AKT/PKB Phosphorylation of p21Cip/WAF1 Enhances Protein Stability of p21Cip/WAF1 and Promotes Cell Survival

Name: Work Video:
Duration: 3 min 30 s
Ying Li; Donald Dowbenko; Laurence A. Lasky
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'proliferating': [25, 234, 1066], 'nuclear': [27, 236, 620, 1068], 'antigen': [28, 237, 1069], 'cyclin': [30, 58, 159, 167, 239, 267, 368, 376, 1424, 1434, 2414, 2421, 2480], 'A/E-CDK2': [31, 240], 'complexes.': [32, 60, 241, 269, 1447], 'Recently,': [33, 242, 654], 'has': [35, 244, 671, 1024, 1458, 1781], 'also': [36, 245, 595, 1208, 1329, 1459, 1793, 2359, 3336, 4485], 'been': [37, 67, 246, 276, 672, 1025, 1460, 4253, 4287], 'shown': [38, 247, 2108, 2166, 3434, 3547, 3829, 4288, 4429], 'be': [40, 249, 596, 1108, 2064, 2125, 2174, 3310, 3767, 3910, 3971, 4070], 'positive': [42, 251, 1333, 1785, 1797, 1846], 'progression': [47, 256, 469, 1114, 1142, 1181, 1853], 'as': [48, 73, 75, 257, 282, 284, 1040, 1090, 1314, 1331, 1439, 1476, 1571, 1581, 1795, 1828, 2142, 2180, 2182, 3054, 3742, 3915, 3917, 4249], 'necessary': [51, 260], 'for': [52, 261, 427, 821, 2159, 2353, 2432, 2496, 2597, 2854, 2913, 2922, 3017, 3168, 3179, 3218, 3456, 3573, 3744], 'assembly': [54, 157, 263, 366, 1430, 2318], 'activation': [56, 265, 822, 1432, 2410, 3549, 4407, 4457], 'D1-CDK4/6': [59, 268, 1435], 'Furthermore,': [61, 189, 270, 398, 1626], 'elevated': [62, 271, 1550, 1814, 3788, 4024, 4257], 'protein': [64, 133, 273, 342, 563, 1037, 1083, 1207, 1562, 1811, 2131, 2372, 2809, 3686, 3824, 3840, 3870, 3897, 3903, 3926, 4035, 4037, 4157, 4189, 4196, 4212, 4236, 4305], 'levels': [65, 175, 274, 384, 777, 1551, 3789, 3904, 3966, 4025, 4258, 4364, 4394, 4446, 4483, 4515], 'have': [66, 275, 1324, 1417, 1975, 4252, 4286], 'observed': [68, 277, 1026, 3759, 3786, 4164], 'in': [69, 95, 105, 115, 118, 178, 182, 278, 304, 314, 324, 327, 387, 391, 446, 487, 494, 496, 544, 546, 627, 674, 855, 944, 990, 1033, 1079, 1100, 1139, 1175, 1178, 1267, 1453, 1466, 1564, 1591, 1787, 1815, 1821, 2100, 2119, 2128, 2178, 2183, 2254, 2267, 2356, 2366, 2370, 2394, 2400, 2602, 2627, 2669, 2702, 2733, 2821, 2833, 2919, 2970, 3040, 3099, 3112, 3214, 3279, 3343, 3452, 3565, 3576, 3606, 3665, 3692, 3722, 3727, 3760, 3794, 3826, 3830, 3841, 3847, 3884, 4028, 4055, 4072, 4155, 4165, 4170, 4198, 4208, 4211, 4430, 4441, 4451, 4469, 4518], 'various': [70, 279, 450, 832, 1154, 1630], 'aggressive': [71, 280, 1825], 'tumors': [72, 179, 281, 388, 685, 1826, 1839, 4247], 'well': [74, 283, 2181, 3916], 'linked': [76, 285], 'chemoresistance.': [78, 287], 'Here': [79, 288, 2342], 'we': [80, 289, 2343, 2403, 3785, 4101], 'demonstrate': [81, 290, 2344, 2360, 2404], 'that': [82, 92, 173, 192, 291, 301, 382, 401, 454, 504, 564, 774, 827, 1010, 1133, 1205, 1311, 1419, 1837, 1977, 2109, 2153, 2167, 2249, 2261, 2297, 2345, 2361, 2388, 2405, 2428, 3227, 3307, 3338, 3356, 3435, 3488, 3548, 3589, 3660, 3691, 3736, 3752, 3756, 3787, 3874, 3962, 4045, 4084, 4110, 4134, 4142, 4159, 4163, 4179, 4202, 4220, 4306, 4382, 4462, 4481], 'directly': [85, 294], 'phosphorylated': [86, 112, 295, 321, 2065, 2127, 2175, 2263, 3445, 3492, 3664], 'by': [87, 113, 186, 296, 322, 395, 598, 792, 830, 852, 1143, 1202, 1236, 1641, 1981, 2130, 2176, 2408, 2442, 2574, 2591, 2634, 2725, 2864, 2889, 2948, 2955, 2959, 3012, 3028, 3163, 3220, 3234, 3251, 3268, 3698, 3912, 3918, 3973, 4088, 4478, 4488, 4525, 4532], 'AKT/PKB,': [88, 297, 824, 3314, 4292], 'survival': [90, 201, 299, 410, 428, 1651, 1801, 1856, 1984, 2437], 'kinase': [91, 300, 610, 631, 786, 826, 993, 1063, 1072, 1084, 2141, 2835, 3065, 3114, 3454, 3491, 3555, 3805, 3866, 3976], 'hyperactivated': [94, 303, 4291], 'many': [96, 305], 'late': [97, 306, 678, 1823], 'stage': [98, 307, 679, 4246], 'tumors.': [99, 308], 'Two': [100, 309, 3484], 'sites': [101, 310, 2097, 2113, 2158, 2350, 3213, 3321, 4118], '(Thr145': [102, 311, 2567], 'Ser146)': [104, 313, 2569], 'carboxyl': [107, 316, 3216], 'terminus': [108, 317, 3217], 'are': [111, 147, 180, 320, 356, 389, 444, 455, 516, 819, 1306, 2351, 3907, 4474, 4484, 4523], 'AKT/PKB': [114, 140, 154, 196, 323, 349, 363, 405, 853, 992, 1012, 1983, 2160, 2177, 2192, 2354, 2409, 2466, 3222, 3280, 3286, 3339, 3490, 3574, 3603, 3655, 3676, 3745, 3782, 3810, 3818, 3854, 3883, 4029, 4079, 4089, 4123, 4166, 4185, 4206, 4226, 4308, 4367, 4396, 4426, 4449, 4456], 'vitro': [116, 325, 2129, 2179, 3723], 'vivo.': [119, 328, 2357, 2401, 3827], 'Phosphorylation': [120, 329], 'Thr145': [122, 331, 2069, 2347, 2392, 3231, 3447, 3494, 3596, 3705, 3712, 3738, 3762], 'PCNA': [124, 333, 1274, 2102, 2115, 2314], 'binding,': [125, 334], 'whereas': [126, 335, 4135, 4398], 'phosphorylation': [127, 185, 336, 394, 846, 938, 2096, 2110, 2157, 2246, 2299, 2355, 2362, 2390, 2443, 2565, 3219, 3281, 3320, 3575, 3586, 3604, 3636, 3656, 3746, 3755, 3771, 4085, 4180], 'Ser146': [129, 338, 2071, 2349, 2364, 3248, 3265, 3708, 3740, 3774, 4153, 4233], 'significantly': [130, 339, 3845], 'increases': [131, 340, 1649], 'stability.': [134, 343, 4190], 'Glioblastoma': [135, 344], 'lines': [137, 346, 2647, 4376, 4402, 4443, 4453], 'with': [138, 347, 457, 624, 996, 1016, 1075, 1308, 2304, 2311, 2418, 2675, 2706, 2729, 2758, 