Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2039911756', 'doi': 'https://doi.org/10.1002/ana.10424', 'title': "Assessing the onset of structural change in familial Alzheimer's disease", 'display_name': "Assessing the onset of structural change in familial Alzheimer's disease", 'publication_year': 2002, 'publication_date': '2002-12-04', 'ids': {'openalex': 'https://openalex.org/W2039911756', 'doi': 'https://doi.org/10.1002/ana.10424', 'mag': '2039911756', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12557284'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/ana.10424', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S114530997', 'display_name': 'Annals of Neurology', 'issn_l': '0364-5134', 'issn': ['0364-5134', '1531-8249'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5045615014', 'display_name': 'Jonathan M. Schott', 'orcid': 'https://orcid.org/0000-0003-2059-024X'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Jonathan M. Schott', 'raw_affiliation_strings': ['Dementia Research Group, Institute of Neurology, University College London, Queen Square, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'Dementia Research Group, Institute of Neurology, University College London, Queen Square, United Kingdom.', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018836358', 'display_name': 'Nick C. Fox', 'orcid': 'https://orcid.org/0000-0002-6660-657X'}, 'institutions': [{'id': 'https://openalex.org/I4210126463', 'display_name': 'UK Dementia Research Institute', 'ror': 'https://ror.org/02wedp412', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210126463']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I4210151618', 'display_name': 'National Hospital for Neurology and Neurosurgery', 'ror': 'https://ror.org/048b34d51', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1340918713', 'https://openalex.org/I4210151618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Nick C. Fox', 'raw_affiliation_strings': ['Dementia Research Group, Institute of Neurology, University College London, Queen Square, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Dementia Research Group, Institute of Neurology, University College London, Queen Square, London, United Kingdom', 'institution_ids': ['https://openalex.org/I4210126463', 'https://openalex.org/I45129253', 'https://openalex.org/I4210151618']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088018986', 'display_name': 'Chris Frost', 'orcid': 'https://orcid.org/0000-0003-0098-9915'}, 'institutions': [{'id': 'https://openalex.org/I4210126463', 'display_name': 'UK Dementia Research Institute', 'ror': 'https://ror.org/02wedp412', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210126463']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I4210151618', 'display_name': 'National Hospital for Neurology and Neurosurgery', 'ror': 'https://ror.org/048b34d51', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1340918713', 'https://openalex.org/I4210151618']}, {'id': 'https://openalex.org/I4210089966', 'display_name': 'London School of Hygiene & Tropical Medicine', 'ror': 'https://ror.org/00a0jsq62', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I4210089966']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Chris Frost', 'raw_affiliation_strings': ['Dementia Research Group, Institute of Neurology, University College London, Queen Square, London, United Kingdom', 'Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Dementia Research Group, Institute of Neurology, University College London, Queen Square, London, United Kingdom', 'institution_ids': ['https://openalex.org/I4210126463', 'https://openalex.org/I45129253', 'https://openalex.org/I4210151618']}, {'raw_affiliation_string': 'Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom', 'institution_ids': ['https://openalex.org/I4210089966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004911280', 'display_name': 'Rachael I. Scahill', 'orcid': 'https://orcid.org/0000-0002-1832-106X'}, 'institutions': [{'id': 'https://openalex.org/I4210126463', 'display_name': 'UK Dementia Research Institute', 'ror': 'https://ror.org/02wedp412', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210126463']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I4210151618', 'display_name': 'National Hospital for Neurology and Neurosurgery', 'ror': 'https://ror.org/048b34d51', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1340918713', 'https://openalex.org/I4210151618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Rachael I. Scahill', 'raw_affiliation_strings': ['Dementia Research Group, Institute of Neurology, University