Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2037247089', 'doi': 'https://doi.org/10.1210/endo-122-2-402', 'title': 'Effects of Opioid Peptides on Aldosterone Production: Stimulatory Effect of Leu-Enkephalin*', 'display_name': 'Effects of Opioid Peptides on Aldosterone Production: Stimulatory Effect of Leu-Enkephalin*', 'publication_year': 1988, 'publication_date': '1988-02-01', 'ids': {'openalex': 'https://openalex.org/W2037247089', 'doi': 'https://doi.org/10.1210/endo-122-2-402', 'mag': '2037247089', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/3276498'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1210/endo-122-2-402', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5062238694', 'display_name': 'M. E. Bruzzone', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I69737025', 'display_name': 'University of Chile', 'ror': 'https://ror.org/047gc3g35', 'country_code': 'CL', 'type': 'education', 'lineage': ['https://openalex.org/I69737025']}], 'countries': ['CL'], 'is_corresponding': False, 'raw_author_name': 'M. EUGENIA BRUZZONE', 'raw_affiliation_strings': ['Department of Physiology and Biophysics, Faculty of Medicine, University of ChileCasilla 70055, Santiago, Chile'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Biophysics, Faculty of Medicine, University of ChileCasilla 70055, Santiago, Chile', 'institution_ids': ['https://openalex.org/I69737025']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109522247', 'display_name': 'Elisa T. Marusic', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I69737025', 'display_name': 'University of Chile', 'ror': 'https://ror.org/047gc3g35', 'country_code': 'CL', 'type': 'education', 'lineage': ['https://openalex.org/I69737025']}], 'countries': ['CL'], 'is_corresponding': False, 'raw_author_name': 'ELISA T. MARUSIC', 'raw_affiliation_strings': ['Department of Physiology and Biophysics, Faculty of Medicine, University of ChileCasilla 70055, Santiago, Chile'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Biophysics, Faculty of Medicine, University of ChileCasilla 70055, Santiago, Chile', 'institution_ids': ['https://openalex.org/I69737025']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3400, 'currency': 'USD', 'value_usd': 3400, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.128, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.245673, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 66, 'max': 69}, 'biblio': {'volume': '122', 'issue': '2', 'first_page': '402', 'last_page': '406'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11541', 'display_name': 'Neuroendocrine regulation and behavior', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/3207', 'display_name': 'Social Psychology'}, 'field': {'id': 'https://openalex.org/fields/32', 'display_name': 'Psychology'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/etorphine', 'display_name': 'Etorphine', 'score': 0.8792658}, {'id': 'https://openalex.org/keywords/diprenorphine', 'display_name': 'Diprenorphine', 'score': 0.7829046}, {'id': 'https://openalex.org/keywords/mineralocorticoid', 'display_name': 'Mineralocorticoid', 'score': 0.42954013}], 'concepts': [{'id': 'https://openalex.org/C2779166228', 'wikidata': 'https://www.wikidata.org/wiki/Q416827', 'display_name': 'Etorphine', 'level': 5, 'score': 0.8792658}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.81109774}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.8012882}, {'id': 'https://openalex.org/C2779012664', 'wikidata': 'https://www.wikidata.org/wiki/Q424009', 'display_name': 'Diprenorphine', 'level': 5, 'score': 0.7829046}, {'id': 'https://openalex.org/C2778525890', 'wikidata': 'https://www.wikidata.org/wiki/Q184564', 'display_name': 'Aldosterone', 'level': 2, 'score': 0.7758983}, {'id': 'https://openalex.org/C2777803847', 'wikidata': 'https://www.wikidata.org/wiki/Q325101', 'display_name': 'Enkephalin', 'level': 4, 'score': 0.75975823}, {'id': 'https://openalex.org/C88016717', 'wikidata': 'https://www.wikidata.org/wiki/Q417189', 'display_name': 'Opioid peptide', 'level': 4, 'score': 0.68967986}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6067879}, {'id': 'https://openalex.org/C2778750930', 'wikidata': 'https://www.wikidata.org/wiki/Q4540629', 'display_name': '(+)-Naloxone', 'level': 4, 'score': 0.50363797}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.47225514}, {'id': 'https://openalex.org/C2779886867', 'wikidata': 'https://www.wikidata.org/wiki/Q421797', 'display_name': 'Opioid receptor', 'level': 4, 'score': 0.45585167}, {'id': 'https://openalex.org/C2776069600', 'wikidata': 'https://www.wikidata.org/wiki/Q422519', 'display_name': 'Mineralocorticoid', 'level': 3, 'score': 0.42954013}, {'id': 'https://openalex.org/C2781063702', 'wikidata': 'https://www.wikidata.org/wiki/Q427523', 'display_name': 'Opioid', 'level': 3, 'score': 0.4211777}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.3432979}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.1991227}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.18609893}], 