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222, 287, 412, 455, 651, 682, 1162, 1196, 3409, 4057], 'utility': [56, 289], 'because': [57, 186, 290, 419, 933, 2826], 'several': [58, 291, 2814, 2893], 'agents': [59, 154, 292, 387, 962, 2735, 2762, 2817, 2861, 2902], 'showing': [60, 293], 'promise': [61, 161, 294, 394, 822, 970], 'vitro': [64, 297, 3076], 'animal': [66, 299, 824], 'models': [67, 300, 1875], 'have': [68, 301, 820, 952, 1313, 1321, 1546, 1682, 1880, 2599, 2868, 2889, 2928, 3471], 'failed': [69, 302], 'studies.': [72, 305], 'Novel': [73, 306, 826, 3092], 'approaches': [75, 308, 828, 860], 'include': [76, 309, 833], 'Toll-like': [77, 310, 834, 1359, 1631, 1698, 1898], 'receptor': [78, 94, 104, 311, 327, 337, 835, 846, 1360, 1423, 1565, 1632, 1699, 1719, 1899, 1919, 2271, 2634, 3357, 3399], '4': [79, 312, 1424, 3311, 3756, 4123], '9': [81, 314, 1361, 1633, 1700, 1720, 1900, 1920, 2635], 'agonists,': [82, 315, 837], 'immunostimulatory': [83, 316, 1547, 2125, 2146, 2189, 2215], 'oligodeoxynucleotides,': [84, 317], 'oral': [85, 318, 838, 2901], 'parenterally': [87, 320, 840], 'administered': [88, 321, 841, 1461], 'cytokine': [89, 93, 322, 326, 842, 845, 1305, 2048, 2053, 2821, 2905, 2972, 3070], 'blockers,': [90, 323, 843], 'specific': [92, 157, 177, 325, 390, 410, 844], 'antagonists.': [95, 328], 'Transcription': [96, 329], 'factor': [97, 108, 330, 341, 849], 'modulators': [98, 331], 'targeting': [99, 332, 2736, 2818], 'syk': [100, 333], 'kinase,': [101, 334], 'peroxisome': [102, 335], 'proliferator-activated': [103, 336], 'γ,': [105, 338], 'nuclear': [107, 340], 'κB': [109, 342], 'also': [111, 344, 867, 2946, 3302, 4204], 'being': [112, 345, 2651, 2823, 3189], 'evaluated': [113, 346, 1404, 2891, 3165, 3323, 3484, 4206], 'treatment': [116, 131, 349, 364, 795, 2468, 2611, 3107, 3360, 3613, 3661, 3962, 3999, 4025, 4148], 'diseases,': [119, 352, 772, 1690, 2619, 2709], 'especially': [120, 353, 921, 944, 3457], 'asthma.': [121, 201, 354, 434], 'anti-IgE': [123, 356, 852], 'mAb': [124, 357, 3424], 'omalizumab': [125, 358], 'already': [127, 360], 'used': [128, 361, 1325, 1684], 'asthma,': [134, 367, 3840], 'but': [135, 368, 1512, 2560, 3134, 3616, 4169], 'its': [136, 369], 'potential': [137, 370, 794, 1357, 1407, 1531, 1629, 1696, 1896, 2757, 2802], 'role': [138, 371, 674, 1188, 1285, 1533, 3696, 3766, 3859], 'other': [140, 373, 535, 1041, 1537, 3455], 'yet': [144, 377], 'be': [146, 379, 474, 507, 528, 539, 548, 868, 882, 929, 979, 1013, 1034, 1045, 1055, 2698, 2798, 3445, 4082], 'clearly': [147, 380], 'defined.': [148, 381], 'Overall,': [149, 382, 957, 2690], 'new': [153, 386, 793, 961, 1861], 'that': [155, 174, 388, 407, 797, 819, 895, 947, 963, 1385, 1401, 1485, 1554, 2362, 2694, 2903, 3638], 'inhibit': [156, 389, 965, 1507, 2904, 2917], 'immunopathogenic': [158, 391, 967], 'mechanisms': [159, 392, 683, 776, 968, 1197, 3451], 'holds': [160, 393, 969], 'beneficial': [163, 396, 972], 'outcomes': [164, 397, 973], 'patients': [166, 399, 1481, 2059, 2312, 2368, 2390, 2519, 3198, 3271, 3392, 3632, 3927, 4027, 4050, 4094, 4124, 4150, 4186], 'with': [167, 216, 231, 400, 449, 464, 647, 715, 725, 1158, 1232, 1242, 1447, 2022, 2060, 2083, 2115, 2232, 2237, 2269, 2290, 2310, 2386, 2511, 2522, 2669, 2725, 2755, 2926, 3097, 3131, 3153, 3181, 3199, 3249, 3294, 3316, 3363, 3486, 3491, 3583, 3589, 3633, 3722, 3739, 3928, 3979, 3995, 4028, 4052, 4095, 4111, 4151, 4198, 4235], 'least': [169, 402], 'amount': [170, 403], 'risk.': [172, 405], 'However,agents': [173, 406], 'too': [176, 409], 'targets': [180, 413, 2871], 'might': [181, 414, 2721, 2788, 3442, 4081], 'not': [182, 415, 538, 707, 924, 1044, 1223, 2561, 2592, 2822, 3617], 'exhibit': [183, 416], 'benefits': [185, 418, 905], 'redundancy': [189, 422, 2829, 3449], 'immune': [192, 425, 886, 892, 1295, 1654, 2013, 2111, 2747, 2765, 2832], 'system': [193, 426, 1655, 2748], 'heterogeneity': [196, 429], 'such': [199, 432, 894, 2620], 'as': [200, 433, 1405, 2605, 2621, 2700, 3699, 3769, 3862, 4170], 'goal': [203, 436, 872], 'this': [205, 438, 487, 510, 831, 992, 1016, 3132], 'review': [206, 439, 484, 989], 'summarize': [209, 442], 'data': [211, 444, 935, 2692, 3136], 'from': [212, 445, 736, 1253, 2057, 2301, 2366, 3728], 'trials': [215, 448, 810, 1328, 2598, 2660, 2925, 3130], 'immunomodulators,': [217, 450], 'discussing': [218, 451], 'rationale': [220, 453], 'use,': [223, 456, 3287], 'efficacy': [224, 457, 689, 1204, 1993, 2483, 3167, 4139], 'results,': [225, 458], 'putative': [227, 460], 'adverse': [228, 461, 907, 1476, 2794], 'events': [229, 462], 'associated': [230, 463, 2082, 3978], 'them.': [232, 465], 'Information': [466], 'category': [468], '1': [469, 635, 639, 1146, 1150, 2001, 2044, 2122, 2157, 3266, 3989], 'CME': [470, 704, 1220], 'creditCredit': [471], 'can': [472, 506, 977, 1012, 1301, 1806, 1989], 'now': [473, 978], 'obtained,': [475, 980], 'free': [476, 981], 'limited': [479, 