Title: The impact of graft-versus-host disease in the development of oral cancer after allogeneic hematopoietic stem cell transplantation: report of 2 cases
Abstract: Background:The development of oral cancer following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rare and its etiology is controversial.Oral graft-versus-host disease (GVHD) has been described as a possible risk factor for this condition. Methods and Results:The authors report 2 cases of oral squamous cell carcinoma developed 13 and 15 years after allo-HSCT, respectively.Both patients had no history of smoking or alcohol consumption and the tumor developed in the same area previously affected by oral chronic GVHD.Treatment consisted of surgery and adjuvant radiotherapy in one patient and radiotherapy associated to targettherapy in the other one.The patients are alive and no recurrence was detected after 24 and 22 months of follow-up.Conclusions: This article showed that oral chronic GVHD following allo-HSCT seem to be a potential risk factor in the development of oral carcinoma and emphasized the importance of long term follow-up periods for hematological transplanted patients.