, 1688, 1801, 1873, 2161, 2267, 2674, 2723, 2900, 3456, 4098, 4123, 4716, 4828, 5296, 5677], '98:': [645], '5550-5555Crossref': [646], '(421)': [649], '6Moore': [652], 'K.A.': [653, 4698], 'Sethi': [654], 'Doanes': [656], 'Johnson': [658], 'T.M.': [659, 3098], 'Pracyk': [660], 'J.B.': [661], 'Kirby': [662], 'Irani': [664], 'K.': [665, 977, 1023, 1027, 1121, 1206, 1237, 1319, 4112, 4382, 5381, 5416, 5666, 5697], 'Goldschmidt-Clermont': [666], 'P.J.': [667], 'Finkel': [668], 'Biochem.': [670], '326:': [673], '17-20Crossref': [674], '(69)': [677], 'Scholar),': [679, 1146, 1514, 3183, 3347, 4155, 4246, 4777, 4998, 5025, 5308, 5391, 5595], 'changes': [680, 4341], 'cellular': [682, 733, 5652], 'shape': [683], '(7Nimnual': [684], 'A.S.': [685, 1406, 5177], 'Taylor': [686], 'L.J.': [687], 'Bar-Sagi': [688, 1103, 1132], 'D.': [689, 1104, 1133], 'Nat.': [690, 1054], '5:': [694], '236-241Crossref': [695], '(426)': [698], 'Scholar)': [700, 1088, 3502, 4392, 5079, 5528], 'involved': [703, 1614, 4665], 'transcriptional': [705], 'regulation': [706, 3058, 5239], '(2Janssen-Heininger': [707, 886], 'Despite': [725, 3427], 'emerging': [727], 'role': [728, 1283, 1894, 2985, 3407, 5792], 'redox': [730, 1285, 5357, 5732], 'physiology,': [734], 'exact': [736, 4157], 'mechanisms': [737], 'act': [741], 'molecules': [744], 'under': [746, 3905, 3966, 4175, 4292, 5795], 'intense': [747], 'investigation,': [748], 'many': [750, 931, 1001], 'critical': [751, 1381, 1661, 5085], 'targets': [752, 5533], 'remain': [753, 5487], 'enigmatic.': [754], 'have': [756, 1262, 1449, 1891, 4812, 5314, 5442, 5450, 5647], 'been': [757, 1201, 1264, 1450, 1623, 3314, 3778, 4075, 4165, 4508, 5399], 'regulate': [760], '(JNK),': [767], '1The': [768], 'abbreviations': [769, 824], 'used': [770, 825], 'are:': [771, 826], 'JNK,': [772, 827, 1844, 1986, 2205, 3437, 4005, 4047, 4488, 4939], 'kinase;': [775, 784, 830, 839], 'IκB,': [776, 831, 2949], 'κB;': [779, 834], 'IKK,': [780, 835, 1842, 1987, 3872, 4478, 4491], 'factor': [788, 800, 843, 855, 884, 1272], 'α;': [789, 844], 'TNF': [791, 846, 2639], 'receptor': [792, 847, 1533, 3137, 5347, 5555], '1;': [793, 848], 'TRADD,': [794, 849, 1483, 3126, 3391], 'TNF-R1-associated': [795, 850], 'death': [796, 803, 851, 858, 1476, 1479, 2820, 4277, 4503, 5781], 'domain;': [797, 804, 852, 859], 'TNF-R-associated': [799, 854], '2;': [801, 856], 'DD,': [802, 857], 'receptor-interacting': [806, 861], 'protein;': [807, 862], 'PBS,': [808, 863, 2144, 2522], 'phosphate-buffered': [809, 864], 'saline;': [810, 818, 865, 873], 'HA,': [811, 866], 'hemagglutinin;': [812, 867], 'GST,': [813, 868], 'glutathione': [814, 869, 2111], 'S-transferase;': [815, 870], 'TBS,': [816, 871], 'Tris-buffered': [817, 872], 'GA,': [819, 874], 'geldanamycin;': [820, 875], 'CA,': [821, 876], 'constitutively': [822, 877, 3012, 4804, 5214], 'active.1The': [823], 'active.': [878, 4805], 'well': [880, 917, 1161, 1523, 5127, 5656], 'transcription': [883, 1271, 1374, 1773], 'NF-κB': [885, 1288, 1333, 1365, 1448, 1643, 1734, 1920, 2611, 2938, 2970, 3006, 3444, 3528, 3890, 4534, 4743, 4798, 4819, 4959, 5028, 5258, 5322], 'member': [907], 'family': [910, 4980], 'mitogen-activated': [912], 'kinases,': [914], 'known': [918, 5611, 5657], 'be': [920, 3002, 3355, 3854, 4305, 4450, 4658, 4783, 5244, 5546], 'activated': [921], 'variety': [926], 'other': [928, 1166, 2416], 'stresses': [929], 'types,': [933], 'including': [934, 1004, 1379, 5769], '8Korn': [952, 1862], 'S.H.': [953, 1863, 2151, 2257, 2664, 2713, 3446, 4088, 5286], 'Wouters': [954, 1864, 2152, 2258, 2665, 2714, 3447, 4089, 5287], 'E.F.': [955, 1033, 1865, 2153, 2259, 2666, 2715, 3448, 4090, 5288], 'Vos': [956, 1866, 2154, 2260, 2667, 2716, 3449, 4091, 5289], 'N.': [957, 1291, 1867, 2155, 2261, 2668, 2717, 3450, 4092, 4311, 5011, 5290], 'Janssen-Heininger': [958, 1868, 2156, 2262, 2669, 2718, 3451, 4093, 5291], 'Chem.': [962, 982, 1216, 1246, 1872, 2160, 2266, 2673, 2722, 3455, 3545, 4097, 4122, 4320, 4574, 4641, 4715, 4764, 4874, 5295, 5676, 5706], '276:': [964, 1218, 1874, 2162, 2268, 2675, 2724, 3457, 4099, 4124, 4717, 5297, 5678], '35693-35700Abstract': [965, 1875, 2163, 2269, 2676, 2725, 3458, 4100, 5298], 'Full': [966, 968, 986, 988, 1012, 1014, 1079, 1081, 1184, 1186, 1220, 1222, 1250, 1252, 1426, 1428, 1507, 1550, 1552, 1595, 1597, 1759, 1761, 1876, 1878, 2164, 