984, 2593], 'time,': [480, 985], 'by': [481, 609, 814, 986, 1120, 1606, 2118, 2184, 2335, 2800, 3730, 3737], 'reading': [482, 987], 'articles': [485, 990], 'issue.': [488, 993], 'Please': [489, 994], 'note': [490, 995], 'following': [492, 997], 'instructions.Method': [493], 'Physician': [495, 1001], 'Participation': [496, 1002], 'Learning': [498, 1004], 'Process:': [499, 1005], 'core': [501, 1007], 'material': [502, 1008], 'these': [504, 551, 628, 792, 919, 1010, 1058, 1139, 1657], 'activities': [505, 630, 1011, 1141], 'read': [508, 1014], 'issue': [511, 1017], 'Journal': [514, 1020], 'or': [515, 534, 580, 954, 1021, 1040, 1089, 1298, 1453, 1458, 1536, 1692, 1985, 2244, 2542, 2608, 2666, 2784, 2806, 3256, 3259, 3336, 3419, 3500, 3503, 3577, 3990], 'online': [516, 530, 1022, 1036], 'at': [517, 531, 862, 1023, 1037, 1520, 2782, 2863, 2880, 3310, 3331, 3385, 4077], 'JACI': [519, 1025], 'Web': [520, 1026], 'site:': [521, 1027], 'www.jacionline.org.': [522, 532, 1028, 1038], 'accompanying': [524, 1030], 'tests': [525, 1031], 'may': [526, 547, 1032, 1054], 'only': [527, 643, 1033, 1154, 3555, 3701, 3735, 3771, 3864, 4061], 'submitted': [529, 1035], 'Fax': [533, 1039], 'copies': [536, 1042], 'will': [537, 866, 1043, 1527], 'accepted.Date': [540], 'Original': [542, 1049], 'Release:': [543, 1050], 'February': [544, 1051], '2008.': [545, 1052], 'Credit': [546, 596, 976, 1053, 1107], 'obtained': [549, 1056], 'courses': [552, 1059], 'until': [553, 1060], 'January': [554, 1061], '31,': [555, 1062], '2010.Copyright': [556], 'Statement:': [557, 1065], 'Copyright': [558, 1064, 1066], '©': [559, 1067], '2008-2010.': [560, 1068], 'All': [561, 1069, 3261], 'rights': [562, 1070], 'reserved.Overall': [563], 'Purpose/Goal:': [564, 1073], 'To': [565, 671, 686, 1074, 1185, 1201], 'provide': [566, 619, 1075, 1130, 2789, 2836], 'excellent': [567, 1076], 'reviews': [568, 789, 1077], 'on': [569, 696, 745, 758, 807, 1078, 1211, 1262, 1275, 1342, 1578, 2539, 2763, 2974, 3011, 3043, 3128, 3811, 3836, 3904], 'key': [570, 966, 1079, 1284, 2865], 'aspects': [571, 1080], 'disease': [574, 694, 1083, 1209, 1879, 4084], 'those': [576, 1085, 2387, 3295], 'who': [577, 1086], 'research,': [578, 1087], 'treat,': [579, 1088], 'manage': [581, 1090], 'disease.Target': [583], 'Audience:': [584, 1094], 'Physicians': [585, 641, 1095, 1152], 'researchers': [587, 1097], 'within': [588, 1098], 'field': [590, 1100], 'disease.Accreditation/Provider': [593], 'Statements': [594, 1105], 'Designation:': [597, 1108], 'American': [599, 1110], 'Academy': [600, 1111], 'Allergy,': [602, 1113], 'Asthma': [603, 1114, 1431], '&': [604, 1115], 'Immunology': [605, 1116], '(AAAAI)': [606, 1117], 'accredited': [608, 1119], 'Accreditation': [611, 1122], 'Council': [612, 1123], 'Continuing': [614, 1125], 'Medical': [615, 1126], 'Education': [616, 1127], '(ACCME)': [617, 1128], 'continuing': [620, 1131], 'medical': [621, 1132], 'education': [622, 1133], 'physicians.': [624, 1135], 'AAAAI': [626, 1137], 'designates': [627, 1138], 'educational': [629, 1140], 'maximum': [633, 1144], 'AMA': [636, 1147], 'PRA': [637, 1148], 'Category': [638, 1149], 'Credit™.': [640, 1151], 'should': [642, 881, 928, 1153], 'claim': [644, 1155], 'credit': [645, 1156], 'commensurate': [646, 1157], 'extent': [649, 1160], 'participation': [652, 1163], 'activity.List': [655], 'Design': [657, 1169], 'Committee': [658, 1170], 'Members:': [659, 1171], 'Authors:': [660, 1172], 'Thomas': [661, 719, 1173, 1236], 'B.': [662, 720, 1174, 1237, 4254], 'Casale,': [663, 1175], 'MD,': [664, 1176], 'Jeffrey': [666, 754, 1178, 1271], 'R.': [667, 755, 1179, 1272, 1937, 2033, 2169, 2171, 2266, 3003], 'Stokes,': [668, 1180], 'MDActivity': [669], 'Objectives1.': [670], 'understand': [672, 687, 1186, 1202], 'treating': [678, 1192], 'action.2.': [685], 'based': [695, 1210], 'trials.Recognition': [699], 'Commercial': [701, 717, 1217, 1234], 'Support:': [702, 1218], 'This': [703, 787, 1219, 2079, 2796, 3441], 'activity': [705, 1221, 3099], 'received': [708, 733, 1224, 1250, 4187], 'external': [709, 1225], 'commercial': [710, 1226], 'support.Disclosure': [711], 'Significant': [713, 1230], 'Relationships': [714, 1231], 'Relevant': [716, 1233], 'Companies/Organizations:': [718, 1235], 'Casale': [721, 1238, 2475], 'consulting': [723, 1240], 'arrangements': [724, 1241], 'Genentech,': [726, 739, 751, 1243, 1256, 1268], 'Novartis,': [727, 738, 1244, 1255], 'OSI,': [728, 1245], 'Pharma,': [729, 1246], 'Zymo/Genetics;': [731, 1248], 'research': [734, 1251], 'support': [735, 938, 1252], 'Dynavax,': [737, 1254], 'Amgen,': [740, 1257], 'Schering;': [742, 1259], "speakers'": [747, 760, 1264, 1277], 'bureau': [748, 761, 1265, 1278], 'Merck,': [750, 1267], 'Novartis.': [753, 1270], 'Stokes': [756, 1273], 'GlaxoSmithKline.New': [763], 'including': [773, 2710, 3841], 'molecular': [775], 'involved,': [777], 'article': [788, 832], 'some': [790, 917, 2761], 'modalities': [796], 