Publication Information

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4114, 4167, 4176, 4239, 4250, 4361, 4387], 'best': [14, 254], 'known': [15, 255, 1949], 'for': [16, 25, 79, 237, 256, 265, 319, 477, 633, 834, 851, 1012, 1133, 1139, 1556, 2006, 2094, 2136, 2343, 2365, 2502, 2572, 2582, 2603, 2656, 2767, 2779, 2788, 2975, 3050, 3271, 3446, 3605, 3665, 3827, 3943, 4019, 4068, 4102, 4115, 4126, 4185, 4198, 4203, 4223], 'its': [17, 83, 209, 257, 323, 449, 1904, 2008, 2012, 3557, 4020, 4240], 'role': [18, 175, 258, 415, 495, 886], 'in': [19, 148, 176, 179, 228, 232, 259, 388, 416, 419, 468, 472, 496, 869, 887, 1257, 1269, 1378, 1454, 1464, 1751, 1835, 1901, 1906, 2040, 2061, 2067, 2079, 2172, 2357, 2511, 2514, 2595, 2652, 2659, 2685, 2702, 2810, 2832, 2847, 2852, 2891, 2925, 2929, 2945, 2983, 3024, 3040, 3053, 3057, 3415, 3625, 3682, 3727, 3743, 3815, 3825, 3832, 3851, 3882, 3883, 3909, 4056, 4143, 4172, 4236], 'targeting': [20, 260], 'tumor': [22, 262, 1278], 'suppressor': [23, 263, 1279], 'p53': [24, 177, 229, 233, 264, 417, 469, 473, 1280, 1395, 1455, 1465, 1907, 1914, 2066, 2398, 2503, 2529, 2552, 2629, 2742, 3045, 3092, 3142, 3160, 3258, 3279, 3294, 3339], 'ubiquitination': [26, 178, 230, 266, 418, 470, 1837, 2062, 2812, 3048, 3140, 3874], 'degradation.': [28, 268], 'can': [30, 270, 598, 1676, 4244], 'bind': [31, 271, 3975, 4014], 'to': [32, 35, 81, 121, 131, 186, 272, 275, 321, 361, 371, 426, 871, 881, 893, 977, 1563, 1739, 1903, 2000, 2385, 2420, 2437, 2500, 2546, 2717, 3113, 3213, 3391, 3448, 3468, 3783, 3830, 3847, 3920, 3974, 4013, 4039, 4045, 4053, 4105, 4131, 4181, 4253, 4379, 4388], 'itself': [33, 124, 273, 364], 'structurally': [37, 277, 1148], 'related': [38, 278, 1149], 'protein': [39, 279, 1918, 2762, 3065], 'MdmX,': [40, 52, 280, 292, 2142, 3837], 'these': [42, 91, 282, 331, 1976, 3659, 3891, 3939, 4394], 'interactions': [43, 283, 3458], 'involve': [44, 284, 1000], 'domain': [48, 66, 288, 306, 608, 838, 848, 878, 1168, 1988, 3108, 3537, 3610, 3956, 4075], 'respectively.': [53, 293, 3101], 'In': [54, 294, 1439, 1833, 2948, 3563, 3698], 'this': [55, 167, 217, 295, 407, 457], 'study,': [56, 296], 'we': [57, 70, 182, 297, 310, 422, 1979, 2017, 4372], 'performed': [58, 298, 1980, 2468, 2508, 3353], 'mutational': [60, 300, 1982, 4046], 'analysis': [61, 301, 1983, 2404, 2558, 2635, 2756], 'Mdm2,': [68, 187, 308, 427, 2141, 2749, 2815, 2904, 2935, 3674, 3681, 3840, 4112], 'identified': [71, 311], 'several': [72, 312], 'amino': [73, 313, 590, 3546, 3686], 'acid': [74, 314, 591, 3547, 3687, 3965], 'residues': [75, 92, 112, 315, 332, 352, 3548, 3614, 3660, 3688, 3713, 3905, 3940, 3966, 4025, 4217], 'that': [76, 99, 169, 196, 199, 219, 316, 339, 409, 436, 439, 459, 619, 818, 1261, 1448, 1458, 1550, 1755, 1840, 1995, 2019, 2049, 2428, 2451, 2474, 2648, 2799, 3103, 3896, 3916, 3938, 4137, 4192, 4213], 'are': [77, 317, 1147, 1745, 2035, 2654, 3000, 3093, 3689, 3906, 3941], 'important': [78, 318, 494], 'exert': [82, 322], 'ligase': [85, 141, 193, 203, 211, 325, 381, 433, 443, 451, 1955, 1966, 2010, 2014, 2023, 2027, 2323, 2328, 2479, 2676, 2681], 'function.': [86, 326], 'Mutation': [87, 109, 327, 349], 'some': [89, 329, 970, 2030], 'interfered': [93, 333], 'with': [94, 123, 133, 158, 334, 363, 373, 398, 595, 636, 854, 984, 1135, 1141, 1443, 1735, 1737, 1760, 1915, 2085, 2340, 2405, 2469, 2524, 2579, 2636, 2698, 2909, 3008, 3039, 3156, 3290, 3580, 3611, 3773, 3785, 3788, 3856, 4107, 4110, 4189, 4248, 4368, 4381, 4404], 'Mdm2-Mdm2': [96, 165, 336, 405, 3666, 3720, 3945, 4158, 4204, 4412], 'interaction': [97, 155, 337, 395, 635, 853, 1134, 1140, 1732, 3481, 3500, 3667, 3721, 3946, 4205, 4401, 4413], 'indicating': [98, 338, 4136], 'homomeric': [101, 341, 2002], 'complex': [102, 190, 342, 430, 1029, 2052], 'represents': [103, 343], 'active': [105, 345], 'form': [106, 346, 978, 1677, 2001, 3085, 3705, 4132, 4245], 'Mdm2.': [108, 348, 1958, 1990, 3952], 'other': [111, 351, 806, 863, 985, 1142], 'did': [113, 353, 4154], 'not': [114, 354, 1561, 1948, 2435, 2455, 3126, 3732, 3888, 3894, 3934, 4017, 4124, 4140, 4155, 4202, 4207], 'detectably': [115, 355, 4156], 'affect': [116, 200, 208, 356, 440, 448, 992, 2456, 4157], 'ability': [118, 128, 358, 368, 976, 1997, 3463, 3779, 3829, 4010, 4104, 4128, 4376], 'interact': [122, 132, 362, 372, 3784, 4106, 4380], 'but': [125, 365, 868, 1137, 1457, 2513, 4201], 'reduced': [126, 366, 3793, 4171], 'UbcH5.': [134, 374], 'Remarkably,': [135, 375], 'MdmX': [136, 159, 376, 399, 1146, 1265, 1451, 1459, 1559, 1675, 1736, 1758, 1843, 1951, 1974, 2039, 4227, 4238, 4360, 4378, 4403], 'efficiently': [137, 377, 2036], 'rescued': [138, 378, 1390, 2037], 'activity': [142, 194, 204, 382, 434, 444, 597, 994, 1567, 1742, 1763, 1847, 1956, 1967, 2028, 2056, 2324, 2329, 2480, 3019, 3117, 3672, 3800, 3863, 3950, 4117, 4163, 4200, 4257, 4392], 'latter': [145, 385], 'mutants': [147, 387, 2034, 2147, 2259, 2332, 