Ceramides Are Bound to Structural Proteins of the Human Foreskin Epidermal Cornified Cell Envelope

Name: Work Video:
Duration: 3 min 30 s
Lyuben N. Marekov; Peter M. Steinert
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343, 3071], 'total': [130, 346, 3105, 3139, 3647, 3851, 3875, 4332], 'CE': [132, 153, 173, 209, 348, 369, 389, 425, 1397, 1642, 1704, 1920, 2136, 2170, 2544, 2615, 2809, 3165, 3267, 3652, 3658, 3663, 3702, 3794, 3881], 'ceramides.': [133, 349, 3469, 3541, 4316], 'amino': [135, 351, 2274, 3190, 3903, 4144, 4261, 4299, 4362], 'sequencing,': [137, 353], '35%': [139, 355, 4329], 'derived': [144, 158, 360, 374], 'ancestral': [146, 362, 4374], 'glutamine-glutamate-rich': [147, 363], 'regions': [148, 364, 3163], 'involucrin,': [150, 188, 366, 404, 1914, 2641, 4176, 4352], 'an': [151, 367, 444, 560, 2357, 2449, 2762, 3407, 3417, 3991, 4116, 4137, 4172, 4183], 'structural': [154, 194, 370, 410, 624, 2536, 2605], 'protein.': [155, 371, 3659, 4290], 'Another': [156, 372, 3871], '18%': [157, 373], 'rod': [160, 376], 'domain': [161, 377], 'sequences': [162, 378, 1713, 3914, 4074, 4325, 4350, 4369], 'periplakin': [164, 380], 'envoplakin,': [166, 189, 382, 405, 2642], 'also': [169, 385, 2668, 3587], 'known': [170, 386, 1775, 2051], 'or': [171, 387, 834, 2127, 2144, 2277, 2611, 2848, 2852, 3119, 3145, 3511, 3537, 3924], 'suspected': [172, 388], 'proteins.': [174, 390, 1921], 'Other': [175, 391], 'too': [178, 394], 'short': [179, 395], 'unequivocal': [181, 397], 'identification.': [182, 398], 'Together,': [183, 399], 'these': [184, 400, 2738, 3723, 3964, 4150], 'indicate': [186, 402, 3535], 'periplakin,': [190, 406], 'possibly': [192, 408], 'other': [193, 409, 1400, 1918, 2671], 'serve': [196, 412], 'as': [197, 413, 829, 1168, 1403, 1915, 1917, 1935, 2187, 2287, 2393, 2418, 2480, 3949, 3996], 'substrates': [198, 414, 2735], 'attachment': [201, 417, 4275, 4313], 'epidermis.': [215, 431], 'Mammalian': [432], 'lies': [434], 'at': [435, 833, 2013, 2043, 2067, 2112, 2158, 2234, 2800, 2822, 3233, 4338], 'interface': [437], 'with': [438, 820, 1660, 2002, 2071, 2142, 2241, 2249, 2402, 2470, 2782, 2846, 3042, 3050, 3482, 3567, 3978, 4175], 'environment,': [440], 'where': [441, 2905], 'it': 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[471, 499, 1113, 1298, 1447, 1684, 1811], 'Dermatology': [472, 500, 1114, 1299, 1448, 1685, 1812], 'General': [474, 502, 1116, 1301, 1450, 1687, 1814], 'Medicine.': [475, 503, 1117, 1302, 1451, 1688, 1815], 'McGraw-Hill,': [476, 504, 1118, 1303, 1452, 1689, 1816], 'Inc.,': [477, 505, 525, 691, 775, 1119, 1139, 1304, 1324, 1453, 1473, 1622, 1690, 1817, 3367], 'New': [478, 506, 692, 776, 1120, 1305, 1364, 1454, 1603, 1691, 1818, 3348], 'York1993:': [479, 507, 693, 777, 1121, 1306, 1455, 1692, 1819], '97-145Google': [480], 'Scholar,': [481, 509, 529, 657, 673, 695, 741, 757, 779, 796, 850, 870, 890, 983, 1003, 1023, 1042, 1055, 1123, 1143, 1199, 1219, 1237, 1308, 1328, 1457, 1477, 1494, 1513, 1525, 1545, 1563, 1585, 1606, 1730, 1750, 1821, 1843, 1947, 1967, 2309, 2564, 2695, 2919, 2939, 3290, 3308, 3330, 3351, 3371, 3745, 3763, 3824, 4022, 4037, 4390], '2Downing': [482, 1281], 'D.T.': [483, 1097, 1207, 1225, 1247, 1282, 1350, 1431, 1533, 1551, 1573, 1589, 1668, 1795, 1831, 1849, 3278, 3296, 3318, 3334, 3377, 3733, 3751, 3773, 3812, 3830], 'Stewart': [484, 1098, 1283, 1432, 1669, 1796], 'M.E.': [485, 1099, 1284, 1433, 1670, 1797], 'Wertz': [486, 1100, 1202, 1285, 1434, 1528, 1671, 1798, 3273, 3728, 3807], 'P.W.': [487, 1101, 1203, 1221, 1239, 1286, 1348, 1435, 1529, 1547, 1565, 1587, 1672, 1799, 1823, 3274, 3292, 3310, 3332, 3729, 3747, 3765, 3808, 3826], 'Strauss': [488, 1102, 1287, 1436, 1673, 1800], 'J.S.': [489, 1103, 1288, 1437, 1674, 1801], '210-221Google': [508, 1122, 1307, 1456, 1693, 1820], '3Elias': [510, 1124, 1309, 1458], 'P.M.': [511, 515, 842, 852, 872, 921, 975, 985, 1005, 1027, 1046, 1061, 1125, 1129, 1189, 1310, 1314, 1459, 1463, 1500, 1515, 1610, 1612, 1722, 1732, 1752, 1939, 1949, 1969, 2022, 2190, 2199, 2291, 2311, 2546, 2566, 2618, 2646, 2677, 2911, 2921, 2941, 3075, 3355, 3357], 'Menon': [512, 1126, 1311, 1460], 'G.K.': [513, 1127, 1312, 1461], 'Elias': [514, 1128, 1313, 1462, 1609, 1611, 3354, 3356], 