'importance': [804, 2842], 'focusing': [806], 'become': [812], 'evident': [813], 'failure': [816], 'treatments': [818], 'shown': [821, 2915, 2929, 2948, 3063], 'models.': [825], 'reviewed': [829, 2810], '(TLR)': [836], 'antagonists,': [847], 'transcription': [848], 'modulators,': [850], 'mAbs': [853, 3470], '(Fig': [854], '1).': [855], 'risk/benefit': [857, 2776], 'ratio': [858], 'aimed': [861, 2781, 2862, 2879], 'certain': [863], 'processes': [865], 'reviewed.': [869], 'Ultimately,': [870], 'induction': [884], 'tolerance,': [887], 'change': [889], 'response': [893, 2080, 4022], 'discontinuation': [896, 3434], 'results': [900], 'continued': [902], 'long-lasting': [903], 'without': [906, 3598], 'consequences.': [908], 'discussion': [910], 'economics': [913], 'involved': [914], 'using': [916], 'agents,': [920], 'mAbs,': [922], 'included.': [925], 'However,': [926, 2450, 2754, 3833], 'costs': [927], 'kept': [930], 'mind': [932], 'pharmacoeconomic': [934], 'need': [936], 'use': [940], 'expensive': [942], 'medications,': [943], 'disorders': [946], 'very': [949], 'common': [950, 1351], 'little': [953], 'no': [955, 1490, 1498, 2447, 2535, 2579, 3428, 3834], 'mortality.': [956], 'specifically': [964], 'patients.': [975], 'instructions.': [998], 'Method': [999], 'accepted.': [1046], 'Date': [1047], '2010.': [1063], 'reserved.': [1071], 'Overall': [1072], 'disease.': [1092, 1103, 2596, 2851], 'Target': [1093, 1759, 1785, 1831], 'Accreditation/Provider': [1104], 'activity.': [1166], 'List': [1167], 'MD': [1181], 'Activity': [1182], 'Objectives': [1183], '1.': [1184, 2222], 'action.': [1199, 2753], '2.': [1200], 'Recognition': [1215], 'support.': [1227], 'Disclosure': [1228], 'GlaxoSmithKline.': [1280], 'TLRs': [1281, 1300, 1312, 2737], 'play': [1282], 'activating': [1287], 'antigen-presenting': [1288], 'cells': [1289, 1580, 1588, 1604, 1618, 2379, 2384, 3152], 'both': [1291, 1649, 2314, 2339, 2739], 'innate': [1292, 1651, 2741], 'adaptive': [1294], 'responses.': [1296, 1388], 'Blocking': [1297], 'stimulating': [1299], 'modify': [1302], 'TH1/TH2': [1304], 'balance': [1306], 'affecting': [1307], 'diseases.': [1309, 1335, 2877], 'Eleven': [1310], 'different': [1311], 'been': [1314, 1322, 1403, 1683, 2869, 2890, 2914, 2947, 3062, 3472, 4205], 'identified.': [1315], 'Agonists': [1316], 'TLR4': [1318, 1336, 1383, 1399, 1538], 'TLR9': [1320, 1346, 1562, 1607, 1646, 2589, 2675, 2695], 'developed': [1323], 'respiratory': [1334, 2712], 'binds': [1337, 1347], 'LPSs': [1338], 'endotoxins': [1340], 'expressed': [1341, 1574], 'cell': [1344, 3081], 'surface.': [1345], 'CpG': [1348, 1552, 1567, 1664, 1680, 1740, 1885, 1965, 1988, 1995, 2007, 2150, 2524, 2604, 2648, 2718], 'motifs': [1349, 2151], 'most': [1350], 'bacterial': [1353], 'pathogens.1Krieg': [1354], 'A.M.': [1355, 1627, 1694, 1894, 2629, 2672], 'Therapeutic': [1356, 1628, 1695, 1895, 2734], 'activation.Nat': [1362, 1634, 1701, 1901], 'Rev': [1363, 1635, 1702, 1725, 1902, 1925], 'Drug': [1364, 1636, 1703, 1903], 'Discov.': [1365, 1637, 1704, 1904], '2006;': [1366, 1433, 1638, 1705, 1728, 1905, 1928, 1947, 2199, 2280, 2570, 4034], '5:': [1367, 1639, 1706, 1906], '471-484Crossref': [1368, 1640, 1707, 1907], 'PubMed': [1369, 1439, 1641, 1708, 1731, 1908, 1931, 1956, 1977, 2074, 2138, 2207, 2283, 2429, 2573, 2643, 2685, 2989, 3021, 3055, 3117, 3239, 3376, 3543, 3625, 3682, 3716, 3786, 3828, 3879, 3921, 3969, 4042, 4157, 4244], 'Scopus': [1370, 1440, 1642, 1709, 1732, 1909, 1932, 1957, 1978, 2075, 2139, 2208, 2284, 2430, 2574, 2644, 2686, 2990, 3022, 3056, 3118, 3240, 3377, 3544, 3626, 3683, 3717, 3787, 3829, 3880, 3922, 3970, 4043, 4158, 4245], '(1088)': [1371, 1643, 1710, 1910], 'Google': [1372, 1442, 1644, 1711, 1734, 1911, 1934, 1959, 1980, 2077, 2141, 2210, 2286, 2432, 2508, 2576, 2646, 2688, 2992, 3024, 3058, 3120, 3242, 3379, 3546, 3628, 3685, 3719, 3789, 3831, 3882, 3924, 3972, 4045, 4160, 4247], 'Scholar': [1373, 1443, 1645, 1981, 2078, 2142, 2211, 2287, 2433, 2509, 2577, 2647, 2689, 3059, 3121, 3243, 3380, 3547, 3629, 3720, 3832, 3925, 3973, 4046, 4161], 'Lipid': [1374], 'A,': [1375, 1395, 1666], 'active': [1377], 'component': [1378], 'LPS,': [1380], 'agonist': [1384, 1400, 1425, 2272], 'induces': [1386, 3140], 'TH1': [1387, 1754, 1829, 2012, 2047], 'An': [1389], 'aqueous': [1390], 'formulation': [1391], 'monophosphoryl': [1393], 'lipid': [1394], 'CRX-675,': [1396], 'seasonal': [1410, 2226, 2325, 2443], 'rhinitis.2Casale': [1412], 'T.B.': [1413, 4136], 'Kessler': [1414], 'J.': [1415, 2173, 2954, 2964, 3345, 3621, 3796, 3889, 3952], 'Romero': [1416], 'F.A.': [1417], 'Safety': [1418, 2481, 4137], 'intranasal': [1421, 1473], 'toll-like': [1422, 1718, 1918, 2633], 'CRX-675': [1426, 1454, 1505, 1535], 'rhinitis.Ann': [1429], 'Allergy': [1430, 2063, 2127, 2196, 2418, 2497, 3365, 4031], 'Immunol.': [1432, 2065, 2129, 2198, 2420, 2499, 3367, 4033], '97:': [1434], '454-456Abstract': [1435], 'Full': [1436, 