2812, 2895, 2943, 2964, 3046, 3087, 3150, 3155, 3174, 3289, 3313, 3560, 3668, 3679, 3710, 3797, 3873, 4122, 4173, 4188, 4369, 4444, 4454], 'activated': [139, 187, 348, 396, 2191, 4366, 4448], 'show': [141, 350], 'enhanced': [142, 174, 351, 383, 991, 1002], 'stability,': [144, 353, 4371], 'they': [146, 190, 355, 399, 2154], 'more': [148, 357, 4439, 4476], 'resistant': [149, 358], 'taxol-mediated': [151, 360], 'toxicity.': [152, 361], 'Finally,': [153, 362, 1005, 2402, 4191], 'controls': [155, 364], 'D1-CDK4': [160, 369, 2422], 'complexes': [161, 370, 1156], 'through': [162, 371], 'modulation': [163, 372], 'D1': [168, 377], 'levels.': [169, 378, 4244, 4458], 'These': [170, 379, 817, 3721, 3749, 4081, 4176, 4282], 'data': [171, 380, 1305, 2386, 2426, 3724, 4218], 'imply': [172, 381], 'due,': [181, 390], 'part,': [183, 392], 'AKT/PKB.': [188, 397, 4175], 'suggest': [191, 400, 1836, 2427, 3751], 'one': [193, 402, 2168, 3228, 3430, 3543, 3601, 4221], 'mechanism': [194, 403, 2431, 3924], 'regulation': [197, 406, 471, 1018, 2312, 2434, 4531], 'tumor': [199, 408, 451, 488, 592, 661, 668, 4284, 4301, 4519], 'and/or': [202, 411, 2438], 'proliferation': [203, 412, 2440], 'stabilize': [206, 415], 'protein.': [208, 417, 1093, 4096, 4130], 'Tumors': [418], 'utilize': [419], 'diversity': [421, 459, 676, 1817], 'genetic': [423, 485], 'mechanisms': [424], 'allow': [426], 'under': [429, 3202, 3875], 'onslaught': [431], 'immune': [434], 'system': [435], 'or': [436, 1645, 1655, 1694, 1707, 1805, 2189, 2568, 2607, 2806, 2903, 3069, 3650, 3678, 4058, 4106, 4116, 4169], 'radiation': [437], 'chemotherapy.': [439], 'The': [440, 588, 845, 1196, 1692, 2462, 2490, 2501, 2562, 2583, 2621, 2644, 2690, 2766, 2780, 2792, 2860, 2872, 3036, 3080, 3145, 3159, 3858, 3902], 'most': [441, 839], 'notable': [442], 'modifications': [443], 'found': [445, 1039, 1547, 2062, 2099, 2266, 3278, 3793, 4254], 'deletion': [448, 492, 600], 'suppressor': [452, 4302], 'genes': [453], 'involved': [456, 1015, 2303, 2310, 3559, 4187], 'cellular': [461, 3685], 'functions': [462, 1452, 1786, 1833, 4224], 'ranging': [463], 'from': [464, 1339, 1634, 2057, 2378, 2455, 2470, 2485, 2499, 2507, 2521, 2540, 2547, 2581, 2665, 2698, 2775, 3073, 3438, 4162], 'control': [465, 2771, 2793], 'apoptotic': [473, 1565], 'death.': [475, 1567], 'For': [476, 1470, 3059], 'example,': [477, 1471], 'loss': [479, 542, 657, 986, 4297], 'p53': [481, 536, 1095, 1656, 4489], 'common': [484], 'lesion': [486], 'cells,': [489, 1474], 'this': [491, 1163, 1561, 2245, 2298, 3329, 3351, 3457, 4099, 4460], 'results': [493, 543, 854, 989, 2365, 2393, 3750, 4082, 4177, 4473], 'changes': [495, 545], "cell's": [498], 'response': [499], 'damage': [502], 'such': [503, 554, 1475, 1827, 2260, 4248], 'transformed': [506], 'cells': [507, 593, 1478, 1496, 1582, 1633, 1701, 2060, 2184, 2377, 2717, 2728, 2892, 2910, 3139, 3147, 3160, 3191, 3196, 3443, 3666, 3795, 3843, 3888, 4031, 4073, 4120, 4168, 4171, 4200, 4520], 'become': [508], 'less': [509], 'prone': [510], 'apoptosis': [512, 829, 1595], 'when': [513, 3853], 'their': [514, 856, 937], 'genomes': [515], 'toxically': [517], 'modified': [518, 2671], '(1.Vousden': [519], 'K.H.': [520, 644], 'Cell.': [521, 913, 970, 1250, 1484, 1603, 2044, 2229, 2332, 3419, 3532, 3621, 3943], '2000;': [522, 914, 1404, 1486, 1512, 1773, 1866, 1995, 2081, 3370, 3471, 3944, 3993, 4015], '103:': [523, 915], '691-694Abstract': [524], 'Full': [525, 527, 807, 809, 901, 903, 917, 919, 974, 976, 1254, 1256, 1407, 1409, 1869, 1871, 1998, 2000, 2084, 2086, 3373, 3375, 3474, 3476, 3947, 3949, 4352, 4354], 'Text': [526, 528, 808, 810, 902, 904, 918, 920, 975, 977, 1255, 1257, 1408, 1410, 1870, 1872, 1999, 2001, 2085, 2087, 3374, 3376, 3475, 3477, 3948, 3950, 4353, 4355], 'PDF': [529, 811, 905, 921, 978, 1258, 1411, 1873, 2002, 2088, 3377, 3478, 3951, 4356], 'PubMed': [530, 583, 649, 724, 764, 812, 879, 906, 922, 979, 1125, 1191, 1231, 1259, 1298, 1362, 1390, 1412, 1489, 1515, 1541, 1608, 1687, 1738, 1760, 1874, 1940, 1967, 2003, 2026, 2049, 2089, 2211, 2234, 2288, 2337, 3378, 3401, 3424, 3479, 3514, 3537, 3626, 3952, 3996, 4330, 4357, 4505], 'Scopus': [531, 584, 650, 725, 765, 813, 880, 923, 980, 1058, 1126, 1192, 1232, 1260, 1299, 1363, 1391, 1413, 1490, 1516, 1542, 1609, 1688, 1739, 1761, 1875, 1941, 1968, 2004, 2027, 2050, 2090, 2212, 2235, 2289, 2338, 3379, 3402, 3425, 3480, 3515, 3538, 3627, 3953, 3997, 4331, 4506], '(713)': [532], 'Google': [533, 586, 652, 727, 767, 815, 882, 907, 925, 982, 1060, 1128, 1194, 1234, 1262, 1301, 1365, 1393, 1415, 1492, 1518, 1544, 1611, 1690, 1741, 1763, 1776, 1877, 1918, 1943, 1970, 2006, 2029, 2052, 2092, 2214, 2237, 2291, 2340, 3381, 3404, 3427, 3482, 3517, 3540, 3629, 3955, 3999, 4018, 4333, 4358, 4508], 'Scholar).': [534, 587, 653, 768, 816, 926, 983, 1061, 1129, 1195, 1263, 1302, 1625, 1691, 1777, 1971, 2053, 2093, 2238, 2292, 2341, 3428, 3483, 3541, 3630, 3956, 4019, 4281, 4359, 4509], 'Because': [535, 927, 1094, 1808], 'transcription': [539, 639, 843, 929, 999, 1045], 'factor,': [540], 'its': [541, 1421], 'expression': [548, 933, 1643, 2598, 4203], 'downstream': [550], 'target': [551, 555], 'genes.': [552], 'One': [553], 'gene': [556, 1647], 