Dependence of Selective Gene Activation on the Androgen Receptor NH2- and COOH-terminal Interaction

Name: Work Video:
Duration: 3 min 30 s
Bin He; Lori W. Lee; John T. Minges; Elizabeth M. Wilson
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3272, 3285, 3296, 3306, 3327, 3339, 3347, 3361, 3380, 3406, 3416, 3433, 3437, 3450, 3464, 3470, 3477, 3484, 3494, 3512, 3517, 3522, 3560, 3648, 3666, 3681, 3684, 3718, 3731, 3763, 3767, 3808, 3816, 3843, 3848, 3851, 3857, 3867, 3875, 3905, 3917, 3921, 3926, 3963, 3980, 3984, 4002, 4008, 4021, 4025, 4040, 4044, 4051, 4057, 4062, 4169, 4172, 4177, 4237, 4258, 4262, 4275, 4283, 4292, 4307, 4311, 4317, 4331, 4346, 4356, 4365, 4413, 4425, 4429, 4433, 4444, 4448], 'FXXLF': [13, 132, 161, 217, 336, 365, 1010, 1051, 1188, 1266, 2466, 2486, 2535, 2574, 2707, 2760, 2885, 2933, 2936, 3001, 3052, 3061, 3687, 3817, 3852, 3868, 4174, 4380], 'WXXLF': [15, 114, 137, 166, 219, 318, 341, 370, 1012, 1090, 1103, 1173, 1224, 1268, 2464, 2491, 2601, 2628, 2709, 2722, 2771, 2871, 2883, 2938, 2958, 3003, 3057, 3088, 3101, 3121, 3142, 3819, 3854, 3876, 3918, 3964, 4003, 4022, 4041, 4058, 4308, 4417, 4426, 4449], 'NH2-terminal': [16, 67, 220, 271, 413, 488, 758, 997, 1193, 1580, 2895, 3562, 3686], 'motifs.': [17, 175, 221, 379, 3820], 'Here': [18, 222, 1134], 'we': [19, 223, 1135, 1220, 3170, 3834, 4453], 'demonstrate': [20, 106, 224, 310], 'that': [21, 107, 129, 225, 311, 333, 441, 474, 535, 584, 618, 1000, 1049, 1127, 1171, 1222, 1245, 1637, 1705, 2260, 2680, 2994, 3060, 3086, 3221, 3358, 3391, 3402, 3505, 3527, 3551, 3824, 3923, 4020, 4056, 4073, 4273, 4424], 'agonist-dependent': [22, 226], 'transactivation': [23, 102, 227, 306, 526, 2506, 2542, 2581, 2649, 2719, 2738, 2806, 2857, 2875, 2943, 2977, 3012, 3108, 3161, 3294, 3359, 3377, 3420, 3646, 3761, 3792], 'of': [24, 52, 91, 111, 143, 159, 172, 196, 228, 256, 295, 315, 347, 363, 376, 400, 448, 511, 531, 582, 745, 748, 1057, 1086, 1088, 1101, 1115, 1140, 1161, 1177, 1230, 1236, 1255, 1264, 1277, 1413, 1582, 1603, 1635, 1648, 1721, 1771, 1854, 1865, 1870, 1886, 1897, 1926, 2000, 2007, 2012, 2026, 2045, 2050, 2054, 2060, 2089, 2110, 2127, 2188, 2191, 2210, 2227, 2462, 2470, 2507, 2533, 2543, 2553, 2567, 2572, 2582, 2591, 2599, 2608, 2627, 2636, 2650, 2661, 2691, 2714, 2728, 2769, 2807, 2858, 2869, 2876, 2902, 2909, 2916, 2944, 2953, 2998, 3016, 3031, 3045, 3079, 3099, 3112, 3162, 3173, 3219, 3226, 3244, 3253, 3295, 3338, 3360, 3386, 3396, 3408, 3421, 3436, 3479, 3509, 3511, 3516, 3539, 3544, 3557, 3647, 3665, 3683, 3717, 3762, 3769, 3802, 3827, 3845, 3850, 3866, 3907, 3909, 3925, 3971, 3986, 3996, 4039, 4047, 4070, 4171, 4248, 4257, 4264, 4274, 4285, 4291, 4306, 4313, 4345, 4432, 4447], 'prostate-specific': [25, 229, 428], 'antigen': [26, 230, 429, 1155], '(PSA)': [27, 231, 1156], 'probasin': [29, 55, 95, 233, 259, 299, 1158, 1731, 2325, 2511, 2547, 2612, 2654, 2695, 3115, 3266, 3368, 3399, 3495], 'enhancer/promoter': [30, 234, 1148, 1691, 1732, 2240, 2262, 2512, 2696, 2879, 3165], 'regions': [31, 57, 235, 261, 1149, 1164, 1634, 2236, 2241, 2263, 2513, 2697, 3556], 'requires': [32, 236, 3514, 3829], 'N/C': [34, 99, 190, 238, 303, 394, 895, 1143, 1248, 1280, 2249, 2702, 2751, 2765, 2778, 2810, 2851, 3158, 3184, 3373, 3410, 3466, 3732, 3809, 4178], 'interaction,': [35, 239, 2766], 'whereas': [36, 240, 2734, 2767], 'sex-limited': [38, 242, 1709, 2366], 'protein': [39, 243, 593, 1710, 2367], 'gene': [40, 202, 244, 406, 443, 763, 2253, 3066, 3320], 'mouse': [42, 246, 430], 'mammary': [43, 247, 431, 1742], 'tumor': [44, 248, 432, 1743], 'virus': [45, 249, 433, 1744], 'long': [46, 250], 'terminal': [47, 251], 'repeat': [48, 252], 'do': [49, 253], 'not.': [50, 254], 'Transactivation': [51, 255, 3475], 'PSA': [53, 93, 257, 297, 2268, 2509, 2545, 2610, 2652, 2693, 2878, 3113, 3164, 3262, 3366, 3397], 'response': [56, 260, 462, 2235, 2607, 2635, 3287, 3337, 3385, 