2356, 2484, 2594, 2825, 3023, 3124, 3172, 3302, 3583, 3679, 3740, 3782, 3822, 3867, 3879, 4099, 4384], 'vitro': [149, 389, 1836, 2041, 2811, 2892, 3041, 3728, 3826, 3833, 3884, 4173], 'within': [151, 391, 2043, 2277, 2333, 3143, 3259, 3280, 3542], 'cells.': [152, 392, 2044, 2334, 2471], 'Because': [153, 393, 796, 3716], 'more': [161, 401, 4408], 'stable': [162, 402], 'than': [163, 403, 807, 864, 3486, 3923, 4410], 'interaction,': [166, 406], 'suggests': [168, 218, 408, 458], 'Mdm2-MdmX': [170, 189, 410, 429, 1024, 2051], 'complexes': [171, 411, 980, 983, 1679, 2003, 4247], 'play': [172, 412, 882, 1266], 'prominent': [174, 414], 'vivo.': [180, 420, 2068], 'Furthermore,': [181, 421, 1895, 2016, 3876], 'show': [183, 423, 2018], 'that,': [184, 424, 1900, 3772], 'similar': [185, 236, 425, 476, 627, 842, 2465, 3576, 4364], 'has': [191, 431, 1460, 2053, 3602, 3971, 4050], 'Nedd8': [192, 210, 432, 450, 1919, 1954, 1965, 2013, 2026, 2283, 2327], 'all': [197, 437], 'mutations': [198, 438, 2265], 'also': [207, 447, 1138, 1461], 'activity.': [212, 452, 2015, 2739, 4187, 4226], 'From': [213, 453], 'mechanistic': [215, 455], 'perspective,': [216, 456], 'actual': [221, 461], 'function': [222, 462, 822, 1905], 'Mdm2-MdmX,': [226, 466], 'respectively,': [227, 467, 1375, 2750, 4113], 'neddylation': [234, 474, 2064, 3256], 'both': [238, 478, 1153, 1262, 2007, 2020, 2320, 2801, 3581, 3944, 4369], 'processes.': [239, 479], 'Covalent': [480], 'modification': [481, 1912], 'proteins': [483, 554, 594, 801, 825, 830, 895, 1150, 2099, 2139, 2388, 2618, 2831, 2942, 2989, 3030, 3036, 3230, 3485, 3808, 3814], 'by': [484, 562, 804, 861, 1391, 2038, 2158, 2268, 2389, 2401, 2555, 2620, 2632, 2711, 2736, 2753, 2757, 2856, 2992, 3075, 3078, 3095, 3266, 3343, 3354, 3413, 3461, 3691, 3695], '("ubiquitination")': [486], 'selective': [489], 'process': [490], 'plays': [492], 'an': [493, 631, 1155, 1554, 3096, 3099, 3104, 3268], 'control': [498, 1271], 'many': [500], 'fundamental': [501], 'cellular': [502], 'processes': [503], '(1Pickart': [504], 'C.M.': [505], 'Annu.': [506, 537], 'Rev.': [507, 522, 538], 'Biochem.': [508, 4083], '2001;': [509, 1043, 1315, 1431, 1825], '70:': [510], '503-533Crossref': [511], 'PubMed': [512, 526, 545, 659, 688, 720, 741, 770, 791, 925, 940, 963, 1046, 1071, 1095, 1117, 1188, 1210, 1250, 1294, 1318, 1337, 1366, 1410, 1434, 1483, 1509, 1541, 1579, 1605, 1620, 1640, 1665, 1699, 1721, 1785, 1800, 1828, 1865, 1890, 1939, 2128, 2212, 2228, 2249, 2885, 3208, 3250, 3333, 3385, 3521, 3651, 3765, 4003, 4091, 4279, 4301, 4321, 4346, 4431], 'Scopus': [513, 527, 546, 660, 689, 721, 742, 771, 792, 926, 941, 964, 1047, 1072, 1096, 1118, 1189, 1211, 1251, 1295, 1319, 1338, 1367, 1411, 1435, 1484, 1510, 1542, 1580, 1606, 1621, 1641, 1666, 1700, 1722, 1786, 1801, 1829, 1866, 1891, 1940, 2129, 2213, 2229, 2250, 2886, 3209, 3251, 3334, 3386, 3522, 3652, 3766, 4004, 4092, 4280, 4302, 4322, 4347], '(2993)': [514], 'Google': [515, 529, 548, 662, 691, 723, 744, 773, 794, 928, 943, 966, 1049, 1074, 1098, 1120, 1191, 1213, 1253, 1297, 1321, 1340, 1369, 1413, 1437, 1486, 1512, 1544, 1582, 1608, 1623, 1643, 1668, 1702, 1724, 1788, 1803, 1831, 1868, 1893, 1942, 2131, 2215, 2231, 2252, 2888, 3211, 3253, 3336, 3388, 3524, 3654, 3768, 4006, 4094, 4282, 4304, 4324, 4349], 'Scholar,': [516, 530, 663, 692, 724, 745, 774, 929, 944, 1050, 1075, 1099, 1192, 1214, 1298, 1322, 1341, 1414, 1487, 1513, 1583, 1609, 1624, 1644, 1703, 1789, 1804, 1869, 2216, 2232, 4283, 4305, 4325], '2Glickman': [517], 'M.H.': [518], 'Ciechanover': [519, 1649, 1874, 2112, 2196, 4330], 'A.': [520, 716, 737, 910, 921, 1060, 1109, 1202, 1216, 1302, 1418, 1505, 1537, 1648, 1650, 1661, 1713, 1873, 1875, 1886, 2111, 2113, 2124, 2195, 2197, 2208, 2238, 2573, 3195, 3239, 3320, 3370, 3381, 3506, 3517, 3757, 4293, 4329, 4331, 4342, 4423], 'Physiol.': [521], '2002;': [523, 685, 1632, 1857, 4313], '82:': [524], '373-428Crossref': [525], '(3450)': [528], '3Kerscher': [531], 'O.': [532, 1058, 3984], 'Felberbaum': [533], 'R.': [534, 680, 709, 1285, 1401, 1569, 1806, 1812, 2871], 'Hochstrasser': [535], 'M.': [536, 705, 747, 749, 753, 899, 931, 1063, 1111, 1204, 1227, 1353, 1524, 1613, 1654, 1715, 1879, 2117, 2201, 2222, 2240, 2873, 3203, 3241, 3328, 3372, 3508, 3759, 3988, 4295, 4335, 4425], 'Cell': [539, 2069], 'Dev.': [540], 'Biol.': [541, 1042, 1085, 1178, 1479, 1595, 1616, 1630, 1689, 1775, 1796, 1855, 2245, 2875, 3246, 4269, 4311], '2006;': [542, 788, 1068, 1358, 1480, 1506, 1538, 3648], '22:': [543], '159-180Crossref': [544], '(1253)': [547], 'Scholar).': [549, 795, 967, 1121, 1254, 1370, 1438, 1545, 1669, 1725, 1832, 1894, 1943, 2132, 2253, 2889, 3254, 3525, 3655, 3769, 4007, 4095], 'Specific': [550], 'recognition': [551, 798, 858], 'substrate': [553, 800, 829, 857, 894, 2902], 'ubiquitin-conjugation': [557], 'system': [558, 2850, 2861, 3358, 3747], 'mainly': [560], 'mediated': [561, 803, 860], 