Title: Dietary fatty acids — Cholesterol interaction and serum cholesterol in the hypercholesterolemic mouse
Abstract: Male C57BR/cdJ mice were fed diets containing mixtures of palm and sunflower oils with different ratios of polyunsaturated to saturated (P/S) fatty acids and supplemented with 0 or 1% cholesterol. Serum total cholesterol varied linearly and inversely with dietary P/S ratio when cholesterol was fed; no such relationship was evident in the absence of dietary cholesterol. Distribution of cholesterol between serum high density (HDL) and total low density (TLDL) lipoproteins varied with dietary P/S ratio, with the ratio of HDL to TLDL increasing linearly with P/S ratio, irrespective of the cholesterol content of the diet. Both HDL and TLDL cholesterol declined with increasing P/S ratio when 1% cholesterol was fed but TLDL cholesterol declined more rapidly than the HDL component. In the absence of dietary cholesterol, HDL cholesterol increased and TLDL cholesterol declined with increasing P/S ratio. Diets containing 0.01% cholesterol produced similar though less pronounced effects to those observed with diets containg 1% cholesterol.
Publication Year: 1984
Publication Date: 1984-07-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 5
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