3400], 'also': [58, 262, 899, 4371], 'depends': [59, 263, 527, 1105, 2698], 'on': [60, 97, 264, 301, 528, 1106, 2473, 2580, 2633, 2671, 2699, 2805, 3010, 3130, 3370, 3847, 4288], 'activation': [61, 80, 265, 284, 408, 416, 444, 483, 491, 3067, 3321], 'function': [62, 81, 266, 285, 409, 417, 484, 492], '1': [63, 267, 410, 485, 589, 2048, 2052, 2211, 2515, 2524, 2557, 2595, 2622, 2641, 2664, 3125, 3254], '(AF1)': [64, 268], 'in': [65, 84, 108, 140, 147, 183, 193, 200, 269, 288, 312, 344, 351, 387, 397, 404, 495, 504, 630, 761, 769, 1054, 1169, 1227, 1340, 1375, 1401, 1428, 1495, 1791, 1906, 1923, 1963, 1985, 2023, 2083, 2105, 2124, 2135, 2185, 2205, 2219, 2251, 2484, 2501, 2550, 2561, 2588, 2681, 2711, 2718, 2731, 2737, 2756, 2861, 2873, 2888, 2892, 2905, 2911, 2926, 2948, 2963, 2976, 2995, 3013, 3037, 3076, 3135, 3146, 3160, 3180, 3223, 3238, 3304, 3319, 3418, 3448, 3476, 3549, 3644, 3662, 3714, 3766, 3815, 3904, 3979, 3983, 4001, 4005, 4030, 4176, 4261, 4282, 4304, 4310, 4326, 4355, 4374, 4437, 4462], 'region': [68, 272, 489, 760, 1182, 1235, 1412, 1581, 1692, 3218, 3235, 3435, 3525, 3563, 4431], 'but': [69, 273, 946, 1183, 3678, 3772, 3872, 4321], 'can': [70, 274], 'be': [71, 275], 'increased': [72, 276, 2527, 2605, 2616, 2941, 3384, 3637], 'binding': [74, 87, 150, 174, 278, 291, 354, 378, 455, 460, 498, 502, 507, 628, 635, 767, 773, 1006, 1239, 1317, 1559, 2229, 2645, 2886, 3040, 3232, 3431, 3439, 3668, 3682, 3720, 3729, 3830, 3859, 3903, 3927, 3975, 4028, 4053, 4064, 4084, 4170, 4240, 4247, 4297, 4305, 4327, 4336, 4348, 4367, 4382, 4435, 4446], 'an': [75, 121, 279, 325, 620, 1945, 2725, 2889, 2921, 3182, 3371, 3409, 3552, 3863, 4031, 4438], 'overexpressed': [76, 280], 'p160': [77, 281, 532, 577, 614, 749], 'coactivator': [78, 282, 533, 588, 603, 615, 3674], 'to': [79, 105, 123, 283, 309, 327, 461, 541, 777, 1167, 1397, 1423, 1432, 1644, 2489, 2494, 2539, 2683, 3091, 3128, 3312, 3388, 3405, 3432, 3443, 3456, 3460, 3530, 3635, 3831, 3841, 3999, 4077, 4316, 4361, 4416, 4451], '2': [82, 286, 418, 422, 493, 594, 1804, 1868, 1933, 1977, 2087], '(AF2)': [83, 287, 494], 'ligand': [86, 149, 290, 353, 497, 506, 634, 772, 1005, 1238, 1558, 3039, 3231, 3438, 3667, 3719, 3858, 3974, 4027, 4052, 4239, 4296, 4335, 4434], 'domain.': [88, 151, 292, 355, 499, 1240, 3041, 3440, 3860, 4337], 'dependence': [90, 294, 4046], 'enhancer/promoters': [96, 300, 2587, 3364], 'for': [101, 180, 186, 305, 384, 390, 901, 948, 1252, 1339, 1755, 1763, 1911, 2074, 2102, 2116, 2246, 2749, 2855, 2924, 3156, 3344, 3375, 3642, 3672, 3680, 3724, 4379], 'allowed': [103, 307, 1165], 'us': [104, 308, 1166], 'presence': [110, 142, 314, 346, 1056, 1229, 2109, 2187, 2207, 2713, 2915, 2952, 3225, 3252, 3478, 3981, 4263, 4284, 4312], 'androgen,': [112, 316, 4286], 'motif': [115, 138, 162, 319, 342, 366, 617, 1052, 1091, 1104, 1174, 1225, 2536, 2575, 2602, 2730, 2761, 2772, 2872, 2959, 3089, 3102, 3217, 3676, 3688, 3728, 3869, 3877, 3919, 4004, 4023, 4059, 4083, 4175, 4381, 4418, 4427, 4450], 'with': [116, 145, 164, 320, 349, 368, 479, 608, 753, 1002, 1059, 1232, 1328, 1333, 1388, 1514, 1565, 1618, 1810, 1862, 1894, 1914, 1970, 2141, 2150, 2667, 2758, 3050, 3055, 3119, 3228, 3247, 3284, 3379, 3521, 3856, 3870, 3874, 3958, 4050, 4061, 4330], 'sequence433WHTLF437': [118, 322], 'contributes': [119, 323, 3090], 'as': [120, 324, 1287, 1918, 2119, 2155, 3534, 4370], 'inhibitor': [122, 326, 3538], 'AR': [124, 328, 757, 771, 996, 1004, 1142, 1247, 1279, 1330, 1579, 1814, 2480, 2483, 2505, 2701, 2732, 2890, 3011, 3419, 3462, 3465, 3523, 3561, 3645, 3657, 3685, 3783, 3791, 3799, 3828, 3973, 4026, 4173, 4228], 'transactivation.': [125, 329, 2928, 3638], 'We': [126, 330, 2231, 2863, 2992, 3412, 3861, 3952, 4066], 'further': [127, 331, 1272, 2617, 2865, 3084, 3153, 4442], 'show': [128, 332, 1136, 1221], 'like': [130, 334], 'LXXLL': [134, 338, 616, 3216, 3308, 3452, 3519, 3675, 3727, 