Publication Information

{'id': 'https://openalex.org/W2039249121', 'doi': 'https://doi.org/10.1371/journal.pone.0106085', 'title': 'Shigella flexneri Infection in Caenorhabditis elegans: Cytopathological Examination and Identification of Host Responses', 'display_name': 'Shigella flexneri Infection in Caenorhabditis elegans: Cytopathological Examination and Identification of Host Responses', 'publication_year': 2014, 'publication_date': '2014-09-04', 'ids': {'openalex': 'https://openalex.org/W2039249121', 'doi': 'https://doi.org/10.1371/journal.pone.0106085', 'mag': '2039249121', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25187942', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4154869'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0106085', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0106085&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0106085&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5019219719', 'display_name': 'Divya T. George', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I118347636', 'display_name': 'Australian National University', 'ror': 'https://ror.org/019wvm592', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I118347636']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Divya T. George', 'raw_affiliation_strings': ['Division of Biomedical Science and Biochemistry, Research School of Biology, The Australian National University, Canberra, Australia,'], 'affiliations': [{'raw_affiliation_string': 'Division of Biomedical Science and Biochemistry, Research School of Biology, The Australian National University, Canberra, Australia,', 'institution_ids': ['https://openalex.org/I118347636']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039166833', 'display_name': 'Carolyn A. Behm', 'orcid': 'https://orcid.org/0000-0002-0603-221X'}, 'institutions': [{'id': 'https://openalex.org/I118347636', 'display_name': 'Australian National University', 'ror': 'https://ror.org/019wvm592', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I118347636']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Carolyn A. Behm', 'raw_affiliation_strings': ['Division of Biomedical Science and Biochemistry, Research School of Biology, The Australian National University, Canberra, Australia,'], 'affiliations': [{'raw_affiliation_string': 'Division of Biomedical Science and Biochemistry, Research School of Biology, The Australian National University, Canberra, Australia,', 'institution_ids': ['https://openalex.org/I118347636']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026382723', 'display_name': 'David H. Hall', 'orcid': 'https://orcid.org/0000-0001-8459-9820'}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David H. Hall', 'raw_affiliation_strings': ['Center for C. elegans Anatomy, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, United States of America.'], 'affiliations': [{'raw_affiliation_string': 'Center for C. elegans Anatomy, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, United States of America.', 'institution_ids': ['https://openalex.org/I129975664']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002900420', 'display_name': 'Ulrike Mathesius', 'orcid': 'https://orcid.org/0000-0002-3557-0105'}, 'institutions': [{'id': 'https://openalex.org/I118347636', 'display_name': 'Australian National University', 'ror': 'https://ror.org/019wvm592', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I118347636']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Ulrike Mathesius', 'raw_affiliation_strings': ['Division of Plant Science, Research School of Biology, The Australian National University, Canberra, Australia.'], 'affiliations': [{'raw_affiliation_string': 'Division of Plant Science, Research School of Biology, The Australian National University, Canberra, Australia.', 'institution_ids': ['https://openalex.org/I118347636']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012370134', 'display_name': 'Melanie Rug', 'orcid': 'https://orcid.org/0000-0002-4687-9677'}, 'institutions': [{'id': 'https://openalex.org/I118347636', 'display_name': 'Australian National University', 'ror': 'https://ror.org/019wvm592', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I118347636']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Melanie