2166, 2270, 2272, 2677, 2679, 2726, 2728, 3107, 3148, 3176, 3213, 3215, 3338, 3340, 3459, 3461, 3493, 3495, 3549, 3551, 3814, 3816, 4101, 4103, 4126, 4128, 4324, 4326, 4421, 4423, 4548, 4550, 4578, 4580, 4645, 4647, 4719, 4721, 4768, 4770, 4831, 4833, 4878, 4880, 5070, 5072, 5299, 5301, 5521, 5680, 5682, 5710, 5712], 'Text': [967, 969, 987, 989, 1013, 1015, 1080, 1082, 1185, 1187, 1221, 1223, 1251, 1253, 1427, 1429, 1508, 1551, 1553, 1596, 1598, 1760, 1762, 1877, 1879, 2165, 2167, 2271, 2273, 2678, 2680, 2727, 2729, 3108, 3149, 3177, 3214, 3216, 3339, 3341, 3460, 3462, 3494, 3496, 3550, 3552, 3815, 3817, 4102, 4104, 4127, 4129, 4325, 4327, 4422, 4424, 4549, 4551, 4579, 4581, 4646, 4648, 4720, 4722, 4769, 4771, 4832, 4834, 4879, 4881, 5071, 5073, 5300, 5302, 5522, 5681, 5683, 5711, 5713], 'PDF': [970, 990, 1016, 1083, 1188, 1224, 1254, 1430, 1509, 1554, 1599, 1763, 1880, 2168, 2274, 2681, 2730, 3109, 3150, 3178, 3217, 3342, 3463, 3497, 3553, 3818, 4105, 4130, 4328, 4425, 4552, 4582, 4649, 4723, 4772, 4835, 4882, 5074, 5303, 5523, 5684, 5714], '(171)': [973, 1883, 2171, 2277, 2684, 2733, 3466, 4108, 5306], '9Amdjadi': [976], 'Sefton': [978], 'B.M.': [979], '275:': [984, 3547, 4576, 4643, 4766], '22520-22525Abstract': [985], '(5)': [993], 'contribution': [997], 'phenotypic': [1002], 'outcomes,': [1003], '(10Davis': [1006], 'R.J.': [1007, 1053, 1073, 1110, 1135, 1178, 1753], 'Cell.': [1008, 1075, 1180, 1503, 1755, 3103, 3144, 3172, 3489, 4544, 5517], '103:': [1010], '239-252Abstract': [1011], '(3611)': [1019], '11Sabapathy': [1022], 'Jochum': [1024], 'W.': [1025, 5506, 5516], 'Hochedlinger': [1026], 'Chang': [1028], 'L.': [1029, 3540, 4569, 4636, 4759], 'Karin': [1030, 1292, 1316, 1418, 1683, 1796, 2104, 2895, 4379, 4823, 5014, 5378], 'Wagner': [1032], 'Mech.': [1034], 'Dev.': [1035, 5017], '1999;': [1036, 1296, 4148, 5018, 5427], '89:': [1037], '115-124Crossref': [1038], '(301)': [1041], '12Hess': [1044], 'P.': [1045, 1069, 1094, 1174, 1749, 3485, 4540], 'Pihan': [1046], 'G.': [1047, 1674, 1699, 1787, 1812, 2886, 2911, 3483, 4189, 4231, 4538, 5190], 'Sawyers': [1048], 'C.L.': [1049], 'Flavell': [1050, 1070, 1107, 1128, 1175, 1750], 'R.A.': [1051, 1071, 1108, 1129, 1176, 1751], 'Davis': [1052, 1072, 1109, 1134, 1177, 1752], 'Genet.': [1055], '32:': [1057], '201-205Crossref': [1058], '(141)': [1061], '13Lamb': [1064], 'Ventura': [1066, 1171, 1746], 'J.J.': [1067, 1172, 1747], 'Hess': [1068, 1093, 1173, 1748], 'Mol.': [1074, 1136, 1179, 1708, 1754, 1821, 2920, 3488, 4146, 4543, 5199, 5425, 5585, 5750], '11:': [1077, 1182, 1424, 1757, 4829], '1479-1489Abstract': [1078, 1183, 1758], '(216)': [1086, 1191, 1766], 'apoptosis': [1090, 1204, 1785, 1847, 5166, 5567, 5664, 5809], '(14Tournier': [1091], 'Yang': [1095], 'D.D.': [1096], 'Xu': [1097], 'Turner': [1099], 'T.K.': [1100], 'Nimnual': [1101, 1122], 'Jones': [1105], 'S.N.': [1106], 'Science.': [1111, 1387, 1407, 4896, 4990, 5178], '288:': [1113], '870-874Crossref': [1114], '(1537)': [1117], '15Lei': [1120], 'Zong': [1124], 'W.X.': [1125], 'Kennedy': [1126], 'N.J.': [1127], 'Thompson': [1130], 'C.B.': [1131], '22:': [1140, 1323, 1712, 1825, 2924, 4386, 5203, 5385], '4929-4942Crossref': [1141], '(440)': [1144], 'appears': [1147, 4616], 'depend': [1149], 'upon': [1150], 'type,': [1153], 'stimulus,': [1154], 'duration': [1156, 1648, 2861], 'engagement': [1164], 'modules': [1168], '(13Lamb': [1169, 1744], 'this': [1195, 4161, 4779, 5613], 'regard,': [1196], 'oxidant-induced': [1197, 5262, 5562, 5659], 'has': [1200, 1622, 3313, 3777, 4074, 4163, 4507, 5398], 'linked': [1202], '(16Chen': [1205, 5665], 'Vita': [1207, 4113, 5667], 'Berk': [1209, 4115, 5669], 'B.C.': [1210, 4116, 5670], 'Keaney': [1211, 4117, 5671], 'Jr.,': [1212, 1405, 4118, 4697, 5176, 5672], 'J.F.': [1213, 4119, 5673], '16045-16050Abstract': [1219, 4125, 5679], '(184)': [1227, 4133, 5687], '17Aoki': [1230, 5690], 'H.': [1231, 1307, 1313, 1315, 1498, 3139, 4181, 4370, 4376, 4378, 5369, 5375, 5377, 5408, 5412, 5420, 5514, 5578, 5580, 5582, 5691], 'Kang': [1232, 5692], 'P.M.': [1233, 5693], 'Hampe': [1234, 5694], 'Yoshimura': [1236, 5696], 'Noma': [1238, 5698], 'Matsuzaki': [1240, 5700], 'Izumo': [1242, 5702], '277:': [1248, 5708], '10244-10250Abstract': [1249, 5709], '(294)': [1257, 3556, 4585, 4652, 4775, 5717], 'implicated': [1265], 'NF-κB,': [1273, 3060, 3873], 