Publication Information

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[43, 374, 1057, 1331], 'study,': [44, 378], '18': [45, 287], 'higher-risk': [46, 169, 264, 288], 'patients': [48, 64, 81, 266, 347, 395, 419, 1061, 1197, 1226, 1274, 1353], 'were': [49, 337, 351, 507, 1108, 1187, 1269, 1354], 'treated': [50, 338], 'with': [51, 70, 86, 103, 108, 114, 120, 163, 172, 339, 396, 403, 417, 429, 435, 452, 488, 520, 547, 586, 608, 616, 633, 649, 680, 697, 704, 725, 779, 790, 800, 828, 859, 877, 914, 961, 986, 1071, 1085, 1117, 1126, 1153, 1192, 1212, 1347], 'for': [54, 129, 204, 305, 314, 342, 357, 552, 560, 592, 629, 730, 762, 807, 882, 890, 924, 995, 1041, 1097, 1169, 1216], 'seven': [55, 343, 360, 927], 'cycles,': [56, 344], 'after': [57, 345, 1076], 'which': [58, 292, 346, 1239, 1258], 'discontinued': [61], 'eight': [63], 'who': [65, 82, 399], 'achieved': [66, 400, 569, 743, 847], 'a': [67, 115, 123, 156, 185, 277, 293, 318, 329, 349, 376, 401, 404, 570, 623, 639, 670, 791, 816, 848, 918, 954, 1007, 1069, 1112, 1243, 1249, 1318], 'complete': [68, 124, 330], 'response,': [69], 'monotherapy': [72, 85, 259, 413, 1079], 'continuing': [73, 756, 912], 'until': [74, 414, 672], 'disease': [75, 415, 1103, 1176], 'progression.': [76], 'We': [77, 135, 272, 391], 'report': [78, 392, 1048], 'on': [79, 84, 237, 353, 411, 798, 978, 1024, 1149, 1159], 'three': [80, 394, 1196], 'relapsed': [83, 772, 959], 'excess': [87, 173], 'blasts': [88, 651, 830, 963], 'at': [89, 111, 301, 363, 622, 803, 917, 980, 991, 1201, 1204, 1260], '12,': [90], '19,': [91], '24': [93], 'months,': [94], 'whom': [96], 'then': [99, 755, 1082, 1124], 'resumed': [100, 621], 'azacitidine.': [104, 390, 634, 1045], 'Each': [105], 'patient,': [106], 'one': [107, 113, 119, 1114, 1233], 'normal': [109, 397, 526, 617, 653, 702, 832, 865, 965, 1199], 'cytogenetics': [110, 398, 1200], 'relapse;': [112, 1232], '+8': [116, 793], 'abnormality;': [117], 'del(4q25),': [121], 'recaptured': [122, 425], 'response': [125, 324, 331, 1129], 'that': [126, 137, 1120, 1185, 1281], 'sustained': [128], '5,': [130], '7,': [131], '7+': [133], 'months.': [134], 'conclude': [136], 'addition': [139, 988], 'of': [140, 158, 188, 207, 219, 281, 317, 334, 432, 449, 474, 479, 483, 542, 626, 658, 682, 716, 871, 920, 989, 1054, 1119, 1134, 1147, 1157, 1172, 1179, 1263, 1321, 1330, 1339, 1454], 'to': [142, 190, 268, 359, 370, 510, 598, 678, 768, 841, 926, 932, 1012, 1036, 1102, 1142, 1174, 1276, 1293, 1304, 1326], 'provides': [144], 'additional': [145, 386, 706, 969], 'clinical': [146, 1344], 'benefit': [147, 387, 1053, 1329, 1345], 'over': [148, 388], 'monotherapy.': [150], 'The': [151, 322, 491, 1131, 1312], 'myelodysplastic': [152], 'syndromes': [153], '(MDS)': [154], 'comprise': [155], 'spectrum': [157], 'disorders': [161], 'associated': [162], 'cytopenias,': [164], 'cytogenetic': [165, 422, 794], 'abnormalities,': [166], 'subtypes': [170], '(patients': [171], 'myeloblasts': [174], 'or': [175], 'an': [176, 539, 713, 868], 'International': [177, 512], 'Prognostic': [178], 'Scoring': [179], 'System': [180], '(IPSS)': [181], 'risk': [182], 'score': [183, 541, 715, 870], '>1.0),': [184], 'high': [186], 'likelihood': [187], 'transformation': [189], 'acute': [191], 'myeloid': [192], 'leukemia': [193], '(AML)': [194], '[1-5].': [195], 'Three': [196, 1060], 'drugs,': [197], 'azacitidine,': [198, 799], 'decitabine': [199, 244], 'lenalidomide,': [201, 1043], 'approved': [203], 