College London, Queen Square, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Dementia Research Group, Institute of Neurology, University College London, Queen Square, London, United Kingdom', 'institution_ids': ['https://openalex.org/I4210126463', 'https://openalex.org/I45129253', 'https://openalex.org/I4210151618']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111930088', 'display_name': 'John C. Janssen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126463', 'display_name': 'UK Dementia Research Institute', 'ror': 'https://ror.org/02wedp412', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210126463']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I4210151618', 'display_name': 'National Hospital for Neurology and Neurosurgery', 'ror': 'https://ror.org/048b34d51', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1340918713', 'https://openalex.org/I4210151618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'John C. Janssen', 'raw_affiliation_strings': ['Dementia Research Group, Institute of Neurology, University College London, Queen Square, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Dementia Research Group, Institute of Neurology, University College London, Queen Square, London, United Kingdom', 'institution_ids': ['https://openalex.org/I4210126463', 'https://openalex.org/I45129253', 'https://openalex.org/I4210151618']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030979652', 'display_name': 'Dennis Chan', 'orcid': 'https://orcid.org/0000-0003-2089-1501'}, 'institutions': [{'id': 'https://openalex.org/I4210126463', 'display_name': 'UK Dementia Research Institute', 'ror': 'https://ror.org/02wedp412', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210126463']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I4210151618', 'display_name': 'National Hospital for Neurology and Neurosurgery', 'ror': 'https://ror.org/048b34d51', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1340918713', 'https://openalex.org/I4210151618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Dennis Chan', 'raw_affiliation_strings': ['Dementia Research Group, Institute of Neurology, University College London, Queen Square, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Dementia Research Group, Institute of Neurology, University College London, Queen Square, London, United Kingdom', 'institution_ids': ['https://openalex.org/I4210126463', 'https://openalex.org/I45129253', 'https://openalex.org/I4210151618']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111741435', 'display_name': 'Rhian Jenkins', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126463', 'display_name': 'UK Dementia Research Institute', 'ror': 'https://ror.org/02wedp412', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210126463']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I4210151618', 'display_name': 'National Hospital for Neurology and Neurosurgery', 'ror': 'https://ror.org/048b34d51', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1340918713', 'https://openalex.org/I4210151618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Rhian Jenkins', 'raw_affiliation_strings': ['Dementia Research Group, Institute of Neurology, University College London, Queen Square, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Dementia Research Group, Institute of Neurology, University College London, Queen Square, London, United Kingdom', 'institution_ids': ['https://openalex.org/I4210126463', 'https://openalex.org/I45129253', 'https://openalex.org/I4210151618']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5032450718', 'display_name': 'Martin N. Rossor', 'orcid': 'https://orcid.org/0000-0001-8215-3120'}, 'institutions': [{'id': 'https://openalex.org/I4210126463', 'display_name': 'UK Dementia Research Institute', 'ror': 'https://ror.org/02wedp412', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210126463']}, {'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I4210151618', 'display_name': 'National Hospital for Neurology and Neurosurgery', 'ror': 'https://ror.org/048b34d51', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1340918713', 'https://openalex.org/I4210151618']}, {'id': 'https://openalex.org/I47508984', 'display_name': 'Imperial College London', 'ror': 'https://ror.org/041kmwe10', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I47508984']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Martin N. Rossor', 'raw_affiliation_strings': ['Dementia Research Group, Institute of Neurology, University College London, Queen Square, London, United Kingdom', 'Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College