'Skin': [516, 1130, 1315, 1464, 1613, 3358], 'Lipids,': [517, 1131, 1316, 1465, 1614, 3359], 'Advances': [518, 1132, 1317, 1466, 1615, 3360], 'Lipid': [520, 1134, 1319, 1468, 1617, 3362], 'Research.': [521, 1135, 1320, 1469, 1618, 3363], '24.': [522, 1136, 1321, 1470, 1619, 3364], 'Academic': [523, 689, 773, 1137, 1322, 1471, 1620, 3365], 'Press': [524, 1138, 1323, 1472, 1621, 3366], 'San': [526, 1140, 1325, 1474, 1623, 3368], 'Diego1991:': [527, 1141, 1326, 1475, 1624, 3369], '1-26Google': [528, 1142, 1327, 1476], '4Ponec': [530, 1144, 1329, 1478], 'M.': [531, 681, 683, 697, 765, 767, 781, 1057, 1145, 1330, 1479, 1496, 2429, 3436, 3677, 3679, 4087], 'Leigh': [532, 698, 782, 1146, 1331, 1480], 'Lane': [534, 700, 784, 1148, 1333, 1482], 'E.': [535, 701, 785, 1149, 1334, 1483], 'Watt': [536, 702, 786, 1150, 1335, 1484], 'F.M.': [537, 703, 787, 1151, 1336, 1485], 'Keratinocyte': [539, 705, 789, 1153, 1338, 1487], 'Handbook.': [540, 706, 790, 1154, 1339, 1488], 'Cambridge': [541, 707, 791, 1155, 1340, 1489], 'University': [542, 708, 792, 1156, 1341, 1362, 1490, 1601, 3346], 'Press,': [543, 709, 793, 1157, 1342, 1363, 1491, 1602, 3347], 'Cambridge1994:': [544, 710, 794, 1158, 1343, 1492], '351-363Google': [545, 1159, 1344, 1493], 'Scholar).': [546, 712, 814, 1074, 1160, 1259, 1367, 1626, 1694, 1770, 1987, 2217, 2329, 2444, 2584, 2636, 2719, 2959, 3391, 3451, 3842, 4051], 'Cornified': [547], 'keratinocytes,': [548], 'constitute': [550, 4372], 'type': [554], 'epidermis,': [557], 'evolved': [559], 'elaborate': [561], 'system.': [563], 'Part': [564], '(CE),': [574], '1The': [575, 588], 'abbreviations': [576, 589], 'used': [577, 590, 2120, 2233, 2479, 3168, 3406, 3901], 'are:': [578, 591], 'CE,': [579, 592, 2904], 'envelope;': [582, 595], 'HPLC,': [583, 596], 'high': [584, 597], 'performance': [585, 598, 2182, 2460], 'liquid': [586, 599, 2183], 'chromatography.': [587, 600], '15–20-nm': [604], 'thick': [605, 3668], 'layer': [606, 620, 1171, 2462, 3802], 'on': [607, 628, 1184, 1709, 2179, 2794, 2862, 3198, 3220, 3456, 3718, 4201], 'periphery': [609], 'corneocyte,': [612], 'consists': [614], 'two': [616, 3955], 'components.': [617], '≈15-nm-thick': [619], 'defined': [623], 'deposited': [627], 'intracellular': [630], 'surface': [631, 1187, 1639, 1646, 3795], 'membrane': [635, 1165], 'upper': [638, 1085], 'spinous': [639], 'granular': [641, 1086, 1272], 'cells': [642, 1273], 'living': [645], '(5Hohl': [647, 731], 'H.': [648, 732, 942, 4379, 4392], 'Dermatologica.': [649, 733], '1990;': [650, 734, 807], '180:': [651, 735, 2438, 3445], '201-211Crossref': [652, 736], 'PubMed': [653, 669, 737, 753, 810, 866, 886, 910, 935, 954, 999, 1019, 1038, 1053, 1072, 1195, 1217, 1235, 1257, 1511, 1521, 1543, 1561, 1583, 1746, 1766, 1841, 1859, 1963, 1983, 2036, 2213, 2305, 2325, 2440, 2560, 2580, 2632, 2660, 2691, 2715, 2935, 2955, 3089, 3288, 3306, 3328, 3387, 3447, 3743, 3761, 3783, 3822, 3840, 4033, 4047], 'Scopus': [654, 670, 738, 754, 811, 867, 887, 911, 936, 1000, 1020, 1039, 1196, 1522, 1747, 1767, 1860, 1964, 1984, 2037, 2214, 2306, 2326, 2441, 2561, 2581, 2633, 2661, 2692, 2716, 2936, 2956, 3090, 3388, 3448, 4034, 4048, 4387], '(170)': [655, 739], 'Google': [656, 672, 740, 756, 813, 849, 869, 889, 913, 938, 955, 982, 1002, 1022, 1041, 1054, 1073, 1198, 1218, 1236, 1258, 1512, 1524, 1544, 1562, 1584, 1729, 1749, 1769, 1842, 1862, 1946, 1966, 1986, 2039, 2197, 2216, 2308, 2328, 2443, 2563, 2583, 2635, 2663, 2694, 2718, 2918, 2938, 2958, 3092, 3289, 3307, 3329, 3390, 3450, 3688, 3744, 3762, 3784, 3823, 3841, 4021, 4036, 4050, 4389], '6Greenberg': [658, 742], 'C.S.': [659, 743], 'Birckbichler': [660, 744], 'P.J.': [661, 745], 'Rice': [662, 746], 'R.H.': [663, 747], 'FASEB': [664, 748], 'J.': [665, 749, 806, 855, 875, 899, 924, 945, 988, 1008, 1047, 1066, 1190, 1208, 1226, 1248, 1505, 1516, 1534, 1552, 1574, 1735, 1755, 1832, 1850, 1952, 1972, 2025, 2202, 2294, 2314, 2434, 2549, 2569, 2621, 2649, 2680, 2704, 2924, 2944, 3078, 3279, 3297, 3319, 3378, 3441, 3682, 3734, 3752, 3774, 3813, 3831], '1991;': [666, 750], '5:': [667, 751], '3071-3077Crossref': [668, 752], '(931)': [671, 755], '7Reichert': [674, 758], 'U.': [675, 759, 1032, 1063, 1502], 'Michel': [676, 760], 'S.': [677, 