'currently': [1274], 'number': [1276], 'significant': [1278], 'controversies': [1279], 'exist': [1280], 'around': [1281], 'events': [1286, 1438, 4662, 5358, 5441], '(18Li': [1290], 'FASEB': [1294], '13:': [1297, 5019], '1137-1143Crossref': [1298], '(780)': [1301], '19Hayakawa': [1304], 'Miyashita': [1306, 4369, 5368], 'Sakamoto': [1308, 4371, 5370], 'I.': [1309, 4139, 4208, 4372, 5371], 'Kitagawa': [1310, 4373, 5372], 'Tanaka': [1312, 4375, 5374], 'Yasuda': [1314, 4377, 5376], 'Kikugawa': [1318, 4381, 5380], 'EMBO': [1320, 4383, 5382], '3356-3366Crossref': [1324, 4387, 5386], '(363)': [1327, 4390, 5389], 'Under': [1330], 'basal': [1331], 'conditions': [1332, 3907, 3968, 4177, 4922, 5797], 'sequestered': [1335], 'cytoplasm': [1338], 'through': [1339, 1567, 5618, 5802], 'binding': [1340, 3791, 5342, 5361, 5574], '(IκB).': [1346], 'Upon': [1347, 3115], 'phosphorylation': [1348], 'IκB': [1350, 1352, 1355], '(IKK),': [1354], 'rapidly': [1357], 'degraded': [1358], 'via': [1359, 1729, 1912, 2940, 4049, 5810], '26': [1361], 'S': [1362], 'proteasome,': [1363], 'allowing': [1364, 1780], 'translocate': [1367], 'nucleus': [1370], 'over': [1376], '100': [1377], 'genes,': [1378, 5153], 'genes': [1380, 1656], '(20Barinaga': [1385], '1996;': [1388, 4875], '274:': [1389], '724Crossref': [1390], '(59)': [1393], '21Wang': [1396], 'C.Y.': [1397, 5168], 'Mayo': [1398, 5169], 'M.W.': [1399, 5170], 'Korneluk': [1400, 5171], 'R.G.': [1401, 5172], 'Goeddel': [1402, 1501, 3101, 3142, 3170, 3486, 4541, 4847, 4870, 4894, 4988, 5173], 'D.V.': [1403, 1502, 3102, 3143, 3171, 3487, 4542, 4848, 4871, 4895, 4989, 5174], 'Baldwin': [1404, 5175], '1998;': [1408, 5179], '281:': [1409, 5180], '1680-1683Crossref': [1410, 5181], '(2566)': [1413, 5184], '22Baud': [1416], 'V.': [1417, 4822, 4891, 4985, 5005], 'Trends': [1420, 4825], '372-377Abstract': [1425, 4830], '(1367)': [1433, 4838], 'great': [1453], 'detail': [1454], 'using': [1455, 2217, 2237, 2285, 2344], 'ligand': [1457, 3116], '(TNFα).': [1461], 'binds': [1463, 1484, 3131], 'trimer': [1466], 'three': [1468, 2463, 2519, 2587], 'monomers': [1470], 'causing': [1471, 4687, 5799], 'aggregation': [1472], 'intracellular': [1475, 2819, 3088, 3119, 4276, 5543], 'domains.': [1477], 'domain': [1480, 2058, 2821, 3089, 3120, 4504, 5494], '(DD)': [1481], 'containing-protein,': [1482], 'directly': [1485, 1608, 2737, 5278], 'DD': [1488, 3134, 5544], 'then': [1492, 4024], 'recruits': [1493], 'molecule': [1496, 4082], '(23Hsu': [1497, 3138], 'Xiong': [1499, 3140], '1995;': [1504, 3145, 4897, 4991], '81:': [1505, 3146], '495-504Abstract': [1506, 3147], '(1738)': [1512, 3153], 'TRAF2.': [1515], 'recruitment': [1526, 3082, 3192, 3230, 3477, 3782, 4344, 4500, 5050, 5484], 'complex': [1530], '(24Devin': [1534, 1579, 3197, 3322, 3798, 4405, 5054], 'Cook': [1536, 1581, 3199, 3324, 3800, 4407, 5056], 'Lin': [1538, 1583, 1685, 1706, 1798, 1819, 2897, 2918, 3201, 3326, 3535, 3802, 4409, 4564, 4631, 4754, 5058, 5197], 'Y.': [1539, 1541, 1584, 1586, 1676, 1789, 2888, 3202, 3204, 3327, 3329, 3536, 3538, 3803, 3805, 4410, 4412, 4565, 4567, 4632, 4634, 4706, 4755, 4757, 5013, 5059, 5061], 'Rodriguez': [1540, 1585, 3203, 3328, 3537, 3804, 4411, 4566, 4633, 4756, 5060], 'Kelliher': [1542, 1587, 3205, 3330, 3806, 4413, 5062], 'Liu': [1544, 1589, 3207, 3332, 3541, 3808, 4415, 4570, 4637, 4760, 5006, 5064], 'Z.': [1545, 1590, 1682, 1795, 2894, 3208, 3333, 3809, 4416, 5065], 'Immunity.': [1546, 1591, 3209, 3334, 3810, 4417, 5066], '12:': [1548, 1593, 3211, 3336, 3812, 4419, 5068], '419-429Abstract': [1549, 1594, 3212, 3337, 3813, 4420, 5069], '(356)': [1557, 1602, 3220, 3345, 3821, 4428, 5077], 'Receptor-interacting': [1560], '(RIP)': [1562], 'interaction': [1568], 'can': [1607, 1724, 3853, 4084, 4304, 4448, 5026, 5318, 5340, 5349, 5662, 5729], 'interact': [1609], 'FADD,': [1611], 'executing': [1616], 'caspase-dependent': [1617], 'Recently': [1620], 'it': [1621, 3312, 4073, 4605, 4688, 4730, 4926, 4969, 5436], 'following': [1631, 2428, 2854, 3039, 3295], 'stimulation': [1632, 4353], 'regulates': [1644], 'extent': [1646, 5765], 'Transcription': [1652], 'NF-κB-driven': [1654], 'anti-apoptotic': [1655, 5152], 'such': [1657, 2873], 'X-IAP': [1659], 'preventing': [1663], 'sustained': [1664, 2882, 2956], '(25Tang': [1673, 1786, 2885], 'Minemoto': [1675, 1788, 2887], 'Dibling': [1677, 1790, 2889], 