Rug', 'raw_affiliation_strings': ['Centre for Advanced Microscopy, The Australian National University, Canberra, Australia.'], 'affiliations': [{'raw_affiliation_string': 'Centre for Advanced Microscopy, The Australian National University, Canberra, Australia.', 'institution_ids': ['https://openalex.org/I118347636']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058876504', 'display_name': 'Ken C. Q. Nguyen', 'orcid': 'https://orcid.org/0000-0002-3479-2611'}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ken C. Q. Nguyen', 'raw_affiliation_strings': ['Center for C. elegans Anatomy, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, United States of America.'], 'affiliations': [{'raw_affiliation_string': 'Center for C. elegans Anatomy, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, United States of America.', 'institution_ids': ['https://openalex.org/I129975664']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5023007212', 'display_name': 'Naresh K. Verma', 'orcid': 'https://orcid.org/0000-0001-8109-2215'}, 'institutions': [{'id': 'https://openalex.org/I118347636', 'display_name': 'Australian National University', 'ror': 'https://ror.org/019wvm592', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I118347636']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Naresh K. Verma', 'raw_affiliation_strings': ['Division of Biomedical Science and Biochemistry, Research School of Biology, The Australian National University, Canberra, Australia,'], 'affiliations': [{'raw_affiliation_string': 'Division of Biomedical Science and Biochemistry, Research School of Biology, The Australian National University, Canberra, Australia,', 'institution_ids': ['https://openalex.org/I118347636']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 0.402, 'has_fulltext': False, 'cited_by_count': 22, 'citation_normalized_percentile': {'value': 0.743567, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '9', 'issue': '9', 'first_page': 'e106085', 'last_page': 'e106085'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10676', 'display_name': 'Genetics, Aging, and Longevity in Model Organisms', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1302', 'display_name': 'Aging'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10676', 'display_name': 'Genetics, Aging, and Longevity in Model Organisms', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1302', 'display_name': 'Aging'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10943', 'display_name': 'Escherichia coli research studies', 'score': 0.9807, 'subfield': {'id': 'https://openalex.org/subfields/1310', 'display_name': 'Endocrinology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10066', 'display_name': 'Gut microbiota and health', 'score': 0.9806, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2781217973', 'wikidata': 'https://www.wikidata.org/wiki/Q1644417', 'display_name': 'Shigella flexneri', 'level': 4, 'score': 0.98905134}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.79097164}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.7448935}, {'id': 'https://openalex.org/C2778944004', 'wikidata': 'https://www.wikidata.org/wiki/Q91703', 'display_name': 'Caenorhabditis elegans', 'level': 3, 'score': 0.7152976}, {'id': 'https://openalex.org/C2776460866', 'wikidata': 'https://www.wikidata.org/wiki/Q170065', 'display_name': 'Pathogen', 'level': 2, 'score': 0.56800354}, {'id': 'https://openalex.org/C2778830712', 'wikidata': 'https://www.wikidata.org/wiki/Q5185', 'display_name': 'Nematode', 'level': 2, 'score': 0.43860275}, {'id': 'https://openalex.org/C166703698', 'wikidata': 'https://www.wikidata.org/wiki/Q201993', 'display_name': 'RNA interference', 'level': 4, 'score': 0.4175048}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.21717274}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.18492833}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.14362523}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.06476918}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017173', 'descriptor_name': 'Caenorhabditis elegans', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D029742', 'descriptor_name': 'Caenorhabditis