761, 800, 894, 1033, 2699], 'Schmidt': [678, 762], 'R': [679, 763], 'Darmon': [680, 764], 'Blumenberg': [682, 766], 'Molecular': [684, 768, 1356, 1595, 3340], 'Biology': [685, 769, 1357, 1596, 3341], 'Skin.': [688, 772, 1360, 1599, 3344], 'press,': [690, 774], '107-150Google': [694, 778], '8Simon': [696, 780], '275-292Google': [711, 795], 'These': [713, 2637, 3244, 3617, 4344], 'become': [715, 1177, 1385], 'cross-linked': [716, 4077], 'together': [717, 916], 'disulfide': [719], 'bonds': [720, 724], 'andNε(γ-glutamyl)lysine': [721], 'orN1,N8-bis(γ-glutamyl)spermidine': [722], 'isopeptide': [723], 'formed': [725], 'action': [728], 'transglutaminases': [730, 3979], '9Martinet': [797], 'N.': [798, 4083], 'Beninati': [799], 'Nigra': [801], 'T.P.': [802], 'Folk': [803], 'J.E.': [804, 4011, 4039], 'Biochem.': [805, 4029], '271:': [808], '305-308Crossref': [809], '(40)': [812], 'This': [815, 2445, 3704], 'process': [816], 'appears': [817], 'begin': [819], 'cross-linking': [822, 3976], 'certain': [824, 1907], 'early': [825], 'components,': [827], 'such': [828, 1402, 3995, 4070, 4092], 'involucrin': [830, 3946], 'envoplakins,': [832], 'site': [838, 4273, 4311], 'desmosomes': [840], '(10Steinert': [841, 974, 1721, 1938, 2189, 2910], 'Cell': [843, 976, 1048, 1067, 1506, 1723, 1940, 2191, 2912, 3683], 'Death': [844, 977, 1724, 1941, 2192, 2913], 'Differ.': [845, 978, 1725, 1942, 2193, 2914], '1995;': [846, 858, 979, 991, 1726, 1738, 1853, 1943, 1955, 2194, 2205, 2297, 2552, 2915, 2927, 3081, 3381], '2:': [847, 980, 1727, 1944, 2195, 2916], '33-41PubMed': [848, 981, 1728, 1945, 2196, 2917], '11Steinert': [851, 984, 1731, 1948, 2920, 3074], 'Marekov': [853, 873, 922, 986, 1006, 1733, 1753, 1950, 1970, 2023, 2200, 2292, 2312, 2547, 2567, 2619, 2647, 2678, 2922, 2942, 3076, 4084], 'L.N.': [854, 874, 923, 987, 1007, 1734, 1754, 1951, 1971, 2024, 2201, 2293, 2313, 2548, 2568, 2620, 2648, 2679, 2923, 2943, 3077], 'Biol.': [856, 876, 900, 925, 946, 989, 1009, 1736, 1756, 1953, 1973, 2026, 2203, 2295, 2315, 2550, 2570, 2622, 2650, 2681, 2705, 2925, 2945, 3079, 4017, 4396], 'Chem.': [857, 877, 901, 926, 947, 990, 1010, 1737, 1757, 1954, 1974, 2027, 2204, 2296, 2316, 2551, 2571, 2623, 2651, 2682, 2706, 2926, 2946, 3080], '270:': [859, 992, 1739, 1956, 2206, 2298, 2553, 2928, 3082], '17702-17711Abstract': [860, 993, 1740, 1957, 2207, 2299, 2554, 2929, 3083], 'Full': [861, 863, 881, 883, 905, 907, 930, 932, 951, 994, 996, 1014, 1016, 1214, 1232, 1254, 1540, 1558, 1580, 1741, 1743, 1761, 1763, 1838, 1856, 1958, 1960, 1978, 1980, 2031, 2033, 2208, 2210, 2300, 2302, 2320, 2322, 2555, 2557, 2575, 2577, 2627, 2629, 2655, 2657, 2686, 2688, 2710, 2712, 2930, 2932, 2950, 2952, 3084, 3086, 3285, 3303, 3325, 3384, 3740, 3758, 3780, 3819, 3837, 4384], 'Text': [862, 864, 882, 884, 906, 908, 931, 933, 952, 995, 997, 1015, 1017, 1215, 1233, 1255, 1541, 1559, 1581, 1742, 1744, 1762, 1764, 1839, 1857, 1959, 1961, 1979, 1981, 2032, 2034, 2209, 2211, 2301, 2303, 2321, 2323, 2556, 2558, 2576, 2578, 2628, 2630, 2656, 2658, 2687, 2689, 2711, 2713, 2931, 2933, 2951, 2953, 3085, 3087, 3286, 3304, 3326, 3385, 3741, 3759, 3781, 3820, 3838, 4385], 'PDF': [865, 885, 909, 934, 953, 998, 1018, 1216, 1234, 1256, 1542, 1560, 1582, 1745, 1765, 1840, 1858, 1962, 1982, 2035, 2212, 2304, 2324, 2559, 2579, 2631, 2659, 2690, 2714, 2934, 2954, 3088, 3287, 3305, 3327, 3386, 3742, 3760, 3782, 3821, 3839, 4386], '(480)': [868, 1001, 1748, 1965, 2215, 2307, 2562, 2937, 3091], '12Steinert': [871, 1004, 1751, 1968, 2310, 2565, 2940], '1997;': [878, 902, 927, 1011, 1758, 1975, 2028, 2317, 2572, 2624, 2652, 2683, 2707, 2947], '272:': [879, 903, 928, 1012, 1759, 1976, 2029, 2318, 2573, 2625, 2653, 2684, 2708, 2948], '2021-2030Abstract': [880, 929, 1013, 1760, 1977, 2030, 2319, 2574, 2626, 2654, 2685, 2949], '(200)': [888, 937, 1021, 1768, 1985, 2038, 2327, 2582, 2634, 2662, 2693, 2957], '13Robinson': [891, 2696], 'N.A.': [892, 2697], 'Lapic': [893, 2698], 'Welter': [895, 2700], 'J.F.': [896, 2701], 'Eckert': [897, 943, 2702], 'R.L.': [898, 944, 2703, 4377], '12035-12046Abstract': [904, 2709], '(207)': [912, 2717], 'Scholar),': [914, 1863, 2664, 3689], 'form': [917, 1412], 'scaffold': [919], '(12Steinert': [920, 2021, 2617, 2645, 