Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2037992892', 'doi': 'https://doi.org/10.1021/bi00188a013', 'title': 'Electrostatic potential of the acetylcholine binding sites in the nicotinic receptor probed by reactions of binding-site cysteines with charged methanethiosulfonates', 'display_name': 'Electrostatic potential of the acetylcholine binding sites in the nicotinic receptor probed by reactions of binding-site cysteines with charged methanethiosulfonates', 'publication_year': 1994, 'publication_date': '1994-06-07', 'ids': {'openalex': 'https://openalex.org/W2037992892', 'doi': 'https://doi.org/10.1021/bi00188a013', 'mag': '2037992892', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8204619'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi00188a013', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5077421769', 'display_name': 'David A. Stauffer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David A. Stauffer', 'raw_affiliation_strings': ['Center for Molecular Recognition, Columbia University, New York, New York 10032.'], 'affiliations': [{'raw_affiliation_string': 'Center for Molecular Recognition, Columbia University, New York, New York 10032.', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5004944388', 'display_name': 'Arthur Karlin', 'orcid': 'https://orcid.org/0000-0002-4813-752X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Arthur Karlin', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.671, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 255, 'citation_normalized_percentile': {'value': 0.938051, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '33', 'issue': '22', 'first_page': '6840', 'last_page': '6849'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11818', 'display_name': 'Nicotinic Acetylcholine Receptors Study', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11818', 'display_name': 'Nicotinic Acetylcholine Receptors Study', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12023', 'display_name': 'Cholinesterase and Neurodegenerative Diseases', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13454', 'display_name': 'Phenothiazines and Benzothiazines Synthesis and Activities', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.88338697}, {'id': 'https://openalex.org/C123419017', 'wikidata': 'https://www.wikidata.org/wiki/Q7826734', 'display_name': 'Torpedo', 'level': 4, 'score': 0.5105568}, {'id': 'https://openalex.org/C107824862', 'wikidata': 'https://www.wikidata.org/wiki/Q616005', 'display_name': 'Binding site', 'level': 2, 'score': 0.50740093}, {'id': 'https://openalex.org/C187428577', 'wikidata': 'https://www.wikidata.org/wiki/Q898396', 'display_name': 'Ionic strength', 'level': 3, 'score': 0.4608938}, {'id': 'https://openalex.org/C93391505', 'wikidata': 'https://www.wikidata.org/wiki/Q658700', 'display_name': 'Reaction rate constant', 'level': 3, 'score': 0.45191532}, {'id': 'https://openalex.org/C2182769', 'wikidata': 'https://www.wikidata.org/wiki/Q62500', 'display_name': 'Ionic bonding', 'level': 3, 'score': 0.438537}, {'id': 'https://openalex.org/C2779570518', 'wikidata': 'https://www.wikidata.org/wiki/Q412256', 'display_name': 'Nicotinic acetylcholine receptor', 'level': 4, 'score': 0.42565793}, {'id': 'https://openalex.org/C2775910092', 'wikidata': 'https://www.wikidata.org/wiki/Q180623', 'display_name': 'Acetylcholine', 'level': 2, 'score': 0.41531217}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.39485022}, {'id': 'https://openalex.org/C147597530', 'wikidata': 'https://www.wikidata.org/wiki/Q369472', 'display_name': 'Computational chemistry', 'level': 1, 'score': 0.36683667}, {'id': 'https://openalex.org/C80161118', 'wikidata': 'https://www.wikidata.org/wiki/Q408520', 'display_name': 'Acetylcholine receptor', 'level': 3, 'score': 0.36164343}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.2410489}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.20645031}, {'id': 'https://openalex.org/C145148216', 