1951, 1953, 2069, 2071, 2133, 2135, 2202, 2204, 2424, 2426, 2503, 2505, 2984, 2986, 3371, 3373, 3823, 3825, 3916, 3918, 4037, 4039], 'Text': [1437, 1952, 1954, 2070, 2072, 2134, 2136, 2203, 2205, 2425, 2427, 2504, 2506, 2985, 2987, 3372, 3374, 3824, 3826, 3917, 3919, 4038, 4040], 'PDF': [1438, 1955, 2073, 2137, 2206, 2428, 2507, 2988, 3375, 3827, 3920, 4041], '(34)': [1441], 'Patients': [1444, 2288, 3244], 'were': [1445, 1494, 2235, 2454, 2520, 3137, 3245, 3264, 3383, 3405, 3415, 3581, 3849], 'treated': [1446, 2236, 2289, 2521, 3490, 4051], 'either': [1448, 2242, 2606, 2664, 3253], 'placebo': [1449, 2245, 2459, 3504, 3996], '(n': [1450], '=': [1451, 1464], '16)': [1452], '(2,': [1455], '20,': [1456], '100,': [1457], '200': [1459], 'μg': [1460, 3255, 3258], 'intranasally;': [1462], 'n': [1463], '12': [1465, 3329, 4167], 'per': [1466], 'arm)': [1467], '24': [1468], 'hours': [1469], 'before': [1470, 2246], 'ragweed': [1472, 2004, 2023, 2061, 2116, 2225, 2233, 2248, 2254, 2322, 2356, 2393, 2490], 'challenge.': [1474], 'event': [1477], 'profile': [1478, 2729], 'CRX-675–treated': [1480], 'was': [1482, 1497, 1518, 2081, 2333, 2351, 2537, 2584, 3176, 3553, 3932, 3993, 4068], 'similar': [1483], 'placebo-treated': [1487, 2311, 2389], 'patients,': [1488], 'dose-related': [1491], 'toxic': [1492], 'effects': [1493, 1818, 2759, 2883, 3835], 'observed.': [1495], 'There': [1496, 1659], 'clear': [1499], 'trend': [1500], 'ability': [1503], 'nasal': [1508, 1515, 2298, 2363, 2415, 4002, 4029, 4058, 4073], 'allergen': [1509, 2045, 2731], 'challenge': [1510], 'responses,': [1511, 2860], 'improvement': [1513, 2931, 3280, 4055, 4113, 4196], 'symptom': [1516, 2299, 2452, 3283, 3573], 'scores': [1517, 2300, 2453], 'observed': [1519], '100': [1521], 'μg.': [1522], 'Appropriate': [1523], 'dosing': [1524, 3325], 'timing': [1526], 'define': [1529], 'agonists': [1539, 1647, 2676, 2696], 'allergies.': [1541], 'Bacterial': [1542], 'viral': [1544], 'genomes': [1545], 'DNA': [1548, 1966, 2039, 2147], 'sequences': [1549, 1553, 2148, 2556], 'containing': [1550, 2149], 'unmethylated': [1551], 'suppressed': [1556, 2016, 2334, 3592, 4164], 'methylated': [1558], 'vertebrate': [1560], 'genomes.': [1561], 'DNA,': [1568], 'which': [1569, 1670], 'highest': [1576], 'concentrations': [1577], 'B': [1579, 1603, 1822, 1833], 'plasmacytoid': [1582, 1586], 'dendritic': [1583, 1587, 1848, 1865], 'cells.': [1584], 'TLR9-activated': [1585], 'produce': [1589, 1608], 'IFN-α,': [1590, 1752, 1825, 2087], 'leading': [1591, 3431], 'secondary': [1593], 'activation': [1594], 'natural': [1596, 1851, 1868], 'killer': [1597], 'T': [1598], 'cells,': [1599], 'monocytes,': [1600], 'neutrophils.': [1602], 'activated': [1605], 'IL-6': [1609, 1784], 'IL-10': [1611], 'while': [1612, 2050], 'inducing': [1613], 'B-cell': [1614, 1757, 1775, 1826], 'differentiation': [1615, 3464], 'into': [1616, 3150, 3438], 'plasma': [1617], 'triggering': [1620], 'IgG': [1621, 2349], 'isotype': [1622, 3142], 'switching': [1623, 3143], 'antibody': [1625, 3810, 3903, 3958, 4144, 4230], 'production.1Krieg': [1626], 'activate': [1648], 'humoral': [1653, 2743], 'through': [1656, 2526, 2749, 3402], 'interactions.': [1658], '3': [1661, 3991], 'classes': [1662, 1738], 'molecules,': [1665], 'B,': [1667, 2623], 'C,': [1669, 2625], 'described': [1672], 'Table': [1674], 'I.': [1675], 'Both': [1676], 'B-': [1677], 'C-class': [1679], 'oligodeoxynucleotides': [1681], 'vaccine': [1686, 2273, 2487], 'infectious': [1689, 1799, 1843, 2618], 'cancer,': [1691], 'both.1Krieg': [1693], 'Scholar,': [1712, 1912, 1935, 1960, 2993, 3025, 3686, 3790, 3883, 4248], '3Bhattacharjee': [1713, 1913], 'R.N.': [1714, 1914], 'Akira': [1715, 1915], 'S.': [1716, 1916, 2027, 2031, 2997, 3652, 3654, 4224], 'Modifying': [1717, 1917], 'signaling': [1721, 1921], 'use.Mini': [1724, 1924], 'Med': [1726, 1926, 3112], 'Chem.': [1727, 1927, 3113], '6:': [1729, 1929], '287-291Crossref': [1730, 1930], '(24)': [1733, 1933], 'ScholarTable': [1735], 'IThree': [1736], 'major': [1737], 'oligodeoxynucleotideA': [1741], 'class:': [1742, 1764, 1801], 'Chimeric': [1743], 'backbone': [1744], 'Examples:': [1745, 1768, 1809], 'ODN': [1746, 1769, 1810], '2216,': [1747], '1583': [1748], '(5′-G∗G∗G-T-C-A-A-C-G-T-T-G-A-G∗G∗G∗G∗G∗G-3′)': [1749], 'Responses:': [1750, 1774, 1815], 'High': [1751], 'IFN-γ,': [1753], 'inducer,': [1755], 'poor': [1756], 'stimulator': [1758], 'cells:': [1760, 1786, 1832], 'pDC,': [1761, 1787, 1835, 1863], 'PBMC,': [1762], 'NKB': [1763], 'Phosphorothioate': [1765, 1802], 'backbone,': [1766, 1803], 'linear': [1767], 'PF-3512676,': [1770], '1018,': [1771], '1826': [1772], '(5′-T∗C∗C∗A∗T∗G∗A∗C∗G∗T∗T∗C∗C∗T∗G∗A∗C∗G∗T∗T-3′)': [1773], 'proliferation,': [1776], 'pDC': [1777], 'maturation,': [1778], 'secrete': [1779], 'IgG,': [1780], 'high': [1781, 1824], 'IgM,': [1782], 'IP-10,': [1783], 'monocyte,': [1788], 'NK': [1789, 1836], 'Clinical': [1790, 1839, 2924], 