2676], 'Scholar,14Yaffe': [939], 'M.B.': [940], 'Beegen': [941], '1992;': [948], '267:': [949], '12233-12238Abstract': [950], 'Scholar)': [956, 2040, 3093], 'subsequent': [959, 2844], 'stages': [960, 2613], 'addition': [962, 1872], 'elafin,': [964], 'small': [965], 'proline-rich': [966], 'proteins,': [967], 'much': [969], 'larger': [970], 'loricrin': [973], '15Yoneda': [1024], 'Steinert': [1026, 1045, 1060, 1499], 'Proc.': [1028], 'Natl.': [1029], 'Acad.': [1030], 'Sci.': [1031, 1049, 1068, 1507, 3684], 'A.': [1034, 2421, 3428], '1993;': [1035], '90:': [1036], '10754-10758Crossref': [1037], '(61)': [1040], '16Steven': [1043], 'A.C.': [1044, 1065, 1504, 3681], '1994;': [1050, 2437, 3444], '107:': [1051], '693-700Crossref': [1052], '17Jarnik': [1056, 1495], 'Kartasova': [1058, 1497], 'T.': [1059, 1498], 'Lichti': [1062, 1501], 'Steven': [1064, 1503, 3680], '1996;': [1069, 1192, 1508, 1518], '109:': [1070, 1509], '1381-1391Crossref': [1071, 1510], 'At': [1075], 'late': [1077], 'stage': [1078], 'assembly,': [1082], 'perhaps': [1083, 1662], 'cells,': [1087], 'lipid': [1089, 1779, 1871, 2784, 3170, 3262, 4111, 4159, 4178], 'assembled': [1093], '(reviewed': [1094, 1278], 'Refs.2Downing': [1096], 'phospholipid-rich': [1162], 'cellular': [1163], 'plasma': [1164], 'rebuilt': [1167], '5-nm-thick': [1170], 'lipids,': [1174, 1401], 'subsequently': [1176], 'covalently': [1178, 1386, 2741], 'attached': [1179, 1387, 1782, 1905, 2278, 2752, 4181, 4346], 'extracellular': [1186], '(18Elias': [1188], 'Dermatol.': [1191, 1210, 1228, 1250, 1517, 1536, 1554, 1576, 1834, 1852, 3281, 3299, 3321, 3380, 3736, 3754, 3776, 3815, 3833], '23:': [1193, 1519], '756-758Crossref': [1194, 1520], '(67)': [1197, 1523], '19Swartzendruber': [1200, 1526, 3726], 'D.C.': [1201, 1241, 1527, 1567, 1825, 3272, 3312, 3727, 3767, 3806], 'Madison': [1204, 1222, 1244, 1530, 1548, 1570, 1828, 3275, 3293, 3315, 3730, 3748, 3770, 3809, 3827], 'K.C.': [1205, 1223, 1245, 1531, 1549, 1571, 1829, 3276, 3294, 3316, 3731, 3749, 3771, 3810, 3828], 'Downing': [1206, 1224, 1246, 1349, 1532, 1550, 1572, 1588, 1830, 1848, 3277, 3295, 3317, 3333, 3376, 3732, 3750, 3772, 3811, 3829], 'Invest.': [1209, 1227, 1249, 1535, 1553, 1575, 1833, 1851, 3280, 3298, 3320, 3379, 3735, 3753, 3775, 3814, 3832], '1987;': [1211, 1537, 3282, 3737, 3816], '88:': [1212, 1538, 3283, 3738, 3817], '709-713Abstract': [1213, 1539, 3284, 3739, 3818], '20Wertz': [1220, 1546, 3291, 3746, 3825], '1989;': [1229, 1251, 1555, 1577, 1835, 3300, 3322, 3755, 3777, 3834], '92:': [1230, 1556, 3301, 3756, 3835], '109-112Abstract': [1231, 1557, 3302, 3757, 3836], '21Wertz': [1238, 1564, 1822, 3309, 3764], 'Swartzendruber': [1240, 1566, 1824, 3311, 3766], 'Kitko': [1242, 1568, 1826, 3313, 3768], 'D.J.': [1243, 1569, 1827, 3314, 3769], '93:': [1252, 1578, 1836, 3323, 3778], '169-172Abstract': [1253, 1579, 1837, 3324, 3779], 'lipids': [1261, 1666, 1888, 2092, 2601, 2739, 2818, 2906], 'synthesized,': [1263], 'packaged': [1264], 'into': [1265, 1274, 2097, 2263], 'lamellar': [1266], 'bodies,': [1267], 'extruded': [1269], 'intercellular': [1276, 1417, 1665], 'space': [1277], 'Refs.': [1280], 'Scholar': [1345, 3785], '22Wertz': [1347, 1586, 3331], 'Goldsmith': [1351, 1590, 3335], 'L.A.': [1352, 1591, 3336], 'Physiology,': [1353, 1592, 3337], 'Biochemistry,': [1354, 1593, 3338], 'Oxford': [1361, 1600, 3345], 'York1991:': [1365, 1604, 3349], '205-236Google': [1366, 1605, 3350], 'A': [1368, 4103], 'minor': [1369], 'but': [1370, 2665, 3980, 4187], 'acylglucosyl-ceramides,': [1375], 'two-thirds': [1379], 'converted': [1381], 'ω-hydroxyceramides': [1383], 'complete': [1396, 3068, 3983], 'assembly.': [1398], 'Many': [1399], 'cholesterol': [1404], 'esters': [1405], 'free': [1407, 2817], 'acids,': [1409], 'lamellae': [1414], 'milieu': [1418], 'contribute': [1420, 1643], 'way': [1424], 'against': [1428], 'desiccation': [1429], '(2Downing': [1430, 1667, 1794], '18Elias': [1514], '23Schurer': [1607, 3352], 'N.Y.': [1608, 3353], '27-56Google': [1625, 3370], 'One': [1627], 'idea': [1628], 'ester-linked': [1635, 1887, 2600, 2783, 3250, 3264], 'outer': [1638], 'hydrophobic': [1645, 3251], 'corneocyte': [1649], 'has': [1651, 1791, 1896], 'consequences': [1653], 'associations': [1659], 