'action': [564], 'ubiquitin-protein': [566, 574], '(E3).': [568], '2The': [569], 'abbreviations': [570], 'used': [571, 2171, 2384, 2419, 2766], 'are:': [572], 'E3,': [573], 'ligase;': [575], 'GST,': [576], 'glutathione': [577, 2095], 'S-transferase;': [578], 'HA,': [579], 'hemagglutinin;': [580], 'E2,': [581], 'ubiquitin-conjugating': [582, 640, 2842], 'enzyme.': [583], 'Based': [584, 3589], 'on': [585, 1975, 3428, 3470, 3476, 3488, 3493, 3590], 'presence': [587, 2361, 2599, 2704, 2931, 3059], 'distinct': [589], 'sequence': [592], 'motifs,': [593], 'E3': [596, 1555, 1566, 1741, 1762, 1846, 2055, 2675, 3018, 3116, 3597, 3671, 3799, 3862, 3949, 4021, 4116, 4162, 4186, 4199, 4225, 4256, 4391], 'be': [599, 2164, 3568, 3663, 4054, 4066, 4182, 4356], 'roughly': [600], 'grouped': [601], 'into': [602, 831, 2272, 2310], 'three': [603, 3005, 3009, 3429], 'classes': [604], 'as': [605, 823, 1131, 1152, 1553, 2368, 2509, 2570, 2606, 2828, 2862, 3068, 3192, 3232, 3317, 3811, 4118], 'follows:': [606], 'HECT': [607, 837, 847, 866, 877], 'E3s,': [609, 612, 876], 'U-box': [614, 624, 875, 1009, 1126, 3596], 'E3s.': [615, 988, 1143], 'Structural': [616], 'studies': [617, 1753], 'indicate': [618, 1447, 1839, 1994, 3937, 4212], 'domains': [622, 625, 1127], 'adopt': [626], 'structural': [628, 4069], 'folds': [629], 'providing': [630], 'interface': [632, 3631], 'their': [637, 2487, 3828, 4103], 'cognate': [638, 855], 'E2': [639], 'enzymes': [641], '(4Zheng': [642], 'N.': [643, 1220], 'Wang': [644, 949], 'P.': [645, 755, 1033, 1056, 1225, 1517, 2869], 'Jeffrey': [646], 'P.D.': [647], 'Pavletich': [648, 957], 'N.P.': [649, 958], 'Cell.': [650, 761, 1357, 1478, 1795, 1930, 2244, 3245, 3994], '2000;': [651, 1597, 1797, 2714, 3382, 3518], '102:': [652, 739], '533-539Abstract': [653], 'Full': [654, 656, 765, 767, 1090, 1092, 1183, 1185, 1361, 1363, 1600, 1602, 1635, 1637, 1694, 1696, 1780, 1782, 1860, 1862, 1934, 1936, 2880, 2882, 3998, 4000, 4088, 4274, 4276, 4316, 4318], 'Text': [655, 657, 766, 768, 1091, 1093, 1184, 1186, 1362, 1364, 1601, 1603, 1636, 1638, 1695, 1697, 1781, 1783, 1861, 1863, 1935, 1937, 2881, 2883, 3999, 4001, 4089, 4275, 4277, 4317, 4319], 'PDF': [658, 769, 1094, 1187, 1365, 1604, 1639, 1698, 1784, 1864, 1938, 2884, 4002, 4090, 4278, 4320], '(728)': [661], '5Albert': [664], 'T.K.': [665, 1065], 'Hanzawa': [666], 'H.': [667, 698, 728, 1571, 1573, 3201, 3326], 'Legtenberg': [668], 'Y.I.': [669], 'de': [670, 1282, 1398], 'Ruwe': [671], 'M.J.': [672, 1081, 1174, 1685, 1771, 4265], 'van': [673, 1053, 1061, 1221, 1228, 1231, 1234, 1239, 1813], 'den': [674], 'Heuvel': [675], 'F.A.': [676], 'Collart': [677], 'M.A.': [678], 'Boelens': [679], 'Timmers': [681], 'H.T.': [682], 'EMBO': [683, 1066, 1245, 1823, 2223], 'J.': [684, 730, 784, 1067, 1084, 1177, 1246, 1300, 1416, 1594, 1629, 1688, 1774, 1854, 2224, 2874, 4268, 4310], '21:': [686], '355-364Crossref': [687], '(164)': [690], '6Brzovic': [693], 'P.S.': [694, 1031, 4079], 'Keeffe': [695], 'J.R.': [696], 'Nishikawa': [697], 'Miyamoto': [699], 'K.': [700, 1105, 1107, 1198, 1200, 1709, 1711, 3366, 3502, 3753, 3755, 4289, 4291, 4419, 4421], 'Fox': [701], 'III,': [702], 'D.': [703, 1611, 3199, 3324], 'Fukuda': [704], 'Ohta': [706], 'T.': [707, 1223], 'Klevit': [708, 1038], 'Proc.': [710, 731, 904, 915, 1499, 1531, 1655, 1880, 2118, 2202, 3375, 3511, 4336], 'Natl.': [711, 732, 905, 916, 1500, 1532, 1656, 1881, 2119, 2203, 3376, 3512, 4337], 'Acad.': [712, 733, 906, 917, 1501, 1533, 1657, 1882, 2120, 2204, 3377, 3513, 4338], 'Sci.': [713, 734, 907, 918, 1502, 1534, 1658, 1883, 2121, 2205, 3378, 3514, 4084, 4339], 'U.': [714, 735, 908, 919, 933, 1503, 1535, 1659, 1884, 2122, 2206, 2865, 3379, 3515, 4340], 'S.': [715, 736, 786, 901, 909, 920, 952, 1101, 1103, 1194, 1196, 1470, 1489, 1504, 1515, 1519, 1522, 1536, 1585, 1652, 1660, 1705, 1707, 1877, 1885, 2115, 2123, 2199, 2207, 2234, 2867, 3235, 3380, 3516, 3749, 3751, 4285, 4287, 4333, 4341, 4415, 4417], '2003;': [717, 1617, 1662, 1887, 2125, 2209, 2246, 3247, 3995, 4343], '100:': [718, 1663, 1888, 2126, 2210, 4344], '5646-5651Crossref': [719], '(292)': [722], '7Ozkan': [725], 'E.': [726, 948, 1528, 2853, 3816], 'Yu': [727], 'Deisenhofer': [729], '2005;': [738, 762, 1334], '18890-18895Crossref': [740], '(154)': [743], '8Zhang': [746], 'Windheim': [748], 'Roe': [750], 'S.M.': [751], 'Peggie': [752], 'Cohen': [754], 'Prodromou': [756], 'C.': [757, 2242, 3243, 3368, 3504, 3982, 3992], 'Pearl': [758], 'L.H.': [759], 'Mol.': [760, 1477, 1794, 2243, 3244, 3993], '20:': [763, 1798], '525-538Abstract': [764], '(340)': [772], '9Xu': [775], 'Z.': [776], 'Devlin': [777], 'K.I.': [778], 'Ford': [779], 'M.G.': [780], 'Nix': [781], 'J.C.': [782, 1530, 1626, 1851, 1925, 4307], 'Qin': [783], 'Misra': [785], 'Biochemistry.': [787, 3647], '45:': [789, 3649], '4749-4759Crossref': [790], '(49)': [793], 'specific': [797], 'regions': [805, 862], 'or': [811, 874, 1008, 2352, 