Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2038715496', 'doi': 'https://doi.org/10.1002/pbc.21727', 'title': 'High level of mitogen‐activated protein kinase phosphatase‐1 expression is associated with cisplatin resistance in osteosarcoma', 'display_name': 'High level of mitogen‐activated protein kinase phosphatase‐1 expression is associated with cisplatin resistance in osteosarcoma', 'publication_year': 2008, 'publication_date': '2008-08-22', 'ids': {'openalex': 'https://openalex.org/W2038715496', 'doi': 'https://doi.org/10.1002/pbc.21727', 'mag': '2038715496', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18726921', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2728603'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/pbc.21727', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119714264', 'display_name': 'Pediatric Blood & Cancer', 'issn_l': '1545-5009', 'issn': ['1545-5009', '1545-5017'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'http://deepblue.lib.umich.edu/bitstream/2027.42/61231/1/21727_ftp.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100461015', 'display_name': 'Zhihong Wang', 'orcid': 'https://orcid.org/0000-0003-1667-3536'}, 'institutions': [{'id': 'https://openalex.org/I1288882113', 'display_name': "Boston Children's Hospital", 'ror': 'https://ror.org/00dvg7y05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1288882113']}, {'id': 'https://openalex.org/I4210130818', 'display_name': "Children's Hospital of Michigan", 'ror': 'https://ror.org/0429x9p85', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800326109', 'https://openalex.org/I4210130818']}, {'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhihong Wang', 'raw_affiliation_strings': ["Carman & Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan", "Division of Hematology/Oncology, Children's Hospital of Michigan, 3901 Beaubien, Detroit, MI 48201."], 'affiliations': [{'raw_affiliation_string': "Division of Hematology/Oncology, Children's Hospital of Michigan, 3901 Beaubien, Detroit, MI 48201.", 'institution_ids': ['https://openalex.org/I1288882113']}, {'raw_affiliation_string': "Carman & Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan", 'institution_ids': ['https://openalex.org/I4210130818', 'https://openalex.org/I185443292']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048064996', 'display_name': 'Junying Zhou', 'orcid': 'https://orcid.org/0000-0001-5060-3879'}, 'institutions': [{'id': 'https://openalex.org/I4210090317', 'display_name': 'The Barbara Ann Karmanos Cancer Institute', 'ror': 'https://ror.org/00ee40h97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2800590384', 'https://openalex.org/I4210090317']}, {'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jun‐Ying Zhou', 'raw_affiliation_strings': ['Program in Molecular Biology and Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University, Detroit, Michigan'], 'affiliations': [{'raw_affiliation_string': 'Program in Molecular Biology and Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University, Detroit, Michigan', 'institution_ids': ['https://openalex.org/I4210090317', 'https://openalex.org/I185443292']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017169335', 'display_name': 'Deepa Kanakapalli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Deepa Kanakapalli', 'raw_affiliation_strings': ["Carman and Ann Adams Department of Pediatrics Children's Hospital of Michigan/Wayne State University Detroit Michigan"], 'affiliations': [{'raw_affiliation_string': "Carman and Ann Adams Department of Pediatrics Children's Hospital of Michigan/Wayne State University Detroit Michigan", 'institution_ids': ['https://openalex.org/I185443292']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033131000', 'display_name': 'Steven Buck', 'orcid': 'https://orcid.org/0000-0001-5015-0187'}, 'institutions': [{'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven Buck', 'raw_affiliation_strings': ["Carman and Ann Adams Department of Pediatrics Children's Hospital of Michigan/Wayne State University Detroit Michigan"], 'affiliations': [{'raw_affiliation_string': "Carman and Ann Adams Department of Pediatrics Children's Hospital of Michigan/Wayne State University Detroit Michigan", 'institution_ids': ['https://openalex.org/I185443292']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059971077', 'display_name': 'Gen Sheng Wu', 'orcid': 'https://orcid.org/0000-0001-8166-5474'}, 'institutions': [{'id': 'https://openalex.org/I4210090317', 'display_name': 'The Barbara Ann Karmanos Cancer Institute', 'ror': 'https://ror.org/00ee40h97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2800590384', 'https://openalex.org/I4210090317']}, {'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gen Sheng Wu', 'raw_affiliation_strings': ['Program in Molecular Biology and Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University, Detroit, Michigan'], 'affiliations': [{'raw_affiliation_string': 'Program in Molecular Biology and Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University, Detroit, Michigan', 'institution_ids': ['https://openalex.org/I4210090317', 'https://openalex.org/I185443292']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062366315', 'display_name': 'Yaddanapudi Ravindranath', 'orcid': 'https://orcid.org/0000-0001-9577-9624'}, 'institutions': [{'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yaddanapudi Ravindranath', 'raw_affiliation_strings': ["Carman and Ann Adams Department of Pediatrics Children's Hospital of Michigan/Wayne State University Detroit Michigan"], 'affiliations': [{'raw_affiliation_string': "Carman and Ann Adams Department of Pediatrics Children's Hospital of Michigan/Wayne State University Detroit Michigan", 'institution_ids': ['https://openalex.org/I185443292']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4330, 'currency': 'USD', 'value_usd': 4330, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.263, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 19, 'citation_normalized_percentile': {'value': 0.756214, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '51', 'issue': '6', 'first_page': '754', 'last_page': '759'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13026', 'display_name': 'Natural Compounds in Disease Treatment', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12827', 'display_name': 'Biochemical and Molecular Research', 'score': 0.9915, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2778239845', 'wikidata': 'https://www.wikidata.org/wiki/Q412415', 'display_name': 'Cisplatin', 'level': 3, 'score': 0.9514643}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.71511865}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.66361314}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.61571467}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.60937977}, {'id': 'https://openalex.org/C119056186', 'wikidata': 'https://www.wikidata.org/wiki/Q1431332', 'display_name': 'Gene silencing', 'level': 3, 'score': 0.4744602}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.47411114}, {'id': 'https://openalex.org/C2777760704', 'wikidata': 'https://www.wikidata.org/wiki/Q549534', 'display_name': 'Osteosarcoma', 'level': 2, 'score': 0.46183538}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.42254862}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.4154845}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.41533673}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.29199186}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.27761585}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.22228971}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.18394381}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.14513475}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0602881}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D054638', 'descriptor_name': 'Dual Specificity Phosphatase 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012516', 'descriptor_name': 'Osteosarcoma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D012516', 'descriptor_name': 'Osteosarcoma', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015152', 'descriptor_name': 'Blotting, Northern', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054638', 'descriptor_name': 'Dual Specificity Phosphatase 1', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D054638', 'descriptor_name': 'Dual Specificity Phosphatase 1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D054638', 'descriptor_name': 'Dual Specificity Phosphatase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054637', 'descriptor_name': 'Dual-Specificity Phosphatases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005434', 'descriptor_name': 'Flow Cytometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048031', 'descriptor_name': 'JNK Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D048031', 'descriptor_name': 'JNK Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054639', 'descriptor_name': 'Mitogen-Activated Protein Kinase Phosphatases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012516', 'descriptor_name': 'Osteosarcoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D012516', 'descriptor_name': 'Osteosarcoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/pbc.21727', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119714264', 'display_name': 'Pediatric Blood & Cancer', 'issn_l': '1545-5009', 'issn': ['1545-5009', '1545-5017'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/2027.42/61231', 'pdf_url': 'http://deepblue.lib.umich.edu/bitstream/2027.42/61231/1/21727_ftp.pdf', 'source': {'id': 'https://openalex.org/S4306400393', 'display_name': 'Deep Blue (University of Michigan)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I27837315', 'host_organization_name': 'University of Michigan–Ann Arbor', 'host_organization_lineage': ['https://openalex.org/I27837315'], 'host_organization_lineage_names': ['University of Michigan–Ann Arbor'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2728603', 'pdf_url': 'https://europepmc.org/articles/pmc2728603?