Publication Information

{'id': 'https://openalex.org/W2037322299', 'doi': 'https://doi.org/10.1002/jbm.10465', 'title': 'Effect of TEGDMA on the intracellular glutathione concentration of human gingival fibroblasts', 'display_name': 'Effect of TEGDMA on the intracellular glutathione concentration of human gingival fibroblasts', 'publication_year': 2002, 'publication_date': '2002-01-01', 'ids': {'openalex': 'https://openalex.org/W2037322299', 'doi': 'https://doi.org/10.1002/jbm.10465', 'mag': '2037322299', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12418019'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/jbm.10465', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbm.10465', 'source': {'id': 'https://openalex.org/S34814058', 'display_name': 'Journal of Biomedical Materials Research', 'issn_l': '0021-9304', 'issn': ['0021-9304', '1097-4636'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbm.10465', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5112374678', 'display_name': 'J Engelmann', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I34809795', 'display_name': 'Medizinische Hochschule Hannover', 'ror': 'https://ror.org/00f2yqf98', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I34809795']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'J. Engelmann', 'raw_affiliation_strings': ['Department of Conservative Dentistry and Periodontology, Medical University Hannover, D-30625 Hannover, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Conservative Dentistry and Periodontology, Medical University Hannover, D-30625 Hannover, Germany', 'institution_ids': ['https://openalex.org/I34809795']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073621441', 'display_name': 'Gabriele Leyhausen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I34809795', 'display_name': 'Medizinische Hochschule Hannover', 'ror': 'https://ror.org/00f2yqf98', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I34809795']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'G. Leyhausen', 'raw_affiliation_strings': ['Department of Conservative Dentistry and Periodontology, Medical University Hannover, D-30625 Hannover, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Conservative Dentistry and Periodontology, Medical University Hannover, D-30625 Hannover, Germany', 'institution_ids': ['https://openalex.org/I34809795']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071919946', 'display_name': 'Dieter Leibfritz', 'orcid': 'https://orcid.org/0000-0002-0867-7222'}, 'institutions': [{'id': 'https://openalex.org/I180437899', 'display_name': 'University of Bremen', 'ror': 'https://ror.org/04ers2y35', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I180437899']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'D. Leibfritz', 'raw_affiliation_strings': ['Department of Organic Chemistry, University of Bremen, NW2, FB2, POB 330440, D-28334 Bremen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Organic Chemistry, University of Bremen, NW2, FB2, POB 330440, D-28334 Bremen, Germany', 'institution_ids': ['https://openalex.org/I180437899']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5025913916', 'display_name': 'Werner Geurtsen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I34809795', 'display_name': 'Medizinische Hochschule Hannover', 'ror': 'https://ror.org/00f2yqf98', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I34809795']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'W. Geurtsen', 'raw_affiliation_strings': ['Department of Conservative Dentistry and Periodontology, Medical University Hannover, D-30625 Hannover, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Conservative Dentistry and Periodontology, Medical University Hannover, D-30625 Hannover, Germany', 'institution_ids': ['https://openalex.org/I34809795']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.975, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 97, 'citation_normalized_percentile': {'value': 0.948047, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '63', 'issue': '6', 'first_page': '746', 'last_page': '751'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11481', 'display_name': 'Sulfur Compounds in Biology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11481', 'display_name': 'Sulfur Compounds in Biology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9797, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10458', 'display_name': 'Bladder and Urothelial Cancer Treatments', 'score': 0.9616, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.61441433}], 'concepts': [{'id': 'https://openalex.org/C538909803', 'wikidata': 'https://www.wikidata.org/wiki/Q116907', 'display_name': 'Glutathione', 'level': 3, 'score': 0.94429576}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.88758874}, {'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.61441433}, {'id': 'https://openalex.org/C25642318', 'wikidata': 'https://www.wikidata.org/wiki/Q1992532', 'display_name': 'Incubation', 'level': 2, 'score': 0.5393318}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.482301}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.41520542}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.39025795}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.3798476}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.24979326}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.090232015}], 'mesh': [{'descriptor_ui': 'D003188', 'descriptor_name': 'Composite Resins', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D005881', 'descriptor_name': 'Gingiva', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D005881', 'descriptor_name': 'Gingiva', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005978', 'descriptor_name': 'Glutathione', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011092', 'descriptor_name': 'Polyethylene Glycols', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D011109', 'descriptor_name': 'Polymethacrylic Acids', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003188', 'descriptor_name': 'Composite Resins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D005456', 