'which': [560, 633, 663, 1279, 1437], 'encodes': [561], 'regulates': [565, 775], '(see': [571], 'below)': [572], '(2.Xiong': [573, 1115], 'Y.': [574, 1116, 1746, 2011, 2196, 2273, 3386, 3499, 4002], 'Zhang': [575, 1117, 1745, 1893, 4275], 'H.': [576, 715, 738, 1118, 1380, 1527, 1766, 3981], 'Beach': [577, 1119, 1290], 'D.': [578, 691, 885, 895, 1120, 1291, 1506, 1529, 1909, 4336, 4346], 'Nature.': [579, 1054, 1121, 1294], '1993;': [580, 1122], '366:': [581, 1123], '701-704Crossref': [582, 1124], '(3179)': [585, 1127], 'can': [594, 1628, 1792, 3820], 'modulated': [597, 1980, 3972, 4487], 'retinoblastoma': [603], 'substrate': [606, 3572], 'molecule': [607], 'cyclin-dependent': [609, 1062], '(CDK),': [611], '1The': [612], 'abbreviations': [613], 'used': [614, 2495, 3053], 'are:': [615], 'CDKcyclin-dependent': [616], 'kinasePI3phosphatidylinositol': [617], '3PCNAproliferating': [618], 'antigenGSTglutathione': [621], 'S-transferaseKDkinase': [622], 'deadPTENphosphatase': [623], 'tensin': [625, 1076], 'homologyMMACmutated': [626], 'multiple': [628, 1080], 'advanced': [629, 1081, 1838], 'cancersPKBprotein': [630], 'B': [632, 1085, 4433], 'negatively': [634], 'modulates': [635], 'mitosis-inducing': [637], 'E2F': [638], 'factors': [640, 930, 1443], '(3.Phillips': [641], 'A.C.': [642], 'Vousden': [643], 'Apoptosis.': [645], '2001;': [646, 2023, 2046, 2208, 2231, 2285, 2334, 3398, 3421, 3511, 3534, 3623], '6:': [647], '173-182Crossref': [648], '(119)': [651], 'homozygous': [656], 'PTEN/MMAC': [660, 769, 988], 'suppressor,': [662], 'appears': [664, 4068], 'positively': [666], 'modulate': [667], 'survival,': [670], 'identified': [673, 3461], 'cancers': [680, 1082], 'including': [681, 834], 'glioblastoma': [682, 1829, 2645, 4250, 4374], 'prostate': [684], '(4.Li': [686], 'J.': [687, 699, 801, 967, 1051, 1185, 1241, 1245, 1249, 1348, 1354, 1358, 1370, 1376, 1401, 1537, 1601, 1754, 1863, 1880, 1882, 1935, 1958, 1962, 1992, 2078, 3367, 3468, 3933, 3935, 3939, 4012, 4262, 4264], 'Yen': [688], 'C.': [689, 701, 750, 1183, 1356, 1378, 1400, 1674, 1862, 1952, 1956, 2036, 2038, 2221, 2223, 2324, 2326, 3411, 3413, 3524, 3526, 3613, 3615], 'Liaw': [690], 'Podsypanina': [692], 'K.': [693, 862, 1531, 1533, 1724, 1730, 1750, 1991, 2077, 3366, 3467, 3979, 3987, 3989, 4313, 4491, 4497], 'Bose': [694], 'S.': [695, 874, 1287, 1535, 1599, 1884, 1903, 1927, 1929, 2042, 2227, 2330, 3417, 3530, 3619, 3983, 3985, 4004, 4008, 4266, 4325], 'Wang': [696, 1675], 'S.I.': [697], 'Puc': [698], 'Miliaresis': [700], 'Rodgers': [702], 'L.': [703, 1374, 1748, 1886, 2032, 2217, 2320, 3407, 3520, 3609, 4268], 'McCombie': [704], 'R.': [705, 719, 752, 1047, 1396, 1858, 1946, 3931], 'Bigner': [706], 'S.H.': [707], 'Giovanella': [708], 'B.C.': [709], 'Ittmann': [710], 'M.': [711, 744, 889, 1224, 1247, 1344, 1350, 1352, 1372, 1480, 1508, 1523, 1672, 1680, 1987, 2017, 2019, 2073, 2202, 2204, 2279, 2281, 3362, 3392, 3394, 3463, 3505, 3507, 3937, 4006, 4340], 'Tycko': [712], 'B.': [713, 742, 754, 1053, 1293, 1621, 1718, 1732, 1752, 2009, 2015, 2194, 2200, 2271, 2277, 3384, 3390, 3497, 3503, 3941, 4499], 'Hibshoosh': [714], 'Wigler': [716], 'M.H.': [717], 'Parsons': [718], 'Science.': [720, 1511], '1997;': [721, 761, 1387, 1684, 1757, 1964], '275:': [722, 1405, 1867, 1996, 2082, 3371, 3472], '1943-1947Crossref': [723], '(4315)': [726], 'Scholar,': [728, 883, 908, 1394, 1612, 1670, 1722, 1742, 1764, 1878, 1899, 1919, 1944, 2007, 2030, 2215, 3382, 3405, 3518, 4000, 4334], '5.Steck': [729], 'P.': [730, 959, 1346, 1482, 1678, 1923, 1931], 'Pershouse': [731], 'M.A.': [732], 'Jasser': [733], 'S.A.': [734], 'Yung': [735], 'W.K.A.': [736], 'Lin': [737, 956], 'Ligon': [739], 'A.H.': [740], 'Langford': [741, 1885, 4267], 'Baumgard': [743], 'Hattier': [745], 'T.': [746, 748, 798, 1498, 1525, 1726, 1728, 1744, 1770, 1890, 1905, 1950, 4010, 4272, 4493, 4495], 'Davis': [747], 'Frye': [749], 'Hu': [751, 960], 'Swedlund': [753], 'Teng': [755], 'D.H.': [756], 'Tavtigian': [757], 'S.V.': [758], 'Nat.': [759, 1755, 2020, 2205, 2282, 3395, 3508], 'Genet.': [760], '15:': [762], '356-362Crossref': [763], '(2526)': [766], 'lipid': [772], 'phosphatase': [773, 1074], 'two': [779, 2067, 3211, 3958, 4383], 'phospholipid': [780], 'products': [781, 2874], 'pro-survival': [784], 'PI3': [785, 3865, 3975], 'pathway,': [787], 'phosphatidylinositol': [788, 1064], 'phosphate-3,4': [789], '-3,4,5,': [791], 'dephosphorylation': [793], 'at': [794, 1444, 2111, 2363, 2391, 2857, 3014, 3020, 3165, 3182, 3230, 3247, 3264, 3446, 3594, 3599, 3638, 3648, 3772, 4113, 4152, 4183, 4231], 'position': [795, 3639, 3713, 4232], '3': [796, 1065], '(6.Maehama': [797], 'Dixon': [799], 'J.E.': [800], 'Biol.': [802, 897, 1402, 1485, 1604, 1864, 1993, 2022, 2045, 2079, 2207, 2230, 2284, 2333, 3368, 3397, 3420, 3469, 3510, 3533, 3622, 4348], 'Chem.': [803, 1403, 1865, 1994, 2080, 3369, 3470], '1998;': [804, 876, 898, 4327, 4349], '273:': [805], '13375-13378Abstract': [806], '(2614)': [814], 'phospholipids': [818], 'required': [820], 'down-regulates': [828, 4307], 'phosphorylating': [831], 'substrates': [833, 2515, 3743], 'BAD,': [835], 'caspase': [836], '9,': [837], 'importantly,': [840], 'forkhead': [841, 849, 998], 