elegans Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D018834', 'descriptor_name': 'Chaperonin 60', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004405', 'descriptor_name': 'Dysentery, Bacillary', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D055785', 'descriptor_name': 'Gene Knockdown Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005798', 'descriptor_name': 'Genes, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017238', 'descriptor_name': 'Genes, Helminth', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058507', 'descriptor_name': 'Host Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054884', 'descriptor_name': 'Host-Pathogen Interactions', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D007501', 'descriptor_name': 'Iron', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D046529', 'descriptor_name': 'Microscopy, Electron, Transmission', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012763', 'descriptor_name': 'Shigella flexneri', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D014774', 'descriptor_name': 'Virulence', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0106085', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0106085&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/cff684404e9a4de8bbfdaedfdb3759e1', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4154869', 'pdf_url': 'https://europepmc.org/articles/pmc4154869?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/1885/16314', 'pdf_url': 'https://openresearch-repository.anu.edu.au/bitstream/1885/16314/1/01_George_Shigella_flexneri_infection_in_2014.pdf', 'source': {'id': 'https://openalex.org/S4306402539', 'display_name': 'ANU Open Research (Australian National University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I118347636', 'host_organization_name': 'Australian National University', 'host_organization_lineage': ['https://openalex.org/I118347636'], 'host_organization_lineage_names': ['Australian National University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154869', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25187942', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0106085', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0106085&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.66, 'display_name': 'Life on land', 'id': 'https://metadata.un.org/sdg/15'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 55, 'referenced_works': ['https://openalex.org/W1515211957', 'https://openalex.org/W1551978657', 'https://openalex.org/W1821270395', 'https://openalex.org/W1832876371', 'https://openalex.org/W1841963910', 'https://openalex.org/W1920211008', 'https://openalex.org/W1944127002', 'https://openalex.org/W195904295', 'https://openalex.org/W1962032019', 'https://openalex.org/W1971702054', 'https://openalex.org/W1997969528', 'https://openalex.org/W2003262556', 'https://openalex.org/W2005222994', 'https://openalex.org/W2005576753', 'https://openalex.org/W2009516061', 'https://openalex.org/W2014100067', 'https://openalex.org/W2015313456', 'https://openalex.org/W2015346570', 'https://openalex.org/W2016036595', 'https://openalex.org/W2016786613', 'https://openalex.org/W2019615869', 'https://openalex.org/W2028568975', 'https://openalex.org/W2034633886', 'https://openalex.org/W2039424037', 'https://openalex.org/W2041694079', 'https://openalex.org/W2041756762', 'https://openalex.org/W2065419969', 'https://openalex.org/W2068795747', 'https://openalex.org/W2072379547', 'https://openalex.org/W2085034589', 'https://openalex.org/W2090611703', 'https://openalex.org/W2095785516', 'https://openalex.org/W2096653826', 'https://openalex.org/W2100939012', 'https://openalex.org/W2101455204', 'https://openalex.org/W2105928896', 'https://openalex.org/W2119175743', 'https://openalex.org/W2121168589', 'https://openalex.org/W2128635872', 'https://openalex.org/W2129642099', 'https://openalex.org/W2132493451', 'https://openalex.org/W2132655534', 'https://openalex.org/W2134814839', 'https://openalex.org/W2135686321', 'https://openalex.org/W2148161423', 'https://openalex.org/W2149062152', 'https://openalex.org/W2156531131', 'https://openalex.org/W2162100181', 'https://openalex.org/W2163828696', 