'mesh': [{'descriptor_ui': 'D000450', 'descriptor_name': 'Aldosterone', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D004743', 'descriptor_name': 'Enkephalin, Leucine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000302', 'descriptor_name': 'Adrenal Cortex', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000302', 'descriptor_name': 'Adrenal Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000302', 'descriptor_name': 'Adrenal Cortex', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000450', 'descriptor_name': 'Aldosterone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002417', 'descriptor_name': 'Cattle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004174', 'descriptor_name': 'Diprenorphine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004174', 'descriptor_name': 'Diprenorphine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004743', 'descriptor_name': 'Enkephalin, Leucine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004743', 'descriptor_name': 'Enkephalin, Leucine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D016308', 'descriptor_name': 'Enkephalin, Leucine-2-Alanine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009270', 'descriptor_name': 'Naloxone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009270', 'descriptor_name': 'Naloxone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009271', 'descriptor_name': 'Naltrexone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009271', 'descriptor_name': 'Naltrexone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010477', 'descriptor_name': 'Perfusion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1210/endo-122-2-402', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/3276498', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.47, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1789439462', 'https://openalex.org/W1978703741', 'https://openalex.org/W1981394480', 'https://openalex.org/W1984082164', 'https://openalex.org/W1989980988', 'https://openalex.org/W1993088841', 'https://openalex.org/W1999800182', 'https://openalex.org/W2021010194', 'https://openalex.org/W2031331121', 'https://openalex.org/W2031688315', 'https://openalex.org/W2034720418', 'https://openalex.org/W2036976041', 'https://openalex.org/W2046678593', 'https://openalex.org/W2057959883', 'https://openalex.org/W2084723323', 'https://openalex.org/W2086073910', 'https://openalex.org/W2138930451', 'https://openalex.org/W2142174162', 'https://openalex.org/W2167042503', 'https://openalex.org/W2273760613', 'https://openalex.org/W2460277341', 'https://openalex.org/W2472949332'], 'related_works': ['https://openalex.org/W2413496956', 'https://openalex.org/W2165864711', 'https://openalex.org/W2093515812', 'https://openalex.org/W2066917834', 'https://openalex.org/W2066579695', 'https://openalex.org/W2060551888', 'https://openalex.org/W2060281199', 'https://openalex.org/W2037247089', 'https://openalex.org/W1968180707', 'https://openalex.org/W1904370736'], 'abstract_inverted_index': {'The': [0, 73, 88], 'effects': [1], 'of': [2, 50, 68, 75, 92, 119], 'several': [3], 'opioid': [4, 44, 78, 134], 'peptides': [5], '(Leu-enkephalin,': [6], 'Met-enkephalin,': [7], 'D-Ala2,D-Leu5-enkephalin,': [8, 45], 'and': [9, 103], 'peptide': [10], 'E)': [11], 'on': [12, 37, 70, 109, 121], 'aldosterone': [13, 27, 71, 93, 122], 'secretion': [14, 94], 'have': [15], 'been': [16], 'studied': [17], 'in': [18, 29], 'isolated': [19], 'bovine': [20], 'adrenal': [21], 'glomerulosa': [22], 'cells.': [23], 'Leu-enkephalin': [24, 69, 91, 120], 'significantly': [25], 'increased': [26], 'production': [28, 123], 'a': [30, 76, 128], 'dose-dependent': [31], 'manner': [32], '(10(-10)-10(-7)': [33], 'M).': [34], 'Similar': [35], 'results': [36], 'steroidogenesis': [38], 'were': [39, 52], 'obtained': [40], 'with': [41], 'the': [42, 66, 116, 132], 'synthetic': [43], 'whereas': [46], 'much': [47], 'higher': [48], 'concentrations': [49], 'Met-enkephalin': [51], 'required.': [53], 'Peptide': [54], 'E': [55], 'did': [56], 'not': [57], 'affect': [58], 'steroidogenesis.': [59, 111], 'Naltrexone': [60], 'or': [61, 81], 'naloxone': [62], '(10(-5)': [63], 'M)': [64, 105], 'potentiated': [65], 'effect': [67, 74, 108, 118], 'secretion.': [72], 'general': [77], 'antagonist': [79], '(diprenorphine)': [80], 'an': [82], 'agonist': [83], '(etorphine)': [84], 'was': [85, 95], 'also': [86], 'studied.': [87], 'stimulation': [89], 'by': [90, 99, 127], 'only': [96], 'partially': [97], 'blocked': [98], 'diprenorphine.': [100], 'Etorphine': [101], '(10(-6)': [102], '10(-8)': [104], 'had': [106], 'no': [107], 'basal': [110], 'It': [112], 'is': [113], 'proposed': [114], 'that': [115], 'stimulatory': [117], 'could': [124], 'be': [125], 'mediated': [126], 'different': [129], 'receptor': [130], 'than': [131], 'classical': [133], 'receptors': [135], 'presently': [136], 'known.': [137]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2037247089', 'counts_by_year': [], 'updated_date': '2024-12-08T19:46:23.453720', 'created_date': '2016-06-24'}