'treatment': [206, 1191], '[6-8].': [209], 'selectively': [211], 'suppresses': [212], 'deletion': [213], '5q': [214], 'clones': [216], 'through': [217], 'inhibition': [218, 251], 'haplodeficient': [220], 'cell': [221, 1309], 'cycle': [222, 320], 'regulatory': [223], 'targets': [224], 'coded': [225], 'within': [226], 'common': [228], 'deleted': [229], 'region': [230], '(CDR)': [231], '[9,': [232], '10]': [233], 'complemented': [234], 'effects': [236, 247, 1146, 1156], 'microenvironment.': [241, 1163], 'Azacitidine': [242], 'exert': [245], 'their': [246, 426, 1064, 1357], 'via': [248], 'DNA': [249], 'methyltrasferase': [250], 'also': [253], 'direct': [254], 'cytotoxicity,': [255], '[11]': [256], 'improves': [260], 'overall': [261, 323], 'survival': [262], 'compared': [267, 1346], 'conventional': [269], 'care': [270], '[12].': [271], 'recently': [273, 1300], 'reported': [274], 'results': [275], 'from': [276, 462, 467], 'study': [280, 448, 492, 578, 751, 908, 1031, 1139, 1320], 'II': [295], 'dose': [296, 625, 919, 983], 'established:': [298], 'administered': [300, 356], '75': [302, 364, 589, 759, 921], 'mg/m2': [303, 365, 558, 590, 736, 760, 888, 922], 'daily': [304, 313, 551, 559, 591, 624, 729, 737, 761, 806, 881, 889, 923, 994], 'five': [306, 358, 925], 'consecutive': [307, 361], 'days,': [308, 316, 594, 764, 928], '10': [311, 627, 804, 992], 'mg': [312, 550, 628, 728, 805, 880, 993], '21': [315, 553, 630, 808, 883, 996], '28-day': [319], '[13].': [321], 'rate': [325, 333], '67%,': [327], 'including': [328], '(CR)': [332], '44%.': [335], 'Patients': [336], 'therapy': [341, 384, 451, 546, 583, 721, 876, 913], 'achieving': [348, 1068, 1242], 'CR': [350, 402, 427, 571, 647, 671, 744, 818, 850, 897, 1070, 1084, 1265], 'continued': [352, 410, 797, 977], 'monotherapy,': [355, 588, 758, 916], 'days': [362, 631], 'daily,': [366], 'repeated': [367, 595, 765, 929], 'every': [368, 596, 766, 930], 'four': [369, 597, 767, 931], 'six': [371, 593, 599, 763, 769, 933], 'weeks.': [372, 600, 770, 934], 'As': [373], 'single-arm': [377], 'it': [379], 'unknown': [381], 'whether': [382], 'provided': [385], 'single-agent': [389], 'herein': [393], 'regimen;': [409, 1074], 'relapse,': [416], 'two': [418, 1038, 1273], 'demonstrating': [420], 'distinct': [421], 'abnormalities;': [423], 'status': [428], 'reinitiation': [431], 'combined': [434, 632], '(see': [437], 'Fig.': [438], '1).': [439], 'Treatment': [440], 'course.': [441], 'This': [442, 517, 693, 855], 'multicenter,': [443], 'single-arm,': [444], 'open-label,': [445], 'received': [456], 'local': [457], 'Institutional': [458], 'Review': [459], 'Board': [460, 473], 'approval': [461], 'all': [463], 'participating': [464], 'sites': [465], 'Data': [469], 'Safety': [470], 'Monitoring': [472], 'Rare': [476], 'Diseases': [477], 'Branch': [478], 'National': [481], 'Institutes': [482], 'Health,': [484], 'registered': [487], 'http//:clinicaltrials.gov': [489], '(NCT00352001).': [490], 'opened': [493], 'May,': [495, 504, 564, 826], '2005': [496], 'last': [499], 'subject': [500], 'enrolled': [502], '2008.': [505], 'Responses': [506], 'defined': [508], 'according': [509], '2006': [511], 'Working': [513], 'Group': [514], 'criteria': [515], '[14].': [516], '70-year-old': [518], 'man': [519, 695, 857], 'newly': [521, 860], 'diagnosed': [522, 861], 'RAEB-2': [523, 862], '(15%': [524], 'blasts),': [525, 701, 864], 'cytogenetics,': [527, 703, 866, 966], 'no': [528, 705, 836, 939, 968, 1015], 