4082], 'motifs,': [135, 339, 3027], 'interacts': [139, 343, 1053, 1226, 3222, 4060], 'AF2': [146, 199, 350, 403, 501, 529, 609, 626, 746, 766, 1060, 1181, 1234, 3036, 3234, 3434, 3524, 3643, 3658, 3804, 4063, 4071, 4229, 4347, 4357, 4430], 'Sequence': [152, 356], 'comparisons': [153, 357], 'among': [154, 358, 1270], 'species': [155, 359, 1271], 'indicate': [156, 360, 2679, 3823, 4019], 'greater': [157, 361, 3043, 3292, 4271], 'conservation': [158, 362, 1263], 'compared': [163, 367, 3054, 3246, 3378], 'motif,': [167, 371], 'paralleling': [168, 372], 'functional': [170, 374, 743, 1138, 1275], 'significance': [171, 375], 'these': [173, 377, 1162, 3803], 'data': [177, 381, 754, 1242, 3503, 4421], 'provide': [178, 382, 1243, 4422], 'evidence': [179, 383, 1244, 2821, 3085, 4423], 'promoter-specific': [181, 385], 'differences': [182, 386], 'requirement': [185, 389, 2245, 2748, 3155], 'contributions': [195, 399], 'AF1': [197, 401, 759, 2896, 2903, 2925, 2965, 3131, 3148], 'androgen-induced': [201, 405, 2248], 'regulation.': [203, 407, 2254], 'transcriptional': [419, 591], 'intermediary': [420, 592], 'factor': [421], 'glutathione': [423], 'S-transferase': [424], 'glucocorticoid': [425, 950], 'luciferase': [427, 1118, 1818, 2117, 2474, 2548, 3047, 3077, 3116, 3279], 'dihydrotestosterone': [434, 2213], 'Steroid': [435], 'receptors': [436, 927], 'are': [437, 482, 579, 898, 1008, 2755, 3403, 4343], 'ligand-activated': [438], 'transcription': [439, 1124], 'factors': [440], 'regulate': [442], 'through': [445, 1125, 3035], 'a': [446, 580, 1191, 1502, 1573, 1587, 1600, 1687, 2243, 2735, 2746, 2973, 3006, 3021, 3174, 3239, 3446, 3531, 3535, 3836, 3910, 3955, 3959, 4068, 4301, 4455], 'series': [447, 4069], 'events': [449], 'triggered': [450], 'high': [452, 1261], 'affinity': [453, 1045, 3838, 4376], 'hormone': [454, 520, 1917, 4045, 4319], 'element': [463], 'DNA': [464, 1316, 1622, 1636, 1825, 2068], 'coactivators.': [466], 'At': [467], 'least': [468], 'two': [469, 1256, 3656], 'domains': [470], 'have': [471, 536, 2242, 3005], 'been': [472], 'identified': [473], 'mediate': [475, 778, 3636], 'nuclear': [476, 524, 632], 'interactions': [478, 897, 3733], 'coregulators.': [480], 'These': [481], '(AF1)1in': [486], 'surface': [503, 629, 4368], 'domain': [508, 636, 774, 1007, 1318, 1560, 3233, 3669, 3721, 3976, 4029, 4054, 4241, 4298, 4436], 'comprised': [510], 'helices': [512], '3,': [513], '4,': [514], '12': [516, 3716], 'forms': [518, 619], 'after': [519], 'binding.': [521, 1108, 4419], 'For': [522, 737], 'many': [523], 'receptors,': [525], 'recruitment': [530, 747, 1176], 'complexes': [534], 'histone': [537], 'acetyl': [538], 'transferase': [539], 'activity': [540, 2118, 2475, 2562, 2910, 3048, 3078, 3117, 3136, 3784], 'modify': [542], 'chromatin': [543], 'structure': [544, 4038], '(1Spencer': [545], 'T.E.': [546], 'Jenster': [547], 'G.': [548, 2412, 3595], 'Burcin': [549], 'M.M.': [550], 'Allis': [551], 'C.D.': [552], 'Zhou': [553, 788, 826], 'J.': [554, 794, 830, 852, 878, 979, 1022, 1067, 1204, 1297, 1351, 1444, 1468, 1538, 1667, 1737, 1836, 2163, 2281, 2282, 2314, 2372, 2433, 2786, 2833, 3196, 3574, 3695, 3740, 3886, 3936, 4152, 4190, 4212, 4393, 4473], 'Mizzen': [555], 'C.A.': [556], 'McKenna': [557], 'N.J.': [558], 'Onate': [559], 'S.A.': [560, 933, 2335], 'Tsai': [561, 563], 'S.Y.': [562], 'M.J.': [564, 929], "O'Malley": [565], 'B.W.': [566], 'Nature.': [567, 645, 700, 4105], '1997;': [568, 646, 2317], '389:': [569], '194-198Crossref': [570], 'PubMed': [571, 649, 675, 704, 732, 803, 821, 841, 863, 889, 920, 943, 968, 990, 1033, 1078, 1215, 1308, 1362, 1455, 1479, 1549, 1678, 1847, 2174, 2293, 2320, 2361, 2383, 2404, 2423, 2437, 2455, 2797, 2844, 3207, 3585, 3606, 3627, 3706, 3751, 3897, 3947, 4109, 4137, 4163, 4201, 4223, 4404], 'Scopus': [572, 650, 676, 705, 733, 842, 864, 890, 921, 991, 1034, 1079, 1216, 1309, 1363, 1456, 1480, 1550, 