'family': [842, 850], 'factors.': [844], 'proteins': [851, 2624, 2886, 3025, 3335], 'cytoplasmic': [857, 941], 'localization': [858, 2257, 2306], '(7.Wu': [859, 4310], 'X.': [860, 1676, 4311], 'Senechal': [861, 4312], 'Neshat': [863, 4314], 'M.S.': [864, 4315], 'Whang': [865, 4316], 'Y.E.': [866, 4317], 'Sawyers': [867, 4318], 'C.L.': [868, 4319], 'Proc.': [869, 4320], 'Natl.': [870, 4321], 'Acad.': [871, 4322], 'Sci.': [872, 4323], 'U.': [873, 4324], 'A.': [875, 910, 912, 951, 953, 1382, 1398, 1860, 1888, 1907, 1911, 1933, 1954, 2034, 2040, 2219, 2225, 2322, 2328, 3409, 3415, 3522, 3528, 3611, 3617, 4270, 4326], '95:': [877, 4328], '15587-15591Crossref': [878, 4329], '(595)': [881, 4332], '8.Haas-Kogan': [884, 4335], 'Shalev': [886, 4337], 'N.': [887, 1500, 1666, 1682, 1921, 1989, 2075, 3364, 3465, 4338], 'Wong': [888, 4339], 'Mills': [890, 4341], 'G.': [891, 893, 1049, 1289, 4342, 4344], 'Yount': [892, 4343], 'Stokoe': [894, 4345], 'Curr.': [896, 4347], '8:': [899, 4350], '1195-1198Abstract': [900, 4351], '9.Toker': [909], 'Cantley': [911], '185-188Abstract': [916], '(367)': [924], 'these': [928, 1028, 1171, 1304, 2095, 2112, 2122, 2136, 2150, 2425, 4065, 4217, 4385], 'mediate': [931], 'pro-apoptotic': [935], 'genes,': [936], 'then': [940, 2917, 2929, 2953, 3153], 'sequestration': [942], 'result': [943, 1042, 4294], 'inhibition': [946, 1269, 1282, 1422, 1556, 2396], 'death': [949, 1635], '(10.Brunet': [950], 'Bonni': [952], 'Zigmond': [954], 'M.J.': [955, 963], 'M.Z.': [957], 'Juo': [958], 'L.S.': [961], 'Anderson': [962], 'Arden': [964], 'K.C.': [965], 'Blenis': [966], 'Greenberg': [968], 'M.E.': [969], '1999;': [971, 1055, 1188, 1359, 1538, 1605], '96:': [972], '857-868Abstract': [973], '(5454)': [981], 'Thus,': [984, 4510], 'activity': [994, 1000, 1169, 3819, 4309], 'along': [995, 1027], 'decreased': [997], 'although': [1006, 1030, 3295, 3450, 3921], 'it': [1007, 1791, 2106, 2163, 2250, 3432, 3545, 3732], 'likely': [1009, 3765], 'pathway': [1013, 1985, 3557, 3977], 'cycle,': [1021, 1456, 1789], 'very': [1022], 'little': [1023, 4404], 'lines,': [1029, 4386], 'an': [1031, 1158, 1268, 1315, 2395, 3055, 3680, 4209, 4419], 'increase': [1032, 2369, 3821, 4210, 4235], 'p27kip1cyclin': [1035], 'inhibitor': [1036, 1316], 'forkhead-induced': [1044], '(11.Medema': [1046], 'Kops': [1048], 'Bos': [1050], 'Burgering': [1052], '404:': [1056], '782-787Crossref': [1057], '(1231)': [1059], 'glutathione': [1070], 'S-transferase': [1071], 'dead': [1073, 3190, 3806], 'homology': [1077], 'mutated': [1078, 2571, 3591, 3647, 4112], 'was': [1087, 1096, 1105, 1200, 2061, 2107, 2164, 2265, 2301, 2308, 2498, 2546, 2555, 2570, 2589, 2697, 2810, 2862, 2928, 2941, 2952, 3038, 3052, 3071, 3433, 3444, 3459, 3546, 3558, 3570, 3590, 3637, 3733, 3757, 3844, 3855, 3889, 4032, 4160, 4186, 4437], 'initially': [1088], 'isolated': [1089, 2056, 3437], 'known': [1097, 3236, 3908], 'function': [1099, 1330, 1438], 'regulation,': [1103], 'proposed': [1106, 2138], 'Subsequent': [1130], 'studies': [1131, 1203, 1323, 3292, 3960, 4039], 'revealed': [1132, 1201, 1325, 3210, 3337, 4418], 'played': [1135], 'dual': [1137], 'role': [1138, 1465, 4468], 'regulating': [1144], 'CDK': [1149], 'activity.': [1150], 'bound': [1152, 1209], 'cyclin-CDK': [1155, 2317], 'via': [1157], 'amino-terminal': [1159], 'binding': [1160, 2103, 2116, 2315, 2399], 'site,': [1161, 2104, 3255], 'interaction': [1164, 1239, 1265], 'acted': [1165], 'inhibit': [1167, 2413], 'complexes,': [1172, 1426, 1436], 'thus': [1173], 'resulting': [1174, 1590], 'block': [1177], '(12.Sherr': [1182], 'Roberts': [1184, 1353, 3938], 'Genes': [1186, 1385, 1733, 4500], 'Dev.': [1187, 1386, 1734, 4501], '13:': [1189], '1501-1512Crossref': [1190], '(5159)': [1193], 'versatility': [1197], 'demonstrating': [1204], 'PCNA,': [1211], 'co-activator': [1213], 'polymerase': [1216], 'δ': [1217], 'ε': [1219], 'activities': [1220], '(13.Kelman': [1221], 'Z.': [1222, 1243, 1597], "O'Donnell": [1223, 1246], 'Nucleic': [1225], 'Acids': [1226], 'Res.': [1227, 1772, 1914, 4014], '1995;': [1228, 1896, 1915, 1937, 4278], '23:': [1229], '3613-3620Crossref': [1230], '(150)': [1233], 'Scholar),': [1235, 1493, 1545], 'carboxyl-terminal': [1238], '(14.Gulbis': [1240], 'Kelman': [1242], 'Hurwitz': [1244], 'Kuriyan': [1248], '1996;': [1251, 1735, 4502], '87:': [1252], '297-306Abstract': [1253], '(647)': [1261], 'This': [1264], 'resulted': [1266, 1563, 4154, 4207], 'ability': [1272], 'assist': [1276], 'polymerases,': [1278], 'led': [1280], '(15.Waga': [1286], 'Hannon': [1288], 'Stillman': [1292], '1994;': [1295], '369:': [1296], '574-578Crossref': [1297], '(1591)': [1300], 'Although': [1303, 2121, 4459], 'consistent': [1307], 'suggestion': [1310], 'acts': [1313], 'progression,': [1320], 'several': [1321], 'recent': [1322, 1973], 'could': [1328, 2124, 2173, 3309], 'cycle.': [1337], 'Studies': [1338], 'Sherr': [1340, 1355], 'et': [1341], 'al.': [1342], '(17.Cheng': [1343], 'Olivier': [1345], 'Diehl': [1347], 'Fero': [1349], 'Roussel': [1351], 'EMBO': [1357, 1536], '18:': [1360, 1539], '1571-1583Crossref': [1361], '(974)': [1364], 'Scholar)': [1366, 1416, 1519], 'others': [1368], '(16.LaBaer': [1369], 'Garrett': [1371], 'Stevenson': [1373], 