'https://openalex.org/W2166146113', 'https://openalex.org/W2403688190', 'https://openalex.org/W2406527052', 'https://openalex.org/W2407499244', 'https://openalex.org/W24192852', 'https://openalex.org/W91584898'], 'related_works': ['https://openalex.org/W4233486228', 'https://openalex.org/W2980252621', 'https://openalex.org/W2753580244', 'https://openalex.org/W2465409402', 'https://openalex.org/W2356314753', 'https://openalex.org/W2151401272', 'https://openalex.org/W2107739100', 'https://openalex.org/W2086019404', 'https://openalex.org/W2039249121', 'https://openalex.org/W1495803789'], 'abstract_inverted_index': {'The': [0], 'Gram-negative': [1], 'bacterium': [2], 'Shigella': [3], 'flexneri': [4, 20, 66, 82, 95, 124, 137, 171, 202, 221, 265, 287], 'is': [5, 271], 'the': [6, 22, 41, 44, 61, 84, 91, 100, 104, 118, 141, 175, 210, 260, 275], 'causative': [7], 'agent': [8], 'of': [9, 27, 35, 43, 50, 64, 106, 174, 227, 259, 267, 278], 'shigellosis,': [10], 'a': [11, 33, 248], 'diarrhoeal': [12], 'disease': [13], 'also': [14], 'known': [15], 'as': [16, 68, 196, 247], 'bacillary': [17], 'dysentery.': [18], 'S.': [19, 65, 81, 94, 123, 136, 170, 201, 220, 224, 264, 286], 'infects': [21, 71, 83], 'colonic': [23], 'and': [24, 31, 73, 96, 103, 125, 149, 181, 188, 191, 232], 'rectal': [25], 'epithelia': [26], 'its': [28], 'primate': [29], 'host': [30, 45, 62, 161, 228], 'induces': [32], 'cascade': [34], 'inflammatory': [36], 'responses': [37], 'that': [38, 80, 134, 163, 242], 'culminates': [39], 'in': [40, 53, 140, 167, 198, 209, 263, 281], 'destruction': [42], 'intestinal': [46, 143, 152], 'lining.': [47], 'Molecular': [48], 'characterization': [49], 'host-pathogen': [51, 120], 'interactions': [52, 92, 121], 'this': [54, 279], 'infection': [55, 211, 266], 'has': [56], 'been': [57], 'challenging': [58], 'due': [59], 'to': [60, 114, 169, 200, 206, 219, 239, 274, 284], 'specificity': [63], 'strains,': [67], 'it': [69], 'strictly': [70], 'humans': [72], 'non-human': [74], 'primates.': [75], 'Recent': [76], 'studies': [77], 'have': [78], 'shown': [79], 'soil': [85], 'dwelling': [86], 'nematode': [87, 107, 142, 151], 'Caenorhabditis': [88], 'elegans,': [89, 269], 'however,': [90], 'between': [93, 122], 'C.': [97, 126, 252, 268], 'elegans': [98], 'at': [99], 'cellular': [101], 'level': [102], 'cause': [105], 'death': [108], 'are': [109, 164, 245], 'unknown.': [110], 'Here': [111], 'we': [112, 132, 159], 'attempt': [113], 'gain': [115], 'insight': [116], 'into': [117], 'complex': [119], 'elegans.': [127, 253], 'Using': [128, 154], 'transmission': [129], 'electron': [130], 'microscopy,': [131], 'show': [133], 'live': [135], 'cells': [138], 'accumulate': [139], 'lumen,': [144], 'produce': [145], 'outer': [146], 'membrane': [147], 'vesicles': [148], 'invade': [150], 'cells.': [153], 'two-dimensional': [155], 'differential': [156], 'in-gel': [157], 'electrophoresis': [158], 'identified': [160, 176, 195], 'proteins': [162], 'differentially': [165], 'expressed': [166], 'response': [168, 199], 'infection.': [172], 'Four': [173], 'genes,': [177], 'aco-1,': [178], 'cct-2,': [179], 'daf-19': [180, 233], 'hsp-60,': [182], 'were': [183, 194, 204, 216, 236], 'knocked': [184], 'down': [185], 'using': [186], 'RNAi': [187, 214, 234], 'ACO-1,': [189], 'CCT-2': [190], 'DAF-19,': [192], 'which': [193, 270], 'up-regulated': [197], 'infection,': [203, 222, 240], 'found': [205], 'be': [207], 'involved': [208, 262], 'process.': [212], 'aco-1': [213], 'worms': [215, 235], 'more': [217, 237], 'resistant': [218], 'suggesting': [223, 241], 'flexneri-mediated': [225], 'disruption': [226], 'iron': [229], 'homeostasis.': [230], 'cct-2': [231], 'susceptible': [238], 'these': [243], 'genes': [244], 'induced': [246], 'protective': [249], 'mechanism': [250], 'by': [251], 'These': [254], 'observations': [255], 'further': [256], 'our': [257], 'understanding': [258], 'processes': [261], 'immensely': [272], 'beneficial': [273], 'routine': [276], 'use': [277], 'new': [280], 'vivo': [282], 'model': [283], 'study': [285], 'pathogenesis.': [288]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2039249121', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}], 'updated_date': '2024-12-08T21:58:09.889245', 'created_date': '2016-06-24'}