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728603', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18726921', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/2027.42/61231', 'pdf_url': 'http://deepblue.lib.umich.edu/bitstream/2027.42/61231/1/21727_ftp.pdf', 'source': {'id': 'https://openalex.org/S4306400393', 'display_name': 'Deep Blue (University of Michigan)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I27837315', 'host_organization_name': 'University of Michigan–Ann Arbor', 'host_organization_lineage': ['https://openalex.org/I27837315'], 'host_organization_lineage_names': ['University of Michigan–Ann Arbor'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.82, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1854116296', 'https://openalex.org/W1974693247', 'https://openalex.org/W1982390204', 'https://openalex.org/W1998935881', 'https://openalex.org/W2008302942', 'https://openalex.org/W2009338557', 'https://openalex.org/W2014994298', 'https://openalex.org/W2032124472', 'https://openalex.org/W2033881945', 'https://openalex.org/W2038959355', 'https://openalex.org/W2044733296', 'https://openalex.org/W2055489321', 'https://openalex.org/W2057685998', 'https://openalex.org/W2073541193', 'https://openalex.org/W2075554815', 'https://openalex.org/W2086033457', 'https://openalex.org/W2093132464', 'https://openalex.org/W2127532437', 'https://openalex.org/W2128260825', 'https://openalex.org/W2132990773', 'https://openalex.org/W2136693393', 'https://openalex.org/W2148077417', 'https://openalex.org/W2153526687', 'https://openalex.org/W2154663755', 'https://openalex.org/W2547451769', 'https://openalex.org/W4243636416', 'https://openalex.org/W4246742253'], 'related_works': ['https://openalex.org/W4323315835', 'https://openalex.org/W4306641919', 'https://openalex.org/W4241436983', 'https://openalex.org/W3178656640', 'https://openalex.org/W3146832629', 'https://openalex.org/W2620289816', 'https://openalex.org/W2388705147', 'https://openalex.org/W2375068014', 'https://openalex.org/W2356699866', 'https://openalex.org/W2320346276'], 'abstract_inverted_index': {'Cisplatin': [0], 'is': [1, 46, 183], 'one': [2], 'of': [3, 12, 23, 57, 71, 121, 131, 208], 'the': [4, 10, 63, 78], 'most': [5], 'effective': [6], 'chemotherapeutic': [7], 'agents': [8], 'in': [9, 41, 51, 152, 154, 195], 'treatment': [11, 44, 149], 'several': [13], 'solid': [14], 'tumors': [15], 'including': [16], 'osteosarcoma': [17], '(OS).': [18], 'Despite': [19], 'aggressive': [20], 'treatment,': [21], '25%': [22], 'patients': [24], 'with': [25, 185], 'OS': [26, 42, 72, 84, 196], 'continue': [27], 'to': [28, 53, 61, 76, 126, 139, 156, 191], 'die': [29], 'from': [30], 'their': [31, 90], 'disease.': [32], 'Since': [33], 'cisplatin': [34, 54, 69, 94, 148, 166, 209], 'based': [35], 'regimens': [36], 'have': [37], 'been': [38], 'uniformly': [39], 'used': [40, 204], 'therapy,': [43], 'failure': [45], 'likely': [47], 'due,': [48], 'at': [49], 'least': [50], 'part,': [52], 'resistance.The': [55], 'objective': [56], 'this': [58, 81], 'study': [59], 'was': [60, 101, 150], 'determine': [62], 'relationship': [64], 'between': [65], 'MKP-1': [66, 91, 132, 161, 171, 174, 181, 200], 'expression': [67, 92, 162, 175, 182], 'and': [68, 75, 93, 98, 105, 111, 163, 176, 199, 211], 'sensitivity': [70, 187], 'cell': [73, 85, 128, 141, 179, 193, 197], 'lines': [74, 86], 'explore': [77], 'mechanism': [79], 'underlying': [80], 'relationship.': [82], 'Three': [83], 'were': [87, 114], 'examined': [88], 'for': [89, 215], 'sensitivity.': [95], 'JNK': [96, 158], 'phosphorylation': [97], 'apoptosis': [99, 145], 'induction': [100, 146], 'also': [102], 'measured.': [103], 'Western': [104], 'Northern': [106], 'blot,': [107], 'flow': [108], 'cytometry,': [109], 'siRNA,': [110], 'MTT': [112], 'assays': [113], 'used.U2OS': [115], 'cells,': [116], 'which': [117], 'express': [118], 'high': [119], 'level': [120], 'MKP-1,': [122], 'are': [123], 'less': [124], 'sensitive': [125], 'cisplatin-induced': [127, 140, 178, 192], 'death.': [129, 142], 'Inhibition': [130], 'by': [133], 'siRNA': [134], 'silencing': [135], 'sensitizes': [136], 'U2OS': [137], 'cells': [138], 'Furthermore,': [143], 'delayed': [144], 'following': [147], 'observed': [151], 'U2OS,': [153], 'parallel': [155], 'decreased': [157, 186], 'activation,': [159], 'increased': [160, 165, 189], 'relatively': [164], 'resistance.': [167], 'Interestingly,': [168], 'triptolide,': [169], 'an': [170], 'inhibitor,': [172], 'blocks': [173], 'enhances': [177], 'death.High': [180], 'associated': [184], 'or': [188], 'resistance': [190, 210], 'death': [194], 'lines,': [198], 'could': [201], 'potentially': [202], 'be': [203], 'as': [205], 'a': [206, 212], 'marker': [207], 'therapeutic': [213], 'target': [214], 'molecular': [216], 'therapies.': [217]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2038715496', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-21T19:44:13.507300', 'created_date': '2016-06-24'}