'Slingerland': [1375], 'Sandhu': [1377], 'Chou': [1379], 'Fattaey': [1381], 'Harlow': [1383], 'E.': [1384, 1768, 2628], '11:': [1388, 1897, 4279], '847-862Crossref': [1389], '(1225)': [1392], '18.Weiss': [1395], 'Joo': [1397, 1859], 'Randour': [1399, 1861], '10285-10290Abstract': [1406, 1868], '(104)': [1414, 1876], 'demonstrated': [1418, 2296, 3487, 3583, 3735, 3961, 4178, 4201], 'despite': [1420], 'E-CDK2': [1425, 2415], 'mediates': [1428], 'sensors': [1440], 'growth': [1442], 'G1-S': [1445], 'phase': [1446], 'In': [1448, 1778, 3259, 3429, 3542, 3879, 4062], 'addition': [1449, 3859, 4052], 'suggested': [1461, 1976, 2152, 2248, 4083, 4219], 'play': [1463, 4465], 'enhancing': [1467], 'terminally': [1472], 'differentiated': [1473], 'muscle': [1477], '(19.Lawlor': [1479], 'Rotwein': [1481], 'Mol.': [1483, 1602, 2043, 2228, 2331, 3418, 3531, 3620, 3942], '20:': [1487], '8983-8995Crossref': [1488], '(166)': [1491], 'hematopoietic': [1494], 'stem': [1495], '(20.Cheng': [1497], 'Rodrigues': [1499], 'Shen': [1501], 'H.M.': [1502], 'Yang': [1503], 'Y.G.': [1504], 'Dombkowski': [1505], 'Sykes': [1507], 'Scadden': [1509], 'D.T.': [1510], '287:': [1513], '1804-1808Crossref': [1514], '(1085)': [1517], 'macrophages': [1521], '(21.Asada': [1522], 'Yamada': [1524], 'Ichijo': [1526], 'Delia': [1528], 'Miyazano': [1530], 'Fukumuro': [1532], 'Mizutani': [1534], '1223-1234Crossref': [1540], '(537)': [1543], 'were': [1546, 2098, 2155, 2454, 2468, 2484, 2506, 2520, 2538, 2613, 2625, 2663, 2723, 2743, 2756, 2773, 2875, 2887, 2893, 2911, 2962, 3010, 3026, 3085, 3140, 3148, 3161, 3197, 3302, 3643, 3725, 3792, 4040, 4111, 4143, 4377], 'contain': [1549, 4290], 'p21,': [1553, 2259, 3290, 3784], 'up-regulation': [1559, 2445], 'may': [1569, 4464], 'act': [1570, 1794], 'coordinator': [1573], 'arrest,': [1580], 'lacking': [1583], 'undergo': [1585], 'damage-mediated': [1587], 'replication,': [1589], 'endoreduplication': [1592], 'subsequent': [1594], '(22.Stewart': [1596], 'Leach': [1598], 'Pietenpol': [1600], '19:': [1606], '205-215Crossref': [1607], '(155)': [1610], '23.Waldman,': [1613], 'T.,': [1614, 1711], 'Lengauer,': [1615, 1712], 'C.,': [1616, 1713], 'Kinzler,': [1617, 1714], 'K.,': [1618, 1663, 1715], 'Vogelstein,': [1620, 1717], '(1996)': [1622, 1667, 1719], '381,': [1623, 1720], '713–716Google': [1624, 1721], 'protect': [1629], 'types': [1631, 4285], 'following': [1636, 2762], 'anticancer': [1637], 'treatments.': [1638], 'overexpressed': [1640], 'inducible': [1642], 'systems': [1644], 'adenovirus': [1646], 'transfer': [1648], 'against': [1652, 2493], 'prostaglandin': [1653, 1708], 'A2': [1654, 1709], 'overproduction': [1657], '(24.Gorospe,': [1658], 'M.,': [1659], 'Wang,': [1660], 'X.,': [1661], 'Guyton,': [1662], 'Holbrook,': [1665], '16,': [1668], '6654–6660Google': [1669], '25.Gorospe': [1671], 'Cirielli': [1673], 'Seth': [1677], 'Capogrossi': [1679], 'Holbrook': [1681], 'Oncogene.': [1683, 1895, 2500, 4277], '14:': [1685], '929-935Crossref': [1686], '(293)': [1689], 'reduction': [1693], 'absence': [1695], 'expression,': [1698], 'however,': [1699], 'sensitizes': [1700], 'adriamycin,': [1703], 'camptothecin,': [1704], 'etoposide,': [1705], 'γ-irradiation,': [1706], '(23.Waldman,': [1710], '26.Polyak': [1723], 'Waldman': [1725, 4492], 'He': [1727, 4494], 'Kinzler': [1729, 1749, 4496], 'Vogelstein': [1731, 1751, 4498], '10:': [1736, 4503], '1945-1952Crossref': [1737, 4504], '(474)': [1740, 4507], '27.Waldman': [1743], 'Dillehay': [1747], 'Williams': [1753, 4007], 'Med.': [1756], '3:': [1758, 2024, 2209, 2286, 3399, 3512], '1034-1036Crossref': [1759], '(362)': [1762], '28.Tian': [1765], 'Wittmack': [1767], 'Jorgensen': [1769], 'Cancer': [1771, 1913, 4013], '60:': [1774, 4016], '679-684PubMed': [1775], 'summary,': [1779], 'negative': [1783], 'mediator': [1798, 2145], 'upon': [1802], 'terminal': [1803], 'differentiation': [1804], 'genotoxic': [1806], 'damage.': [1807], 'level': [1812, 3825, 3836, 3871, 3894], 'tumors,': [1819], 'particularly': [1820], 'stage,': [1824], 'multiforme,': [1830], 'complex': [1832, 4477], 'appear': [1840, 3326], 'take': [1842], 'advantage': [1843], 'effects': [1847, 2243, 3780], 'on': [1850, 2066, 2638, 2877, 3199, 3587, 3702, 3783], '(18.Weiss': [1857], '29.Jung': [1879], 'Bruner': [1881, 4263], 'Ruan': [1883, 4265], 'Kyritsis': [1887, 4269], 'Kobayashi': [1889, 1904, 4271], 'Levin': [1891, 4273], 'V.': [1892, 1925, 4274], 'W.': [1894, 1901, 1948, 2013, 2198, 2275, 3388, 3501, 4276], '201-208Google': [1898, 4280], '30.Zhang': [1900], 'Kornblau': [1902], 'Gambel': [1906], 'Claxton': [1908], 'Deisseroth': [1910], 'Clin.': [1912], '1:': [1916], '1051-1057PubMed': [1917], '31.Barboule': [1920], 'Mazars': [1922], 'Baldin': [1924], 'Vidal': [1926], 'Jozan': [1928], 'Martel': [1930], 'Valette': [1932], 'Int.': [1934, 1961], 'Cancer.': [1936, 1963], '63:': [1938], '611-615Crossref': [1939], '(67)': [1942], '32.Erber': [1945], 'Klein': [1947], 'Andl': [1949], 'Enders': [1951], 'Born': [1953], 'Coradt': [1955], 'Bartek': [1957], 'Bosch': [1959], 'F.': [1960], '74:': [1965], '383-389Crossref': [1966], '(118)': [1969], 'Three': [1972], 'papers': [1974], '(33.Scott': [1986, 2072, 3361, 3462], 'Morrice': [1988, 