'organization': [1663], 'We': [1695, 2754, 2825, 4052], 'been': [1697, 1792, 4098], 'interested': [1698], 'structure': [1701], 'devised': [1707], 'models': [1708], 'nature': [1711, 1865, 2730], 'involved': [1717], 'its': [1719, 3670], 'formation': [1720], 'However,': [1771, 4161], 'rather': [1772], 'less': [1773], 'how': [1777], 'becomes': [1781], 'envelope.': [1786], 'Specifically,': [1787], 'although': [1788], 'model': [1790], 'suggested': [1793, 2594], '24Lazo': [1844, 3372], 'N.D.': [1845, 3373], 'Meine': [1846, 3374], 'J.G.': [1847, 3375], '105:': [1854, 3382], '296-300Abstract': [1855, 3383], '(42)': [1861, 3389], 'substrate': [1869, 3993], 'not': [1874, 2370, 2812, 3029, 4096, 4194], 'yet': [1875], 'known.': [1876], 'study,': [1879], 'explored': [1881], 'question.': [1883], 'Partial': [1884], 'removal': [1885, 2167], 'allowed': [1897], 'isolation': [1899], 'lipopeptides': [1901, 2387], 'consisting': [1902], 'glutamines': [1908], 'and/or': [1909, 3570], 'glutamic': [1910], 'residues': [1912, 3966, 4152, 4211, 4219, 4232, 4240, 4242, 4244, 4252, 4364], 'well': [1916, 2992], 'likely': [1919, 2524, 4140, 4155, 4180], '"Mature"': [1922], 'prepared': [1925], 'stratum': [1928], 'corneum': [1929], 'tissue': [1930], 'freshly-prepared': [1932], 'described': [1936, 2288, 2394, 2419], 'previously': [1937, 2289], 'They': [1988], 'resuspended': [1990, 2056, 2132], 'buffer': [1993, 2139], '0.1m': [1995], 'N-ethylmorpholine': [1996], 'acetate': [1997], '(pH': [1998], '8.3)': [1999], 'digested': [2001], 'trypsin': [2003, 2143, 2847, 2856], '(Sigma,': [2004], 'sequencing': [2005, 2286, 4146], 'grade,': [2006], '1%': [2007, 2150], 'weight,': [2009], '2': [2011, 2391, 3013, 3463, 3586], 'h': [2012, 2157, 2392, 2984], '37': [2014, 2159], '°C)': [2015], 'remove': [2017], 'contaminating': [2018], 'adherent': [2019], 'pelleted': [2042], '14,000': [2044], '×': [2045, 2229, 3698], 'g.': [2046], 'Aliquots': [2047, 2266, 2384, 3894], 'containing': [2050, 2244], '1': [2058, 3011, 3114, 3402, 3674, 3690, 3710], 'm': [2059], 'KOH': [2060], '95%': [2062], 'methanol': [2063], '15–120': [2065], 'min': [2066, 2966, 2971, 2997, 3006, 3044], '45': [2068], '°C,': [2069], 'washed': [2070], 'methanol,': [2072], 'dried.': [2074, 2102, 2175], 'Potential': [2075], 'ceramide-peptide': [2076], 'adducts': [2077, 2787], 'reacted': [2079], 'similarly': [2080], 'hydrolyze': [2082], '(generally': [2086], '2-h': [2088, 3214, 3599, 3640], 'reaction).': [2089], 'saponified': [2091, 2129, 2389], 'extraction': [2096], 'chloroform/methanol': [2098, 2403], '(1:2': [2099], 'v/v)': [2100], 'Amino': [2103], 'analysis': [2105, 2276], 'hydrolyzed': [2107], 'samples': [2108], '(5.7': [2109], 'n': [2110], 'HCl': [2111], '110': [2113], '°C': [2114], '24': [2116], 'hin': [2117], 'vacuo)': [2118], 'routinely': [2122], 'measure': [2123], 'amounts.': [2125], 'Partially': [2126], 'completely': [2128], '(1': [2133, 3062], 'mg': [2134, 3691], 'protein/ml)': [2137], 'redigested': [2141], 'proteinase': [2145, 2849, 2878, 2973, 3051, 3890], 'K': [2146, 2850, 2879, 2974, 3891], '(Life': [2147], 'Technologies,': [2148], 'Inc.;': [2149], 'weight)': [2152], 'up': [2154, 2254, 2490, 3512], '3': [2156, 2988], '°C.': [2160], 'solubilized': [2162], 'material': [2163, 2892, 3110, 3127, 3176, 4335], 'collected': [2165, 2262], 'following': [2166, 3883, 4124], 'remnants': [2171], 'pelleting': [2173], 'Peptides': [2176], 'fractionated': [2178], 'C18high': [2181], 'chromatography': [2184, 2463, 3219], '(HPLC)': [2185], 'column': [2186, 2227, 2798, 3235, 4203], 'before': [2188, 2344], 'Scholar,11Steinert': [2198], 'To': [2218, 3392], 'recover': [2219], 'potential': [2220, 2386], 'lipopeptide': [2221], 'adducts,': [2222], 'Phenomenex': [2224], 'C4': [2225, 2796, 2864, 4202], 'HPLC': [2226, 2792, 2797, 3131, 3223], '(200': [2228], '2.5': [2230], 'mm)': [2231], 'flow': [2236], 'rate': [2237], '0.22': [2239], 'ml/min': [2240], '10%': [2242], 'acetonitrile': [2243, 2260], '0.08%': [2245], 'trifluoroacetic': [2246], 'linear': [2251], 'gradient': [2252], '15%': [2256], '(v/v)': [2257], 'isopropanol': [2258], '0.11-ml': [2264], 'fractions.': [2265], 'selected': [2268], 'peptide': [2269, 2891, 3036, 3109, 3154, 3457, 3545, 4334], 'peaks': [2270, 