1679, 1848, 2175, 2294, 2321, 2362, 2384, 2405, 2424, 2438, 2456, 2798, 2845, 3208, 3586, 3607, 3628, 3707, 3752, 3898, 3948, 4110, 4138, 4164, 4202, 4224, 4405], '(1070)': [573], 'Google': [574, 652, 678, 707, 735, 804, 822, 844, 866, 892, 923, 944, 969, 993, 1036, 1081, 1218, 1311, 1365, 1458, 1482, 1552, 1681, 1850, 2177, 2296, 2323, 2364, 2386, 2407, 2426, 2440, 2458, 2800, 2847, 3210, 3588, 3609, 3630, 3709, 3754, 3900, 3950, 4112, 4140, 4166, 4204, 4226, 4407], 'Scholar).': [575, 736, 893, 994, 1037, 1082, 1366, 1483, 1682, 1851, 2178, 2459, 2801, 3211, 3710, 3755, 3901, 3951, 4227], 'coactivators': [578, 750], 'group': [581], 'proteins': [583, 1284, 2132, 2182], 'include': [585], 'steroid': [586, 601], '(SRC1),': [590], '(TIF2,': [595], 'GRIP1': [596], 'or': [597, 1332, 1867, 1899, 1915, 2002, 2482, 2496, 2914, 3255, 3302, 3463, 4079, 4244], 'SRC2),': [598], '3': [604, 3215, 3275, 3307, 3315, 3351, 3451, 3664], 'subfamily': [605], '(SRC3).': [606], 'Interaction': [607], 'amphipathic': [621, 4036], 'α-helix': [622], 'binds': [624, 4024, 4428], 'hydrophobic': [627, 4358, 4366], '(2Heery': [637], 'D.M.': [638, 2376, 2397, 3618], 'Kalkhoven': [639], 'E.': [640, 825, 847, 2393, 2828], 'Hoare': [641, 3613], 'S.': [642, 685, 915, 2351, 3614, 4090], 'Parker': [643, 3619], 'M.G.': [644, 693, 2443, 3620, 4098], '387:': [647], '733-736Crossref': [648], '(1778)': [651], 'Scholar,': [653, 679, 708, 805, 823, 845, 867, 970, 1459, 2297, 2387, 2427, 2441, 3589, 3610, 4113, 4141, 4205], '3Darimont': [654], 'B.D.': [655], 'Wagner': [656], 'R.L.': [657], 'Apriletti': [658], 'J.W.': [659], 'Stallcup': [660], 'M.R.': [661], 'Kushner': [662, 717, 4122], 'P.J.': [663, 718, 4123], 'Baxter': [664], 'J.D.': [665], 'Fletterick': [666], 'R.J.': [667, 2355], 'Yamamoto': [668], 'K.R.': [669], 'Genes': [670], 'Dev.': [671], '1998;': [672, 701, 724, 855, 2836, 4106, 4129], '12:': [673], '3343-3356Crossref': [674], '(832)': [677], '4Nolte': [680], 'R.T.': [681, 4086], 'Wisely': [682, 4087], 'G.B.': [683, 4088], 'Westin': [684, 4089], 'Cobb': [686, 4091], 'J.E.': [687, 4092], 'Lambert': [688, 4093], 'M.H.': [689, 4094], 'Kurokawa': [690, 4095], 'R.': [691, 2339, 4096], 'Rosenfeld': [692, 4097], 'Willson': [694, 4099], 'T.M.': [695, 4100], 'Glass': [696, 4101], 'C.K.': [697, 4102], 'Milburn': [698, 4103], 'M.V.': [699, 809, 956, 4104], '395:': [702, 4107], '137-143Crossref': [703, 4108], '(1700)': [706, 4111], '5Shiau': [709, 4114], 'A.K.': [710, 4115], 'Barstad': [711, 4116], 'D.': [712, 4117], 'Loria': [713, 4118], 'P.M.': [714, 4119], 'Cheng': [715, 2336, 4120], 'L.': [716, 4121], 'Agard': [719, 4124], 'D.A.': [720, 4125], 'Greene': [721, 4126], 'G.L.': [722, 2447, 4127], 'Cell.': [723, 2378, 2399, 2448, 3601, 3622, 4128], '95:': [725, 4130], '927-937Abstract': [726, 4131], 'Full': [727, 729, 800, 836, 838, 858, 860, 884, 886, 985, 987, 1028, 1030, 1073, 1075, 1210, 1212, 1303, 1305, 1357, 1359, 1450, 1452, 1474, 1476, 1544, 1546, 1673, 1675, 1842, 1844, 2169, 2171, 2288, 2290, 2452, 2792, 2794, 2839, 2841, 3202, 3204, 3580, 3582, 3701, 3703, 3746, 3748, 3892, 3894, 3942, 3944, 4132, 4134, 4158, 4160, 4196, 4198, 4218, 4220, 4399, 4401], 'Text': [728, 730, 801, 837, 839, 859, 861, 885, 887, 986, 988, 1029, 1031, 1074, 1076, 1211, 1213, 1304, 1306, 1358, 1360, 1451, 1453, 1475, 1477, 1545, 1547, 1674, 1676, 1843, 1845, 2170, 2172, 2289, 2291, 2453, 2793, 2795, 2840, 2842, 3203, 3205, 3581, 3583, 3702, 3704, 3747, 3749, 3893, 3895, 3943, 3945, 4133, 4135, 4159, 4161, 4197, 4199, 4219, 4221, 4400, 4402], 'PDF': [731, 802, 840, 862, 888, 989, 1032, 1077, 1214, 1307, 1361, 1454, 1478, 1548, 1677, 1846, 2173, 2292, 2454, 2796, 2843, 3206, 3584, 3705, 3750, 3896, 3946, 4136, 4162, 4200, 4222, 4403], '(2269)': [734, 4139], '(AR),': [741], 'importance': [744, 1139, 1276], 'unclear,': [752], 'implicating': [755], 'AR-mediated': [762, 1253, 2252, 2856, 2874, 