2360, 2590, 2598, 2743, 2851, 2905, 2928, 2938, 3056, 3122, 3151, 3168, 3298, 3787, 4152], 'U-box,': [813], 'it': [814, 1896, 1946, 2433, 3917], 'commonly': [816], 'assumed': [817, 4052], 'finger/U-box': [820, 972, 987, 1017], 'E3s': [821, 839, 879, 973, 998, 1018], 'adaptor': [824], 'bringing': [826], 'E2s': [827, 1136], 'proper': [832], 'orientation': [833], 'E2-mediated': [835], 'ubiquitination.': [836], 'have': [840, 974, 1259, 1564], 'modular': [843], 'structure': [844, 3593, 3601], '(i.e.': [845], 'responsible': [850], 'E2s;': [856], 'domain),': [867], 'contrast': [870], 'appear': [880, 1562], 'direct': [884], 'catalytic': [885], 'covalent': [889], 'attachment': [890], '(10Huibregtse': [896], 'J.M.': [897, 935, 956, 1474], 'Scheffner': [898, 1653, 1878, 2116, 2200, 2239, 2872, 3202, 3240, 3327, 3371, 3507, 4334], 'Beaudenon': [900, 951], 'Howley': [902, 953], 'P.M.': [903, 954], '1995;': [911, 937, 1291, 1407], '92': [912], '(Correction': [913], '(1995)': [914], '92,': [922], '5249):': [923], '2563-2567Crossref': [924], '(711)': [927], '11Scheffner': [930], 'Nuber': [932], 'Huibregtse': [934, 955], 'Nature.': [936, 1290, 1406], '373:': [938], '81-83Crossref': [939], '(777)': [942], '12Huang': [945], 'L.': [946], 'Kinnucan': [947], 'G.': [950, 1052, 1238, 1289, 1312, 1405, 1428, 1476, 1496, 1498, 1526], 'Science.': [959], '1999;': [960, 1087, 1114, 1180, 1207, 1691, 1718, 1777, 3762, 4271, 4298, 4428], '286:': [961], '1321-1326Crossref': [962], '(453)': [965], 'At': [968, 1944], 'least': [969, 2661, 3004, 3498], 'homo-oligomeric': [979], 'and/or': [981, 990], 'hetero-oligomeric': [982], 'Homo-oligomerization': [989], 'hetero-oligomerization': [991], 'respective': [997, 1005, 1386, 2264, 2298, 2415, 2700, 2940, 3120, 3170, 3300, 3401, 3466, 3484, 3586, 3685, 3807, 4097], 'physical': [1001], 'contacts': [1002], 'between': [1003, 1015, 3553, 3571, 4359], 'domains.': [1010], 'Examples': [1011], 'hetero-oligomer': [1013], 'formation': [1014, 3627, 3911], 'include': [1019], 'BRCA1-BARD1': [1021], 'complex,': [1022, 1025], 'Bmi1-Ring1b': [1028], '(13Brzovic': [1030], 'Rajagopal': [1032], 'Hoyt': [1034], 'D.W.': [1035], 'King': [1036], 'M.C.': [1037], 'R.E.': [1039], 'Nat.': [1040, 1313, 1429], 'Struct.': [1041], '8:': [1044], '833-837Crossref': [1045], '(402)': [1048], '14Buchwald': [1051], 'der': [1054, 1232, 1240, 1814], 'Stoop': [1055], 'Weichenrieder': [1057], 'Perrakis': [1059], 'Lohuizen': [1062], 'Sixma': [1064], '25:': [1069], '2465-2474Crossref': [1070], '(351)': [1073], '15Sharp': [1076], 'D.A.': [1077, 1170, 1681, 1767, 4261], 'Kratowicz': [1078, 1171, 1682, 1768, 4262], 'S.A.': [1079, 1172, 1683, 1769, 4263], 'Sank': [1080, 1173, 1684, 1770, 4264], 'George': [1082, 1175, 1686, 1772, 4266], 'D.L.': [1083, 1176, 1687, 1773, 4267], 'Chem.': [1086, 1179, 1596, 1631, 1690, 1776, 1856, 2876, 4270, 4312], '274:': [1088, 1181, 1692, 1778, 4272], '38189-38196Abstract': [1089, 1182, 1693, 1779, 4273], '(242)': [1097, 1190, 1701, 1787, 4281], '16Tanimura': [1100, 1193, 1704, 4284], 'Ohtsuka': [1102, 1195, 1706, 3750, 4286, 4416], 'Mitsui': [1104, 1197, 1708, 3752, 4288, 4418], 'Shirouzu': [1106, 1199, 1710, 3754, 4290, 4420], 'Yoshimura': [1108, 1201, 1712, 3756, 4292, 4422], 'Ohtsubo': [1110, 1203, 1714, 3758, 4294, 4424], 'FEBS': [1112, 1205, 1574, 1716, 3760, 4296, 4426], 'Lett.': [1113, 1206, 1575, 1717, 3761, 4297, 4427], '447:': [1115, 1208, 1719, 3763, 4299, 4429], '5-9Crossref': [1116, 1209, 1720, 3764, 4300, 4430], '(271)': [1119, 1212, 1723, 3767, 4303], 'Thus,': [1122, 4371], 'cannot': [1128], 'only': [1129], 'serve': [1130], 'interfaces': [1132], 'insofar': [1151], 'contain': [1154], 'N-terminal': [1156], 'p53-binding': [1157], 'domain,': [1158], 'central': [1160], 'zinc-binding': [1161], 'motif,': [1162], 'C-terminal': [1165, 3544, 3712, 3903], '(15Sharp': [1169, 1680, 1766, 4260], '17Shvarts': [1215], 'Steegenga': [1217], 'W.T.': [1218], 'Riteco': [1219], 'Laar': [1222], 'Dekker': [1224], 'Bazuine': [1226], 'Ham': [1229], 'R.C.': [1230], 'Houven': [1233], 'Oordt': [1235], 'W.': [1236, 1306, 1422], 'Hateboer': [1237], 'Eb': [1241, 1815], 'A.J.': [1242, 1816], 'Jochemsen': [1243, 1309, 1425, 1821], 'A.G.': [1244, 1310, 1426, 1822], '1996;': [1247, 2225, 2877], '15:': [1248, 2226], '5349-5357Crossref': [1249], '(526)': [1252], 'Genetic': [1255], 'experiments': [1256, 1838, 2175, 2466, 2506, 3007, 3351], 'mice': [1258, 1446], 'shown': [1260, 1899, 2995, 3973], 'critical': [1267, 3942, 4067, 4184, 4197, 4221], 'roles': [1268], 'growth-suppressive': [1274], 'properties': [1275, 2677], '(18Montes': [1281, 1397], 'Oca': [1283, 1399], 'Luna': [1284, 1400], 'Wagner': [1286, 1402], 'D.S.': [1287, 1403], 'Lozano': [1288, 1311, 1404, 1427, 1475, 1497], '378:': [1292, 1408], '203-206Crossref': [1293, 1409], '(1218)': [1296, 1412], '19Parant': [1299, 1415], 'Chavez-Reyes': [1301, 1417], 'Little': [1303, 1419, 1807], 'N.A.': [1304, 