'use:': [1791, 1840], 'Monotherapy,': [1792], 'vaccines,': [1793], 'combination': [1795, 2668, 2716], 'allergies,': [1797], 'CA,': [1798, 1855, 1872], 'diseasesC': [1800], '3′': [1804], 'palindrome,': [1805], 'form': [1807], 'duplexes': [1808], 'CPG10101,': [1811], '5393,': [1812], '2395': [1813], '(5′-T∗C∗GT∗C∗G∗T∗T∗T∗T∗C∗G∗G∗C∗G∗C∗G∗C∗G∗C∗C∗G)': [1814], 'Combined': [1816], 'intermediate': [1817], 'A': [1820, 2358, 2434, 3313, 3481, 3548], 'classes,': [1823], 'activation,': [1827], 'strong': [1828], 'inducer': [1830], 'cell,': [1834, 1837], 'PBMC': [1838], 'Monotherapy': [1841], '(hepatitis': [1845], 'B)pDC,': [1846], 'Plasmacytoid': [1847, 1864], 'cell;': [1849, 1866], 'NK,': [1850, 1867], 'killer;': [1852, 1869], 'ODN,': [1853, 1870], 'oligodeoxynucleotide;': [1854, 1871], 'cancer.': [1856, 1873], 'Open': [1857], 'table': [1858], 'tab': [1862], 'Murine': [1874], 'lung': [1878, 3410], 'demonstrated': [1881, 2600], 'effectiveness': [1883, 2602], 'prevention': [1888], 'reduction': [1890, 2295], 'airway': [1892, 2563, 2582, 2933, 2935, 3012, 3015, 3044, 3646, 3733, 3813, 3842, 3906], 'inflammation.1Krieg': [1893], '4Hayashi': [1936], 'Raz': [1938], 'E.': [1939, 2480, 2962, 4222], 'TLR9-based': [1940], 'immunotherapy': [1941, 2412, 2732], 'disease.Am': [1944], 'J': [1945, 2278, 2565, 3231, 3535, 3708, 3778, 3871, 4239], 'Med.': [1946, 2279, 2569, 3235, 3539, 3712, 3782, 3875, 4240], '119': [1948], '(e1-e6):': [1949], '897Abstract': [1950], '(50)': [1958], '5Kline': [1961], 'J.N.': [1962], 'Eat': [1963], 'dirt': [1964], 'immunomodulation': [1968], 'asthma.Proc': [1970], 'Am': [1971, 2637], 'Thorac': [1972, 2638], 'Soc.': [1973, 2639], '2007;': [1974, 2500, 2640, 2682], '4:': [1975, 2641], '283-288Crossref': [1976], '(54)': [1979], 'Conjugation': [1982, 1997], 'antigens': [1984], 'allergens': [1986, 2720], 'dramatically': [1990], 'improve': [1991], 'motifs.': [1996], 'Amb': [1999, 2009, 2042, 2120, 2155, 2193, 2220, 2328, 2346], '(the': [2002], 'predominant': [2003], 'allergen)': [2005], 'induced': [2008], '1–specific': [2011, 2330, 2348], 'responses': [2014, 2018, 2583, 2854, 3071], 'TH2': [2017, 2052, 2853, 2866, 3069, 3151], 'allergy.6Marshall': [2024], 'J.D.': [2025], 'Abtahi': [2026], 'Eiden': [2028, 2106], 'J.J.': [2029, 2107], 'Tuck': [2030], 'Milley': [2032, 2170], 'Haycock': [2034], 'F.': [2035, 2405], 'et': [2036, 2178, 2267, 2406, 2965, 3006, 3038, 3218, 3352, 3519, 3659, 3803, 3896, 3953, 4016, 4225, 4261], 'al.Immunostimulatory': [2037], 'sequence': [2038], 'linked': [2040, 2123, 2191, 2218], 'promotes': [2046, 3145], 'expression': [2049, 2054], 'downregulating': [2051], 'PBMCs': [2056], 'allergy.J': [2062], 'Clin': [2064, 2128, 2197, 2419, 2498, 2680, 3366, 3677, 4032], '2001;': [2066, 3018, 3368], '108:': [2067], '191-197Abstract': [2068], '(138)': [2076], 'significant': [2084, 2294, 3279, 3306, 3413, 3567], 'increases': [2085], 'CXCL9,': [2088], 'CXCL10': [2090], 'levels': [2091, 2332, 2350, 3292, 3981, 4019], 'decreases': [2093, 2413, 3740, 3750], 'IL-5,': [2095, 2886, 3159], 'CCL17,': [2096], 'CCL22': [2098], 'levels.7Simons': [2099], 'F.E.R.': [2100], 'Shiykishima': [2101], 'Y.': [2102], 'Van': [2103, 4013], 'Nest': [2104], 'G.': [2105, 3347, 3608], 'HayGlass': [2108], 'K.T.': [2109], 'Selective': [2110], 'redirection': [2112], 'humans': [2114], 'allergy': [2117, 2234, 3109], 'injecting': [2119], 'DNA.J': [2126], '2004;': [2130, 2421, 3114, 4154], '113:': [2131, 2422], '1144-1151Abstract': [2132], '(193)': [2140], 'number': [2144, 2187, 2616], 'bound': [2152], 'protein': [2158, 3643], 'alters': [2159], 'immunogenicity': [2161, 2181], 'allergenicity': [2163, 2183], 'response.8Higgins': [2166], 'D.': [2167, 4006, 4220], 'Rodriquez': [2168], 'Marshall': [2172], 'Abbate': [2174], 'C.': [2175, 3602], 'Cruz': [2176], 'T.D.': [2177], 'al.Modulation': [2179], 'controlling': [2185], 'oligonucleotides': [2190], '1.J': [2195], '118:': [2200, 4035], '504-510Abstract': [2201], '(18)': [2209], 'Tolamba': [2212, 2243, 2291, 2336, 2440, 2488, 2512], 'an': [2214, 2529, 2609, 2930, 3186, 3423, 3806, 3899, 4069, 4228], 'oligonucleotide': [2216], 'covalently': [2217], 'In': [2223, 2778, 3926, 4089], 'rhinitis': [2228, 2445], 'trial,': [2229], 'adult': [2230, 3196], '6': [2238], 'weekly': [2239, 3324, 3401], 'injections': [2240], 'season': [2249, 2308], 'followed': [2251], '2': [2253, 4120, 4184, 4208], 'seasons.9Creticos': [2255], 'P.S.': [2256], 'Shroeder': [2257], 'J.T.': [2258], 'Hamilton': [2259], 'R.G.': [2260], 'Balcer-Whaley': [2261], 'S.L.': [2262], 'Khattignavong': [2263], 'A.P.': [2264], 'Lindblad': [2265], 'al.Immunotherapy': [2268], 'ragweed-toll-like': [2270], 'rhinitis.N': [2276], 'Engl': [2277, 4238], '355:': [2281], '1445-1455Crossref': [2282], '(516)': [2285], 'experienced': [2292], 'total': [2297], 'baseline': [2302, 3729], 'during': [2303], '2-week': [2305], 'peak': [2306, 2940, 3846], 'pollen': [2307], 'compared': [2309, 