Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2039028122', 'doi': 'https://doi.org/10.1021/jm200801h', 'title': 'The 2010 Philip S. Portoghese Medicinal Chemistry Lectureship: Addressing the “Core Issue” in the Design of Estrogen Receptor Ligands', 'display_name': 'The 2010 Philip S. Portoghese Medicinal Chemistry Lectureship: Addressing the “Core Issue” in the Design of Estrogen Receptor Ligands', 'publication_year': 2011, 'publication_date': '2011-06-27', 'ids': {'openalex': 'https://openalex.org/W2039028122', 'doi': 'https://doi.org/10.1021/jm200801h', 'mag': '2039028122', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21707083', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3150643'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm200801h', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3150643?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054090841', 'display_name': 'John A. Katzenellenbogen', 'orcid': 'https://orcid.org/0000-0003-0914-0010'}, 'institutions': [{'id': 'https://openalex.org/I157725225', 'display_name': 'University of Illinois Urbana-Champaign', 'ror': 'https://ror.org/047426m28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I157725225']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'John A. Katzenellenbogen', 'raw_affiliation_strings': ['Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, United States'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, United States', 'institution_ids': ['https://openalex.org/I157725225']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5054090841'], 'corresponding_institution_ids': ['https://openalex.org/I157725225'], 'apc_list': None, 'apc_paid': None, 'fwci': 4.827, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 76, 'citation_normalized_percentile': {'value': 0.999952, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '54', 'issue': '15', 'first_page': '5271', 'last_page': '5282'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12356', 'display_name': 'Bioactive Compounds and Antitumor Agents', 'score': 0.9866, 'subfield': {'id': 'https://openalex.org/subfields/3005', 'display_name': 'Toxicology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T14459', 'display_name': 'Synthesis and Reactions of Organic Compounds', 'score': 0.9457, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2778805511', 'wikidata': 'https://www.wikidata.org/wiki/Q1713', 'display_name': 'Citation', 'level': 2, 'score': 0.71125036}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.5320177}, {'id': 'https://openalex.org/C161191863', 'wikidata': 'https://www.wikidata.org/wiki/Q199655', 'display_name': 'Library science', 'level': 1, 'score': 0.5060987}, {'id': 'https://openalex.org/C518677369', 'wikidata': 'https://www.wikidata.org/wiki/Q202833', 'display_name': 'Social media', 'level': 2, 'score': 0.45657516}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.41738975}, {'id': 'https://openalex.org/C136764020', 'wikidata': 'https://www.wikidata.org/wiki/Q466', 'display_name': 'World Wide Web', 'level': 1, 'score': 0.38531685}, {'id': 'https://openalex.org/C23123220', 'wikidata': 'https://www.wikidata.org/wiki/Q816826', 'display_name': 'Information retrieval', 'level': 1, 'score': 0.3386758}], 'mesh': [{'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011960', 'descriptor_name': 'Receptors, Estrogen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047628', 'descriptor_name': 'Estrogen Receptor alpha', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D047628', 'descriptor_name': 'Estrogen Receptor alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047629', 'descriptor_name': 'Estrogen Receptor beta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D047629', 'descriptor_name': 'Estrogen Receptor beta', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D047629', 'descriptor_name': 'Estrogen Receptor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010636', 'descriptor_name': 'Phenols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010636', 'descriptor_name': 'Phenols', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011960', 'descriptor_name': 'Receptors, Estrogen', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011960', 'descriptor_name': 'Receptors, Estrogen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm200801h', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3150643', 'pdf_url': 'https://europepmc.org/articles/pmc3150643?