1420, 1808], 'Yan': [1305, 1421], 'Reinke': [1307, 1423], 'V.': [1308, 1424], 'Genet.': [1314, 1430], '29:': [1316, 1432], '92-95Crossref': [1317, 1433], '(417)': [1320, 1436], '20Steinman': [1323], 'H.A.': [1324], 'Hoover': [1325], 'K.M.': [1326], 'Keeler': [1327], 'M.L.': [1328, 3640], 'Sands': [1329], 'A.T.': [1330], 'Jones': [1331], 'S.N.': [1332], 'Oncogene.': [1333, 3204, 3329], '24:': [1335], '7935-7940Crossref': [1336], '(35)': [1339], '21Toledo': [1342], 'F.': [1343, 3374, 3510], 'Krummel': [1344], 'K.A.': [1345], 'Lee': [1346], 'C.J.': [1347], 'Liu': [1348, 1495], 'C.W.': [1349, 3634], 'Rodewald': [1350], 'L.W.': [1351], 'Tang': [1352], 'Wahl': [1354], 'G.M.': [1355], 'Cancer': [1356, 1615], '9:': [1359], '273-285Abstract': [1360], '(144)': [1368], 'Mdm2-': [1371], 'MdmX-deficient': [1373], 'mice,': [1374], 'die': [1376], 'early': [1377], 'embryogenesis,': [1379], 'although': [1380], 'at': [1381, 2660, 2972, 3003], 'different': [1382, 3006, 3010, 3430, 3472], 'stages,': [1383], 'lethal': [1387], 'phenotype': [1388], 'concomitant': [1392], 'loss': [1393], 'expression': [1396, 2092, 2134, 2169, 2256, 2289, 2312, 2341, 2363, 2423, 2440, 2453, 2458, 2488, 2521, 2530, 2580, 2601, 2693, 2860, 3157, 3269, 3291], 'addition,': [1440, 2949, 3699], 'data': [1441, 3892], 'obtained': [1442, 1750, 1993, 2658, 3579, 3850, 4211, 4367], 'conditional': [1444], 'knockout': [1445], 'act': [1452], 'synergistically': [1453], 'regulation': [1456, 1466], 'Mdm2-independent': [1462], 'functions': [1463], '(22Grier': [1467], 'J.D.': [1468], 'Xiong': [1469], 'Elizondo-Fraire': [1471, 1493], 'A.C.': [1472, 1494], 'Parant': [1473], '26:': [1481], '192-198Crossref': [1482], '(119)': [1485], '23Xiong': [1488], 'Van': [1490], 'Pelt': [1491], 'C.S.': [1492], '103:': [1507, 1539], '3226-3231Crossref': [1508], '(129)': [1511], '24Francoz': [1514], 'Froment': [1516], 'Bogaerts': [1518], 'De': [1520], 'Clercq': [1521], 'Maetens': [1523], 'Doumont': [1525], 'Bellefroid': [1527], 'Marine': [1529], '3232-3237Crossref': [1540], '(202)': [1543], 'It': [1546], 'well': [1548], 'established': [1549], 'acts': [1552], 'p53,': [1557, 2183, 2344, 2583, 2745, 2789, 3836], 'whereas': [1558, 3491, 4178], 'does': [1560, 2454], 'appreciable': [1565], '(25Honda': [1568], 'Tanaka': [1570], 'Yasuda': [1572], '1997;': [1576], '420:': [1577], '25-27Crossref': [1578], '(1627)': [1581], '26Fang': [1584], 'Jensen': [1586], 'J.P.': [1587], 'Ludwig': [1588], 'R.L.': [1589], 'Vousden': [1590], 'K.H.': [1591], 'Weissman': [1592], 'A.M.': [1593], '275:': [1598], '8945-8951Abstract': [1599], '(889)': [1607], '27Michael': [1610], 'Oren': [1612, 2221], 'Semin.': [1614], '13:': [1618], '49-58Crossref': [1619], '(655)': [1622], '28Badciong': [1625, 4306], 'Haas': [1627, 1852, 4308], 'A.L.': [1628, 1853, 4309], '277:': [1633, 1858, 4314], '49668-49675Abstract': [1634, 1859, 4315], '(98)': [1642, 1867, 4323], '29Linares': [1645, 1870, 4326], 'L.K.': [1646, 1871, 2109, 2193, 4327], 'Hengstermann': [1647, 1872, 2110, 2194, 2237, 3238, 4328], 'Muller': [1651, 1876, 2114, 2198, 4332], '12009-12014Crossref': [1664, 1889, 2127, 2211, 4345], '(286)': [1667, 1892, 2130, 2214, 4348], 'As': [1670, 4397], 'indicated': [1671, 2354, 2571, 2592, 3094, 3460], 'above,': [1672], 'heteromeric': [1678, 4246], 'However,': [1726, 4160], 'functional': [1728], 'consequences': [1729], 'respect': [1738], 'still': [1746], 'controversially': [1747], 'discussed.': [1748], 'Results': [1749, 2994], 'overexpression': [1752], 'suggest': [1754], 'binding': [1756, 1841, 3735, 4145], 'interferes': [1759], '30Jackson': [1790], 'M.W.': [1791], 'Berberich': [1792], 'S.J.': [1793], '1001-1007Crossref': [1799], '(183)': [1802], '31Stad': [1805], 'Xirodimas': [1809], 'D.P.': [1810, 1818, 1921, 1929], 'Frenk': [1811], 'Lane': [1817, 1928], 'Saville': [1819, 1922], 'M.K.': [1820, 1923], 'Rep.': [1824], '2:': [1826], '1029-1034Crossref': [1827], '(190)': [1830], 'contrast,': [1834], 'stimulates': [1844], '(28Badciong': [1850], 'was': [1897, 2284, 2383, 2434, 2734, 2907, 3154, 3264, 3288, 3406, 3714, 3791, 3868, 4123, 4169, 4407], 'recently': [1898], 'addition': [1902], 'ubiquitination,': [1908, 2893], 'facilitates': [1910], 'ubiquitin-like': [1917], '(32Xirodimas': [1920], 'Bourdon': [1924], 'Hay': [1926], 'R.T.': [1927], '2004;': [1931], '118:': [1932], '83-97Abstract': [1933], '(445)': [1941], 'present': [1945], 'whether': [1950, 3658], 'affects': [1952], 'To': [1959, 2449, 3273, 3656, 3796], 'further': [1960], 'characterize': [1961], 'effect': [1972], 'activities,': [1978], 'The': [1991, 2168, 2410, 2764, 2836, 3070, 3220, 3451, 3953, 4096], 'results': [1992, 2650, 2657, 3577, 3849, 4210, 4365], 'required': [2005, 3112, 3664, 4018], 'This': [2045, 2472, 3770], 'supports': [2046], 'notion': [2048, 4191], 'intrinsic': [2054], 'actively': [2059], 'involved': [2060, 3624, 3908, 4055, 4142], 'Lines': [2070], 'Plasmids—H1299': [2072], 