2074, 3363, 3464], 'Ball': [1990, 2076, 3365, 3466], '11529-11537Abstract': [1997, 2083, 3372, 3473], '(88)': [2005, 2091, 3380, 3481], '34.Zhou': [2008, 3383], 'Liao': [2010, 2195, 2272, 3385, 3498], 'Xia': [2012, 2197, 2274, 3387, 3500], 'Spohn': [2014, 2199, 2276, 3389, 3502], 'Lee': [2016, 2201, 2278, 3391, 3504], 'Hung': [2018, 2203, 2280, 3393, 3506], 'Cell': [2021, 2206, 2283, 2471, 3396, 3509], '245-252Crossref': [2025, 2210, 2287, 3400, 3513], '(924)': [2028, 2213, 2290, 3403, 3516], '35.Rossig': [2031, 2216, 3406, 3519], 'Jadidi': [2033, 2218, 2321, 3408, 3521, 3610], 'Urbich': [2035, 2220, 2323, 3410, 3523, 3612], 'Badorff': [2037, 2222, 2325, 3412, 3525, 3614], 'Zeiher': [2039, 2224, 2327, 3414, 3527, 3616], 'Dimmler': [2041, 2226, 2329, 3416, 3529, 3618], '21:': [2047, 2232, 2335, 3422, 3535, 3624], '5644-5657Crossref': [2048, 2233, 2336, 3423, 3536, 3625], '(307)': [2051, 2236, 2339, 3426, 3539, 3628], 'Mammalian': [2054], 'baculovirus-infected': [2058, 3441], 'insect': [2059, 3442], 'residues,': [2068, 2171], 'Interestingly,': [2094, 3579, 3957], 'disrupted': [2114], 'vitro.': [2120], 'residues': [2123, 2151], 'weakly': [2126], 'kinases': [2132], 'A': [2133], 'C,': [2135, 4435], 'investigators': [2137], 'another,': [2139], 'unknown': [2140], 'actual': [2144], 'phosphorylation.': [2147, 3720], 'Examination': [2148, 3205, 3332, 4411], 'consensus': [2156, 3237, 3319], 'kinases,': [2161], 'subsequently': [2165], 'Thr145,': [2172, 4114], 'overexpressing': [2185, 2718, 3881], 'HER-2': [2187, 3552], 'oncogene': [2188], 'moderately': [2190, 3716], '(34.Zhou': [2193, 2270, 3496], 'An': [2239], 'examination': [2240], 'event': [2247, 2300, 3458], 'mediated': [2251], 'change': [2253], 'subcellular': [2256, 2305], 'form': [2264, 3674, 3682, 4077], 'cytoplasm': [2269], 'However,': [2293], 'another': [2294], 'group': [2295, 3582], 'not': [2302, 2412, 3296, 3325, 3460, 3804], 'but': [2307, 2416, 3803], 'instead': [2309], '(35.Rossig': [2319, 3608], 'targets': [2352], 'We': [2358, 2381, 3813], 'significant': [2368], 'stability': [2373, 4093, 4127, 4140, 4197, 4213, 4237, 4414, 4424, 4463], 'protection': [2375], 'taxol-induced': [2379], 'apoptosis.': [2380], 'confirm': [2382], 'extend': [2384], 'suggesting': [2387, 3598], 'p21-PCNA': [2398], 'induced': [2407], 'does': [2411], 'activates': [2420], 'complex.': [2423], 'Together,': [2424, 4216], 'novel': [2430], 'AKT/PKB-mediated': [2433, 3300, 3561, 3770], 'p21.': [2447, 2791], 'Anti-Flag': [2448], '(M2)': [2449], 'anti-Myc': [2451], '(9E10)': [2452], 'antibodies': [2453, 2505], 'Sigma': [2456], 'Roche': [2458, 2522], 'Molecular': [2459, 2523, 2750, 2776], 'Biochemicals,': [2460], 'respectively.': [2461, 2513, 2530], 'anti-AKT/PKB': [2463], 'anti-phospho': [2465], '(T308)': [2467], 'purchased': [2469, 2539, 2774], 'Signaling.': [2472], 'Antibodies': [2473], 'recognizing': [2474], '(C-19': [2476], '187),': [2478], 'CDK2,': [2479], 'D1,': [2481], 'CDK4': [2483, 3064, 3070, 3084], 'Santa': [2486, 2526], 'Cruz': [2487, 2527], 'Biotechnology,': [2488, 2528, 2542, 2819], 'Inc.': [2489], 'polyclonal': [2491], 'antibody': [2492, 2945], 'p21(Ab5)': [2494], 'immunoprecipitation': [2497], 'anti-β-tubulin': [2502], 'anti-PCNA': [2504], 'BD': [2508], 'PharMingen': [2509], 'Transduction': [2511], 'Laboratories,': [2512, 2778], 'Kinase': [2514], 'Histone': [2516], 'H1': [2517, 3092], 'GST-Rb': [2519], 'Biochemicals': [2524], 'Inc.,': [2529, 2543], 'plasmids': [2532, 2730, 2742], 'encoding': [2533], 'Myc-tagged': [2534, 2719, 2896], 'Mys-Akt': [2535, 2897], 'Akt-KD': [2537], 'Upstate': [2541], 'taxol': [2545, 3136], 'Sigma.': [2548], 'Using': [2549], 'standard': [2550], 'PCR': [2551], 'protocols,': [2552], 'Flag-tagged': [2553, 2899], 'cloned': [2556], 'into': [2557, 2615, 4119], 'pcDNA3.1': [2559], 'vector': [2560, 2616], '(Invitrogen).': [2561, 2765], 'putative': [2563], 'Akt': [2564, 2817], 'site': [2566, 3229, 3246, 3263, 3605], 'Ala': [2573], 'site-directed': [2575], 'mutagenesis': [2576], 'using': [2577, 2745, 3645], 'QuickChange™': [2579], 'kit': [2580], 'Stratagene.': [2582], 'presence': [2584, 2823, 3101, 3849], 'introduced': [2587], 'mutations': [2588], 'confirmed': [2590], 'sequence': [2592, 3209, 3238], 'analysis.': [2593], 'To': [2594, 3283, 3631, 4020, 4097, 4360], 'generate': [2595], 'constructs': [2596], 'GST-tagged': [2600, 2803], 'Escherichia': [2603], 'coli,': [2604], 'wild': [2605, 2804, 4104, 4146], 'type': [2606, 2805, 2902, 3274, 4105, 4147], 'mutants': [2608], 'cDNA': [2611], 'fragments': [2612], 'subcloned': [2614], 'pGEX4T-3': [2617], '(Amersham': [2618, 2641], 'Biosciences': [2619, 2642], 'Inc.).': [2620, 2643], 'GST': [2622], 'fusion': [2623], 'expressed': [2626], 'coli': [2629], 'strain': [2630], 'BL21': [2631], 'purified': [2633, 3699], 'glutathione-Sepharose': [2635], 'chromatography': [2636], 'based': [2637], "manufacturer's": [2639], 'instruction': [2640, 2764], 'U-87': [2648, 4387], 'MG,': [2649, 2651, 4391], 'U-118': [2650, 4390], 'A172,': [2652], 'DBTRG-05MG,': [2653], 'T98G': [2655], 'human': [2658, 2692], 'epithelial': [2659], 'line': [2661, 2696], '293E': [2662, 2891], 'obtained': [2664], 'ATCC': [2666, 2699], 