Title: Azides Derived from Colchicine and their Use in Library Synthesis: a Practical Entry to New Bioactive Derivatives of an Old Natural Drug
Abstract: ChemMedChemVolume 5, Issue 5 p. 661-665 Communication Azides Derived from Colchicine and their Use in Library Synthesis: a Practical Entry to New Bioactive Derivatives of an Old Natural Drug Norman Nicolaus, Norman Nicolaus Department of Chemistry, University of Cologne, Greinstr. 4, 50939 Cologne (Germany), Fax: (+49) 221-5102Search for more papers by this authorJanet Zapke, Janet Zapke Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125 Berlin (Germany)Search for more papers by this authorPhilipp Riesterer, Philipp Riesterer Children's Hospital Cologne, Department of Paediatric Oncology, Amsterdamer Str. 59, 50735 Cologne (Germany)Search for more papers by this authorJörg-Martin Neudörfl Dr., Jörg-Martin Neudörfl Dr. Department of Chemistry, University of Cologne, Greinstr. 4, 50939 Cologne (Germany), Fax: (+49) 221-5102Search for more papers by this authorAram Prokop Dr. Dr., Aram Prokop Dr. Dr. Children's Hospital Cologne, Department of Paediatric Oncology, Amsterdamer Str. 59, 50735 Cologne (Germany)Search for more papers by this authorHartmut Oschkinat Prof. Dr., Hartmut Oschkinat Prof. Dr. Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125 Berlin (Germany)Search for more papers by this authorHans-Günther Schmalz Prof. Dr., Hans-Günther Schmalz Prof. Dr. [email protected] Department of Chemistry, University of Cologne, Greinstr. 4, 50939 Cologne (Germany), Fax: (+49) 221-5102Search for more papers by this author Norman Nicolaus, Norman Nicolaus Department of Chemistry, University of Cologne, Greinstr. 4, 50939 Cologne (Germany), Fax: (+49) 221-5102Search for more papers by this authorJanet Zapke, Janet Zapke Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125 Berlin (Germany)Search for more papers by this authorPhilipp Riesterer, Philipp Riesterer Children's Hospital Cologne, Department of Paediatric Oncology, Amsterdamer Str. 59, 50735 Cologne (Germany)Search for more papers by this authorJörg-Martin Neudörfl Dr., Jörg-Martin Neudörfl Dr. Department of Chemistry, University of Cologne, Greinstr. 4, 50939 Cologne (Germany), Fax: (+49) 221-5102Search for more papers by this authorAram Prokop Dr. Dr., Aram Prokop Dr. Dr. Children's Hospital Cologne, Department of Paediatric Oncology, Amsterdamer Str. 59, 50735 Cologne (Germany)Search for more papers by this authorHartmut Oschkinat Prof. Dr., Hartmut Oschkinat Prof. Dr. Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125 Berlin (Germany)Search for more papers by this authorHans-Günther Schmalz Prof. Dr., Hans-Günther Schmalz Prof. Dr. [email protected] Department of Chemistry, University of Cologne, Greinstr. 4, 50939 Cologne (Germany), Fax: (+49) 221-5102Search for more papers by this author First published: 27 April 2010 https://doi.org/10.1002/cmdc.201000063Citations: 38Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Arresting cancer: The well-known tubulin-binding agent colchicine was diversified through a click conjugation approach. The key azide, readily prepared from desacetylcolchicine by diazo transfer, was efficiently converted to various triazoles. Biological evaluation of these triazoles revealed their potential as antitumor agents for further development. Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description cmdc_201000063_sm_miscellaneous_information.pdf3.9 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. 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