Title: Reagents For The Selective Immobilization Of Oligonucleotides On Solid Supports
Abstract: Abstract New reagents (CPGs and phosphoramidites) for automatic solid phase synthesis of modified oligonucleotides were designed. Three oligonucleotides carrying fluorescent label at the 5′-terminus and an anchor group at the 3′-terminus were prepared and their immobilization in orthogonal conditions on solid supports was studied. Keywords: Oligonucleotidesimmobilizationclick chemistrystreptavidin-biotin Acknowledgments We are grateful to Youri Habrus and Marina Zhilinskaya (Institute of Phisical Organic Chemistry NAS, Minsk, Belarus) for the modified olidonucleotides synthesis. The research was supported by grants from the Belarussian Fund for Basic Research (project B06R-004) and Russian Fund for Basic Research (project 06-04-81019).
Publication Year: 2007
Publication Date: 2007-11-26
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 2
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