'wikidata': 'https://www.wikidata.org/wiki/Q36496', 'display_name': 'Ion', 'level': 2, 'score': 0.19169357}, {'id': 'https://openalex.org/C148898269', 'wikidata': 'https://www.wikidata.org/wiki/Q1108792', 'display_name': 'Kinetics', 'level': 2, 'score': 0.1310009}, {'id': 'https://openalex.org/C184651966', 'wikidata': 'https://www.wikidata.org/wiki/Q906356', 'display_name': 'Aqueous solution', 'level': 2, 'score': 0.10222325}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.078211606}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000109', 'descriptor_name': 'Acetylcholine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011978', 'descriptor_name': 'Receptors, Nicotinic', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000109', 'descriptor_name': 'Acetylcholine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003545', 'descriptor_name': 'Cysteine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003545', 'descriptor_name': 'Cysteine', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004563', 'descriptor_name': 'Electrochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007202', 'descriptor_name': 'Indicators and Reagents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007202', 'descriptor_name': 'Indicators and Reagents', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D007202', 'descriptor_name': 'Indicators and Reagents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D008698', 'descriptor_name': 'Mesylates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008698', 'descriptor_name': 'Mesylates', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D008698', 'descriptor_name': 'Mesylates', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D008956', 'descriptor_name': 'Models, Chemical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011978', 'descriptor_name': 'Receptors, Nicotinic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011978', 'descriptor_name': 'Receptors, Nicotinic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013438', 'descriptor_name': 'Sulfhydryl Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013438', 'descriptor_name': 'Sulfhydryl Compounds', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D014101', 'descriptor_name': 'Torpedo', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi00188a013', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8204619', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'score': 0.76, 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1148839277', 'https://openalex.org/W1522291368', 'https://openalex.org/W1528191943', 'https://openalex.org/W1548902459', 'https://openalex.org/W1559153735', 'https://openalex.org/W1574744729', 'https://openalex.org/W1599005607', 'https://openalex.org/W1604384853', 'https://openalex.org/W1901470441', 'https://openalex.org/W1965439766', 'https://openalex.org/W1979234818', 'https://openalex.org/W1979420766', 'https://openalex.org/W1979970939', 'https://openalex.org/W1980541381', 'https://openalex.org/W1991886758', 'https://openalex.org/W1991990318', 'https://openalex.org/W1994522080', 'https://openalex.org/W1998475740', 'https://openalex.org/W2002660032', 'https://openalex.org/W2003848109', 'https://openalex.org/W2005494693', 'https://openalex.org/W2007157361', 'https://openalex.org/W2014853483', 'https://openalex.org/W2018490550', 'https://openalex.org/W2019252070', 'https://openalex.org/W2030197862', 'https://openalex.org/W2035043090', 'https://openalex.org/W2040049703', 'https://openalex.org/W2042806231', 'https://openalex.org/W2046779858', 'https://openalex.org/W2048955811', 'https://openalex.org/W2049722290', 'https://openalex.org/W2050922416', 'https://openalex.org/W2057751422', 'https://openalex.org/W2063413595', 'https://openalex.org/W2064291123', 'https://openalex.org/W2068095679', 'https://openalex.org/W2068120916', 'https://openalex.org/W2075076145', 'https://openalex.org/W2078728304', 'https://openalex.org/W2079977484', 