'cells': [2073, 2076, 2337, 2576, 2695, 3150, 3153, 3186, 3222, 3287, 3410, 3425, 3444, 3467], 'HEK293T': [2075, 2470, 3152], 'were': [2077, 2105, 2156, 2189, 2266, 2308, 2338, 2372, 2399, 2418, 2467, 2507, 2537, 2553, 2577, 2610, 2630, 2696, 2723, 2751, 2769, 2826, 2845, 2981, 2990, 3037, 3073, 3187, 3223, 3311, 3341, 3352, 3411, 3426, 3578, 3693, 3741, 3809, 3823, 3880, 4043, 4100, 4251, 4366], 'grown': [2078], "Dulbecco's": [2080], 'modified': [2081], "Eagle's": [2082], 'medium': [2083], 'supplemented': [2084], '10%': [2086, 2984], '(v/v)': [2087], 'fetal': [2088], 'bovine': [2089], 'serum.': [2090], 'Bacterial': [2091, 2133], 'constructs': [2093, 2135, 2170, 2342, 2364, 2581, 2602, 2701, 3158, 3292], 'S-transferase': [2096], '(GST)': [2097], 'fusion': [2098, 2138, 2830, 3029, 3064, 3813], 'wild-type': [2101, 2179, 2182, 2274, 2349, 2443, 2587, 2814, 3789, 3839, 4111, 4405], 'Hdm2': [2102, 2824, 3035, 3123, 3560, 3587], 'HdmX': [2104, 2188, 2367, 2452, 2475, 2605, 2818, 3067, 3110, 3176, 3306, 4243], 'described': [2106, 2190, 2510, 2863, 3193, 3233, 3318, 4119, 4385], 'previously': [2107, 2191], '(29Linares': [2108, 2192], 'GST': [2137, 2829, 3028, 3063, 3812], 'various': [2144, 2821, 3739, 3803], 'Hdm2,': [2151, 2816, 2936, 3574], 'respectively': [2152, 3841], '(see': [2153, 2260, 2532, 2729, 3218, 3403, 4146], 'Fig.': [2154, 2261, 2491, 3620, 3968], '1),': [2155], 'generated': [2157, 3694], 'PCR-based': [2159, 3696], 'approaches': [2160], '(further': [2161], 'details': [2162], 'will': [2163, 3567, 4355], 'provided': [2165], 'upon': [2166], 'request).': [2167], 'transient': [2173, 2255, 2692], 'transfection': [2174, 2542, 2547, 2615, 2728, 2732, 2759, 3216, 3316], '(Fig.': [2176, 3561], '4)': [2177], 'encoding': [2178, 2709, 3159, 3293, 3676, 3702], '(pCocMdm2),': [2181], 'His-tagged': [2184, 2282, 2345, 2519, 2584, 3163], 'ubiquitin,': [2185], 'HA-tagged': [2187, 2366, 2604, 2746, 2780], '33Haupt': [2217], 'Y.': [2218, 2220], 'Barak': [2219], '1596-1606Crossref': [2227], '(206)': [2230], '34Glockzin': [2233], 'Ogi': [2235, 3236], 'F.X.': [2236, 3237], 'Blattner': [2241, 3242], '23:': [2247, 3248], '8960-8969Crossref': [2248, 3249], '(81)': [2251, 3252], 'For': [2254, 2293, 2890, 3139, 3255], '4),': [2262], 'introduced': [2267], 'site-directed': [2269], 'mutagenesis': [2270], 'PCR': [2271], 'cDNA': [2276, 3701], 'frame': [2279], 'pCocMdm2.': [2281], 'expressed': [2285, 2827, 2846, 2934, 3027, 3062, 3278, 3810], 'from': [2286], 'eukaryotic': [2288], 'vector': [2290], 'pSG5.0': [2291], '(Stratagene).': [2292], 'yeast': [2294, 3745, 3853], 'two-hybrid': [2295, 3350, 3746, 3854], 'assays,': [2296], 'cDNAs': [2299, 3675], '(Mdm2,': [2300], 'mutants,': [2302, 2464, 3805], 'HdmX,': [2303, 2747, 2781, 2937, 4362], 'UbcH5b;': [2304], 'see': [2305], 'Table': [2306, 3404], '1)': [2307, 3405, 3621, 3969, 4135], 'cloned': [2309], 'vectors': [2313], 'pGBKT7': [2314], 'pGADT7': [2316], '(Clontech).FIGURE': [2317], '4HdmX': [2318], 'rescues': [2319, 2476, 3016], 'A,': [2335], 'H1299': [2336, 2575, 3149, 3286], 'cotransfected': [2339, 2578], '(His-ub),': [2347], '(wt)': [2350, 2588], 'absence': [2359, 2516, 2597, 2927, 3055], 'indicated.': [2369, 2607, 3069], 'Protein': [2370, 2535, 2608, 2721, 3309], 'extracts': [2371, 2417, 2536, 2609, 2722, 3310], 'prepared': [2373, 2538, 2611, 2724, 3312], '24': [2374, 2539, 2612, 2725, 3179, 3313], 'h': [2375, 2540, 2613, 2726, 3052, 3180, 3314], 'after': [2376, 2541, 2614, 2727, 3181, 3315], 'transfection,': [2377, 3182], '70%': [2379], 'extract': [2382], 'isolate': [2386], 'ubiquitinated': [2387, 2397, 2495, 2744, 3089, 3229], 'Ni2+-affinity': [2390, 2621], 'chromatography.': [2391, 2622], 'Upon': [2392, 2623, 3818], 'affinity': [2393, 2624], 'purification,': [2394, 2625, 3819], 'levels': [2395, 2424, 2441, 2489, 2550, 2626, 3340], 'determined': [2400, 2554, 2631, 2735, 2752, 3342, 3742], 'Western': [2402, 2556, 2633, 2754, 3344], 'blot': [2403, 2557, 2634, 2755, 3345], 'p53-specific': [2407, 2561, 2638], 'antibody': [2408, 2562, 2639, 2773, 2785, 2794], 'DO1.': [2409, 2563, 2640], 'remaining': [2411, 3221], '30%': [2412, 3183], 'cell': [2416], 'determine': [2421, 2438, 3214], 'HA-HdmX.': [2426], 'Note': [2427, 2647, 3102], 'under': [2429, 3046, 3189, 3225, 3725], 'conditions': [2431, 3049, 3191, 3227, 3730], 'used,': [2432], 'possible': [2436], 'mutants.': [2448, 3588, 4396], 'ensure': [2450], 'showed': [2473], 'without': [2485], 'affecting': [2486], '(supplemental': [2490], '5).': [2492], 'Asterisk': [2493, 2641], 'denotes': [2494, 2642], 'forms': [2496, 2644, 3090], 'p53.': [2498, 2646], 'B,': [2499], 'score': [2501], 'degradation,': [2504], 'cotransfection': [2505], 'A': [2512], 'construct': [2522, 2531, 2708, 3270], 'lower': [2525], 'amounts': [2526], '"Experimental': [2533], 'Procedures").': [2534], 'adjusted': [2544, 2761], 'according': [2545, 2716, 3390], 'efficiency,': [2548], 'using': [2559, 