'somatic': [529, 707, 837, 940, 970, 1016], 'lesions': [530, 708, 971, 1017, 1217, 1230, 1285], 'single': [532, 1348], 'nucleotide': [533], 'polymorphism': [534], 'array': [535], '(SNP-A)': [536], 'karyotyping,': [537, 711, 1257], 'IPSS': [540, 714, 869], '1.5,': [543], 'started': [544, 719], '(5': [549, 727], 'days)': [554, 562, 732, 884, 892], '(75': [557, 887], '5': [561, 891], '2007': [565], '(Table': [566], 'I).': [567], 'He': [568, 667, 687, 718, 742, 771, 796, 839, 873, 976, 1022], 'September,': [573, 723, 894], '2007,': [574, 724, 902], 'completed': [576, 749, 905], 'December,': [580], '2007.': [581, 895], 'Maintenance': [582], 'initiated': [585], 'Nineteen': [601], 'months': [602, 774, 943], 'later': [603], '(April,': [604], '2009)': [605], 'he': [606, 676, 904, 948], 'relapsed,': [607], 'decreased': [609, 780], 'peripheral': [610, 654, 811], 'blood': [611, 812], 'counts': [612, 636, 784, 813], '7%': [614], 'blasts,': [615, 789], 'cytogenetics.': [618, 833], 'His': [635, 810], 'normalized,': [637, 814], 'biopsy': [642, 824, 957, 1001], 'August,': [644], '2009,': [645, 778, 827, 947], 'confirmed': [646, 820, 835, 958, 1203], 'recovery,': [648], '1%': [650], 'counts.': [655], 'microdeletion': [657, 1250], '4q25,': [659], 'spanning': [660], 'nucleotides': [661], '109226732-109731065,': [662], 'detected': [664, 1018, 1254], 'using': [665, 936], 'SNP-A.': [666], 'remained': [668], 'February,': [673], '2010,': [674, 845, 1005], 'when': [675, 1100, 1352], 'progressed': [677, 840, 1275], 'AML': [679, 842], 'persistence': [681], '4q25': [684, 1251], 'SNP-A-detected': [685], 'microdeletion.': [686], 'is': [688, 1279], 'undergoing': [689], 'cytotoxic': [690], 'induction': [691, 853], 'therapy.': [692, 1027], '72-year-old': [694], 'presented': [696, 858], 'newly-diagnosed': [698], 'RAEB-1': [699], '(7%': [700], 'SNP-A-based': [710], '1.0.': [717], '14': [731], '(50': [735], 'Days': [738], '1–5': [739], '8–12).': [741], 'January,': [746, 777, 844], '2008,': [747, 754, 911], 'April,': [753, 1004], 'nine': [773], 'later,': [775, 944], 'platelet': [781], 'neutrophil': [783], '8%': [786], 'new': [792, 1228], 'abnormality.': [795], 'added': [802], 'days.': [809, 997], 'second': [817, 1244, 1247], '3%': [829], 'SNP': [834], 'lesions.': [838, 941], 'third': [849], 'following': [851], 'remission': [852], 'chemotherapy.': [854], '60-year-old': [856], '(16%': [863], '2.0.': [872], 'began': [874], '(10': [879], 'documented': [899], 'November,': [901, 946], 'March,': [910], 'Karyotyping': [935], 'SNP-A': [937, 974, 1020, 1210, 1256], 'identified': [938, 972], 'Twenty': [942], 'developed': [949], 'neutropenia': [950], 'thrombocytopenia,': [952], 'disease,': [960], '6%': [962], 'analysis.': [975], 'same': [982, 1128], 'schedule,': [985], 'performed': [1002, 1364, 1385, 1401, 1409, 1420], 'demonstrated': [1006], 'reduction': [1008], 'blast': [1010], 'percentage,': [1011], '2%,': [1013], 'karyotyping.': [1021], 'continues': [1023], 'Our': [1028], 'first': [1034], 'combine': [1037], 'FDA-approved': [1039], 'drugs': [1040], 'MDS,': [1042], 'Here': [1046], 'we': [1047, 1091, 1093], 'evidence': [1049, 1168], 'supporting': [1050], 'additive': [1052], 'strategy.': [1059], 'served': [1062], 'as': [1063, 1106, 1296, 1301, 1356], 'own': [1065, 1358], 'internal': [1066], 'controls,': [1067], 'relapsing': [1075], 'prolonged': [1077], 'maintenance;': [1080], 'recapturing': [1083], 'readministration.': [1087], 'so': [1089], 