'Purcell': [1679, 1792, 2891], 'N.H.': [1680, 1793, 2892], 'Li': [1681, 1794, 2893], 'Nature.': [1687, 1800, 2899, 4198], '414:': [1689, 1802, 2901], '313-317Crossref': [1690, 1803, 2902], '(660)': [1693, 1806, 2905], '26Tang': [1696, 1809, 2908, 5187], 'F.': [1697, 1810, 2909, 5188], 'Tang': [1698, 1811, 2910, 5189], 'Xiang': [1700, 1813, 2912, 5191], 'Dai': [1702, 1815, 2914, 5193], 'Q.': [1703, 1816, 2915, 5194], 'Rosner': [1704, 1817, 2916, 5195], 'M.R.': [1705, 1818, 2917, 5196], '8571-8579Crossref': [1713, 1826, 2925, 5204], '(121)': [1716, 1829, 2928, 5207], 'transient': [1720], 'mediate': [1726, 5663], 'JunD,': [1730], 'collaborates': [1732], 'increase': [1736], 'gene': [1742, 1772, 2871], 'cIAP-2': [1743], 'Conversely,': [1769, 5210], 'when': [1770], 'NF-κB-dependent': [1771, 2870, 5149], 'prevented,': [1775], 'prolonged': [1779, 5130, 5161], 'execution': [1782], 'TNF-induced': [1784], 'Previously': [1832], '(H2O2)': [1840], 'inhibits': [1841, 4528], 'activates': [1843, 4247], 'causes': [1846, 2698, 3229, 3994], 'present': [1888, 3373, 3630, 4306, 5113, 5311, 5446, 5490, 5785], 'study': [1889, 4913, 5114, 5312], 'here': [1906, 4169, 4445], 'signals': [1909, 3094], 'prevented': [1923], 'degradation': [1928, 3519, 3915, 3949, 4611, 4668, 4741, 5486], 'protein,': [1932, 3125], 'cleavage': [1935, 3653, 3919, 3952, 4464], 'chaperone,': [1938], 'Hsp90.': [1939], 'Culture': [1941], 'Reagents—A': [1943], 'line': [1944], 'spontaneously': [1946], 'transformed': [1947], 'alveolar': [1949], 'II': [1951], 'propagated': [1956], 'CRML-1066': [1958], 'medium': [1959, 2037], 'containing': [1960, 2038, 2444, 2623], '50': [1961, 1964, 2039, 2042], 'units/ml': [1962, 2040], 'penicillin,': [1963, 2041], 'μg/ml': [1965, 2043], 'streptomycin,': [1966, 2044], '2': [1967, 2045, 2564, 2793, 3615, 3636, 3681, 3941, 4021], 'mm': [1968, 2046, 2537, 2542, 2548, 2551], 'l-glutamine,': [1969, 2047], '10%': [1971, 2049, 2379, 2603], 'fetal': [1972, 2050], 'bovine': [1973, 2051], 'serum,': [1974, 2052], 'all': [1975, 2053], 'Invitrogen.': [1977, 2055], 'Murine': [1978], 'recombinant': [1979], 'purchased': [1982, 1994], 'Calbiochem.': [1984], 'antibodies': [1992, 2421], 'Santa': [1996, 2423], 'Cruz': [1997, 2424], 'Biotechnology': [1998], '(Santa': [1999, 2209], 'Cruz,': [2000], 'CA),': [2001], 'antibody': [2004, 2208, 2240, 2410, 2453, 2477, 2562], 'obtained': [2006], 'R&D': [2008, 2242], 'Systems.': [2009, 2243], 'Primary': [2010], 'isolated': [2014, 2750], 'C57BL/6': [2016], 'TNF-R1–/–': [2018, 2752, 2778, 2805], '(Jackson': [2020], 'Laboratories,': [2021, 2479], 'Bar': [2022], 'Harbor,': [2023], 'ME)': [2024], 'mincing': [2026], 'lungs': [2027], 'propagation': [2029], 'explants': [2031], "Dulbecco's": [2033], 'modified': [2034], "Eagle's": [2035], 'medium/F12': [2036], 'p60Δ': [2056], 'cytoplasmic': [2057], 'plasmid': [2059, 2622, 5832], 'provided': [2061, 2088, 2115, 4281], 'Dr.': [2063, 2075, 2090, 2102, 2117], 'Michael': [2064, 2103, 5817, 5821], 'Lenardo': [2065], '(National': [2066], 'Institutes': [2067], 'Health,': [2069], 'Bethesda,': [2070], 'MD)': [2071], 'Flag-TRAF2': [2073], 'Brian': [2076, 5823], 'Seed': [2077], '(Massachusetts': [2078], 'General': [2079], 'Hospital,': [2080], 'Boston,': [2081], 'MA).': [2082], 'NF-κB-luciferase': [2083], 'IκB-SR': [2085], 'plasmids': [2086], 'Patrick': [2091, 5819], '(Micromet,': [2093], 'Martinsreid,': [2094], 'Germany).': [2095], 'CA-IKK': [2096], 'kind': [2099], 'gift': [2100], '(University': [2105], 'California,': [2107], 'San': [2108], 'Diego),': [2109], 'S-transferase': [2112], '(GST)-IκB': [2113], 'Rosa': [2118, 5826], 'Ten': [2119, 5827], '(Mayo': [2120], 'Clinic,': [2121], 'Rochester,': [2122], 'MN).': [2123], 'Kinase': [2124], 'Assays—Cells': [2125], 'test': [2130, 2526], 'agents': [2131, 2527], 'and,': [2132, 4253], 'at': [2133, 2179, 2211, 2301, 2323, 2457, 2485, 2568, 2785, 3775, 3792, 3830, 3859, 3998, 4290, 4440, 4456, 5091, 5124, 5612, 5644], 'indicated': [2135], 'times,': [2136], 'transferred': [2137, 2384], 'ice,': [2139], 'washed': [2140, 2246, 2436, 2462, 2518, 2586], 'once': [2141, 2252], 'cold': [2143], 'lysed': [2146, 2532, 2645], 'described': [2148, 2662], 'elsewhere': [2149], '(8Korn': [2150, 2256, 2663, 2712, 3445, 4087, 5285], 'Lysates': [2174], 'cleared': [2176], 'centrifugation': [2178], '14,000': [2180], 'rpm,': [2181], '4': [2182, 