2860, 2874, 2978, 2987, 3000, 3010, 3491, 3546, 3867, 3909, 3936], 'subjected': [2272], 'solid': [2281], 'support': [2282], '(Sequelon-AA,': [2283], 'Millipore)': [2284], '(11Steinert': [2290, 2545], 'addition,': [2331], 'aliquots': [2332, 3454], '(5–20': [2333, 3895], 'pmol)': [2334, 3896], 'removed': [2336], 'measurements': [2339], 'spectroscopy': [2342], 'both': [2343], 'after': [2346, 2995, 3004], 'saponification,': [2347], 'using': [2348, 2407], 'matrix': [2350], 'assisted': [2351], 'laser': [2352], 'desorption': [2353], 'ionization': [2354], 'procedure.': [2355], 'Following': [2356, 3470, 3638], 'initial': [2358, 2763, 3972], 'scan': [2359], '600': [2361], 'units': [2364], '(below': [2365], 'reliable': [2367], 'could': [2369, 2788, 3845, 4193], 'be': [2371, 2777, 2789, 2813, 2820, 4004, 4195], 'obtained),': [2372], 'scans': [2373, 3472], 'repeated': [2375], 'vicinity': [2378], 'species.': [2383], 'above.': [2395], 'released': [2397, 2857, 2893, 3054], 'then': [2400, 2487], 'extracted': [2401], '(95:5)': [2404], 'quantified': [2406], 'diacylglycerol': [2409], 'assay': [2410], 'reagent': [2411], 'kit': [2412], '[γ-32P]ATP': [2414], '(Amersham': [2415], 'Pharmacia': [2416], 'Biotech)': [2417], '(25Haimovitz-Friedman': [2420, 3427], 'Kan': [2422, 3429], 'C.C.': [2423, 3430], 'Ehleiter': [2424, 3431], 'D.': [2425, 3432], 'Persaud': [2426, 3433], 'R.S.': [2427, 3434], 'McLoughlin': [2428, 3435], 'Fuks': [2430, 3437], 'Z.': [2431, 3438], 'Kolesnick': [2432, 3439], 'R.N.': [2433, 3440], 'Exp.': [2435, 3442], 'Med.': [2436, 3443], '525-535Crossref': [2439, 3446], '(847)': [2442, 3449], 'reaction': [2446, 2765, 3481, 3590, 3601, 3977], 'specifically': [2447, 3411], 'labels': [2448], 'hydroxyl': [2450, 3418], 'moiety': [2454, 3423], 'only.': [2458], 'High': [2459], 'thin': [2461], 'silica': [2464], 'gel': [2465], 'plates': [2466, 2485], '(Merck)': [2467], 'developed': [2469], 'chloroform:acetone:methanol:acetic': [2471], 'acid:water': [2472], '10:4:3:2:1.': [2473], 'N-stearoyl-d-sphingosine': [2474], '(C18': [2475], 'ceramide)': [2476], '(Sigma)': [2477], 'quantitation': [2481], 'standard.': [2482, 3584], 'dried': [2484], 'exposed': [2488], '6': [2492], 'days.': [2493], 'Bands': [2494], 'quantitated': [2496], 'scanning': [2498], 'densitometry': [2499], 'exposures': [2502], 'x-ray': [2505], 'films.': [2506], 'Previously,': [2507], 'demonstrated': [2510, 3256], 'CEs,': [2516, 2598, 3144], 'mild': [2518], 'alkaline': [2519], 'hydrolysis': [2520, 4125, 4138], 'procedure': [2521, 3026], 'cleave': [2526], 'bonds,': [2528], 'exposes': [2529], 'proteolytic': [2531, 2591], 'attack': [2532], 'number': [2534, 2828], 'portion': [2541, 2888, 4375], 'Our': [2585], 'immunogold': [2586], 'electron': [2587], 'microscopy': [2588], 'analyses': [2589], 'digestion': [2592, 2880, 3049, 3892], 'experiments': [2593, 2831, 3857], 'intact': [2597], 'mask': [2602], 'access': [2603], 'corresponding': [2607], 'inner': [2610], 'earlier': [2612, 4340], 'assembly': [2616], 'predominantly': [2640], 'desmoplakin': [2644], 'they': [2666], 'may': [2667, 3534, 3564, 3967], 'consist': [2669], 'desmosomal': [2672], 'calcium-binding': [2674], 'addressed': [2725], 'questions': [2727], 'possible': [2733, 2778, 3956, 4272, 4310], 'attached,': [2742], 'sites': [2744], 'attachment,': [2746], 'properties': [2749], 'lipids.': [2753], 'reasoned': [2755], 'reducing': [2758], 'time': [2760], 'only': [2767, 2994, 4065, 4227, 4286], 'few': [2769, 4067], 'minutes,': [2770], 'should': [2776, 2811], 'isolate': [2780], 'adducts.': [2785], 'Such': [2786, 4136], 'identified': [2790, 3399], 'fractionation': [2793], 'monitored': [2799], '220': [2801, 2823], 'nm.': [2802, 2824], 'Free': [2803], 'hydrophilic': [2804, 4093], 'typically': [2806], 'found': [2807, 4064], 'retarded,': [2814], 'retarded': [2816, 2859, 3108, 3153, 3242, 3396, 4099, 4333], 'cannot': [2819], 'detected': [2821], 'performed': [2826], 'trial': [2830], 'titrating': [2832], 'degree': [2834], '(in': [2837], 'range': [2839], '10–30': [2841], 'min)': [2842], 'proteolysis': [2845], 'singly': [2851], 'combination.': [2854], 'Although': [2855], 'resolvable': [2861], 'column,': [2865, 3132, 3224], 'reproducibly': [2867], 'better': [2868], 'yield': [2869, 