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150643', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21707083', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3150643', 'pdf_url': 'https://europepmc.org/articles/pmc3150643?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.8, 'id': 'https://metadata.un.org/sdg/2', 'display_name': 'Zero hunger'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 90, 'referenced_works': ['https://openalex.org/W112593876', 'https://openalex.org/W113287135', 'https://openalex.org/W135131141', 'https://openalex.org/W137338023', 'https://openalex.org/W1490889690', 'https://openalex.org/W154734720', 'https://openalex.org/W1576412791', 'https://openalex.org/W1604783672', 'https://openalex.org/W1809083310', 'https://openalex.org/W1905012638', 'https://openalex.org/W1966100806', 'https://openalex.org/W1966802748', 'https://openalex.org/W1967273772', 'https://openalex.org/W1969288882', 'https://openalex.org/W1970066136', 'https://openalex.org/W1973772110', 'https://openalex.org/W1979178661', 'https://openalex.org/W1979427043', 'https://openalex.org/W1983738467', 'https://openalex.org/W1990529844', 'https://openalex.org/W1992043185', 'https://openalex.org/W1992556561', 'https://openalex.org/W1997856170', 'https://openalex.org/W2000483250', 'https://openalex.org/W2002737481', 'https://openalex.org/W2003627629', 'https://openalex.org/W2004568789', 'https://openalex.org/W2007331274', 'https://openalex.org/W2011735277', 'https://openalex.org/W2017886735', 'https://openalex.org/W2018633308', 'https://openalex.org/W2019176482', 'https://openalex.org/W2023125910', 'https://openalex.org/W2029397596', 'https://openalex.org/W2030296201', 'https://openalex.org/W2033616764', 'https://openalex.org/W2034299708', 'https://openalex.org/W2035504218', 'https://openalex.org/W2037460676', 'https://openalex.org/W2039479720', 'https://openalex.org/W2039871782', 'https://openalex.org/W2043371605', 'https://openalex.org/W2044730187', 'https://openalex.org/W2046011994', 'https://openalex.org/W2054267961', 'https://openalex.org/W2054372078', 'https://openalex.org/W2054697866', 'https://openalex.org/W2059153388', 'https://openalex.org/W2071535433', 'https://openalex.org/W2071857822', 'https://openalex.org/W2073353512', 'https://openalex.org/W2073883348', 'https://openalex.org/W2074386248', 'https://openalex.org/W2081684816', 'https://openalex.org/W2087382494', 'https://openalex.org/W2088587953', 'https://openalex.org/W2092411075', 'https://openalex.org/W2094202891', 'https://openalex.org/W2095926494', 'https://openalex.org/W2097157376', 'https://openalex.org/W2098617547', 'https://openalex.org/W2101738855', 'https://openalex.org/W2101748792', 'https://openalex.org/W2101833345', 'https://openalex.org/W2103096901', 'https://openalex.org/W2106162177', 'https://openalex.org/W2109282960', 'https://openalex.org/W2109385821', 'https://openalex.org/W2111650618', 'https://openalex.org/W2123260033', 'https://openalex.org/W2123674503', 'https://openalex.org/W2124375064', 'https://openalex.org/W2125260355', 'https://openalex.org/W2139444294', 'https://openalex.org/W2145127139', 'https://openalex.org/W2146919072', 'https://openalex.org/W2150488741', 'https://openalex.org/W2151888740', 'https://openalex.org/W2154937055', 'https://openalex.org/W2161623422', 'https://openalex.org/W2169661929', 'https://openalex.org/W2169726583', 'https://openalex.org/W2170273915', 'https://openalex.org/W2171643283', 'https://openalex.org/W2177009684', 'https://openalex.org/W2346572707', 'https://openalex.org/W2410034064', 'https://openalex.org/W2465421918', 'https://openalex.org/W2785602850', 'https://openalex.org/W4239487857'], 'related_works': ['https://openalex.org/W4317642157', 'https://openalex.org/W4239542068', 