Title: Effect of Steroid Hormones, Ovariectomy, Estrogen Pretreatment, Sex and Immaturity on the Distribution of<sup>3</sup>H-Estradiol
Abstract: Binding sites of limited capacity for 3H-estradiol have been demonstrated in the anterior pituitary, uterus, vagina and hypothalamus. Administration of estrone or estriol decreased the accumulation of 3H-estradiol in the anterior pituitary, uterus, vagina and hypothalamus, whereas the concentration of 3Hestradiol in the heart, cerebrum and plasma was not reduced. High doses of progesterone, testosterone, or hydrocortisone did not reduce the concentration of 3H-estradiol in tissues. These observations indicate a high specificity for attachment to the estradiol binding sites. The distribution of 3H-estradiol was similar in intact and ovariectomized rats except for a lower concentration but higher content in the uterus of the animals with ovaries. Treatment of ovariectomized rats with estrogen increased the capacity of the uterus to bind estradiol. The accumulation of 3H-estradiol in peripheral organs and, probably, in the central nervous system was similar in mature and immature female rats. The central nervous system of male and female rats accumulated 3H-estradiol to the same extent. In contrast to the female sexual organs, the testis, epididymis and prostate did not concentrate 3H-estradiol. (Endocrinology79: 38,1966)
Publication Year: 1966
Publication Date: 1966-07-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 136
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