3648], '10': [2871, 3635, 3866], 'arbitrarily': [2872], 'numbered': [2873], 'alone': [2881, 3027], '(Fig.': [2882, 3560], '1),': [2883], 'even': [2884], 'though': [2885], 'significant': [2887, 3033], 'would': [2894, 3694, 4003, 4095, 4131, 4139], 'originated': [2896], 'cytoplasmic': [2899], '(loricrin-rich)': [2900], 'face': [2901], 'largely': [2908], 'absent': [2909], 'Optimized': [2960], 'conditions': [2961], '15': [2965, 3043, 3666], '10–60': [2970], 'digestion.': [2975], 'Of': [2976, 3102], 'these,': [2977], '5–7': [2979], 'stable': [2981], '≈1': [2983], 'digestion,': [2986, 2999, 3008, 3069], '4': [2990, 3496], 'became': [2991], 'resolved': [2993, 4200], '20–30': [2996, 3187], '8–10': [3001], 'lost': [3003, 3016], '≈20': [3005], 'rapidly': [3015], 'time-': [3019], 'shape-dependent': [3021], 'manner.': [3022], '15-min': [3024, 3885], 'did': [3028], 'result': [3030, 4002], 'release': [3034], 'material.': [3037, 3243], 'typical': [3040], 'experiment': [3041], 'K,': [3052], '5.1%': [3055], '(10': [3056], 'min),': [3057, 3060], '12.7%': [3058], '(30': [3059], '15.8%': [3061], 'h)': [3063], '19.5%': [3065], '(3': [3066], 'h,': [3067], 'cf.': [3070], 'Ref.': [3073], 'used.': [3101, 4265, 4303], 'this,': [3103], 'amount': [3106, 3852], 'Fig.': [3113, 3401, 3462, 3585, 3869, 4205], 'represents': [3115], '≈0.4%': [3116], '(10-min': [3117], 'digestion)': [3118, 3122], '0.25%': [3120], '(60-min': [3121], '220-nm': [3125, 3226], 'absorbing': [3126, 3227], 'eluted': [3128, 3232], 'corresponds': [3134], '0.02–0.05%': [3136], '≈250': [3146], 'ng/mg': [3147], 'CEs.': [3149], 'None': [3150], 'fractions': [3155], 'isodipeptide': [3158], 'cross-link,': [3159], 'indicating': [3160], 'different': [3162, 4320], 'attachments': [3171], 'cross-linking.': [3174], 'each': [3178, 3193, 3230, 3466, 3898], 'peak': [3179, 3231, 3467, 3899], 'pooled': [3184], 'foreskins.': [3188], 'analysis,': [3192], 'protein,': [3195, 4367], 'based': [3197], 'simplest': [3203], '(see': [3205], 'below),': [3206, 3788], 'yields': [3208, 3862], '20–100': [3210], 'pmol.': [3211], 'After': [3212], 'resaponification': [3215], 'reaction,': [3216, 3642], 'same': [3222], 'wash,': [3236], 'there': [3238, 3707, 4170], 'no': [3240], 'detectable': [3241], 'suggest': [3246, 3620], 'presence': [3248, 3622], 'Earlier': [3253], 'class': [3260], 'molecules': [3263], '(19Swartzendruber': [3271, 3805], 'ascertain': [3393], 'whether': [3394], 'peptide-containing': [3397], 'ceramides,': [3404], 'established': [3408], 'method': [3409], 'incorporates': [3412], 'phosphate': [3414], 'group': [3415, 3419], 'onto': [3416], 'Using': [3452], '10–40-pmol': [3453], '(based': [3455], 'content),': [3458], 'demonstrate': [3464], 'contains': [3468], 'densitometric': [3471], 'bands,': [3475], 'relation': [3478], 'C18': [3484, 3557, 3582], 'standard,': [3486], 'calculated': [3488, 3644], 'contain': [3492], '0.6': [3493], 'mol': [3494, 3500, 3504, 3515], '(peaks': [3495, 3505, 3516, 3919, 3927], '10),': [3498], '0.7': [3499], '(peak': [3501], '2),': [3502, 3561], '0.8': [3503], '1,': [3506], '5,': [3507, 3929, 3938], '6,': [3508, 3921, 4165], '9),': [3510], '0.9': [3514], '3,': [3517, 3928, 3937], '7,': [3518, 3940, 4167], '8)': [3520, 3923], 'ceramide/mol': [3522], 'peptide.': [3524], 'somewhat': [3526], 'lower': [3527], 'stoichiometry': [3528], 'multiplicity': [3531], 'degradation': [3536], 'oxidation': [3538], 'Alternatively,': [3542], 'because': [3543, 4061], 'most': [3544, 4353], 'multiple': [3548, 3624], 'bands': [3550, 3563, 3619], 'migrated': [3552], 'significantly': [3553], 'faster': [3554], 'than': [3555, 3578], 'standard': [3559], 'represent': [3565], 'variably-sized': [3568], 'sphingoid': [3569], 'chains': [3573], 'considerably': [3576], 'longer': [3577], 'those': [3579, 3632], 'shows': [3588], '50': [3592], 'pmol': [3593], 'skin': [3608], '(a': [3610], 'kind': [3611], 'gift': [3612], 'Dr.': [3614], 'P.': [3615, 4086, 4394], 'Wertz).': [3616], 'broad': [3618], 'unresolved': [3625], 'size': [3630, 3721], 'peaks.': [3637], '2750': [3655], 'pmol/mg': [3656], 'Assuming': [3660], 'nm': [3667], 'density': [3671], 'g/cm3': [3675], '(26Jarnik': [3676], 'Simon': [3678], '1998;': [3685], '111:': [3686], '1051-1060PubMed': [3687], 