2927, 2942, 3065, 3760], 'activation.': [764], 'site': [768, 1085], 'was': [775, 1092, 1096, 1368, 1399, 1486, 1509, 1570, 1584, 1626, 1693, 1714, 1733, 1746, 1765, 1777, 1942, 2071, 2095, 2487, 2492, 2526, 2563, 2615, 2657, 2812, 2961, 2971, 3020, 3137, 3144, 3186, 3342, 3458, 3481, 3653, 3793, 3811, 3928, 4266, 4328], 'shown': [776, 4075, 4372], '(6Wong': [786], 'C.I.': [787], 'Z.X.': [789, 807, 827, 954], 'Sar': [790], 'M.': [791, 1718, 1750, 2374, 2416], 'Wilson': [792, 814, 828, 850, 876, 961, 977, 1020, 1065, 1202, 1295, 1349, 1442, 1466, 1536, 1665, 1834, 2161, 2784, 2831, 3194, 3572, 3693, 3738, 3884, 3934, 4150, 4188, 4210, 4391, 4471], 'E.M.': [793, 815, 829, 851, 877, 907, 962, 978, 1021, 1066, 1203, 1296, 1350, 1443, 1467, 1537, 1666, 1835, 2162, 2785, 2832, 3195, 3573, 3694, 3739, 3885, 3935, 4151, 4189, 4211, 4392, 4472], 'Biol.': [795, 831, 853, 879, 980, 1023, 1068, 1205, 1298, 1352, 1445, 1469, 1539, 1668, 1837, 2164, 2283, 2379, 2787, 2834, 3197, 3575, 3602, 3623, 3696, 3741, 3887, 3937, 4153, 4191, 4213, 4394, 4474], 'Chem.': [796, 832, 854, 880, 981, 1024, 1069, 1206, 1299, 1353, 1446, 1470, 1540, 1669, 1838, 2165, 2284, 2788, 2835, 3198, 3576, 3697, 3742, 3888, 3938, 4154, 4192, 4214, 4395, 4475], '1993;': [797, 2358], '268:': [798], '19004-19012Abstract': [799], '7Zhou': [806], 'Lane': [808, 955], 'Kemppainen': [810, 848, 870, 957, 1018, 1063, 1200, 1347, 1530, 2159, 2782, 2829, 3566, 3691, 3736, 3882, 3932, 4144, 4182, 4208, 4385], 'J.A.': [811, 849, 871, 958, 1019, 1064, 1201, 1348, 1531, 2160, 2783, 2830, 3567, 3692, 3737, 3883, 3933, 4145, 4183, 4209, 4386], 'French': [812, 959], 'F.S.': [813, 960], 'Mol.': [816, 938, 963, 2315, 2356, 2377, 2398, 3600, 3621], 'Endocrinol.': [817, 939, 964, 2316, 2357, 2400], '1995;': [818, 833, 917, 965], '9:': [819, 966], '208-218Crossref': [820, 967], '8Langley': [824], '270:': [834], '29983-29990Abstract': [835], '(235)': [843], '9Langley': [846], '273:': [856, 2837], '92-101Abstract': [857, 2838], '(210)': [865, 2846], '10He': [868, 4142], 'B.': [869, 972, 1017, 1062, 1199, 1290, 1346, 1437, 1461, 1529, 1660, 1829, 2158, 2431, 2781, 3189, 3565, 3599, 3690, 3735, 3881, 3931, 4143, 4181, 4207, 4384, 4466], 'Voegel': [872, 1532, 3568, 4146, 4184, 4387], 'J.J.': [873, 1533, 3569, 4147, 4185, 4388], 'Gronemeyer': [874, 1534, 3570, 4148, 4186, 4389], 'H.': [875, 1535, 2337, 3571, 4149, 4187, 4390], '1999;': [881, 940, 1541, 3577, 3603, 3624, 4155, 4193, 4396], '274:': [882, 1542, 3578, 4156, 4194, 4397], '37219-37225Abstract': [883, 1543, 3579, 4157, 4195, 4398], '(284)': [891, 1551, 3587, 4165, 4203, 4406], 'Agonist-induced': [894], 'interdomain': [896], 'reported': [900], 'estrogen': [903], '(11Kraus': [904], 'W.L.': [905], 'McInerney': [906], 'Katzenellenbogen': [908], 'B.S.': [909, 2345], 'Proc.': [910], 'Natl.': [911], 'Acad.': [912], 'Sci.': [913], 'U.': [914], 'A.': [916, 2341, 2389], '92:': [918], '12314-12318Crossref': [919], '(184)': [922], 'Scholar)': [924, 1312, 1553, 2848, 3631, 4167], 'progesterone': [926], '(12Tetel': [928], 'Giangrande': [930], 'P.H.': [931], 'Leonhardt': [932], 'McDonnell': [934], 'D.P.': [935, 937], 'Edwards': [936], '13:': [941], '910-924Crossref': [942], 'Scholar),': [945, 1219, 2324, 2365, 2408, 4408], 'not': [947, 1093, 2775, 2990, 3105, 3269, 3282, 3333, 3500, 3633, 3679, 3758, 3794], '(GR)': [952], '(7Zhou': [953], '13He': [971], 'Bowen': [973, 1438, 1661, 1830, 3190], 'N.T.': [974, 1439, 1662, 1831, 3191], 'Minges': [975, 1291, 1440, 1462, 1663, 1832, 3192, 4467], 'J.T.': [976, 1292, 1441, 1463, 1664, 1833, 3193, 4468], '2001;': [982, 1447, 1670, 1839, 3199], '276:': [983, 1448, 1671, 1840, 3200], '42293-42301Abstract': [984, 1449, 1672, 1841, 3201], '(114)': [992, 1457, 1680, 1849, 3209], 'Two': [995], 'LXXLL-like': [998], 'motifs': [999, 1013, 1269, 2467, 2646, 2710, 2887, 2939, 3004, 3309, 3453, 3520, 3855], 