Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2039763161', 'doi': 'https://doi.org/10.1016/s0140-6736(74)91263-x', 'title': 'A DOUBLE-BLIND CROSSOVER SEQUENTIAL TRIAL OF ORAL THYROTROPHIN-RELEASING HORMONE IN DEPRESSION', 'display_name': 'A DOUBLE-BLIND CROSSOVER SEQUENTIAL TRIAL OF ORAL THYROTROPHIN-RELEASING HORMONE IN DEPRESSION', 'publication_year': 1974, 'publication_date': '1974-05-01', 'ids': {'openalex': 'https://openalex.org/W2039763161', 'doi': 'https://doi.org/10.1016/s0140-6736(74)91263-x', 'mag': '2039763161', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/4133645'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0140-6736(74)91263-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S49861241', 'display_name': 'The Lancet', 'issn_l': '0140-6736', 'issn': ['0140-6736', '1474-547X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034927076', 'display_name': 'C.Q. Mountjoy', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800516725', 'display_name': 'Royal Victoria Infirmary', 'ror': 'https://ror.org/01p19k166', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800516725', 'https://openalex.org/I2801663869']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'C.Q. Mountjoy', 'raw_affiliation_strings': ['Departments of Psychological Medicine, Medicine and Clinical Biochemistry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Departments of Psychological Medicine, Medicine and Clinical Biochemistry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom', 'institution_ids': ['https://openalex.org/I2800516725']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040655024', 'display_name': 'Mayara Morena Dél Cambre Amaral Weller', 'orcid': 'https://orcid.org/0000-0002-7216-4587'}, 'institutions': [{'id': 'https://openalex.org/I2800516725', 'display_name': 'Royal Victoria Infirmary', 'ror': 'https://ror.org/01p19k166', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800516725', 'https://openalex.org/I2801663869']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'M. Weller', 'raw_affiliation_strings': ['Departments of Psychological Medicine, Medicine and Clinical Biochemistry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Departments of Psychological Medicine, Medicine and Clinical Biochemistry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom', 'institution_ids': ['https://openalex.org/I2800516725']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049613488', 'display_name': 'R. Hall', 'orcid': 'https://orcid.org/0000-0003-3009-7301'}, 'institutions': [{'id': 'https://openalex.org/I2800516725', 'display_name': 'Royal Victoria Infirmary', 'ror': 'https://ror.org/01p19k166', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800516725', 'https://openalex.org/I2801663869']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'R. Hall', 'raw_affiliation_strings': ['Departments of Psychological Medicine, Medicine and Clinical Biochemistry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Departments of Psychological Medicine, Medicine and Clinical Biochemistry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom', 'institution_ids': ['https://openalex.org/I2800516725']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072635780', 'display_name': 'J. S. Price', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800516725', 'display_name': 'Royal Victoria Infirmary', 'ror': 'https://ror.org/01p19k166', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800516725', 'https://openalex.org/I2801663869']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'J.S. Price', 'raw_affiliation_strings': ['Departments of Psychological Medicine, Medicine and Clinical Biochemistry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Departments of Psychological Medicine, Medicine and Clinical Biochemistry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom', 'institution_ids': ['https://openalex.org/I2800516725']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072400333', 'display_name': 'Peter Hunter', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800516725', 'display_name': 'Royal Victoria Infirmary', 'ror': 'https://ror.org/01p19k166', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800516725', 'https://openalex.org/I2801663869']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'P. Hunter', 'raw_affiliation_strings': ['Departments of Psychological Medicine, Medicine and Clinical Biochemistry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Departments of Psychological Medicine, Medicine and Clinical Biochemistry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom', 'institution_ids': ['https://openalex.org/I2800516725']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103403067', 'display_name': 'J.H. Dewar', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800516725', 'display_name': 'Royal Victoria Infirmary', 'ror': 'https://ror.org/01p19k166', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800516725', 'https://openalex.org/I2801663869']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'J.H. Dewar', 'raw_affiliation_strings': ['Departments of Psychological Medicine, Medicine and Clinical Biochemistry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Departments of Psychological Medicine, Medicine and Clinical Biochemistry, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, United Kingdom', 'institution_ids': ['https://openalex.org/I2800516725']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 6830, 'currency': 'USD', 'value_usd': 6830, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 13.19, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 60, 'citation_normalized_percentile': {'value': 0.874241, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '303', 'issue': '7864', 'first_page': '958', 'last_page': '960'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10293', 'display_name': 'Thyroid Disease and Hormone