Publication Information

{'id': 'https://openalex.org/W2038337238', 'doi': 'https://doi.org/10.1002/eji.1830260425', 'title': 'Regions of RAG1 protein critical for V(D)J recombination', 'display_name': 'Regions of RAG1 protein critical for V(D)J recombination', 'publication_year': 1996, 'publication_date': '1996-04-01', 'ids': {'openalex': 'https://openalex.org/W2038337238', 'doi': 'https://doi.org/10.1002/eji.1830260425', 'mag': '2038337238', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8625984'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/eji.1830260425', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S126191069', 'display_name': 'European Journal of Immunology', 'issn_l': '0014-2980', 'issn': ['0014-2980', '1521-4141'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5045374934', 'display_name': 'Susan A. Kirch', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Susan A. Kirch', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, USA', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002874242', 'display_name': 'Priya Sudarsanam', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Priya Sudarsanam', 'raw_affiliation_strings': ['Department of Genetics, Harvard Medical School, Boston, USA', 'Department of Molecular Biology, Massachusetts General Hospital, Boston, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology, Massachusetts General Hospital, Boston, USA', 'institution_ids': ['https://openalex.org/I4210087915']}, {'raw_affiliation_string': 'Department of Genetics, Harvard Medical School, Boston, USA', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5075159160', 'display_name': 'Marjorie A. Oettinger', 'orcid': 'https://orcid.org/0000-0002-9783-0080'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Marjorie A. Oettinger', 'raw_affiliation_strings': ['Department of Genetics, Harvard Medical School, Boston, USA', 'Department of Molecular Biology, Massachusetts General Hospital, Boston, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology, Massachusetts General Hospital, Boston, USA', 'institution_ids': ['https://openalex.org/I4210087915']}, {'raw_affiliation_string': 'Department of Genetics, Harvard Medical School, Boston, USA', 'institution_ids': ['https://openalex.org/I136199984']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5075159160'], 'corresponding_institution_ids': ['https://openalex.org/I4210087915', 'https://openalex.org/I136199984'], 'apc_list': {'value': 4120, 'currency': 'USD', 'value_usd': 4120, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.639, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 59, 'citation_normalized_percentile': {'value': 0.856678, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '26', 'issue': '4', 'first_page': '886', 'last_page': '891'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12477', 'display_name': 'Toxin Mechanisms and Immunotoxins', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12477', 'display_name': 'Toxin Mechanisms and Immunotoxins', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11663', 'display_name': 'Viral Infectious Diseases and Gene Expression in Insects', 'score': 0.9927, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12856', 'display_name': 'Transgenic Plants and Applications', 'score': 0.9913, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rag2', 'display_name': 'RAG2', 'score': 0.9694618}, {'id': 'https://openalex.org/keywords/v', 'display_name': 'V(D)J recombination', 'score': 0.7516412}, {'id': 'https://openalex.org/keywords/recombination-signal-sequences', 'display_name': 'Recombination signal sequences', 'score': 0.57787204}, {'id': 'https://openalex.org/keywords/coding-region', 'display_name': 'Coding region', 'score': 0.48089194}, {'id': 'https://openalex.org/keywords/site-specific-recombination', 'display_name': 'Site-specific recombination', 'score': 0.42864117}], 'concepts': [{'id': 'https://openalex.org/C2781376893', 'wikidata': 'https://www.wikidata.org/wiki/Q18031023', 'display_name': 'RAG2', 'level': 4, 'score': 0.9694618}, {'id': 'https://openalex.org/C113646796', 'wikidata': 'https://www.wikidata.org/wiki/Q50263283', 'display_name': 'Recombination-activating gene', 'level': 4, 'score': 0.9491441}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.82465553}, {'id': 'https://openalex.org/C2780254951', 'wikidata': 'https://www.wikidata.org/wiki/Q1093098', 'display_name': 'V(D)J recombination', 'level': 4, 'score': 0.7516412}, {'id': 'https://openalex.org/C156695909', 'wikidata': 'https://www.wikidata.org/wiki/Q3373825', 'display_name': 'Recombination', 'level': 3, 'score': 0.7225597}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.61442}, {'id': 'https://openalex.org/C157402786', 'wikidata': 'https://www.wikidata.org/wiki/Q7302710', 'display_name': 'Recombination signal sequences', 'level': 5, 'score': 0.57787204}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.556477}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.54410714}, {'id': 'https://openalex.org/C91779695', 'wikidata': 'https://www.wikidata.org/wiki/Q3780824', 'display_name': 'Coding region', 'level': 3, 'score': 0.48089194}, {'id': 'https://openalex.org/C119898374', 'wikidata': 