'interact': [1001], '(23FQNLF27': [1014], 'and433WHTLF437)': [1015], '(14He': [1016, 1061, 1198, 1345, 2157, 2780, 3689, 3734, 3880, 3930], '2000;': [1025, 1070, 1207, 1354, 2166, 2789, 3698, 3743, 3889, 3939, 4215], '275:': [1026, 1071, 1208, 1355, 2167, 2790, 3699, 3744, 3890, 3940, 4216], '22986-22994Abstract': [1027, 1072, 1209, 1356, 2168, 2791, 3700, 3745, 3891, 3941, 4217], '(365)': [1035, 1080, 1217, 1364, 2176, 2799, 3708, 3753, 3899, 3949, 4225], 'Mutagenesis': [1038], 'studies': [1039, 1112], 'mammalian': [1041, 1760], 'two-hybrid': [1042, 4457], 'GST': [1044, 2130, 3837, 4375], 'matrix': [1046, 3839, 4377], 'assays': [1047, 4378], 'demonstrated': [1048, 3862], 'However': [1083], 'determined,': [1094], 'nor': [1095], 'it': [1097, 3392], 'clear': [1098], 'whether': [1099, 2233, 3415], 'In': [1109, 2179, 2569, 2624, 3250, 3335, 3441, 3993], 'addition,': [1110, 1170, 3550, 3994], 'previous': [1111, 2820], 'made': [1113, 3171], 'use': [1114, 3172], 'MMTV': [1117, 2410, 2521, 2675, 2687, 3168, 3273, 3381], 'reporter': [1119, 1819, 2256, 2947, 2988, 3298, 3341, 3472, 3650, 3765], 'vector,': [1120], 'which': [1121, 1427, 1685, 1725, 2485, 2614, 2656, 2893, 3181, 3305, 3449], 'may': [1122], 'direct': [1123], 'mechanisms': [1126], 'differ': [1128], 'from': [1129, 1151, 2238, 2264, 2822, 3288, 3365], 'other': [1130, 3555], 'responsive': [1132, 1147, 1163, 1690, 1712, 1730, 3363], 'enhancer/promoters.': [1133], 'using': [1145, 1408, 1490, 1501, 1572, 1586, 1628, 1640, 1821, 1944, 1995, 2040, 2196, 2478, 2985, 3326, 3469, 3493, 3655], 'derived': [1150, 2237], 'prostate': [1153], 'specific': [1154, 3640], 'genes.': [1159, 1258], 'Use': [1160], 'demonstrate,': [1168], 'inhibits': [1175, 3064], 'TIF2': [1178, 1764, 2471, 2530, 2554, 2592, 2619, 2662, 2815, 2917, 2954, 3017, 3033, 3069, 3095, 3220, 3428, 3430, 3487, 3508, 3518, 3558, 3652, 3673, 3726, 3770, 3776, 3797, 3825, 4081], 'less': [1184, 3138, 3482], 'than': [1185, 1195, 3070, 3299, 3483, 3982, 4272, 4412], 'does': [1186, 2774, 3071], 'motif.': [1189, 3965], 'Using': [1190], 'shorter': [1192, 3960], 'fragment': [1194, 1379, 1384, 1508, 4299], 'previously': [1196, 3175, 4076, 4373, 4460], 'described': [1197, 1288, 1344, 1435, 1658, 2120, 2156, 3176, 4461], 'required': [1251, 3429, 3723], 'regulation': [1254, 2690], 'androgen-dependent': [1257, 2859, 3864, 4009, 4032, 4246, 4439, 4445], 'relatively': [1260, 2630, 2668], 'sequence': [1262, 1331, 1374, 1494, 3961, 4042], 'supports': [1273], 'interaction.': [1281, 2752, 3411], 'GAL-peptide': [1282], 'fusion': [1283, 2131, 3914, 3956], 'were': [1285, 1343, 1434, 1521, 1610, 1638, 1642, 1789, 1808, 1860, 1892, 1904, 1921, 1961, 1983, 2021, 2081, 2100, 2133, 2183, 2217, 2258, 2476, 2499, 2899, 2983, 3310, 3324, 3454, 3491, 3632, 3878, 4074], 'constructed': [1286], '(15He': [1289, 4465], 'Lee': [1293, 1464, 4469], 'L.W.': [1294, 1465, 2312, 4470], '2002;': [1300, 1471, 4476], '277:': [1301, 1472, 4477], '10226-10235Abstract': [1302, 1473], '(164)': [1310, 1481], 'contain': [1314, 2261], 'GAL4': [1315], 'residues': [1319, 2897, 3977, 3997], '1–147': [1320], 'peptide': [1323, 3915, 3957, 4309, 4456], 'sequences': [1324], 'indicated.': [1325, 1919], 'pcDNA3HA-': [1326], 'AR624–919': [1327], 'wild-type': [1329, 1811, 1855, 1887, 2001, 2479, 3248, 4259], 'mutations': [1334, 2498, 2826, 2930, 3805, 3814, 4230], 'K720A,': [1335], 'V716R,': [1336, 4277], 'E897K': [1338, 4295], 'vitro': [1341, 2180], 'translation': [1342], 'GST·AR-(412–460)': [1367, 3966, 4249], 'created': [1369, 1400, 1487, 1522, 1571, 2500], 'amplifying': [1371, 1407, 1489], 'coding': [1373, 1493], 'pCMVhAR,': [1376, 2004], 'digesting': [1377, 1524], 'withBamHI/EcoRI,': [1380], 'cloning': [1382, 1556], 'into': [1385, 1511, 1562, 1615, 2931, 4236], 'pGEX3X': [1386], 'digested': [1387, 1513, 1564, 1611, 1617], 'same': [1390, 1403, 1516, 1567, 1620, 2503], 'enzymes.': [1391, 1517, 