2758, 2857, 3267, 3355], 'Loading': [2564], 'individual': [2567, 3456], 'lanes': [2568], 'C,': [2574], 'Nedd8,': [2585], 'neddylated': [2617, 2628, 2643], 'purified': [2619, 3231], 'presented': [2651], 'A–C': [2653], 'representative': [2655, 3001], 'four': [2662, 3612], 'independent': [2663], 'experiments.View': [2664], 'Large': [2665, 3131], 'Image': [2666, 3132], 'Figure': [2667, 3133], 'ViewerDownload': [2668, 3134], 'Hi-res': [2669, 3135], 'image': [2670, 3136], 'Download': [2671, 3137], '(PPT)TABLE': [2672], '1Binding': [2673], 'mutantsAD-Mdm2AD-HdmXAD-selfAD-Mdm2AD-HdmXAD-selfBD-UbcH5E3': [2680], 'activity-MdmX+MdmXBD------AD---Mdm2++++++-++-Mdm2++++++G446S++++++-++-G446S+++++G446A++++++-++-G446A++++++G451S++++++-++-G451S++/-++T453C++++-++-T453C++/-++T453A++++++-++-T453A++/-++ΔC7++----ΔC7+--I448E++----I448E++--L456E++++-++-L456E++-+/-I483E++--+-I483E++-+/-L485E++++++-++-L485E++++++AdeUraHis': [2682], 'Open': [2683], 'table': [2684], 'new': [2687], 'tab': [2688], 'Transfection': [2689], 'Antibodies—In': [2691], 'experiments,': [2694, 2813], 'transfected': [2697, 3155, 3289], 'reporter': [2707, 3431, 3473], 'β-galactosidase': [2710, 2738], 'lipofection': [2712], '(Lipofectamine': [2713], 'Invitrogen)': [2715], "manufacturer's": [2719, 3393], 'instructions.': [2720], 'below),': [2730], 'efficiency': [2733, 2760, 3217, 3718], 'measuring': [2737], 'Levels': [2740], 'amounts.': [2763], 'antibodies': [2765], 'detection': [2768], 'mouse': [2771, 2783, 2792, 3554], 'monoclonal': [2772, 2784, 2793], 'HA.11': [2774], '(Hiss': [2775], 'Diagnostics,': [2776], 'Freiburg,': [2777], 'Germany)': [2778], 'DO1': [2786], '(Calbiochem)': [2787], 'SMP14': [2795], '(Santa': [2796], 'Cruz': [2797], 'Biotechnology)': [2798], 'detects': [2800], 'Hdm2.': [2804], 'Ubiquitination,': [2805], 'Neddylation,': [2806], 'Degradation': [2808], 'Assays—For': [2809], 'Escherichia': [2833], 'coli': [2834, 2854], 'DH5α.': [2835], 'ubiquitin-activating': [2837, 2913], 'enzyme': [2838, 2843], 'E1': [2839], 'UbcH5b': [2844], 'baculovirus': [2849], 'BL21': [2855], 'pET': [2859], '(35Nuber': [2864], 'Schwarz': [2866], 'Kaiser': [2868], 'Schneider': [2870], '271:': [2878], '2795-2800Abstract': [2879], '(138)': [2887], '1': [2894, 2960, 3397, 3843, 4175], 'μl': [2895], 'rabbit': [2897], 'reticulocyte': [2898], 'lysate': [2899], 'extract-translated': [2900], '35S-labeled': [2901, 2988, 3835], '(p53,': [2903], 'HdmX)': [2906], 'incubated': [2908, 3038], '50': [2910, 2915, 2957], 'ng': [2911, 2916], 'enzyme,': [2914], 'UbcH5,': [2918], '20': [2920], 'μg': [2921, 3398], '(Sigma)': [2924], 'bacterially': [2933, 3061], 'mutant': [2941], '(200': [2943, 3161, 3173, 3303], 'ng)': [2944], '40-μl': [2946], 'volumes.': [2947], 'reactions': [2950], 'contained': [2951], '25': [2952], 'mm': [2953, 2958, 2961, 2964, 2968], 'Tris-HCl': [2954], '(pH': [2955], '7.5),': [2956], 'NaCl,': [2959], 'dithiothreitol,': [2962], '2': [2963, 2976, 3051], 'ATP,': [2965], '4': [2967], 'MgCl2.': [2969], 'After': [2970, 3422], 'incubation': [2971], '30': [2973], '°C': [2974], 'h,': [2977], 'total': [2978], 'reaction': [2979, 3071], 'mixtures': [2980], 'electrophoresed': [2982], 'SDS-polyacrylamide': [2985], 'gels,': [2986], 'detected': [2991], 'fluorography.': [2993, 3079], '(Figs.': [2996, 3842, 4174], '1,': [2997], '2,': [2998], '3)': [2999], 'preparations': [3011], 'each': [3013], 'protein.FIGURE': [3014], '3HdmX': [3015], 'E3-defective': [3021], 'vitro.': [3025], 'Bacterially': [3026], 'translated': [3042, 3834], 'radiolabeled': [3044], 'standard': [3047, 3726], 'products': [3072], 'analyzed': [3074], 'SDS-PAGE': [3076], 'followed': [3077, 3445], 'Running': [3080], 'positions': [3081], 'nonmodified': [3084], 'arrowhead': [3097], 'asterisk,': [3100], 'intact': [3105], 'rescue': [3114, 4389], '(data': [3125, 3731, 3887, 4206], 'shown).': [3127, 3889], 'wt,': [3128], 'wild': [3129], 'type.View': [3130], '(PPT)': [3138], 'cells,': [3144, 3260, 3281], 'one': [3145, 3282], '6-cm': [3146, 3283], 'plate': [3147, 3284], 'ng),': [3162, 3174, 3296, 3304], '(1': [3165], 'μg),': [3166], '(600': [3177, 3307], 'ng).': [3178, 3308], 'lysed': [3188, 3224], 'nondenaturing': [3190], '(36Hengstermann': [3194, 3319], 'Whitaker': [3196, 3321], 'N.J.': [3197, 3322], 'Zimmer': [3198, 3323], 'Zentgraf': [3200, 3325], '1998;': [3205, 3330], '17:': [3206, 3331], '2933-2941Crossref': [3207, 3332], '(29)': [3210, 3335], 'Scholar)': [3212, 3389, 4350], 'above).': [3219], 'denaturing': [3226], '(34Glockzin': [3234], 'same': [3262], 'procedure': [3263], 'applied': [3265], 'His-Nedd8.': [3272], 'monitor': [3274], 'degradation': [3275], 'ectopically': [3277], '(10': [3295], 'Scholar),': [3337], 'analysis.': [3346], 'Yeast': [3347], 'Two-hybrid': [3348], 'Assays—Yeast': [3349], 'MatchMaker': [3357], 'Saccharomyces': [3361], 'cerevisiae': [3362], 'strain': [3363], 'KF1': [3364], '(37Butz': [3365, 3501], 'Denk': [3367, 3503], 