of Science, Engineering and Medicine, London, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Dementia Research Group, Institute of Neurology, University College London, Queen Square, London, United Kingdom', 'institution_ids': ['https://openalex.org/I4210126463', 'https://openalex.org/I45129253', 'https://openalex.org/I4210151618']}, {'raw_affiliation_string': 'Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College of Science, Engineering and Medicine, London, United Kingdom', 'institution_ids': ['https://openalex.org/I47508984']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3610, 'currency': 'USD', 'value_usd': 3610, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 5.869, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 163, 'citation_normalized_percentile': {'value': 0.918862, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '53', 'issue': '2', 'first_page': '181', 'last_page': '188'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10009', 'display_name': 'Dementia and Cognitive Impairment Research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10241', 'display_name': 'Functional Brain Connectivity Studies', 'score': 0.9923, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cerebral-atrophy', 'display_name': 'Cerebral atrophy', 'score': 0.43254226}], 'concepts': [{'id': 'https://openalex.org/C2781172350', 'wikidata': 'https://www.wikidata.org/wiki/Q194520', 'display_name': 'Atrophy', 'level': 2, 'score': 0.88583136}, {'id': 'https://openalex.org/C2781099131', 'wikidata': 'https://www.wikidata.org/wiki/Q744385', 'display_name': 'Temporal lobe', 'level': 3, 'score': 0.8743414}, {'id': 'https://openalex.org/C65835030', 'wikidata': 'https://www.wikidata.org/wiki/Q1030681', 'display_name': 'Brain size', 'level': 3, 'score': 0.567299}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.5290336}, {'id': 'https://openalex.org/C2781161787', 'wikidata': 'https://www.wikidata.org/wiki/Q48360', 'display_name': 'Hippocampus', 'level': 2, 'score': 0.5183862}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.51615655}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.46690208}, {'id': 'https://openalex.org/C2777910003', 'wikidata': 'https://www.wikidata.org/wiki/Q1707292', 'display_name': 'Asymptomatic', 'level': 2, 'score': 0.46462804}, {'id': 'https://openalex.org/C2779281540', 'wikidata': 'https://www.wikidata.org/wiki/Q5062122', 'display_name': 'Central nervous system disease', 'level': 2, 'score': 0.44502544}, {'id': 'https://openalex.org/C2779717322', 'wikidata': 'https://www.wikidata.org/wiki/Q1620193', 'display_name': 'Cerebral atrophy', 'level': 3, 'score': 0.43254226}, {'id': 'https://openalex.org/C207886595', 'wikidata': 'https://www.wikidata.org/wiki/Q1456138', 'display_name': 'Pathological', 'level': 2, 'score': 0.4290011}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4199409}, {'id': 'https://openalex.org/C2779483572', 'wikidata': 'https://www.wikidata.org/wiki/Q83030', 'display_name': 'Dementia', 'level': 3, 'score': 0.41471574}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.35501832}, {'id': 'https://openalex.org/C143409427', 'wikidata': 'https://www.wikidata.org/wiki/Q161238', 'display_name': 'Magnetic resonance imaging', 'level': 2, 'score': 0.3513252}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.3444456}, {'id': 'https://openalex.org/C2778186239', 'wikidata': 'https://www.wikidata.org/wiki/Q41571', 'display_name': 'Epilepsy', 'level': 2, 'score': 0.27764204}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.24572945}, {'id': 'https://openalex.org/C126838900', 'wikidata': 'https://www.wikidata.org/wiki/Q77604', 'display_name': 'Radiology', 'level': 1, 'score': 0.18060446}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.08471054}], 'mesh': [{'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001284', 'descriptor_name': 'Atrophy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018728', 'descriptor_name': 'Entorhinal Cortex', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D018728', 'descriptor_name': 'Entorhinal Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006624', 'descriptor_name': 'Hippocampus', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006624', 'descriptor_name': 'Hippocampus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008279', 'descriptor_name': 'Magnetic Resonance Imaging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013702', 'descriptor_name': 'Temporal Lobe', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D013702', 'descriptor_name': 'Temporal Lobe', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/ana.10424', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S114530997', 