'occupy': [3695], '7': [3697], '1016': [3699], 'nm2': [3700, 3714], 'surface.': [3703], 'means': [3705, 3790], 'molecule': [3711], 'ceramide/40': [3713], 'CE.': [3716], 'Based': [3717], 'predicted': [3720], '(Refs.': [3725], 'see': [3787], 'entire': [3793], 'effectively': [3797], 'coated': [3798], 'monomolecular': [3801], 'Finally,': [3843], 'account': [3846], '15–20%': [3848], 'separate': [3856], 'summation': [3859], '1.': [3870], '≈70%': [3872], 'present': [3878], 'pellet': [3882], '60-min': [3889], 'procedures.': [3893], 'sequencing.': [3905], 'As': [3906, 4279], 'TableI': [3907], 'shows,': [3908], '3–8': [3910], 'either': [3917], 'identical': [3918], '4,': [3920, 4164], 'very': [3925], '7)': [3931], 'involucrin.': [3934], 'Gln': [3942, 3965, 4008, 4121, 4216, 4237, 4249, 4257], 'residue': [3943, 4009, 4189], 'sequenced': [3948], 'Glu': [3951, 4134, 4185], 'residue.': [3952, 4135], 'There': [3953], 'explanations': [3957], 'this.': [3959], 'first': [3961, 4360], 'participated': [3969], 'step': [3973], 'failed': [3981], 'transfer': [3985], 'enzyme-substrate': [3988], 'complex': [3989], 'acceptor': [3992], 'amine,': [3994], 'Lys': [3998], 'residue:': [3999], 'net': [4001], 'deamidation': [4005], '(27Folk': [4010], 'Adv.': [4012], 'Enzymol.': [4013, 4043], 'Relat.': [4014], 'Areas': [4015], 'Mol.': [4016, 4027, 4395], '1983;': [4018], '54:': [4019], '1-56PubMed': [4020], '28Lorand': [4023], 'L.': [4024], 'Conrad': [4025], 'S.M.': [4026], 'Cell.': [4028, 4380], '1984;': [4030], '58:': [4031], '9-35Crossref': [4032], '(658)': [4035], '29Folk': [4038], 'Chung': [4040], 'S.-I.': [4041], 'Methods': [4042], '1985;': [4044], '113:': [4045], '358-375Crossref': [4046], '(250)': [4049], 'think': [4053], 'relatively': [4058], 'rare': [4059], 'event': [4060], 'cases': [4068], 'modifications': [4071], 'many': [4076], 'characterized': [4079], 'date.': [4081], '2L.': [4082], 'Steinert,': [4088], 'unpublished': [4089], 'observations.': [4090], 'Moreover,': [4091], 'C4column.': [4102], 'second,': [4104], 'more': [4105], 'plausible': [4106], 'possibility': [4107], 'adduct': [4112], 'linked': [4114], 'through': [4115, 4347], 'bond': [4118], 'residue,': [4122, 4186], 'which,': [4123], '(saponification)': [4126], 'bond,': [4130], 'generate': [4132], 'occur': [4141], 'during': [4142], 'chemistry': [4147], 'reactions.': [4148], 'Thus,': [4149], 'modified': [4151], 'identify': [4153], 'target': [4156], 'position': [4157, 4190], 'exact': [4173], 'match': [4174], 'existing': [4184], 'modification': [4192], 'ascertained.Table': [4196], 'ISequences': [4197], '1Peak': [4206], 'numberSequenceCalculated': [4207], 'massCommentatomic': [4208], 'units1Complex2Complex3PEQECEQQEK1246Involucrin-like,': [4210], '70–79': [4212], 'Glu78': [4213], 'involucrin4EEEKKL775Involucrin': [4218], '123–1285QQEHWaAs': [4220], 'determined': [4221, 4280], 'databases,': [4223, 4282], 'sequence': [4225, 4284], 'occurs': [4226, 4285], 'Drosophila': [4230, 4289], 'protein.725Involucrin-like,': [4231], '87–91': [4233], 'Glu89': [4234], 'involucrin6EEEEGQL833Involucrin,': [4239], '386–3927NTHQEQMK886Involucrin,': [4241], '27–338aDQELNKQ872Involucrin-like,': [4243], '115–121': [4245], 'Glu117': [4246], 'involucrin8bDQELDQEL986Involucrin-like,': [4251], '130–137': [4253], 'Glu132': [4254], 'involucrin9Complex10ComplexSingle': [4259], 'letter': [4260, 4298], 'code': [4263, 4301], 'letters': [4267, 4305], 'boldface': [4269, 4307], 'delineate': [4270, 4308], 'ester-lined': [4277, 4315], 'ceramides.a': [4278], 'Open': [4291], 'table': [4292], 'new': [4295], 'tab': [4296], 'Single': [4297], 'total,': [4318], 'experiments,': [4321], 'identifiable': [4323, 4349], 'involucrin-like': [4324], '(molar': [4336], 'amount)': [4337], 'times': [4341], 'proteolysis.': [4343], 'seven': [4348], 'located': [4357], '140': [4361], 'thought': [4370], '(30Eckert': [4376], 'Green': [4378], '1988;': [4381], '46:': [4382], '583-589Abstract': [4383], '(320)': [4388], '31Green': [4391], 'Dijan': [4393], 'Evol': [4397]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2038346886', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2025-01-03T07:43:49.221710', 'created_date': '2016-06-24'}
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