'cultured': [2668], "Dulbecco's": [2670], "Eagle's": [2672], 'medium': [2673, 2736, 2921], 'supplemented': [2674, 2705], '10%': [2676, 2707, 3851], 'fetal': [2677, 2709], 'calf': [2678, 2710], 'serum': [2679, 2711, 3852, 3876], '(Invitrogen)': [2680, 2704, 2712, 2761], 'antibiotics': [2682], '(50': [2683, 2974], 'units/ml': [2684], 'penicillin': [2685], '50': [2687, 2829, 2992, 3023], 'μg/ml': [2688, 2739], 'streptomycin).': [2689], 'MCF7': [2691, 2716, 3842, 3887, 4199], 'breast': [2693], 'carcinoma': [2694], 'grown': [2701, 2918], 'RPMI': [2703, 2735], 'heat-inactivated': [2708], 'antibiotics.': [2714], 'Stable': [2715], 'Mys-AKT/PKB': [2720], 'AKT/PKB-KD': [2722], 'generated': [2724], 'transfecting': [2726], 'selecting': [2732], 'containing': [2737], '500': [2738], 'G418.': [2740], 'transfected': [2744, 2757, 3577, 3667, 4030, 4060, 4102, 4172], 'FuGENE™': [2746], '6': [2747], 'reagent': [2748, 2760], '(Roche': [2749], 'Biochemicals).': [2751], 'Phosphorothioate': [2752], 'oligodeoxynucleotides': [2753], '(250': [2754], 'nm)': [2755], 'Oligofectamine™': [2759], "manufacture's": [2763], 'antisense': [2768, 2781], 'oligo': [2769, 2772], 'Research': [2777], 'LLC.': [2779], 'oligo,': [2782, 2794], '5′-CCAACTCATCCCGGCCTCGC-3′,': [2783], 'complementary': [2785], 'coding': [2788], 'region': [2789], '5′-AACCCCTTCCGGCCCCTCAG-3′,': [2795], 'scrambled': [2798], 'sequence.': [2799], '2': [2800, 3088, 3094], 'μg': [2801, 2814, 3024, 3089, 3095], 'mutant': [2807, 3763, 4138], 'incubated': [2811, 3086], '0.5': [2813], 'active': [2816, 3882], '(Upstate': [2818], 'Inc.)': [2820], '10': [2825, 2851, 2865, 2988, 3103, 3130], 'μCi': [2826, 3104], '[γ-32P]ATP': [2827, 3106], 'μm': [2830, 3000, 3109], 'cold': [2831, 2965, 3110], 'ATP': [2832, 3111], 'buffer': [2836, 2973, 3115], '(20': [2837, 3116], 'mm': [2838, 2846, 2852, 2866, 2975, 2980, 2983, 2989, 2993, 2996, 3117, 3125, 3131], 'Hepes,': [2839, 3118], 'pH': [2840, 2977, 3119], '7.2,': [2841, 3120], '25': [2842, 3121], 'mmsodium': [2843, 3122], 'β-glycerophosphate,': [2844, 2991], '5': [2845, 2995, 3124, 3169, 3180], 'EGTA,': [2847, 2984, 3126], '1': [2848, 2979, 2982, 2999, 3074, 3127], 'mmdithiothreitol,': [2849, 3128], 'MgCl2)': [2853], '30': [2855, 2858], 'min': [2856, 3019, 3181], '°C.': [2859], 'reaction': [2861, 2873], 'terminated': [2863], 'EDTA': [2867], 'SDS': [2869], 'sample': [2870], 'buffer.': [2871], 'separated': [2876], '4–20%': [2878, 3029], 'SDS-PAGE': [2879, 3030], 'transferred': [2881, 3032, 3141], 'nitrocellulose': [2883], 'filters.': [2884, 3035], '32P-incorporated': [2885], 'detected': [2888, 2954], 'autoradiography.': [2890], 'cotransfected': [2894], '(wild': [2901], 'mutants).': [2904], '16': [2905], 'h': [2906, 2915, 2936, 3134], 'after': [2907, 2937, 3135, 4050], 'transfection,': [2908], 'serum-starved': [2912, 3886], '12': [2914], 'phosphate-free': [2920], '1.5': [2923, 2925], 'h.': [2924], 'mCi/ml': [2926], '[32P]orthophosphate': [2927], 'added': [2930], 'medium.': [2933], 'At': [2934], '4': [2935, 3021], 'labeling,': [2939], 'immunoprecipitated': [2942, 3072, 3081], 'anti-Flag': [2944], 'resolved': [2947], 'SDS-PAGE.': [2949], 'The32P-labeled': [2950], 'autoradiography': [2956], 'quantified': [2958], 'phosphorimaging.': [2960], 'Cells': [2961], 'washed': [2963], 'phosphate-buffered': [2966], 'saline': [2967], 'lysed': [2969], 'ice-cold': [2971], 'lysis': [2972], 'Tris-HCl,': [2976], '7.5,': [2978], 'EDTA,': [2981], '1%': [2985], 'Triton': [2986], 'X-100,': [2987], 'sodium': [2990, 2997], 'NaF,': [2994], 'pyrophosphate,': [2998], 'Microcystin-LR,': [3001], '0.27': [3002], 'm': [3003], 'sucrose,': [3004], 'protease': [3006], 'inhibitors).': [3007], 'After': [3008, 3171], 'lysates': [3009], 'clarified': [3011], 'centrifugation': [3013, 3164], '14,000': [3015], 'rpm': [3016, 3167], '15': [3018], '°C,': [3022], 'electrophoresed': [3027], 'nictrocellulose': [3034], 'membrane': [3037], 'blocked': [3039], '5%': [3041], 'nonfat': [3042], 'milk': [3043], 'probed': [3045], 'different': [3047, 4373], 'antibodies.': [3048], 'Expression': [3049], 'β-tubulin': [3051], 'equal': [3056], 'loading': [3057], 'control.': [3058], 'assessment': [3060], 'CDK2': [3062, 3068, 3082], 'activities,': [3066], 'endogenous': [3067, 3334, 3817, 3838, 4194, 4416], 'mg': [3075], 'lysate': [3078], 'proteins.': [3079], 'histone': [3091], 'GST-Rb,': [3097], 'respectively,': [3098], '20': [3108], 'α-glycerophosphate,': [3123], 'MgCl2).': [3132], '48': [3133], 'challenge,': [3137], 'floating': [3138, 3157], 'tube.': [3144], 'adherent': [3146], 'treated': [3149], 'trypsin': [3151], 'mixed': [3154], 'cells.': [3158, 3578, 4061], 'collected': [3162], '1500': [3166], 'min.': [3170], 'being': [3172], 'stained': [3173], '0.4%': [3175], 'trypan': [3176, 3188, 3193], 'blue': [3177], '(Sigma)': [3178], 'room': [3183], 'temperature,': [3184], 'numbers': [3186], 'blue-positive': [3189], 'blue-negative': [3194], 'alive': [3195], 'counted': [3198], 'hemocytometer': [3201], 'microscope.': [3204], 'overlapping': [3212], 'kinase.': [3223, 4410], 'Fig.': [3224, 3304, 3658, 3688, 3831, 4042, 4131, 4379, 4431], '1A': [3225], 'shows': [3226, 3306, 3690, 4044, 4133, 4381], 'preceded': [3233, 3250], 'R': [3239], 'XR': [3240, 