Regulation', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10293', 'display_name': 'Thyroid Disease and Hormone Regulation', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10529', 'display_name': 'Effects of Stress on Brain Function and Health', 'score': 0.9891, 'subfield': {'id': 'https://openalex.org/subfields/2802', 'display_name': 'Behavioral Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11521', 'display_name': "Diagnosis and Management of Sjögren's Syndrome", 'score': 0.9821, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/crossover-study', 'display_name': 'Crossover study', 'score': 0.8477559}, {'id': 'https://openalex.org/keywords/thyroid-hormone', 'display_name': 'Thyroid Hormone', 'score': 0.577873}, {'id': 'https://openalex.org/keywords/hyperthyroidism', 'display_name': 'Hyperthyroidism', 'score': 0.531421}, {'id': 'https://openalex.org/keywords/hypothyroidism', 'display_name': 'Hypothyroidism', 'score': 0.508412}, {'id': 'https://openalex.org/keywords/depression', 'display_name': 'Depression', 'score': 0.505884}], 'concepts': [{'id': 'https://openalex.org/C87813604', 'wikidata': 'https://www.wikidata.org/wiki/Q1242899', 'display_name': 'Crossover study', 'level': 4, 'score': 0.8477559}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.7904866}, {'id': 'https://openalex.org/C2991744798', 'wikidata': 'https://www.wikidata.org/wiki/Q608510', 'display_name': 'Double blind', 'level': 4, 'score': 0.77041554}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6886224}, {'id': 'https://openalex.org/C2776867660', 'wikidata': 'https://www.wikidata.org/wiki/Q1814941', 'display_name': 'Depression (economics)', 'level': 2, 'score': 0.6057911}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.5536971}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5089264}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.49742272}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.05499354}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C162324750', 'wikidata': 'https://www.wikidata.org/wiki/Q8134', 'display_name': 'Economics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C139719470', 'wikidata': 'https://www.wikidata.org/wiki/Q39680', 'display_name': 'Macroeconomics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001714', 'descriptor_name': 'Bipolar Disorder', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D003863', 'descriptor_name': 'Depression', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D013973', 'descriptor_name': 'Thyrotropin-Releasing Hormone', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000275', 'descriptor_name': 'Adjustment Disorders', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D000275', 'descriptor_name': 'Adjustment Disorders', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000284', 'descriptor_name': 'Administration, Oral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001714', 'descriptor_name': 'Bipolar Disorder', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002986', 'descriptor_name': 'Clinical Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003863', 'descriptor_name': 'Depression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007275', 'descriptor_name': 'Injections, Intravenous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010919', 'descriptor_name': 'Placebos', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013960', 'descriptor_name': 'Thyroid Function Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013973', 'descriptor_name': 'Thyrotropin-Releasing Hormone', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D013973', 'descriptor_name': 'Thyrotropin-Releasing Hormone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0140-6736(74)91263-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S49861241', 'display_name': 'The Lancet', 'issn_l': '0140-6736', 'issn': ['0140-6736', '1474-547X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/4133645', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.81}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 12, 'referenced_works': ['https://openalex.org/W1991999578', 'https://openalex.org/W2001518916', 'https://openalex.org/W2051267207', 'https://openalex.org/W2085360134', 'https://openalex.org/W2091167563', 'https://openalex.org/W2114291283', 'https://openalex.org/W2132767818', 'https://openalex.org/W2158217068', 'https://openalex.org/W2398599047', 'https://openalex.org/W2613156872', 'https://openalex.org/W3025742634', 'https://openalex.org/W4256003000'], 'related_works': ['https://openalex.org/W4284878710', 'https://openalex.org/W4254727640', 'https://openalex.org/W4241834355', 'https://openalex.org/W2907642600', 'https://openalex.org/W2889029013', 'https://openalex.org/W2325967379', 'https://openalex.org/W2323272802', 'https://openalex.org/W2132710482', 'https://openalex.org/W2126183644', 'https://openalex.org/W2039763161'], 'abstract_inverted_index': {'In': [0], 'a': [1, 15], 'double-blind,': [2], 'crossover,': [3], 'sequential': [4], 'trial,': [5], 'oral': [6, 39], 'thyrotrophin-releasing': [7], 'hormone': [8], '(T.R.H.)': [9], '(40': [10, 41], 'mg.)': [11], 'given': [12], 'daily': [13], 'for': [14, 58], 'week': [16], 'was': [17, 29, 56], 'no': [18, 30], 'more': [19], 'effective': [20], 'than': [21], 'placebo': [22], 'in': [23], 'treating': [24], 'twenty-nine': [25], 'depressed': [26], 'outpatients.': [27], 'There': [28], 'clinical': [31], 'or': [32], 'biochemical': [33], 'evidence': [34], 'that': [35], 'patients': [36], 'continuing': [37], 'on': [38], 'T.R.H.': [40, 55], 'mg.': [42], 'daily)': [43], 'maintenance': [44], 'therapy': [45], 'after': [46], 'completion': [47], 'of': [48], 'the': [49], 'trial': [50], 'became': [51], 'hyperthyroid,': [52], 'even': [53], 'when': [54], 'administered': [57], '12': [59], 'weeks.': [60]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2039763161', 'counts_by_year': [], 'updated_date': '2024-09-24T17:07:58.833951', 'created_date': '2016-06-24'}