Title: Differential involvement of the lipoproteins in cholesterol transport depending on the level of plasma cholesterol. Study in hypercholesterolemic hamsters
Abstract: FEC hamsters were used to explore to what extent the could maintain an unchanged distribution of plasma cholesterol among the lipoproteins in becoming even more hypercholesterolemic when fed high-cholesterol diets (0.1% or 0.5%). The results showed that the percentage of cholesterol was significantly changed only in the VLDL by cholesterol supplement in the diet. These lipoproteins became already maximally enriched with cholesterol in animals fed the diet with the lower percentage of cholesterol. More interesting were the alterations observed in the distribution of the excess exogenous cholesterol among the lipoproteins. Up to 200 mg/100 ml of total cholesterol in whole plasma, the cholesterol transported in the IDL and HDL fractions increased significantly. Above this concentration, the excess exogenous cholesterol was located only to the VLDL. There was a close correlation between the VLDL cholesterol content and the level of cholesterol in whole plasma. Thus, the involvement of the lipoproteins in cholesterol transport depended on the level of plasma cholesterol which was itself related to the dietary cholesterol intake.
Publication Year: 1986
Publication Date: 1986-09-01
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
Cited By Count: 2
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