'https://www.wikidata.org/wiki/Q7531737', 'display_name': 'Site-specific recombination', 'level': 5, 'score': 0.42864117}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3461758}, {'id': 'https://openalex.org/C102414288', 'wikidata': 'https://www.wikidata.org/wiki/Q1172461', 'display_name': 'Recombinase', 'level': 4, 'score': 0.15261456}], 'mesh': [{'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015322', 'descriptor_name': 'Gene Rearrangement, B-Lymphocyte', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004254', 'descriptor_name': 'DNA Nucleotidyltransferases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004254', 'descriptor_name': 'DNA Nucleotidyltransferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016254', 'descriptor_name': 'Mutagenesis, Insertional', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016297', 'descriptor_name': 'Mutagenesis, Site-Directed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017384', 'descriptor_name': 'Sequence Deletion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045567', 'descriptor_name': 'VDJ Recombinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/eji.1830260425', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S126191069', 'display_name': 'European Journal of Immunology', 'issn_l': '0014-2980', 'issn': ['0014-2980', '1521-4141'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8625984', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W112919321', 'https://openalex.org/W1525365796', 'https://openalex.org/W169978917', 'https://openalex.org/W1738249403', 'https://openalex.org/W1762168883', 'https://openalex.org/W1846959000', 'https://openalex.org/W1875421809', 'https://openalex.org/W1972812440', 'https://openalex.org/W1986909515', 'https://openalex.org/W1996303741', 'https://openalex.org/W2012430176', 'https://openalex.org/W2014265802', 'https://openalex.org/W2050034197', 'https://openalex.org/W2051549600', 'https://openalex.org/W2061147591', 'https://openalex.org/W2068012172', 'https://openalex.org/W2070701919', 'https://openalex.org/W2086870938', 'https://openalex.org/W2088091759', 'https://openalex.org/W2089155355', 'https://openalex.org/W2098977954', 'https://openalex.org/W2108082319', 'https://openalex.org/W2140336226', 'https://openalex.org/W2157264868', 'https://openalex.org/W2164859620', 'https://openalex.org/W2168573351', 'https://openalex.org/W4236478138', 'https://openalex.org/W4237792185', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W4386762942', 'https://openalex.org/W4385687889', 'https://openalex.org/W4240283879', 'https://openalex.org/W3196221672', 'https://openalex.org/W24072210', 'https://openalex.org/W2232838049', 'https://openalex.org/W2067706475', 'https://openalex.org/W2065568155', 'https://openalex.org/W2025592993', 'https://openalex.org/W1996426939'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'products': [2], 'of': [3, 24, 34, 41, 71, 100, 107, 112, 122, 134, 150, 172, 182], 'the': [4, 22, 32, 69, 96, 105, 147, 162, 167, 183], 'recombination': [5, 133], 'activating': [6, 14], 'genes': [7], 'RAG1': [8, 101, 123, 173], 'and': [9, 17, 26, 43, 56, 77, 81, 102, 109, 138], 'RAG2': [10, 103], 'are': [11, 19], 'essential': [12, 169], 'for': [13, 21, 46, 127, 132], 'V(D)J': [15, 51], 'recombination,': [16], 'thus': [18], 'indispensable': [20], 'production': [23], 'functional': [25], 'diverse': [27], 'antigen': [28], 'receptors.': [29], 'To': [30], 'investigate': [31], 'function': [33], 'RAG1,': [35], 'we': [36, 63], 'have': [37], 'tested': [38], 'a': [39], 'series': [40], 'insertion': [42], 'substitution': [44], 'mutations': [45, 73], 'their': [47], 'ability': [48], 'to': [49, 67, 82, 161], 'induce': [50], 'rearrangement': [52], 'on': [53, 74], 'both': [54, 75], 'deletional': [55], 'inversional': [57], 'plasmid': [58], 'substrates.': [59], 'With': [60], 'these': [61, 72, 90, 154], 'substrates': [62], 'were': [64], 'also': [65, 158], 'able': [66], 'assess': [68], 'effects': [70], 'coding': [76, 128], 'signal': [78], 'joint': [79, 129], 'formation,': [80], 'show': [83, 116], 'that': [84, 118, 139], 'any': [85], 'one': [86], 'mutant': [87], 'affected': [88], 'all': [89], 'reactions': [91], 'similarly.': [92], 'As': [93], 'defined': [94], 'previously,': [95], 'core': [97, 155, 170], 'active': [98], 'regions': [99, 156], 'permit': [104], 'deletion': [106], '40%': [108], '25%,': [110], 'respectively,': [111], 'well‐conserved': [113], 'sequence.': [114], 'We': [115], 'here': [117], 'this': [119, 140], '“dispensable”': [120, 148], 'region': [121, 149, 171], 'is': [124, 142, 157], 'not': [125, 143], 'necessary': [126], 'formation': [130], 'or': [131], 'an': [135, 178], 'integrated': [136], 'substrate,': [137], 'portion': [141, 181], 'functionally': [144], 'redundant': [145], 'with': [146, 153], 'RAG2.': [151], 'Recombination': [152], 'still': [159], 'subject': [160], '12/23': [163], 'joining': [164], 'rule.': [165], 'Further,': [166], 'minimal': [168], 'can': [174], 'be': [175], 'located': [176], 'within': [177], 'even': [179], 'smaller': [180], 'gene.': [184]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2038337238', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-13T22:41:14.522764', 'created_date': '2016-06-24'}