'doing,': [1090], 'believe': [1092], 'satisfied': [1094], "Koch's": [1095], 'postulates': [1096], 'causality,': [1098], '[15]': [1099], 'applied': [1101], 'general,': [1105], 'agents': [1107], 'introduced': [1109], 'evoked': [1111], 'response;': [1113, 1121], 'withdrawn,': [1116], 'loss': [1118], 'reintroduced,': [1125], 'resulting.': [1130], 'design': [1133], 'initial': [1136], 'intended': [1141], 'antiproliferative': [1145], 'clone': [1152], 'modulatory': [1155], 'These': [1164], 'cases': [1165], 'provide': [1166], 'unambiguous': [1167], 'modifying': [1177], 'effect': [1178], 'regimen,': [1182], 'show': [1184], 'remissions': [1186], 'not': [1188, 1270], 'maintained': [1189], 'alone.': [1194], 'All': [1195], 'had': [1198], 'diagnosis,': [1202], 'molecular': [1206, 1214], 'level': [1207], '250k': [1209], 'analysis,': [1211], 'specific': [1213], 'involving': [1218, 1234, 1248, 1286], 'c-Cbl,': [1219], 'b-Cbl,': [1220], 'JAK2,': [1221], 'TET2': [1223, 1288], 'genes.': [1224], 'Two': [1225], 'acquired': [1227], 'genetic': [1229, 1284], 'during': [1231], 'trisomy': [1235], '8': [1236], '(Case': [1237, 1252], '2),': [1238], 'disappeared': [1240], 'upon': [1241], 'CR;': [1245], '3)': [1253], 'persisted': [1259], 'time': [1262], 'pathologic': [1264], 'recapture.': [1266], 'Second': [1267], 'CRs': [1268], 'durable,': [1271], 'AML.': [1277], 'It': [1278], 'possible': [1280], 'such': [1282], 'cryptic': [1283], 'gene': [1289], 'be': [1291, 1315], 'linked': [1292], 'responsiveness,': [1295], 'has': [1297], 'been': [1298], 'speculated': [1299], 'relates': [1303], 'histone': [1305], 'methylation': [1306], 'Namalwa': [1308], 'lines': [1310], '[16].': [1311], 'latter': [1313], 'will': [1314], 'investigated': [1316], 'comparative': [1319], 'vs.': [1323], 'verify': [1327], 'novel': [1332], 'regimen.': [1334], 'conclusion,': [1336], 'produced': [1343], 'agent': [1349], 'alone,': [1351], 'used': [1355], 'controls.': [1359], 'M.A.S.': [1360], 'designed': [1361, 1382, 1417], 'research,': [1363, 1366, 1384, 1387, 1419, 1422], 'analyzed': [1367, 1375, 1393, 1423], 'data,': [1369, 1425], 'wrote': [1371, 1427], 'manuscript.': [1373, 1380, 1391, 1399, 1407, 1415, 1429], 'C.O.': [1374], 'data': [1376, 1395], 'edited': [1378, 1389, 1397, 1405, 1413], 'A.F.L.': [1381], 'K.P.': [1392], 'M.A.': [1400], 'research': [1403, 1411], 'R.E.': [1408], 'J.P.M.': [1416], 'Mikkael': [1430], 'A.': [1431], 'Sekeres*': [1432], ',': [1433, 1436, 1440, 1451], 'Christine': [1434], "O'Keefe": [1435], 'Alan': [1437], 'F.': [1438], 'List': [1439], 'Katarina': [1441], 'Paulic*,': [1442], 'Manuel': [1443], 'Afable': [1444], 'II*,': [1445], 'Ricki': [1446], 'Englehaupt*,': [1447], 'Jaroslaw': [1448], 'P.': [1449], 'Maciejewski': [1450], '*': [1452], 'Department': [1453], 'Hematologic': [1455], 'Oncology': [1456, 1472], 'Blood': [1458], 'Disorders,': [1459], 'Leukemia': [1460], 'Program,': [1461], 'Cleveland': [1462, 1474], 'Clinic': [1463, 1475], 'Taussig': [1464, 1476], 'Cancer': [1465, 1477, 1484], 'Institute,': [1466, 1478, 1488], 'Cleveland,': [1467, 1479], 'Ohio,': [1468, 1480], 'Translational': [1469], 'Hematology': [1470], 'Research,': [1473], 'H.': [1481], 'Lee': [1482], 'Moffitt': [1483], 'Center': [1485], '&': [1486], 'Research': [1487], 'Tampa,': [1489], 'Florida.': [1490]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2039051754', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2024-12-09T03:19:54.509104', 'created_date': '2016-06-24'}