'https://openalex.org/W2748952813', 'https://openalex.org/W2363440148', 'https://openalex.org/W2352401039', 'https://openalex.org/W2317510431', 'https://openalex.org/W2181265275', 'https://openalex.org/W1990811139', 'https://openalex.org/W1974749013', 'https://openalex.org/W134931362'], 'abstract_inverted_index': {'ADVERTISEMENT': [0], 'RETURN': [1], 'TO': [2], 'ISSUEPerspectiveNEXTThe': [3], '2010': [4], 'Philip': [5], 'S.': [6], 'Portoghese': [7], 'Medicinal': [8], 'Chemistry': [9], 'Lectureship:': [10], 'Addressing': [11], 'the': [12, 16, 85, 116, 121, 150, 161, 174, 177, 182, 189, 195], '"Core': [13], 'Issue"': [14], 'in': [15], 'Design': [17], 'of': [18, 28, 31, 88, 123, 149], 'Estrogen': [19], 'Receptor': [20], 'LigandsAward': [21], 'AddressJohn': [22], 'A.': [23], 'Katzenellenbogen*View': [24], 'Author': [25], 'Information': [26], 'Department': [27], 'Chemistry,': [29], 'University': [30], 'Illinois,': [32], '600': [33], 'South': [34], 'Mathews': [35], 'Avenue,': [36], 'Urbana,': [37], 'Illinois': [38], '61801,': [39], 'United': [40], 'StatesPhone:': [41], '1-217-333-6310.': [42], 'Fax:': [43], '1-217-333-7325.': [44], 'E-mail:': [45], '[email': [46], 'protected]Cite': [47], 'this:': [48], 'J.': [49], 'Med.': [50], 'Chem.': [51], '2011,': [52], '54,': [53], '15,': [54], '5271–5282Publication': [55], 'Date': [56], '(Web):June': [57], '27,': [58], '2011Publication': [59], 'History': [60], 'Received21': [61], 'June': [62], '2011Published': [63, 66], 'online11': [64], 'July': [65], 'inissue': [67], '11': [68], 'August': [69], '2011https://pubs.acs.org/doi/10.1021/jm200801hhttps://doi.org/10.1021/jm200801hreview-articleACS': [70], 'PublicationsCopyright': [71], '©': [72], '2011': [73], 'American': [74], 'Chemical': [75], 'SocietyRequest': [76], 'reuse': [77], 'permissionsArticle': [78], 'Views2457Altmetric-Citations71LEARN': [79], 'ABOUT': [80], 'THESE': [81], 'METRICSArticle': [82], 'Views': [83], 'are': [84, 107, 120], 'COUNTER-compliant': [86], 'sum': [87], 'full': [89], 'text': [90], 'article': [91, 155], 'downloads': [92], 'since': [93], 'November': [94], '2008': [95], '(both': [96], 'PDF': [97], 'and': [98, 103, 132, 176, 193, 209, 211], 'HTML)': [99], 'across': [100], 'all': [101], 'institutions': [102], 'individuals.': [104], 'These': [105], 'metrics': [106], 'regularly': [108], 'updated': [109, 133], 'to': [110, 115], 'reflect': [111], 'usage': [112], 'leading': [113], 'up': [114], 'last': [117], 'few': [118], 'days.Citations': [119], 'number': [122], 'other': [124], 'articles': [125], 'citing': [126], 'this': [127], 'article,': [128], 'calculated': [129], 'by': [130], 'Crossref': [131, 139], 'daily.': [134], 'Find': [135, 185], 'more': [136, 186], 'information': [137, 187], 'about': [138, 173], 'citation': [140], 'counts.The': [141], 'Altmetric': [142, 190], 'Attention': [143, 191], 'Score': [144, 192], 'is': [145, 197], 'a': [146, 153, 166], 'quantitative': [147], 'measure': [148], 'attention': [151], 'that': [152], 'research': [154], 'has': [156], 'received': [157], 'online.': [158], 'Clicking': [159], 'on': [160, 188], 'donut': [162], 'icon': [163], 'will': [164], 'load': [165], 'page': [167], 'at': [168], 'altmetric.com': [169], 'with': [170, 205], 'additional': [171], 'details': [172], 'score': [175, 196], 'social': [178], 'media': [179], 'presence': [180], 'for': [181], 'given': [183], 'article.': [184], 'how': [194], 'calculated.': [198], 'Share': [199, 214], 'Add': [200], 'toView': [201], 'InAdd': [202], 'Full': [203], 'Text': [204], 'ReferenceAdd': [206], 'Description': [207], 'ExportRISCitationCitation': [208], 'abstractCitation': [210], 'referencesMore': [212], 'Options': [213], 'onFacebookTwitterWechatLinked': [215], 'InRedditEmail': [216], 'Other': [217], 'access': [218], 'optionsGet': [219], 'e-Alertsclose': [220], 'SUBJECTS:Crystal': [221], 'structure,Elements,Ligands,Receptors,Substituents': [222], 'Get': [223], 'e-Alerts': [224]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2039028122', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-12-17T13:25:22.779191', 'created_date': '2016-06-24'}