2212, 2458, 2569, 2641], '°C': [2183, 2213, 2303], '10': [2185, 4026], 'min.': [2186, 2306], 'Protein': [2187], 'concentrations': [2188, 4173], 'determined,': [2190], 'immunoprecipitated': [2196, 2231, 3376], '200': [2198], 'μg': [2199, 2234, 2287], 'IKKγ,': [2204, 5001], 'HA': [2207, 2404], 'Cruz)': [2210], '1.5': [2215], 'h': [2216, 2456, 2484, 2565, 3637, 4022], 'G-agarose': [2219, 2576], 'beads': [2220, 2577], '(Invitrogen).': [2221], 'For': [2222, 2508, 4924], 'immunoprecipitation': [2224, 2534], 'assay,': [2228], '700': [2233], 'anti-TNF-R1': [2239], 'Precipitates': [2244, 2584], 'twice': [2247], 'lysis': [2249, 2590], 'buffer': [2250, 2255, 2535], 'reaction': [2282], 'performed': [2284, 2659], '1': [2286, 2455, 2483, 2582, 2637], 'GST-IκBα': [2289], 'GST-c-Jun': [2291], 'substrate': [2294], '5': [2296, 2547, 4032], 'μCi': [2297], '[γ-32P]adenosine': [2299], 'triphosphate': [2300], '30': [2302, 2305, 3644], 'Reactions': [2307], 'stopped': [2309], 'addition': [2312, 5805], '2×': [2314, 2370, 2593], 'Laemmli': [2315, 2371, 2594], 'sample': [2316, 2372], 'buffer.': [2317], 'Samples': [2318], 'boiled': [2320], 'stored': [2322], '–20': [2324], '°C.': [2325, 2459, 2570], 'Proteins': [2326, 2382, 3072], 'separated': [2328], 'on': [2329, 2377, 2866, 4593], '15%': [2331], 'polyacrylamide': [2332, 2380, 2604], 'gel.': [2333, 2381], 'Gels': [2334], 'dried': [2336], 'examined': [2338, 4359], 'autoradiography.': [2340], 'Transfection—Cells': [2341], 'transfected': [2343, 2617], 'LipofectAMINE-Plus': [2345], '(Invitrogen)': [2346, 2578], 'according': [2347, 2425, 2501], "manufacturer's": [2350, 2504], 'directions.': [2351], 'Western': [2354, 2607, 3249, 3591], 'Blotting—A': [2355], 'fraction': [2356], 'lysates': [2358, 2557, 3308], 'analysis': [2360], 'co-immunoprecipitation': [2366, 3245], 'added': [2368, 2580, 2596], 'buffer,': [2373, 2591], 'boiled,': [2374], 'loaded': [2376], 'nitrocellulose': [2386], '(Schleicher': [2387], '&': [2388], 'Shuell),': [2389], 'membranes': [2391], 'subsequently': [2393], 'blocked': [2394, 2431], '5%': [2396], 'milk': [2397], 'tris-buffered': [2399], 'saline': [2400], '(TBS).': [2401], 'Levels': [2402], 'detected': [2406, 2419, 2498], 'monoclonal': [2409], '(12CA5,': [2411], 'Roche': [2412], 'Applied': [2413], 'Science).': [2414], 'All': [2415], 'proteins': [2417, 3085, 4303, 4349], 'protocol.': [2429], 'Membranes': [2430, 2460], 'overnight': [2432], 'TBS/milk': [2434], 'two': [2437], 'times': [2438, 2464, 2520, 2588], '15': [2440, 2790, 4037], 'min': [2441, 2467, 2791, 3645, 4033, 4038], 'TBS': [2443], '0.05%': [2445], 'Tween': [2446], '20': [2447, 2466, 2470], 'incubated': [2449, 2472, 2559], 'primary': [2452, 5841], 'TBS/Tween': [2469, 2493], 'peroxidase-conjugated': [2475], 'secondary': [2476], '(Vector': [2478], 'Burlingame,': [2480], 'CA)': [2481], 'room': [2486], 'temperature.': [2487], 'After': [2488, 2571], '30-min': [2490], 'wash': [2491], '20,': [2494], 'conjugated': [2495], 'peroxidase': [2496], 'ECL': [2500], 'instructions': [2505], '(Amersham': [2506], 'Biosciences).': [2507], 'immunoprecipitations,': [2509], 'grown': [2512], 'confluence': [2514], '100-mm': [2516], 'dishes,': [2517], 'treated': [2524, 2635, 3570, 3660, 3677], 'PBS.': [2529], 'Cells': [2530, 2633, 2643, 4013], '(50': [2536], 'Hepes,': [2538], 'pH': [2539], '7.4,': [2540], '250': [2541], 'NaCl,': [2543], '0.1%': [2544], 'Nonidet': [2545], 'P-40,': [2546], 'EDTA.': [2549], '0.5': [2550], 'phenylmethylsulfonyl': [2552], 'fluoride,': [2553], '1%': [2554], 'aprotinin),': [2555], 'rocking': [2567], 'incubation': [2572, 3360], 'antibody,': [2574], 'h.': [2583, 2642, 2794, 3616], 'followed': [2597], 'boiling,': [2599], 'loading': [2600, 4062], 'onto': [2601], 'gel,': [2605], 'analysis.': [2608, 3593], 'Assessment': [2609], 'Transcriptional': [2612], 'Activity—C10': [2613], 'transiently': [2616], '6': [2620, 2624], 'κB-tk-luc': [2621], 'NFκB': [2625], 'DNA': [2626], 'elements': [2627], 'either': [2629], 'pCDNA3.': [2632], 'ng/ml': [2638, 4027], 'Luciferase': [2647], 'Assay': [2648], 'Lysis': [2649], 'Buffer': [2650], '(Promega,': [2651], 'Madison,': [2652], 'WI),': [2653], 'luciferase': [2656], 'assay': [2657], 'Activates': [2688, 3729], 'TNF-R1-dependent': [2692, 4251, 5604], 'Manner—We': [2693], 'inhibiting': [2707, 3841, 4007], 'TNFα-induced': [2708, 2797, 5165, 