'https://openalex.org/W2089381991', 'https://openalex.org/W2091482647', 'https://openalex.org/W2093442771', 'https://openalex.org/W2099253011', 'https://openalex.org/W2177655263', 'https://openalex.org/W2309527660', 'https://openalex.org/W2325615512', 'https://openalex.org/W2405009767', 'https://openalex.org/W2740242191', 'https://openalex.org/W2799189166', 'https://openalex.org/W62912041'], 'related_works': ['https://openalex.org/W2594449112', 'https://openalex.org/W2336040513', 'https://openalex.org/W2317413890', 'https://openalex.org/W2135831304', 'https://openalex.org/W2088326403', 'https://openalex.org/W2063878922', 'https://openalex.org/W2046718836', 'https://openalex.org/W2011586102', 'https://openalex.org/W196396901', 'https://openalex.org/W1534741036'], 'abstract_inverted_index': {'ADVERTISEMENT': [0], 'RETURN': [1], 'TO': [2], 'ISSUEPREVArticleNEXTElectrostatic': [3], 'potential': [4], 'of': [5, 17, 59, 94, 120], 'the': [6, 11, 56, 87, 92, 121, 132, 145, 148, 153, 160, 166], 'acetylcholine': [7], 'binding': [8], 'sites': [9], 'in': [10], 'nicotinic': [12], 'receptor': [13], 'probed': [14], 'by': [15, 101], 'reactions': [16], 'binding-site': [18], 'cysteines': [19], 'with': [20, 141, 176], 'charged': [21], 'methanethiosulfonatesDavid': [22], 'A.': [23], 'Stauffer': [24], 'and': [25, 69, 74, 103, 147, 164, 180, 182], 'Arthur': [26], 'KarlinCite': [27], 'this:': [28], 'Biochemistry': [29], '1994,': [30], '33,': [31], '22,': [32], '6840–6849Publication': [33], 'Date': [34], '(Print):June': [35], '7,': [36], '1994Publication': [37], 'History': [38], 'Published': [39], 'online1': [40], 'May': [41], '2002Published': [42], 'inissue': [43], '7': [44], 'June': [45], '1994https://pubs.acs.org/doi/10.1021/bi00188a013https://doi.org/10.1021/bi00188a013research-articleACS': [46], 'PublicationsRequest': [47], 'reuse': [48], 'permissionsArticle': [49], 'Views727Altmetric-Citations218LEARN': [50], 'ABOUT': [51], 'THESE': [52], 'METRICSArticle': [53], 'Views': [54], 'are': [55, 78, 91], 'COUNTER-compliant': [57], 'sum': [58], 'full': [60], 'text': [61], 'article': [62, 126], 'downloads': [63], 'since': [64], 'November': [65], '2008': [66], '(both': [67], 'PDF': [68], 'HTML)': [70], 'across': [71], 'all': [72], 'institutions': [73], 'individuals.': [75], 'These': [76], 'metrics': [77], 'regularly': [79], 'updated': [80, 104], 'to': [81, 86], 'reflect': [82], 'usage': [83], 'leading': [84], 'up': [85], 'last': [88], 'few': [89], 'days.Citations': [90], 'number': [93], 'other': [95], 'articles': [96], 'citing': [97], 'this': [98], 'article,': [99], 'calculated': [100], 'Crossref': [102, 110], 'daily.': [105], 'Find': [106, 156], 'more': [107, 157], 'information': [108, 158], 'about': [109, 144], 'citation': [111], 'counts.The': [112], 'Altmetric': [113, 161], 'Attention': [114, 162], 'Score': [115, 163], 'is': [116, 168], 'a': [117, 124, 137], 'quantitative': [118], 'measure': [119], 'attention': [122], 'that': [123], 'research': [125], 'has': [127], 'received': [128], 'online.': [129], 'Clicking': [130], 'on': [131, 159], 'donut': [133], 'icon': [134], 'will': [135], 'load': [136], 'page': [138], 'at': [139], 'altmetric.com': [140], 'additional': [142], 'details': [143], 'score': [146, 167], 'social': [149], 'media': [150], 'presence': [151], 'for': [152], 'given': [154], 'article.': [155], 'how': [165], 'calculated.': [169], 'Share': [170, 185], 'Add': [171], 'toView': [172], 'InAdd': [173], 'Full': [174], 'Text': [175], 'ReferenceAdd': [177], 'Description': [178], 'ExportRISCitationCitation': [179], 'abstractCitation': [181], 'referencesMore': [183], 'Options': [184], 'onFacebookTwitterWechatLinked': [186], 'InRedditEmail': [187], 'Other': [188], 'access': [189], 'optionsGet': [190], 'e-Alertsclose': [191], 'Get': [192], 'e-Alerts': [193]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2037992892', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-08T22:56:46.484003', 'created_date': '2016-06-24'}