Title: Lactobacillus helveticus growth and lactic acid production during pH-controlled batch cultures in whey permeate/yeast extract medium. Part II: kinetic modeling and model validation
Abstract: A kinetic model was developed that describes growth and lactic acid production rates of Lactobacillus helveticus during pH-controlled batch cultures in whey permeate-yeast extract medium as a function of four variables: sugar, nitrogen substrate and lactic acid concentrations, and pH. Since available nitrogen substrate could not be measured directly, it was related to medium composition through a response surface model of maximum biomass concentration in nitrogen-limited growth cultures. The effect of pH on growth was modeled with a Gaussian equation instead of the traditional second order polynomial term. Product inhibition was modeled with a logistic term for lactate and an exponential term for undissociated lactic acid. The kinetic model accurately described the experimental data with few exceptions.
Publication Year: 2002
Publication Date: 2002-02-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 50
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