'display_name': 'Annals of Neurology', 'issn_l': '0364-5134', 'issn': ['0364-5134', '1531-8249'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12557284', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.63}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1517008319', 'https://openalex.org/W1847168837', 'https://openalex.org/W1974621282', 'https://openalex.org/W1976076281', 'https://openalex.org/W1976473223', 'https://openalex.org/W1985612893', 'https://openalex.org/W1992182990', 'https://openalex.org/W2009739635', 'https://openalex.org/W2012133068', 'https://openalex.org/W2015629132', 'https://openalex.org/W2025915778', 'https://openalex.org/W2044367669', 'https://openalex.org/W2046572522', 'https://openalex.org/W2052742260', 'https://openalex.org/W2055106796', 'https://openalex.org/W2063136428', 'https://openalex.org/W2087964262', 'https://openalex.org/W2089244634', 'https://openalex.org/W2095422335', 'https://openalex.org/W2101421921', 'https://openalex.org/W2114545663', 'https://openalex.org/W2122131078', 'https://openalex.org/W2124114508', 'https://openalex.org/W2127384340', 'https://openalex.org/W2134547791', 'https://openalex.org/W2156220037', 'https://openalex.org/W2161144725', 'https://openalex.org/W2171051269', 'https://openalex.org/W2394700887', 'https://openalex.org/W2796616088', 'https://openalex.org/W4241951539', 'https://openalex.org/W4249221250'], 'related_works': ['https://openalex.org/W3026950055', 'https://openalex.org/W2392600402', 'https://openalex.org/W2359577892', 'https://openalex.org/W220777649', 'https://openalex.org/W2078396110', 'https://openalex.org/W2061907775', 'https://openalex.org/W2039911756', 'https://openalex.org/W2014991155', 'https://openalex.org/W2000936098', 'https://openalex.org/W1997829388'], 'abstract_inverted_index': {'Abstract': [0], 'Regional': [1], 'and': [2, 16, 39, 58, 91, 102, 121, 141, 187, 192], 'global': [3], 'cerebral': [4], 'atrophy': [5, 17, 136, 160, 182, 195], 'are': [6, 184], 'inevitable': [7], 'features': [8], 'of': [9, 19, 52, 65, 81, 95, 190, 204], "Alzheimer's": [10], 'disease': [11], '(AD).': [12], 'We': [13, 175], 'assessed': [14], 'volumes': [15, 94], 'rates': [18, 115, 137, 183], 'brain': [20, 49], 'structures': [21, 99], 'in': [22, 78, 112, 126, 149], 'patients': [23, 35, 90, 127, 150, 172], 'with': [24, 36, 129], 'familial': [25], 'AD': [26, 38, 191], 'during': [27], 'the': [28, 202], 'period': [29], 'that': [30, 177, 193], 'they': [31], 'developed': [32], 'symptoms.': [33, 205], 'Five': [34], 'presymptomatic': [37], '20': [40], 'controls': [41, 130], 'had': [42], 'two': [43], 'or': [44, 86], 'more': [45], 'annual': [46], 'volumetric': [47], 'MRI': [48], 'scans.': [50, 72], 'Volumes': [51], 'brain,': [53, 83, 117], 'ventricles,': [54], 'temporal': [55, 84, 97, 118, 158, 180], 'lobes,': [56], 'hippocampi,': [57], 'entorhinal': [59], 'cortices': [60], '(ECs)': [61], 'were': [62, 68, 74, 104, 123, 143, 173], 'measured.': [63], 'Rates': [64], 'volume': [66, 88], 'change': [67], 'calculated': [69], 'from': [70, 138], 'serial': [71], 'There': [73], 'no': [75], 'significant': [76], 'differences': [77], 'baseline': [79], 'measures': [80], 'whole': [82], 'lobe,': [85, 119], 'ventricular': [87], 'between': [89], 'controls;': [92], 'averaged': [93], 'medial': [96, 157, 179], 'lobe': [98, 159, 181], '(both': [100], 'hippocampi': [101, 140], 'ECs)': [103], '16.6%': [105], '(95%': [106, 145, 164], 'confidence': [107], 'interval': [108], '[CI],': [109], '3.3–28.0%)': [110], 'lower': [111], 'patients.': [113], 'Atrophy': [114], 'for': [116], 'hippocampus,': [120], 'EC': [122], 'significantly': [124], 'increased': [125, 178], 'compared': [128], '(': [131], 'p': [132], '<': [133], '0.05).': [134], 'Averaged': [135], 'both': [139], 'ECs': [142], '5.1%': [144], 'CI,': [146, 165], '3.0–7.1%)': [147], 'greater': [148], 'than': [151], 'controls.': [152], 'Linear': [153], 'extrapolation': [154], 'backward': [155], 'suggested': [156], 'commenced': [161], '3.5': [162], 'years': [163, 200], '0.7–7.5': [166], 'years)': [167], 'before': [168, 201], 'onset,': [169], 'when': [170], 'all': [171], 'asymptomatic.': [174], 'conclude': [176], 'an': [185], 'early': [186], 'distinguishing': [188], 'feature': [189], 'pathological': [194], 'probably': [196], 'is': [197], 'occurring': [198], 'several': [199], 'onset': [203], 'Ann': [206], 'Neurol': [207], '2003;53:000–000': [208]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2039911756', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-12T19:13:43.999578', 'created_date': '2016-06-24'}