Title: Ultrastructural changes in primary guinea pig osteoarthritis with special reference to collagen
Abstract: APMISVolume 104, Issue 1-6 p. 374-382 Ultrastructural changes in primary guinea pig osteoarthritis with special reference to collagen HÅKAN HEDLUND, Corresponding Author HÅKAN HEDLUND Divisions of Orthopedics, Karolinska Institutet, Huddinge Hospital, Huddinge, SwedenDepartment of Orthopedics, Karolinska Institutet, Huddinge Hospital, S-141 86 Huddinge, Sweden.Search for more papers by this authorEDIN DE BRI, EDIN DE BRI Divisions of Orthopedics, Karolinska Institutet, Huddinge Hospital, Huddinge, SwedenSearch for more papers by this authorSILWA MENGARELLI-WIDHOLM, SILWA MENGARELLI-WIDHOLM Divisions of Pathology, Karolinska Institutet, Huddinge Hospital, Huddinge, SwedenSearch for more papers by this authorFINN P. REINHOLT, FINN P. REINHOLT Divisions of Pathology, Karolinska Institutet, Huddinge Hospital, Huddinge, Sweden Divisions of Clinical Research Center, Karolinska Institutet, Huddinge Hospital, Huddinge, SwedenSearch for more papers by this authorOLLE SVENSSON, OLLE SVENSSON Divisions of Orthopedics, Karolinska Institutet, Huddinge Hospital, Huddinge, SwedenSearch for more papers by this author HÅKAN HEDLUND, Corresponding Author HÅKAN HEDLUND Divisions of Orthopedics, Karolinska Institutet, Huddinge Hospital, Huddinge, SwedenDepartment of Orthopedics, Karolinska Institutet, Huddinge Hospital, S-141 86 Huddinge, Sweden.Search for more papers by this authorEDIN DE BRI, EDIN DE BRI Divisions of Orthopedics, Karolinska Institutet, Huddinge Hospital, Huddinge, SwedenSearch for more papers by this authorSILWA MENGARELLI-WIDHOLM, SILWA MENGARELLI-WIDHOLM Divisions of Pathology, Karolinska Institutet, Huddinge Hospital, Huddinge, SwedenSearch for more papers by this authorFINN P. REINHOLT, FINN P. REINHOLT Divisions of Pathology, Karolinska Institutet, Huddinge Hospital, Huddinge, Sweden Divisions of Clinical Research Center, Karolinska Institutet, Huddinge Hospital, Huddinge, SwedenSearch for more papers by this authorOLLE SVENSSON, OLLE SVENSSON Divisions of Orthopedics, Karolinska Institutet, Huddinge Hospital, Huddinge, SwedenSearch for more papers by this author First published: January 1996 https://doi.org/10.1111/j.1699-0463.1996.tb00730.xCitations: 8AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Collagen fibril distribution and surface and volume densities in proximal tibial articular cartilage were measured in 6- and 12-month-old Dunkin-Hartley guinea pigs developing primary osteoarthritis. At 12 months, gross fibrillation and ulceration of the articular cartilage were observed on the medial but not on the lateral condyle. Collagen volume density decreased with age in the interterritorial compartments in the superficial zone, medially by 16% and laterally by 8%. In the upper radial zone, collagen volume density decreased interterritorially by 10% on the medial condyle only. Despite gross osteoarthritic changes, only moderate and predominantly focal ultrastructural collagen changes were observed. Thus neither gross network disruption nor fibril thickening seems to be a general feature in early guinea pig osteoarthritis. Citing Literature Volume104, Issue1-6January 1996Pages 374-382 RelatedInformation
Publication Year: 1996
Publication Date: 1996-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 10
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