3257], 'XX,': [3241], 'while': [3242, 3564], 'second': [3244, 3262, 3581], 'adjacent': [3245], 'highly': [3253, 3671], 'conserved': [3254], 'K': [3256], 'XX.': [3258], 'addition,': [3260], 'followed': [3267], 'hydrophobic': [3270], 'residue': [3271, 3276, 3495], '(Met147),': [3272], 'commonly': [3277], 'sites.': [3282, 3657], 'examine': [3284, 3632, 4021, 4098, 4361], 'whether': [3285, 3633, 3816, 4022, 4362], 'physically': [3287], 'interacted': [3288, 3342], 'coprecipitation': [3291], '(an': [3293], 'important,': [3294], 'necessary,': [3297], 'component': [3298], 'phosphorylation)': [3301], 'performed.': [3303, 4041], '1B': [3305], 'effectively': [3311], 'coprecipitated': [3312], 'mutation': [3316, 4151], 'alanine': [3323, 3593], 'did': [3324], 'affect': [3328, 4091], 'molecular': [3330], 'interaction.': [3331], 'vivo': [3344, 3453], '(Fig.': [3345, 3747, 3811, 3898, 4149, 4214, 4521], '1C).': [3346], 'During': [3347], 'preparation': [3349], 'manuscript,': [3352], 'three': [3353, 4400], 'groups': [3354, 3486], 'reported': [3355], 'phosphoprotein': [3360], 'study,': [3431], 'actively': [3439], 'growing': [3440], 'Ser146,': [3449, 3640, 4115], 'responsible': [3455], 'other': [3485, 3567, 3602, 4401], 'case,': [3544, 3568], 'receptor': [3553], 'tyrosine': [3554], 'signaling': [3556], 'phosphorylation,': [3563], 'residual': [3584, 3635, 3754], 'AKT/PKB-dependent': [3585], 'position,': [3597], 'least': [3600], 'transfection': [3641, 3729], 'experiments': [3642], 'performed': [3644], 'either': [3649, 3669, 4056, 4103], 'potential': [3654, 3779], '1Ddemonstrates': [3659], 'indeed': [3663], 'oncogenic': [3672, 4076, 4205], 'myristoylated': [3673], '(Mys-AKT)': [3677], 'epitope-tagged': [3681], '(V5-AKT).': [3687], '1E': [3689], 'vitrophosphorylation': [3693], 'bacterially': [3695], 'produced': [3696], 'AKT': [3700], 'occurs': [3701], 'positions,': [3709], 'showing': [3714], 'higher': [3717, 3846, 4445], 'efficiency': [3718], 'recapitulated': [3726], 'studies,': [3730], 'where': [3731], 'again': [3734], 'served': [3741], '1F).': [3748], 'previously': [3758], 'due': [3768, 4033], 'residue.': [3775], 'While': [3776], 'examining': [3777], 'co-transfected': [3796], 'plasmid': [3799], 'expressing': [3800, 4074], 'activated,': [3802], '(KD)': [3807], 'forms': [3808, 4107], '2A).': [3812], 'further': [3814], 'tested': [3815], 'As': [3828, 4428], '2B': [3832], '(left': [3833], 'panel),': [3834], 'fully': [3856], 'active.': [3857], 'LY': [3861], '294002,': [3862], 'specific': [3864], 'inhibitor,': [3867], 'reduced': [3868], 'comparable': [3872], 'free': [3877], 'conditions.': [3878], 'contrast,': [3880], 'able': [3890], 'restore': [3892], '2B,': [3899], 'right': [3900], 'panel).': [3901], 'regulated': [3911], 'post-translational': [3913], 'degradation': [3914, 3927, 4038], 'transcriptional': [3919, 4530], 'activation,': [3920, 4397], 'exact': [3923, 4420], 'controversial': [3929], '(36.Sheaff': [3930], 'Singer': [3932], 'Swanger': [3934], 'Smitherman': [3936], 'Clurman': [3940], '5:': [3945], '403-410Abstract': [3946], '(361)': [3954], 'previous': [3959], 'steady': [3964, 4241, 4513], 'state': [3965, 4242, 4514], 'appeared': [3969], '(37.Fukuchi': [3978], 'Watanabe': [3980], 'Tmoyasu': [3982], 'Ichimura': [3984], 'Tatsumi': [3986], 'Gomi': [3988], 'Biochim.': [3990], 'Biophys.': [3991], 'Acta.': [3992], '1496:': [3994], '207-220Crossref': [3995], '(33)': [3998], '38.Mitsuuchi': [4001], 'Johnson': [4003], 'Selvakumaran': [4005], 'Hamilton': [4009], 'Testa': [4011], '5390-5394PubMed': [4017], 'stabilization,': [4036], '2C': [4043], 'rapidly': [4048], 'degraded': [4049], 'cycloheximide': [4054], 'nontransfected': [4057, 4167], 'AKT-KD': [4059], 'contrast': [4063], 'results,': [4066], 'stabilized': [4071], '(Mys-AKT).': [4080], 'might': [4090], 'question,': [4100], 'together': [4121], 'examined': [4125], 'each': [4129], '2D': [4132], 'T145A': [4137], 'showed': [4139, 4392, 4403], 'kinetics': [4141], 'similar': [4144], '2C),': [4150], 'half-life': [4158], 'indistinguishable': [4161], 'KD': [4174], 'Ser146by': [4184], 'analysis': [4192], '2E).': [4215], 'phosphorylate': [4229], 'resultant': [4240], 'Advanced': [4245], 'multiformes': [4251], 'express': [4256], '(29.Jung': [4261], 'same': [4283], 'PTEN': [4300], 'phosphatase,': [4303], 'correlated': [4368], 'five': [4372], 'examined.': [4378], '3A': [4380], 'MG': [4388], 'high': [4393], 'if': [4405], 'any': [4406], 'correlation': [4421], 'between': [4422], 'activation.': [4427], '3,': [4432], 'much': [4438], 'stable': [4440], 'than': [4450], 'those': [4452], 'lower': [4455], 'suggests': [4461], 'major': [4467], 'levels,': [4471], 'made': [4475], 'fact': [4480], 'transcriptionally': [4486], '(26.Polyak': [4490], 'overall': [4512], '3A)': [4522], 'achieved': [4524], 'combination': [4527], 'p5': [4533]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2036521316', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 21}, {'year': 2018, 'cited_by_count': 20}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 23}, {'year': 2012, 'cited_by_count': 32}], 'updated_date': '2024-12-09T03:38:53.113923', 'created_date': '2016-06-24'}
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