2385, 3293, 3588, 3994], 'first': [2316, 2355, 3193], 'second': [2318, 2359], 'years': [2319], 'season.': [2323, 2357], 'increase': [2326, 2344, 2373, 2530, 3307], 'IgE': [2331, 2952, 3141], 'years,': [2340], 'whereas': [2341, 3732], 'transient': [2343], 'noted': [2352, 2538, 3416, 3554, 3582, 3637], 'found': [2361], 'biopsy': [2364], 'specimens': [2365], 'Tolamba-treated': [2367], 'had': [2369, 3278, 3427, 4054], 'significantly': [2371], 'reduced': [2372, 3640], 'eosinophils': [2375, 2541, 3552, 3594, 3727, 3734, 3743, 3753], 'IL-4': [2377, 2921, 3139, 3356, 3398, 3426, 3453], 'mRNA–positive': [2378, 2383], 'increased': [2381, 3980, 4070], 'IFN-α': [2382, 2532], 'after': [2391, 3564], 'season.10Tulic': [2394], 'M.K.': [2395], 'Fiset': [2396], 'P.O.': [2397], 'Christodoulopoulos': [2398], 'P.': [2399, 2401, 2478, 3648, 4004, 4130], 'Vaillancourt': [2400], 'Desrosiers': [2402], 'M.': [2403, 2956, 2999, 3027, 3037], 'Lavigne': [2404], 'al.Amb': [2407], '1-immunostimulatory': [2409], 'oligodeoxynucleotide': [2410], 'conjugate': [2411], 'inflammatory': [2416], 'response.J': [2417], '235-241Abstract': [2423], '(222)': [2431], 'large,': [2435], 'multicenter,': [2436], 'placebo-controlled': [2437, 3229], 'trial': [2438], 'ragweed-induced': [2442], 'showed': [2446], 'benefit.': [2449], 'low,': [2455], 'even': [2456], 'group,': [2460], 'potentially': [2461], 'making': [2462], 'it': [2463], 'difficult': [2464], 'discern': [2466, 2840], 'effect.11Bernstein': [2469], 'D.I.': [2470], 'Segall': [2471], 'N.': [2472, 2958], 'Nayak': [2473], 'A.': [2474, 3005, 3087, 3514, 3604, 3650, 3656, 3950, 4008], 'T.': [2476, 2995, 3606, 3946, 4015], 'Korenblatt': [2477], 'Martins': [2479], 'adults,': [2492], 'dose': [2494, 3188, 3275, 3301, 3493, 3585, 3985, 4099], 'finding': [2495], 'study.J': [2496], '119:': [2501], 'S78-S79Abstract': [2502], 'Treatment': [2510, 3721], 'generally': [2514], 'well': [2515, 3179], 'tolerated.': [2516], 'Atopic': [2517, 3223], 'asthmatic': [2518, 3318, 3596, 3706, 3776, 3818, 3869, 3911], 'preparation': [2525], 'inhalation.': [2527], 'Despite': [2528], 'gene': [2533, 2544], 'expression,': [2534], 'effect': [2536], 'allergen-induced': [2540], 'TH2-related': [2543], 'expression.12Guavreau': [2545], 'G.M.': [2546], 'Hessel': [2547], 'E.M.': [2548], 'Boulet': [2549], 'L.P.': [2550], 'Coffman': [2551], 'R.L.': [2552], "O'Byrne": [2553], 'P.M.': [2554], 'Immunostimulatory': [2555], 'regulate': [2557], 'interferon-inducible': [2558], 'genes': [2559], 'responses.Am': [2564], 'Respir': [2566, 3232, 3536, 3620, 3709, 3779, 3872], 'Crit': [2567, 3233, 3537, 3710, 3780, 3873], 'Care': [2568, 3538, 3711, 3781, 3874], '174:': [2571], '15-20Crossref': [2572], '(122)': [2575], 'Furthermore,': [2578], 'inhibition': [2580], 'noted.': [2585], 'application': [2587], 'ligands': [2590], 'Human': [2597], 'monotherapy': [2607], 'adjunctive': [2610], 'vaccines': [2613], 'hepatitis': [2622, 2624], 'anthrax,': [2626], 'influenza.13Krieg': [2628], 'Antiinfective': [2630], 'applications': [2631], 'agonists.Proc': [2636], '289-294Crossref': [2642], '(94)': [2645], 'studied': [2652, 3473], 'phase': [2654, 2657, 2894, 2897, 3226], 'II': [2655, 2898], 'III': [2658], 'cancer': [2662, 2678], 'treatment,': [2663], 'alone': [2665], 'standard': [2670], 'chemotherapy.14Krieg': [2671], 'Development': [2673], 'therapy.J': [2679], 'Invest.': [2681, 3678], '117:': [2683], '1184-1194Crossref': [2684], '(356)': [2687], 'suggest': [2693], 'could': [2697], 'valuable': [2699], 'adjuvants': [2701], 'disorders.': [2713], 'Indeed,': [2714], 'prove': [2722], 'more': [2723, 4085], 'effective,': [2724, 2824], 'better': [2727], 'safety': [2728, 3135, 3169], 'than': [2730], 'alone.': [2733], 'affect': [2738], 'arms': [2744], 'multiplicity': [2751], 'broad-ranging': [2758], 'system,': [2766], 'there': [2767, 2812], 'concern': [2770], 'shift': [2773], 'ratio.': [2777], 'contrast,': [2779], 'strategies': [2780], 'single': [2783, 2820], 'multiple': [2785], 'related': [2786], 'cytokines': [2787, 2867], 'lower': [2791], 'risk': [2792], 'events.': [2795], 'must': [2797], 'balanced': [2799], 'less-efficacious': [2805], 'nonefficacious': [2807], 'therapy.': [2808], 'As': [2809], 'below,': [2811], 'examples': [2815], 'perhaps': [2825], 'system.': [2833], 'Anticytokine': [2834], 'therapies': [2835], 'way': [2838], 'individual': [2844], 'molecules': [2845], 'Because': [2852], 'drivers': [2857], 'blocking': [2864, 2881, 3808, 3901], 'logical': [2870], 'Strategies': [2878], 'IL-4,': [2885, 3158], 'IL-13': [2888], 'I': [2895], 'Two': [2900, 3162, 3467], 'synthesis': [2906], 'Suplatast': [2911, 2944], 'tosilate': [2912, 3010, 3042], 'production': [2919], 'IL-5.': [2923, 3983], 'suplatast': [2927, 2968, 3009, 3041], 'inflammation,': [2934], 'hyperresponsiveness,': [2936, 3814, 3843, 3907], 'symptoms,': [2938], 'expiratory': [2941], 'flow': [2942, 3847], 'rates.': [2943], 'decrease': [2950, 3549], 