5321, 5808], 'To': [2736, 2981, 3843], 'mediated': [2744], 'mice,': [2753], 'assessed.': [2758], 'shown': [2761, 3252, 3366, 4813, 5110], 'Fig.': [2763, 3254, 3368, 3597], '1A': [2764], 'substantially': [2775, 4259], 'wild': [2782, 3864], 'controls': [2784, 3694], 'time': [2786, 3610, 3944, 5614], 'points': [2787], 'ranging': [2788], 'As': [2795, 3251, 3365, 3594, 3932], 'expected,': [2796, 3933], 'abrogated': [2803], 'fibroblasts.': [2806, 5843], 'truncated': [2811, 4270], '(p60ΔCD),': [2815], 'lacks': [2817], 'resulted': [2826, 5219], 'inhibition': [2828, 2936, 3959], 'TNFα-': [2831, 3275], '(Fig.': [2837, 2979, 3045, 3284, 3301, 3309, 3638, 3663, 3695, 3891, 3908, 3953, 3987, 5464], '1B).': [2838], 'These': [2839, 3989], 'requires': [2847, 3080, 3475], 'TNF-R1.': [2848, 3236, 4457], 'Activation': [2849], 'regulated;': [2859], 'depends': [2865], 'activity': [2868, 2884, 2939, 2958, 3371, 3870, 5163], 'products': [2872], 'XIAP,': [2875], 'associates': [2877], 'repress': [2881], 'agreement': [2932, 3666, 4296, 4362, 4589, 5099], 'findings,': [2935, 3669, 5102], 'dominant': [2945], 'acting': [2946, 5617], 'version': [2947, 3014, 4271], 'IκB-SR,': [2950], 'led': [2951, 3900, 3955], 'augmented': [2954], 'profile': [2959], 'after': [2960, 3359, 3380, 3631, 3643, 4352, 4745], 'exposure': [2961, 3296, 3381, 3647, 3685], 'illustrating': [2964, 3047, 5466], 'repression': [2966, 4744], 'downstream': [2972], '2A).': [2980], 'further': [2982], 'support': [2983, 3405, 5080], 'addressed': [2994], 'whether': [2995, 3226, 3351, 3562, 3913, 4660, 5249, 5615, 5772], 'could': [3000, 3353, 5553], 'pathway.': [3007], 'therefore': [3009, 3224, 3560, 5530], 'expressed': [3010, 4347], 'active': [3013, 4455, 5215], 'IKKβ': [3016], '(CA-IKKβ),': [3017], 'assessed': [3019, 3350, 3582], 'JNK.': [3028, 3875, 5133, 5607], 'Compared': [3029], 'vector': [3031], 'controls,': [3032], 'CA-IKKβ-expressing': [3033], 'displayed': [3035], 'attenuated': [3036], 'treatment': [3040, 3632, 4747], '2B),': [3046], 'subject': [3055, 5235], 'negative': [3057, 5237], 'analogous': [3061, 4432, 5264], 'TNFα.': [3066, 3931, 3964, 5268, 5639], 'Causes': [3068, 3418], 'Recruitment': [3069], 'Adapter': [3071], 'TNF-R1—': [3074], 'catalytically': [3077], 'inactive': [3078], 'order': [3091], 'transmit': [3093], '(28Tartaglia': [3095], 'L.A.': [3096], 'Ayres': [3097], 'Wong': [3099, 3166], 'G.H.': [3100], '1993;': [3104, 5518], '74:': [3105], '845-853Abstract': [3106], '(1165)': [3112], 'binding,': [3117], 'aggregates': [3121], 'DD-containing': [3124], 'forms': [3157], 'platform': [3159], 'RIP': [3163, 3421, 3479, 3509, 3518, 3578, 3670, 3689, 3702, 3760, 3774, 3797, 3917, 3948, 4462, 4525, 4610, 4667, 4740, 5088, 5107], '(29Rothe': [3164], 'S.C.': [3167], 'Henzel': [3168], 'W.J.': [3169], '1994;': [3173], '78:': [3174], '681-692Abstract': [3175], '(929)': [3181], 'Endogenous': [3237], 'immunoprecipitated,': [3240], 'evaluated': [3247], 'blotting.': [3250], '3A,': [3255], 'co-precipitated': [3257], 'unstimulated': [3261], 'increased': [3264, 3294, 3379], 'samples': [3273], 'H2O2-exposed': [3277], 'post-immunoprecipitation,': [3279], 'levels': [3281, 3584, 3600, 3671, 4950, 4974], '3B).': [3285], 'co-immunoprecipitated': [3288], 'cells,': [3293], '3C),': [3302], 'post-immunoprecipitate': [3307], '3D).': [3310], 'Because': [3311, 3701], 'next': [3349], '3E,': [3369], 'Collectively,': [3386], 'our': [3387, 4591, 4809, 4912, 5445], 'findings': [3388, 4364, 4909, 5786], 'suggest': [3389], 'associated': [3396, 3946, 5117], 'they': [3404], 'Degradation': [3419], 'Cleavage': [3423], '—': [3426], 'dependence': [3429], 'does': [3439], '(30Chen': [3482, 4537], 'Cao': [3484, 4539], '9:': [3491, 4546], '401-410Abstract': [3492, 4547], '(333)': [3500, 4555], 'DD.': [3506], 'complex;': [3512], 'destabilization': [3513, 3576, 3711, 4460, 4523, 5105], 'leads': [3516, 4520, 4817], 'consequently': [3521, 4254, 4527], 'prevents': [3522], '(31Lewis': [3529, 4625, 4748], 'Devin': [3531, 4560, 4627, 4750], 'Miller': [3533, 4562, 4629, 4752], 'Neckers': [3539, 4568, 4635, 4758], 'Z.G.': [3542, 4571, 4638, 4761, 5007], '10519-10526Abstract': [3548, 4577, 4644, 4767], 'lack': [3564], 'due': [3574], 'and/or': [3579, 4975], 'blot': [3592], 'seen': [3595], '4A,': [3598], 'frame': [3611], 'up': [3613], 'Evaluation': [3617], 'lower': [3623], 'molecular': [3624], 