Publication Information

{'id': 'https://openalex.org/W2040255341', 'doi': 'https://doi.org/10.1158/1538-7445.am2013-1449', 'title': 'Abstract 1449: ApoStream™, a new dielectrophoretic device for antibody-independent isolation and recovery of circulating tumor cells from blood of patients with metastatic pancreatic adenocarcinoma.', 'display_name': 'Abstract 1449: ApoStream™, a new dielectrophoretic device for antibody-independent isolation and recovery of circulating tumor cells from blood of patients with metastatic pancreatic adenocarcinoma.', 'publication_year': 2013, 'publication_date': '2013-04-01', 'ids': {'openalex': 'https://openalex.org/W2040255341', 'doi': 'https://doi.org/10.1158/1538-7445.am2013-1449', 'mag': '2040255341'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2013-1449', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5113794025', 'display_name': 'Gauri R. 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'abstract_inverted_index': {'Abstract': [0], 'Pancreatic': [1], 'adenocarcinoma': [2], '(PAC)': [3], 'remains': [4], 'the': [5, 43, 56, 80, 89, 109, 138, 168, 184, 301, 380, 436, 441], 'fourth': [6], 'most': [7], 'common': [8], 'cause': [9], 'of': [10, 18, 48, 58, 83, 92, 132, 170, 257, 267, 286, 296, 303, 307, 354, 372, 420, 426, 435, 440], 'cancer-related': [11], 'mortality': [12], 'with': [13, 76, 172, 276, 298, 334, 339, 428], 'a': [14, 150, 160, 350, 362, 411], '5-year': [15], 'survival': [16], 'rate': [17], 'less': [19], 'than': [20], '5%.': [21], 'The': [22, 123], 'available': [23], 'diagnostic': [24], 'tools': [25], 'and': [26, 34, 39, 46, 65, 100, 129, 136, 175, 187, 195, 216, 230, 245, 261, 274, 316, 324, 346, 367, 418], 'biomarkers': [27, 369], 'for': [28, 55, 61, 140, 365, 415, 444], 'PAC': [29, 111, 133, 174, 210, 355, 373], 'fail': [30], 'at': [31], 'early': [32], 'detection': [33, 266], 'suffer': [35], 'from': [36, 167, 207, 279, 424], 'low': [37], 'specificity': [38], 'sensitivity.': [40], 'Advances': [41], 'in': [42, 74, 108, 143, 159, 180, 284, 294, 300, 313, 337, 349, 370, 377], 'isolation,': [44], 'recovery,': [45], 'characterization': [47, 82, 179], 'circulating': [49, 421], 'tumor': [50, 422], 'cells': [51, 219, 269, 293, 310, 423], '(CTCs)': [52], 'offer': [53, 86], 'hope': [54], 'development': [57], 'noninvasive': [59], 'techniques': [60], 'disease': [62, 93], 'detection,': [63], 'monitoring,': [64], 'biomarker': [66, 141], 'discovery.': [67], 'While': [68], 'CTC': [69, 104, 232], 'enumeration': [70, 233], 'provides': [71], 'prognostic': [72], 'information': [73, 142], 'patients': [75, 171, 211, 297, 338, 427], 'various': [77], 'cancer': [78], 'types,': [79], 'biological': [81], 'CTCs': [84, 166, 333, 371], 'may': [85], 'insight': [87], 'into': [88], 'molecular': [90], 'determinants': [91], 'progression.': [94], 'Epithelial': [95], 'cell': [96, 252], 'adhesion': [97], 'molecule': [98], '(EpCAM)': [99], 'cytokeratin': [101], '(CK)': [102], 'dependent': [103], 'technologies': [105], 'fare': [106], 'poorly': [107], 'metastatic': [110, 130, 173, 209, 340, 429], 'setting,': [112], 'due': [113], 'to': [114, 164, 182, 250, 360], 'altered': [115], 'phenotypes': [116, 253, 336], 'acquired': [117], 'during': [118], 'epithelial': [119], 'mesenchymal': [120], 'transition': [121], '(EMT).': [122], 'links': [124], 'between': [125, 272], 'EMT,': [126], 'plectin-1,': [127], 'mesothelin': [128, 262, 325], 'progression': [131], 'are': [134], 'emerging': [135], 'underscore': [137], 'need': [139], 'real': [144], 'time.': [145], 'Here': [146], 'we': [147], 'used': [148], 'ApoStream™,': [149, 290, 410], 'novel,': [151], 