Title: 288 IMPACT OF HALLUX VALGUS SEVERITY ON GENERAL AND FOOT-SPECIFIC HEALTH-RELATED QUALITY OF LIFE
Abstract: as follows: 0=none; 1=mild; 2=moderate; 3=severe. Twenty of thirty-four patients underwent Gd-MRI. Synovial membrane inflammation was investigated in 5 ROIs. Thickening of the inflamed synovial membrane was determined in each ROI and grade on a 4-point scale. A correlation analysis was conducted by Spearman’s correlation coefficient. Results: The synovitis of the knee joint was evaluated by a histological analysis and Gd-MRI. A statistically significant correlation was observed between the total composite score of synovitis by the histological analysis and the synovitis score evaluated by Gd-MRI in patients of this study (r=0.88, p<0.01). Next, the possible correlation between synovial inflammation and the symptoms and the disability of the patients was assessed. The pain VAS score of patients was not correlated with either the mean total synovitis score evaluated by the histological analysis nor that evaluated by Gd-MRI (r=0.25, p=0.18 and r=0.08, p=0.75, respectively). On the other hand, the total JKOM score of the patients showed a significant positive correlation with both the mean total synovitis score evaluated by the histological analysis and that evaluated by Gd-MRI (r=0.55, p<0.01 and r=0.71, p<0.01, respectively). To further examine whether the WOMAC could obtain a similar result, fourteen of thirty-four patients were evaluated for any disability by both the JKOM and WOMAC. The WOMAC of the fourteen patients did not show a significant correlation with either the mean total synovitis score evaluated by the histological analysis or that evaluated by Gd-MRI. Conclusions: The present study revealed the disability of Japanese patients with knee OA who required TKA using JKOM showed a significant correlation with the severity of synovitis in affected knee joint. This study further confirmed the superiority of the JKOM for evaluating the disability of Japanese patients with knee OA. Synovitis may play a crucial role, not only in the progression of disease, but also in the current functional impairment and disability in patients with end-stage knee OA who required TKA.