'serum': [2951, 3183, 3551, 3593, 3726, 3742], 'levels.15Tamaoki': [2953], 'Kondo': [2955, 3002], 'Sakai': [2957], 'Aoshiba': [2959], 'K.': [2960, 3001, 3033, 3948], 'Tagaya': [2961], 'Nakata': [2963], 'al.Effect': [2966, 3039, 3520], 'tosilate,': [2969], 'Th2': [2971], 'inhibitor,': [2973], 'steroid-dependent': [2975], 'asthma:': [2976, 3531], 'double-blind': [2978], 'randomised': [2979], 'study.Lancet.': [2980], '2000;': [2981, 3820, 3913], '356:': [2982, 3821, 3914], '273-278Abstract': [2983], '(129)': [2991], '16Horiguchi': [2994], 'Tachikawa': [2996], 'Handa': [2998], 'Hanazono': [3000], 'Ishibashi': [3004], 'al.Effects': [3007, 3804, 3897], 'inflammation': [3013, 3047], 'hyperresponsiveness.J': [3016], 'Asthma.': [3017, 3051], '38:': [3019], '331-336Crossref': [3020], '(21)': [3023, 3057], '17Yoshida': [3026], 'Aizawa': [3028], 'H.': [3029, 3031, 3035, 3610, 4010, 4012], 'Inoue': [3030], 'Matsumoto': [3032], 'Koto': [3034], 'Komori': [3036], 'hyperresponsiveness': [3045], 'patients.J': [3050], '2002;': [3052], '39:': [3053], '545-552Crossref': [3054], 'AVP-13358': [3060], 'suppress': [3065], 'IgE,': [3066, 3101], 'CD23,': [3067], 'ex': [3072], 'vivo': [3073], 'mouse': [3078], 'assays.18Richards': [3082], 'M.L.': [3083], 'Lio': [3084], 'S.C.': [3085, 4252], 'Sinha': [3086], 'Tieu': [3088], 'K.K.': [3089], 'Sircar': [3090], 'J.C.': [3091, 3508], '2-(substituted': [3093], 'phenyl)': [3094], 'benzimidazole': [3095], 'derivatives': [3096], 'potent': [3098], 'against': [3100, 3425], 'cytokines,': [3102, 3456], 'CD23': [3104], 'asthma.J': [3111, 3364], '47:': [3115], '6451-6454Crossref': [3116], '(49)': [3119], 'Avanir': [3122], 'Pharmaceuticals': [3123], 'put': [3125], 'hold': [3127], 'compound,': [3133], 'favorable.': [3138], 'naive': [3146], 'lymphocytes': [3147], 'differentiate': [3149], 'subsequent': [3154, 4200], 'release': [3155], 'additional': [3157], 'IL-13.': [3161, 3458], 'studies': [3164, 4210], 'recombinant': [3172, 3955], 'sIL-4R.': [3174], 'sIL-4R': [3175, 3251, 3277, 3327], 'safe': [3177], 'tolerated,': [3180], 'half-life': [3184], 'inhaled': [3187, 3205, 3262, 3321], '5': [3190], 'days.': [3191, 3312], 'enrolled': [3195], 'atopic': [3197, 3635, 3675, 3929, 3964], 'moderate': [3200], 'persistent': [3201, 3488, 3530], 'requiring': [3203, 3320], 'daily': [3204], 'corticosteroids.19Borish': [3206], 'L.C.': [3207, 3341], 'Nelson': [3208, 3342], 'H.S.': [3209, 3343], 'Lanz': [3210], 'M.J.': [3211, 3792, 3885], 'Claussen': [3212], 'L.': [3213], 'Whitmore': [3214, 3350], 'J.B.': [3215, 3351], 'Agosti': [3216], 'J.M.': [3217, 3942], 'al.Interleukin-4': [3219], 'Receptor': [3220], 'Moderate': [3222], 'Asthma:': [3224], 'I/II': [3227], 'randomized,': [3228], 'trial.Am': [3230], 'Car': [3234], '1999;': [3236], '160:': [3237], '1816-1823Crossref': [3238], '(440)': [3241], 'dosed': [3246], 'one': [3247, 3492, 4098], 'time': [3248], 'nebulized': [3250], '500': [3254], '1500': [3257], 'placebo.': [3260, 3298, 3590], 'corticosteroids': [3263, 3322, 3382], 'stopped': [3265], 'day': [3267], 'prior.': [3268], 'Only': [3269, 3391, 4047], 'receiving': [3272, 3296, 3393], '1500-μg': [3274, 3300], 'scores,': [3284, 3574], 'rescue': [3285], 'β-agonist': [3286], 'exhaled': [3289], 'nitric': [3290], 'oxide': [3291], 'resulted': [3303], 'FEV1': [3309], 'follow-up': [3314], '62': [3317], 'weeks': [3330, 3748], '0.75': [3332], 'mg,': [3333, 3335], '1.5': [3334], '3.0': [3337, 3394], 'mg': [3338, 3395], 'placebo.20Borish': [3340], 'Corren': [3344], 'Bensch': [3346], 'Busse': [3348], 'W.W.': [3349], 'al.Efficacy': [3353], 'soluble': [3355, 3397], 'adults': [3362], '107:': [3369], '963-970Abstract': [3370], '(397)': [3378], 'Inhaled': [3381], 'discontinued': [3384], 'start': [3387], 'study.': [3390], '(sIL-4R)': [3400], 'nebulizer': [3404], 'able': [3406], 'maintain': [3408], 'functions.': [3411], 'No': [3412, 3566], 'improvements': [3414], 'symptoms': [3418, 4118, 4178], 'exacerbations.': [3421], 'Similarly,': [3422], 'proved': [3429], 'efficacy,': [3430], 'further': [3436, 4188], 'exploration': [3437], 'anti-IL-4–specific': [3439], 'therapies.': [3440], 'part': [3444], 'due': [3446], 'between': [3452], 'IL-5': [3459, 3469, 4018, 4074], 'eosinophil': [3463, 3615, 4105], 'survival.': [3466], 'humanized': [3468, 3524, 3956], 'subjects:': [3476], 'reslizumab': [3477, 3495, 3587, 3987, 4053, 4103], '(SCH55700)': [3478], 'mepolizumab.': [3480], 'small': [3482, 4091, 4209], 'severe': [3487, 3529, 4001], '(0.03': [3496], 'mg/kg,': [3497, 3499], '0.3': [3498], '1.0': [3501, 4101], 'mg/kg)': [3502, 3560, 3992], '90': [3506], 'days.21Kips': [3507], "O'Connor": [3509, 3799, 3892], 'B.J.': [3510, 3800, 3893], 'Langley': [3511], 'S.J.': [3512], 'Woodcock': [3513], 'Kerstjens': [3515], 'H.A.M.': [3516], 'Postma': [3517], 'D.S.': [3518, 3694, 3764, 3857], 'SCH55700,': [3522], 'anti-human': [3525], 'interleukin-5': [3526, 3807, 3900], 'antibody,': [3527], 'pilot': [3533], 