'weight': [3625], '4B)': [3639], 'first': [3641], 'appeared': [3642], '(data': [3648], 'shown).': [3650, 3700], 'This': [3651], 'product': [3654], 'did': [3655, 3686, 4596, 4604], 'appear': [3657], '4B).': [3664], 'markedly': [3673], 'h,': [3682, 3942], 'whereas': [3683, 3759, 4801], 'affect': [3688, 4598, 4606, 5341, 5359], 'sham': [3693], '4C,': [3696], 'activation,': [3709, 3768, 5226], 'their': [3710, 4908], 'provides': [3714], 'plausible': [3716, 4481, 5337], 'IKK.': [3725, 3842], 'Overexpression': [3726], 'Inhibits': [3732], 'Ability': [3734], 'Activate': [3738], 'NF-κB—The': [3741], 'presented': [3743], 'above': [3744], 'Hsp90,': [3762, 4468, 4518, 5000], 'destabilized.': [3770], 'absence': [3772], 'enhance': [3781], 'suggesting': [3787], 'competition': [3789], 'between': [3794], 'TRADD/TRAF2': [3795], 'Therefore,': [3824], 'enhanced': [3826, 3980, 5120, 5458], 'presence': [3827, 4285, 4437, 5121], 'sustain': [3837, 5027], 'confirm': [3844, 3991], 'effects': [3847], 'mimicked': [3855], 'accumulation': [3858], 'overexpressed': [3863], 'analyzed': [3868], 'inhibit': [3881, 5160, 5320], '5,': [3892], 'A': [3893, 4494], 'B).': [3895], 'Moreover,': [3896], 'base-line': [3906, 4293], '5C).': [3909], 'Lastly,': [3910], 'determined': [3912, 4659], 'would': [3922], 'alter': [3923, 5730], 'pretreatment': [3934, 3977], 'point': [3945, 5787], '4),': [3954], 'complete': [3958], 'no': [3974], 'longer': [3975], 'observed,': [3976], '6).': [3988], 'leading': [4000, 5281], 'preferential': [4002], 'IKK.Fig.': [4008], '6H2O2': [4009], 'disrupts': [4010], 'TNFα-dependent': [4011], 'signaling.': [4012, 5474], '500': [4017], 'μm': [4018], 'additional': [4031, 5048, 5598], '(top': [4034], 'panel)': [4035, 4040], '(middle': [4039], 'assessment': [4043], 'respectively,': [4048], 'vitro': [4051], 'assays.': [4053], 'bottom': [4055], 'panel': [4056], 'demonstrates': [4057], 'levels,': [4059], 'control.View': [4063], 'Large': [4064], 'Image': [4065], 'Figure': [4066], 'ViewerDownload': [4067], 'Hi-res': [4068], 'image': [4069], 'Download': [4070], '(PPT)': [4071], 'established': [4076], '16Chen': [4111], '32Janssen-Heininger': [4136], 'Macara': [4138], 'Respir.': [4144, 5423], '20:': [4149, 5428, 5589], '942-952Crossref': [4150], '(195)': [4153], 'mechanism': [4158], 'occurs': [4162, 5053], 'elucidated.': [4166], 'observed': [4174, 5141], 'inflammatory': [4176, 5796], '(33Reeves': [4178], 'E.P.': [4179], 'Lu': [4180], 'Jacobs': [4182], 'H.L.': [4183], 'Messina': [4184], 'C.G.': [4185, 4214], 'Bolsover': [4186], 'Gabella': [4188], 'Potma': [4190], 'E.O.': [4191], 'Warley': [4192], 'Roes': [4194], 'Segal': [4196], 'A.W.': [4197, 4700], '416:': [4200], '291-297Crossref': [4201], '(889)': [4204], '34Schraufstatter': [4207], 'Hyslop': [4209], 'Jackson': [4211], 'J.H.': [4212], 'Cochrane': [4213], 'Clin.': [4216], 'Investig.': [4217], '1988;': [4218], '82:': [4219], '1040-1050Crossref': [4220], '(311)': [4223], '35Slungaard': [4226], 'Vercellotti': [4228], 'G.M.': [4229, 4317], 'Walker': [4230], 'Nelson': [4232], 'R.D.': [4233], 'Jacob': [4234], 'H.S.': [4235], 'Exp.': [4237], '1990;': [4239], '171:': [4240], '2025-2041Crossref': [4241], '(130)': [4244], 'manner': [4252, 4624, 5636], 'lacking': [4263, 4274], 'domain.': [4278], 'evidence': [4282, 4444], 'conditions,': [4294], 'recent': [4298], 'reports': [4299, 4397], 'nonstimulated': [4308], '(36Harper': [4310], 'Hughes': [4312], 'MacFarlane': [4314], '278:': [4322], '25534-25541Abstract': [4323], '(172)': [4331], 'only': [4336], 'able': [4337, 5471], 'detect': [4339], 'small': [4340], 'endogenously': [4346], 'here,': [4360], 'others': [4366, 4811], '(19Hayakawa': [4367, 5366], 'but': [4393, 4489, 5037], 'contrast': [4395, 4807], 'use': [4399], 'cassettes': [4401], 'immune': [4403], 'Interestingly,': [4431], 'observations': [4434, 4592, 5266, 5354], 'both': [4469], 'similar': [4495], 'disruption': [4496, 4682], 'geldanamycin': [4513], '(GA),': [4514], 'disruptor': [4516], '31Lewis': [4558], 'GA': [4595, 4678, 4746], 'stability': [4600], 'nor': [4603], 'GA-induced': [4609], 'involves': [4612], 'proteasome': [4614], 'occur': [4618, 5497], 'caspase-': [4621], 'lysosome-independent': [4623], 'It': [4655, 4671, 5242, 5335, 5608, 5654, 5720, 5760], 'remains': [4656, 4781], 'interest': [4674, 5246, 5723], 'note': [4676, 5725], 'brings': [4679], 