'Ullmann': [3369, 3505], 'Hoppe-Seyler': [3373, 3509], '97:': [3383, 3519], '6693-6697Crossref': [3384, 3520], '(226)': [3387, 3523], 'instructions': [3394], '(Clontech).': [3395], 'Briefly,': [3396], 'plasmids': [3402], 'transformed,': [3407], 'transformed': [3409], 'selected': [3412], 'growth': [3414, 3441, 3487, 3492], 'media': [3416], 'deficient': [3417], 'leucine': [3419], 'tryptophan.': [3421], '3': [3423], 'days,': [3424], 'streaked': [3427], 'plates': [3432, 3478, 3495], '(deficient': [3433], 'histidine,': [3435], 'adenine,': [3436], 'uracil,': [3438], 'respectively),': [3439], 'up': [3447], '5': [3449], 'days.': [3450], 'relative': [3452], 'strength': [3453], 'protein/protein': [3457], 'grow': [3469], 'plates.': [3474], 'Growth': [3475], 'uracil-deficient': [3477], 'requires': [3479, 3496], 'stronger': [3480], 'adenine-deficient': [3489], 'plates,': [3490], 'histidine-deficient': [3494], 'efficient': [3499, 4409], 'Mutational': [3526], 'Analysis': [3527], 'Ubiquitin': [3530, 4230], 'Ligase': [3531, 4231], 'Activity': [3532, 4232], 'Mdm2—The': [3534], 'located': [3541], '60': [3545], 'highly': [3551], 'conserved': [3552], 'human': [3558, 4241], 'ortholog': [3559, 4242], '1).': [3562, 3795], 'following,': [3565], 'there': [3566, 4354], 'no': [3569, 4357], 'differentiation': [3570, 4358], 'because': [3575, 3925, 4048, 4363], 'crystal': [3592], 'Prp19,': [3598], 'dimeric': [3600], 'been': [3603, 3972, 4051], 'proposed': [3604], 'hydrophobic': [3613], '(Ile-448,': [3615], 'Leu-456,': [3616, 3898], 'Ile-483,': [3617, 3899], 'Leu-485;': [3619], 'being': [3622], 'critically': [3623], 'dimer': [3630], '(38Vander': [3632], 'Kooi': [3633], 'Ohi': [3635], 'M.D.': [3636], 'Rosenberg': [3637], 'J.A.': [3638], 'Oldham': [3639], 'Newcomer': [3641], 'M.E.': [3642], 'Gould': [3643], 'K.L.': [3644, 4081], 'Chazin': [3645], 'W.J.': [3646], '121-130Crossref': [3650], '(90)': [3653], 'test': [3657, 3797], 'may': [3661, 4065], 'indeed': [3662], 'possibly': [3669], 'single': [3677], 'point': [3678, 4098], 'which': [3683], 'substituted': [3690], 'glutamate,': [3692], 'mutagenesis.': [3697], 'truncated': [3704], 'devoid': [3708], 'seven': [3711], 'generated.': [3715], 'rather': [3723, 3922], 'low': [3724], 'coprecipitation': [3729], 'shown),': [3733, 4208], 'abilities': [3736], '(16Tanimura': [3748, 4414], 'revealed': [3771], 'exception': [3775, 3858], 'Mdm2L485E,': [3777, 3860], 'themselves': [3786, 4108], 'significantly': [3792, 3869, 4170], '(Table': [3794, 4134], 'coli.': [3817], 'tested': [3824, 4101, 4374], 'ubiquitinate': [3831], '2).': [3845], 'Similar': [3846], 'system,': [3855], 'reduced,': [3870], 'regardless': [3871], 'substrate.': [3875], 'inactive': [3881], 'auto-ubiquitination': [3885], 'assays': [3886], 'Although': [3890, 4008], 'do': [3893], 'prove': [3895], 'Ile-448,': [3897], 'very': [3902], '7': [3904], 'directly': [3907, 4141], 'homomers': [3914, 3921, 4133], '(note': [3915], 'referred': [3919], 'homodimers': [3924], 'exact': [3927], 'oligomeric': [3928], 'state': [3929], 'full-length': [3931], 'known),': [3935], 'they': [3936], 'contains': [3959], 'putative': [3961], 'WalkerA': [3962, 4028, 4041], 'motif': [3963, 4029, 4042], '(amino': [3964], '446–452;': [3967], 'ATP': [3976, 4015], '(39Poyurovsky': [3977], 'M.V.': [3978], 'Jacq': [3979], 'X.': [3980], 'Ma': [3981], 'Karni-Schmidt': [3983], 'Parker': [3985], 'P.J.': [3986], 'Chalfie': [3987], 'Manley': [3989], 'J.L.': [3990], 'Prives': [3991], '12:': [3996], '875-887Abstract': [3997], '(58)': [4005], 'activity,': [4022], 'glycine': [4024], '(Gly-446': [4030], 'Gly-451)': [4032], 'threonine': [4035], 'residue': [4036], '(Thr-453)': [4037], 'adjacent': [4038], 'subjected': [4044], 'analysis,': [4047], 'Thr-453': [4049, 4064, 4122, 4138], 'coordinating': [4057], 'Zn2+,': [4058], 'thus,': [4060], 'region': [4062, 4215], 'surrounding': [4063], 'integrity': [4070], '(40Boddy': [4076], 'M.N.': [4077], 'Freemont': [4078], 'Borden': [4080], 'Trends': [4082], '1994;': [4085], '19:': [4086], '198-199Abstract': [4087], '(84)': [4093], 'above.': [4120], 'Surprisingly,': [4121], 'essential': [4125], 'Zn2+': [4144], '"Discussion").': [4147], 'Similarly,': [4148], 'mutation': [4149], 'Gly-446': [4151, 4179], 'Gly-451': [4153], 'interaction.': [4159], 'Mdm2G451S,': [4165], 'Mdm2T453C,': [4166], 'Mdm2T453A': [4168], '2),': [4177], 'appeared': [4180], 'less': [4183], 'Together': [4188], 'Cys-447': [4193], 'encompassing': [4216], '447–453': [4218], 'importance': [4222], 'Rescues': [4228], 'Mdm2-Hdm2': [4234], 'Mutants': [4235], 'Vitro—Mouse': [4237], 'reported': [4252, 4398], 'stimulate': [4254], '(in': [4351], 'following': [4353], 'proteins).': [4370], 'next': [4373], 'above': [4386], 'previously,': [4399], 'Sco': [4432]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2040050240', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-17T01:03:51.046656', 'created_date': '2016-06-24'}