'study.Am': [3534], '2003;': [3540, 3622, 3679, 3713, 3783, 3876, 4241], '167:': [3541, 3714, 3784, 3877], '1655-1659Crossref': [3542], '(490)': [3545], 'high-dose': [3558], '(1.0': [3559], 'group': [3561], '30': [3562], 'days': [3563], 'treatment.': [3565], 'sustained': [3568], 'changes': [3569], 'FEV1,': [3571, 3844], 'sputum': [3575, 3752], 'eosinophils,': [3576, 3812, 3905], 'physician-evaluated': [3578], 'overall': [3579], 'condition': [3580], 'any': [3584], 'Mepolizumab': [3591, 4202], 'altering': [3599], 'T-cell': [3600, 3618], 'functions.22Büttner': [3601], 'Lun': [3603], 'Splettstoesser': [3605], 'Kunkel': [3607], 'Renz': [3609], 'Monoclonal': [3611], 'anti-interleukin-5': [3612, 3700, 3770, 3863, 4143, 4229], 'suppresses': [3614], 'function.Eur': [3619], '21:': [3623], '799-803Crossref': [3624], '(112)': [3627], 'Studies': [3630], 'mild': [3634, 3674], 'mepolizumab': [3639, 3723], 'extracellular': [3641], 'matrix': [3642], 'remodeling': [3644], 'eosinphils.23Flood-Page': [3647], 'Menzies-Gow': [3649, 3689, 3759, 3852], 'Phipps': [3651], 'Ying': [3653], 'Wangoo': [3655], 'Ludwig': [3657], 'M.S.': [3658], 'al.Anti-IL-5': [3660, 3954], 'reduces': [3662], 'deposition': [3663], 'ECM': [3665], 'proteins': [3666], 'bronchial': [3669], 'subepithelial': [3670], 'basement': [3671], 'membrane': [3672], 'asthmatics.J': [3676], '112:': [3680], '1029-1036Crossref': [3681], '(750)': [3684], '24Flood-Page': [3687], 'P.T.': [3688, 3758, 3851], 'A.N.': [3690, 3760, 3853], 'Kay': [3691, 3761, 3854], 'A.B.': [3692, 3762, 3855], 'Robinson': [3693, 3763, 3856], "Eosinophil's": [3695, 3765, 3858], 'remains': [3697, 3767, 3860], 'uncertain': [3698, 3768, 3861], 'partially': [3702, 3772, 3865], 'depletes': [3703, 3773, 3866], 'numbers': [3704, 3774, 3867], 'airway.Am': [3707, 3777, 3870], '199-204Crossref': [3715, 3785, 3878], '(761)': [3718, 3788, 3881], 'decreased': [3724, 3736, 4104], 'median': [3725], '100%,': [3731], '55%,': [3738], 'lasting': [3744, 3754], 'up': [3745, 4165], '16': [3747], 'weeks.24Flood-Page': [3757], '25Leckie': [3791, 3884], 'Brinke': [3793, 3886], 'A.T.': [3794, 3887], 'Khan': [3795, 3888], 'Diamant': [3797, 3890], 'Z.': [3798, 3891], 'Walls': [3801, 3894], 'C.M.': [3802, 3895], 'monoclonal': [3809, 3902, 3957, 4142], 'late': [3817, 3910], 'response.Lancet.': [3819, 3912], '2144-2148Abstract': [3822, 3915], '(1689)': [3830, 3923], 'measures': [3838], 'measures,': [3848], 'noted.24Flood-Page': [3850], 'dermatitis,': [3930], 'mepolizuamb': [3931], 'ineffective': [3933], 'improving': [3935], 'physician-based': [3936], 'global': [3937], 'assessment': [3938], 'pruritis': [3940], 'scoring.26Oldhoff': [3941], 'Darsow': [3943, 4217], 'U.': [3944, 4218], 'Werfel': [3945], 'Katzer': [3947], 'Wulf': [3949], 'Laifaoui': [3951], '(mepolizumab)': [3959], 'dermatitis.Allergy.': [3965], '2005;': [3966], '60:': [3967], '693-696Crossref': [3968], '(282)': [3971], 'Nasal': [3974], 'polyps': [3975], 'frequently': [3977], 'One': [3984], '(either': [3988], 'polyposis.27Gevaert': [4003], 'Lang-Loidolt': [4005], 'Lackner': [4007], 'Stammberger': [4009], 'Staudinger': [4011], 'Zele': [4014], 'al.Nasal': [4017], 'anti-IL-5': [4024], 'polyps.J': [4030], '1133-1141Abstract': [4036], '(379)': [4044], '50%': [4048], 'polyps.': [4059], 'marker': [4062], 'predict': [4064], 'responsiveness': [4065], 'level': [4071], '(>40': [4075], 'pg/mL)': [4076], 'baseline.': [4078], 'Hypereosinophilic': [4079], 'syndrome': [4080, 4234], 'responsive': [4086, 4185], 'anti–IL-5.': [4088], 'hypereosinophilic': [4096, 4152, 4180, 4212, 4233], 'syndrome,': [4097], 'mg/kg': [4102], 'counts': [4106], 'normal': [4109], 'range,': [4110], 'marked': [4112], 'signs': [4116, 4176], 'treated.28Klion': [4125], 'A.D.': [4126], 'Law': [4127], 'M.A.': [4128], 'Noel': [4129], 'Kim': [4131], 'Y.J.': [4132], 'Haverty': [4133], 'T.P.': [4134], 'Nutman': [4135], 'SCH55700': [4145], 'syndrome.Blood.': [4153], '103:': [4155], '2939-2941Crossref': [4156], '(157)': [4159], 'Eosinophils': [4162], 'remained': [4163], 'weeks,': [4168], 'eosinophilia': [4171], 'returned,': [4172], 'so': [4173], 'did': [4174], 'syndrome.': [4181], 'When': [4182], 'doses,': [4189], 'magnitude': [4191], 'duration': [4193], 'lessened': [4197], 'each': [4199], 'dose.': [4201], 'syndrome.29Plötz': [4213], 'S.G.': [4214], 'Simon': [4215, 4219], 'H.U.': [4216], 'Vassina': [4221], 'Yousefi': [4223], 'al.Use': [4226], 'eosinophilic': [4236], 'dermatitis.N': [4237], '349:': [4242], '2334-2339Crossref': [4243], '(246)': [4246], '30Garrett': [4249], 'J.K.': [4250], 'Jameson': [4251], 'Thomson': [4253], 'Collins': [4255], 'M.H.': [4256], 'Wagoner': [4257], 'L.E.': [4258], 'Freese': [4259], 'D.K.': [4260], 'al.Anti-interleukin-5': [4262], '(mepoli': [4263]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2036694801', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-09-09T09:51:51.305668', 'created_date': '2016-06-24'}