1568, 1621], 'GST·AR-(412–460)WXXAA,': [1392], 'where': [1393, 1419, 2849, 3807], '433WHTLF437': [1394], 'changed': [1396, 1422, 1431, 2488, 2493, 3455], 'WHTAA,': [1398], 'manner': [1404], 'except': [1405, 2122], 'PCR': [1409, 1491, 1575, 1625, 1641], 'corresponding': [1411], 'mutant': [1415, 1504, 1813, 1857, 1889, 2003, 2891, 2967, 3053, 3058, 3082, 3122, 3143, 3447], 'pCMVhAR': [1416, 1496, 1512, 1858, 1890], 'vector.': [1417], 'AR-FXXAA,': [1418], '23FQNLF27': [1420], 'FQNAA,': [1424], 'AR-FXXAA/AXXAA,': [1426], 'addition': [1429], 'has433WHTLF437': [1430], 'AHTAA,': [1433], '(13He': [1436, 1659, 1828, 3188], '15He': [1460], 'AR-AXXAA': [1484], '(AR-433AHTAA437)': [1485], 'between': [1497, 3554], 'BstEII': [1498, 1605], 'HindIII': [1500], '5′': [1503], 'oligonucleotide': [1505], 'primer.': [1506], 'inserted': [1510], 'AR-FXXAA/AXXAA-K720A': [1518], 'AR-FXXAA/AXXAA-E897K': [1520], 'pCMVhAR-K720A': [1525], 'pCMVhAR-E897K': [1527], '(10He': [1528, 3564, 4180, 4383], 'withHindIII/XbaI': [1554], 'fragments': [1561, 1609], 'AR-FXXAA/AXXAA': [1563, 1583, 1616], 'AR-FXXAA/AXXAAΔ(142–337)': [1569], 'double': [1574, 3081], 'mutagenesis': [1576, 3098], 'strategy.': [1577], 'amplified': [1585, 1608, 1639], '5′-primer': [1588], 'preceding': [1589], 'BglII': [1591], 'site,': [1592], 'internal': [1593], 'primers': [1594], 'flanking': [1595], 'deleted': [1597], 'region,': [1598], 'primer': [1601], '3′': [1602], 'site.': [1606], 'withBglII/BstEII': [1612], 'cloned': [1614], 'amplification': [1623], 'performed': [1627], 'Vent-polymerase': [1629], '(New': [1630], 'England': [1631], 'BioLabs).': [1632], 'All': [1633], 'sequenced': [1643], 'verify': [1645], 'absence': [1647, 2107, 2209, 2552, 2590, 2913, 2950, 2997, 3015, 3768, 3906, 3985], 'random': [1649], 'errors.': [1650], 'human': [1652], 'GR': [1653, 3177, 3230, 3259, 3345, 3348], 'vectors': [1654, 1816, 1820, 1859, 1891, 2257], 'GR(LXXLL)3': [1655, 3179, 3212, 3290, 3323, 3389], 'GR(LXXAA)3were': [1657], 'PSA-61-luciferase': [1683], '(PSA61-Luc),': [1684], 'contains': [1686, 1706, 1726, 3213], '5.8-kb': [1688], 'provided': [1694, 1715, 1734, 1747, 1766, 1778], 'Jan': [1696], 'Trapman,': [1697], 'Erasmus': [1698], 'University,': [1699], 'Rotterdam,': [1700], 'Netherlands.': [1702], 'pGC′Δ9-Luc': [1703], '(pGCΔ9-Luc)': [1704], '120-bp': [1708], 'enhancer': [1713], 'Diane': [1717], 'Robins,': [1719], 'University': [1720, 1770], 'Michigan.': [1722], 'BH500-Luc': [1723], '(probasin-Luc),': [1724], '454-bp': [1728], 'Robert': [1736], 'Matusik,': [1738], 'Vanderbilt': [1739], 'University.': [1740, 1784], 'Mouse': [1741], '(MMTV)-Luc': [1745], 'Ronald': [1749], 'Evans,': [1751], 'Salk': [1753], 'Institute': [1754], 'Biological': [1756], 'Studies.': [1757], 'pSG5': [1759], 'expression': [1761, 1815, 3771], 'vector': [1762], 'Hinrich': [1768], 'Gronemeyer,': [1769], 'Louis': [1772], 'Pasteur,': [1773], 'Strasbourg,': [1774], 'France.': [1775], '5XGAL4Luc3': [1776], 'Donald': [1780], 'P.': [1781, 3591], 'McDonnell,': [1782], 'Duke': [1783], 'Monkey': [1785], 'kidney': [1786], 'CV1': [1787], 'cells': [1788, 1960, 2020, 2080, 2139, 4464], 'maintained': [1790, 1962], "Dulbecco's": [1792], 'modified': [1793], "Eagle's": [1794, 1964], 'medium': [1795, 1967], 'containing': [1796, 2029, 2062, 3916, 3962], '20': [1797], 'mm': [1798, 1805, 1928, 1934, 1978, 2143], 'Hepes,': [1799], 'pH': [1800, 1931], '7.2,': [1801], 'penicillin/streptomycin,': [1802], 'l-glutamine.': [1806], 'Cells': [1807, 1903, 1920, 1982, 2099], 'transfected': [1809, 1994, 2034], 'calcium': [1823], 'phosphate': [1824], 'precipitation': [1826], 'method': [1827, 2038], '50': [1852], 'ng': [1853, 1885], 'cotransfected': [1861], '5': [1863, 1895, 1900, 4251], 'μg': [1864, 1869, 1896, 1901, 1999, 2006, 2011], 'MMTV-Luc': [1866, 2584, 2637, 3497], 'pGCΔ9-Luc': [1871, 2586, 2639, 3330, 3387], 'per': [1872, 1996, 2041, 2097], '6-cm': [1873], 