'antibody-independent': [152, 416], 'device': [153, 414], 'which': [154], 'uses': [155], 'dielectrophoretic': [156, 413], '(DEP)': [157], 'technology': [158], 'continuous': [161], 'flow': [162], 'system': [163], 'isolate': [165], 'blood': [169, 205, 283, 425], 'expand': [176], 'their': [177], 'phenotypic': [178], 'order': [181], 'elucidate': [183], 'population': [185], 'heterogeneity': [186], 'characterize': [188], 'pancreatic': [189, 430], 'specific': [190], 'markers': [191], '(CA19-9,': [192], 'KRAS,': [193, 322], 'plectin-1': [194, 229, 260, 323], 'mesothelin).': [196], 'This': [197], 'prospective': [198], 'study': [199], 'will': [200], 'evaluate': [201], 'thirty': [202], 'patients.': [203, 287, 374], 'Paired': [204], 'samples': [206], '11': [208], 'were': [212, 220, 248, 311], 'analyzed': [213], 'by': [214, 320, 379], 'CellSearch®': [215, 273], 'ApoStream™.': [217, 321], 'Collected': [218], 'immunostained': [221], 'using': [222, 236], 'antibodies': [223], 'against': [224], 'CK,': [225, 258], 'CD45,': [226, 259], 'DAPI,': [227], 'CA19-9,': [228], 'mesothelin.': [231], 'was': [234, 270], 'performed': [235], 'laser': [237], 'scanning': [238], 'cytometry': [239], '(LSC).': [240], 'A': [241], 'multiplexed': [242], 'immunofluorescent': [243], 'assay': [244], 'LSC': [246], 'analysis': [247, 326], 'applied': [249], 'identify': [251], 'based': [254], 'on': [255], 'combinations': [256], 'marker': [263], 'expression.': [264], 'Results:The': [265], 'CK+/CD45−/DAPI+': [268, 315], 'comparable': [271], 'ApoStream™': [275, 330, 357], 'counts': [277, 299], 'ranging': [278], '1-10': [280], 'CTCs/7.5': [281], 'mL': [282, 306], '50%': [285], 'In': [288], 'addition,': [289], 'recovered': [291], 'CK−/CD45−/DAPI+': [292, 317], '100%': [295], 'range': [302], '12-166': [304], 'cells/7.5': [305], 'blood.': [308], 'CA19-9+': [309], 'identified': [312], 'both': [314], 'subpopulations': [318], 'isolated': [319], 'is': [327, 344], 'pending.': [328], 'Conclusions:': [329], 'recovers': [331], 'putative': [332], 'multiple': [335], 'PAC.': [341], 'Preliminary': [342], 'data': [343], 'encouraging': [345], 'if': [347], 'confirmed': [348], 'larger': [351], 'sample': [352], 'size': [353], 'patients,': [356], 'could': [358], 'prove': [359], 'be': [361], 'sensitive': [363], 'method': [364], 'isolating': [366], 'detecting': [368], 'Acknowledgments:': [375], 'Supported': [376], 'part': [378], 'Lockton': [381], 'Fund.': [382], 'Citation': [383], 'Format:': [384], 'Gauri': [385], 'Varadhachary,': [386], 'James': [387], 'Abbruzzese,': [388], 'Rachna': [389], 'Shroff,': [390], 'Vladislava': [391], 'Melnikova,': [392], 'Vishal': [393], 'Gupta,': [394], 'Chris': [395], 'Neal,': [396], 'Miguel': [397], 'Garza,': [398], 'David': [399], 'K.': [400], 'Hasegawa,': [401], 'Kenna': [402], 'L.': [403], 'Anderes,': [404], 'Darren': [405], 'Davis,': [406], 'Robert': [407], 'A.': [408], 'Wolff.': [409], 'new': [412], 'isolation': [417], 'recovery': [419], 'adenocarcinoma.': [431], '[abstract].': [432], 'In:': [433], 'Proceedings': [434], '104th': [437], 'Annual': [438], 'Meeting': [439], 'American': [442], 'Association': [443], 'Cancer': [445, 455], 'Research;': [446], '2013': [447], 'Apr': [448], '6-10;': [449], 'Washington,': [450], 'DC.': [451], 'Philadelphia': [452], '(PA):': [453], 'AACR;': [454], 'Res': [456], '2013;73(8': [457], 'Suppl):Abstract': [458], 'nr': [459], '1449.': [460], 'doi:10.1158/1538-7445.AM2013-1449': [461]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2040255341', 'counts_by_year': [{'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-08T12:48:33.725262', 'created_date': '2016-06-24'}