'descriptor_name': 'Fluorescent Dyes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005881', 'descriptor_name': 'Gingiva', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005881', 'descriptor_name': 'Gingiva', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D005978', 'descriptor_name': 'Glutathione', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008422', 'descriptor_name': 'Materials Testing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011092', 'descriptor_name': 'Polyethylene Glycols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011109', 'descriptor_name': 'Polymethacrylic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/jbm.10465', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbm.10465', 'source': {'id': 'https://openalex.org/S34814058', 'display_name': 'Journal of Biomedical Materials Research', 'issn_l': '0021-9304', 'issn': ['0021-9304', '1097-4636'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12418019', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/jbm.10465', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbm.10465', 'source': {'id': 'https://openalex.org/S34814058', 'display_name': 'Journal of Biomedical Materials Research', 'issn_l': '0021-9304', 'issn': ['0021-9304', '1097-4636'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'score': 0.43, 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1180539591', 'https://openalex.org/W1261161723', 'https://openalex.org/W1488610309', 'https://openalex.org/W1531373906', 'https://openalex.org/W1541793783', 'https://openalex.org/W159813719', 'https://openalex.org/W1928222724', 'https://openalex.org/W1940169030', 'https://openalex.org/W1974565424', 'https://openalex.org/W1974936963', 'https://openalex.org/W1981828558', 'https://openalex.org/W1999838214', 'https://openalex.org/W2008484769', 'https://openalex.org/W2013735458', 'https://openalex.org/W2032735131', 'https://openalex.org/W2032884792', 'https://openalex.org/W2041136773', 'https://openalex.org/W2043635493', 'https://openalex.org/W2045753882', 'https://openalex.org/W2054987594', 'https://openalex.org/W2076305935', 'https://openalex.org/W2079679055', 'https://openalex.org/W2094426750', 'https://openalex.org/W2094829500', 'https://openalex.org/W2095843353', 'https://openalex.org/W2105370577', 'https://openalex.org/W2105529602', 'https://openalex.org/W2106170234', 'https://openalex.org/W2117907789', 'https://openalex.org/W2164014307', 'https://openalex.org/W2258939519', 'https://openalex.org/W2396677194', 'https://openalex.org/W2484370269', 'https://openalex.org/W265096375', 'https://openalex.org/W4245957869'], 'related_works': ['https://openalex.org/W243775755', 'https://openalex.org/W2414990986', 'https://openalex.org/W2369633239', 'https://openalex.org/W2076582678', 'https://openalex.org/W2070361457', 'https://openalex.org/W2037322299', 'https://openalex.org/W1998649742', 'https://openalex.org/W1974921848', 'https://openalex.org/W1966133671', 'https://openalex.org/W1790685047'], 'abstract_inverted_index': {'Abstract': [0], 'Previous': [1], 'studies': [2], 'revealed': [3], 'that': [4], 'primarily': [5], 'small': [6], 'and': [7, 63, 92, 174, 187], 'relatively': [8], 'hydrophilic': [9], 'comonomers,': [10], 'such': [11], 'as': [12, 177], 'TEGDMA,': [13], 'leach': [14], 'out': [15], 'of': [16, 42, 54, 57, 67, 76, 97, 113, 155, 163, 182, 190, 205], 'resin‐based': [17], 'restorative': [18], 'materials': [19], 'into': [20], 'aqueous': [21], 'media.': [22], 'Subsequently,': [23], 'these': [24], 'compounds': [25], 'may': [26, 198], 'cause': [27], 'detrimental': [28], 'reactions': [29], 'with': [30, 44, 88, 99, 159], 'intracellular': [31, 47, 64, 108, 192], 'metabolic': [32], 'systems.': [33], 'The': [34, 52, 95], 'present': [35], 'experiments': [36], 'attempted': [37], 'to': [38, 111, 134, 196, 201], 'elucidate': [39], 'the': [40, 45, 107, 116, 180, 185, 191, 202], 'interactions': [41], 'TEGDMA': [43, 58, 100, 142, 197], 'important': [46, 170], 'reducing': [48], 'agent': [49], 'glutathione': [50, 109, 156, 167, 193], '(GSH).': [51], 'influence': [53], 'various': [55], 'concentrations': [56, 104, 143, 149], '(0.5–7.5': [59], 'mM)': [60], 'on': [61, 125], 'viability': [62, 127], 'GSH': [65], 'concentration': [66, 157], 'primary': [68], 'human': [69], 'gingival': [70], 'fibroblasts': [71, 98], 'was': [72, 128], 'determined': [73], 'by': [74], 'means': [75], 'a': [77, 138, 152, 160], 'fluorescence': [78], 'assay': [79], '(monobromobimane)': [80], 'performed': [81], 'in': [82, 151, 172, 179], 'microtiter': [83], 'plates.': [84], 'Cells': [85], 'were': [86], 'treated': [87], 'TEDGMA': [89], 'between': [90], '2': [91], '24': [93, 135], 'h.': [94], 'incubation': [96, 131], 'even': [101], 'at': [102, 141], 'subtoxic': [103], 'quickly': [105], 'decreased': [106], 'level': [110], '30–50%': [112], 'controls': [114], 'within': [115], 'first': [117], '2–6': [118], 'hours.': [119], 'However,': [120], 'no': [121], 'simultaneous': [122], 'adverse': [123], 'effect': [124], 'cell': [126, 164, 183], 'found.': [129], 'Longer': [130], 'periods': [132], 'up': [133], 'h': [136], 'caused': [137], 'regulatory': [139], 'reincrease': [140], '≤': [144], '2.5': [145], 'mM,': [146], 'whereas': [147], 'higher': [148], 'resulted': [150], 'continuous': [153], 'depletion': [154, 189], 'concomitant': [158], 'significant': [161], 'decrease': [162], 'viability.': [165], 'Because': [166], 'plays': [168], 'an': [169], 'role': [171], 'protection': [173], 'detoxification': [175], 'processes': [176], 'well': [178], 'regulation': [181], 'death,': [184], 'early': [186], 'extensive': [188], 'pool': [194], 'due': [195], 'significantly': [199], 'contribute': [200], 'cytotoxic': [203], 'potency': [204], 'this': [206], 'compound.': [207], '©': [208], '2002': [209, 221], 'Wiley': [210], 'Periodicals,': [211], 'Inc.': [212], 'J': [213], 'Biomed': [214], 'Mater': [215], 'Res': [216], '(Appl': [217], 'Biomater)': [218], '63:': [219], '746–751,': [220]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2037322299', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-17T16:14:51.609830', 'created_date': '2016-06-24'}