'about': [4680], 'endothelial': [4684], 'nitric-oxide': [4685], 'synthase,': [4686], 'produce': [4690], 'superoxide,': [4691], 'precursor': [4693], '(37Pritchard': [4696], 'Ackerman': [4699], 'Gross': [4701], 'Stepp': [4703], 'D.W.': [4704, 5502], 'Fontana': [4707], 'J.T.': [4708], 'Baker': [4709], 'J.E.': [4710], 'Sessa': [4711], 'W.C.': [4712], '17621-17624Abstract': [4718], '(295)': [4726], 'Thus,': [4729], 'conceivable': [4732, 5762], 'although': [4778], 'possibility': [4780], 'tested': [4784], 'formally.': [4785], 'overexpressing': [4788], 'inhibited,': [4800], 'observations,': [4810, 5447], '(22Baud': [4821], '38Song': [4841], 'H.Y.': [4842], 'Regnier': [4843], 'C.H.': [4844], 'Kirschning': [4845], 'C.J.': [4846], 'Rothe': [4849, 4868], '94:': [4859], '9792-9796Crossref': [4860], '(507)': [4863], '39Takeuchi': [4866], '271:': [4876], '19935-19942Abstract': [4877], '(280)': [4885], '40Rothe': [4888], 'Sarma': [4890, 4984], 'Dixit': [4892, 4986], 'V.M.': [4893, 4987], '269:': [4898, 4992], '1424-1427Crossref': [4899, 4993], '(975)': [4902, 4996], 'discrepancy': [4906], 'stem': [4915], 'experimental': [4921], 'used.': [4923], 'example,': [4925], 'possible': [4928, 4971], 'transient,': [4935], 'opposed': [4937], 'missed': [4943], 'elevated': [4945], 'activity,': [4946], 'necessary': [4954], 'higher': [4961], 'than': [4962], 'those': [4963], 'Alternatively,': [4968], 'localization': [4977], 'TNF-R': [4979], 'members': [4981], '(40Rothe': [4982], 'MEKK1': [5003], '(41Baud': [5004], 'Bennett': [5008], 'Suzuki': [5010], 'Xia': [5012], 'Genes': [5016], '1297-1308Crossref': [5020], '(408)': [5023], 'some,': [5036], 'all,': [5039], 'types.': [5041], 'Findings': [5042], 'RIP–/–': [5046], 'notion': [5082], 'balance': [5086], 'NF-κB.': [5097, 5241], 'Sustained': [5134], 'because': [5146], '(21Wang': [5167], 'attenuation': [5222], 'feedback': [5238], 'will': [5243, 5777], 'determine': [5248], 'diminution': [5250], 'represses': [5261], 'apoptosis,': [5263], 'recently': [5271], 'capable': [5276], 'oxidizing': [5279], 'inactivation': [5284], 'upstream': [5324], 'interfering': [5326], 'formation': [5329], 'complex.': [5334], 'promote': [5350, 5554], 'shedding.': [5352], 'Recent': [5353], 'shedding': [5394], 'soluble': [5396], '(42Hino': [5405], 'Nakamura': [5407], 'Abe': [5409], 'Saito': [5411], 'Inage': [5413], 'Terashita': [5415], 'Kato': [5417], 'Tomoike': [5419], '122-128Crossref': [5429], '(28)': [5432], 'unlikely': [5438, 5532], 'contributed': [5443], 'pretreated': [5461], '6),': [5465], 'still': [5470], 'sites': [5476], 'oxidation': [5479, 5535, 5549], 'relevant': [5480], 'elusive.': [5488], 'Cysteines': [5489], 'extracellular': [5493], 'disulfide': [5499], 'bridges': [5500], '(43Banner': [5501], "D'Arcy": [5503], 'Janes': [5505], 'Gentz': [5507], 'Schoenfeld': [5509], 'H.J.': [5510], 'Broger': [5511], 'Loetscher': [5513], 'Lesslauer': [5515], '73:': [5519], '431-445Abstract': [5520], '(978)': [5526], 'cysteines': [5539], 'contained': [5540], 'prone': [5547], 'clustering': [5556], 'recruitment.': [5560], 'dissociation': [5563], 'thioredoxin': [5565], 'signal-regulating': [5568], 'kinase-1': [5569], 'promotes': [5570, 5603], '(44Liu': [5577], 'Nishitoh': [5579], 'Ichijo': [5581], 'Kyriakis': [5583], 'J.M.': [5584], '2198-2208Crossref': [5590], '(445)': [5593], 'providing': [5596, 5829], 'ligand-independent;': [5621], 'however': [5622], 'failure': [5623], 'strongly': [5627], 'suggests': [5628], 'affects': [5631], 'distinct': [5637], 'ramifications': [5649], 'fate.': [5653], 'itself': [5728], 'potential': [5733], 'uses': [5738], 'signal': [5741], '(for': [5742], 'review,': [5743], 'see': [5744], 'Ref.': [5745], '27Garg': [5746], 'A.K.': [5747], 'Aggarwal': [5748], 'B.B.': [5749], 'Immunol.': [5751], '39:': [5753], '509-517Crossref': [5754], '(201)': [5757], 'production,': [5768], 'dictates': [5771], 'lead': [5778], 'survival.': [5783], 'putative': [5790], 'proapoptotic': [5791], 'kinase.': [5813], 'thank': [5815], 'Drs.': [5816], 'Karin,': [5818], 'Baeuerle,': [5820], 'Lenardo,': [5822], 'Seed,': [5824], 'various': [5831], 'constructs': [5833], 'Amy': [5835], 'Guala': [5836], 'establishing': [5838], 'cultures': [5839]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2040332703', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-10T03:43:54.797173', 'created_date': '2016-06-24'}