'dish': [1874], 'plated': [1875, 1984], 'day': [1877], 'before': [1878], 'at': [1879, 1988], '0.42': [1880], '×': [1881, 1990], '106': [1882, 1991], 'cells/dish.': [1883], '100': [1884, 1940], 'expressed': [1893, 2134], 'PSA61-Luc': [1898, 2946, 3297, 3422, 3471, 3649, 3764], 'probasin-Luc.': [1902], 'incubated': [1905, 2101, 2149], 'serum-free,': [1907], 'phenol': [1908, 2093], 'red-free': [1909], 'media': [1910, 2028, 2061, 2091], '40': [1912], 'h': [1913, 2104], 'without': [1916, 3486], 'harvested': [1922, 2123], '0.5': [1924, 2142], 'ml': [1925, 2025, 2088, 2126], '25': [1927, 2189], 'Tris': [1929], 'phosphate,': [1930], '7.8,': [1932], 'EDTA,': [1935], '1%': [1936], 'Triton': [1937], 'X-100,': [1938], 'μl': [1941, 2044, 2049, 2053, 2059], 'analyzed': [1943], 'automated': [1946], 'LumiStar': [1947], 'Galaxy': [1948], '(BMG': [1949], 'Labtechnologies)': [1950], 'multiwell': [1951], 'plate': [1952], 'reader': [1953], 'luminometer.': [1954], 'Human': [1955], 'epithelioid': [1956], 'cervical': [1957], 'carcinoma': [1958], 'HeLa': [1959, 4463], 'minimum': [1965], 'essential': [1966], '(Invitrogen)': [1968], 'supplemented': [1969], '10%': [1971, 2063], 'fetal': [1972], 'bovine': [1973], 'serum': [1974, 2030, 2064], '(Hyclone)': [1975], 'l-glutamine': [1979], 'penicillin/streptomycin.': [1981], '12-well': [1986], 'plates': [1987], '0.1': [1989, 2010], 'cells/well': [1992], 'well': [1997], '0.05': [1998], '0.15': [2005], 'GAL-peptide,': [2008], '5XGAL4Luc3.': [2013], 'After': [2014, 2077], 'plating': [2015], 'incubating': [2017], 'overnight,': [2018], 'placed': [2022], '0.8': [2024], 'fresh': [2027], 'additives': [2032], 'Effectine': [2037, 2055], '(Qiagen)': [2039], 'well:': [2042], '75': [2043], 'EC': [2046], 'buffer,': [2047], 'enhancer,': [2051], 'reagent,': [2056], '400': [2058], 'additives.': [2066], 'transfection': [2069], 'mix': [2070], 'typically': [2072], 'prepared': [2073, 3954], '4': [2075, 3778, 3991], 'wells/tube.': [2076], '24': [2078, 2103], 'h,': [2079], 'washed': [2082], 'phosphate-buffered': [2084], 'saline,': [2085], 'serum-free': [2090], 'lacking': [2092], 'red': [2094], 'added': [2096], 'well.': [2098], 'indicated': [2112], 'hormones': [2113], 'assayed': [2115], 'above': [2121, 3357], '0.22': [2125], 'lysis': [2128], 'buffer/well.': [2129], 'XL1-Blue': [2136], 'Escherichia': [2137], 'coli': [2138], 'treated': [2140], 'isopropyl': [2144], 'β-d-thiogalactopyranoside': [2145], 'extracted': [2147], 'glutathione-agarose': [2151], 'beads': [2152, 2216], '(Amersham': [2153], 'Biosciences)': [2154], 'translated': [2181], 'labeled': [2184], 'μCi': [2190], '[35S]methionine': [2192], '(PerkinElmer': [2193], 'Life': [2194], 'Sciences)': [2195], 'TnT': [2198], 'T7': [2199], 'Quick': [2200], 'Coupled': [2201], 'transcription/translation': [2202], 'system': [2203], '(Promega)': [2204], 'μm': [2212], '(DHT).': [2214], 'Washed': [2215], 'boiled': [2218], 'SDS': [2220], 'buffer': [2221], 'input': [2223], 'lanes': [2224, 3990, 4013, 4253], 'contained': [2225], '∼10%': [2226], 'reactions.': [2230], 'investigated': [2232, 2864, 3414, 3654], 'different': [2239], 'similar': [2244, 3343], 'Luciferase': [2255], 'tested': [2259, 4067], 'androgen-regulated': [2266], 'genes,': [2267], '(16Cleutjens': [2269], 'K.B.J.M.': [2270, 2299], 'van': [2271, 2274, 2300], 'Eekelen': [2272, 2305], 'C.C.E.M.': [2273], 'der': [2275, 2301], 'Korput': [2276, 2302], 'H.A.G.M.': [2277, 2303], 'Brinkmann': [2278], 'A.O.': [2279], 'Trapman': [2280, 2313], '1996;': [2285, 2401], '271:': [2286], '6379-6388Abstract': [2287], '(353)': [2295], '17Cleutjens': [2298], 'Ehren-van': [2304], 'C.C.': [2306], 'Sikes': [2307], 'R.A.': [2308], 'Fasciana': [2309], 'C.': [2310, 2349], 'Chung': [2311], '11:': [2318], '1256-1265Crossref': [2319], '(109)': [2322], '(18Rennie': [2326], 'P.S.': [2327], 'Bruchovsky': [2328], 'N.': [2329], 'Leco': [2330], 'K.J.': [2331], 'Sheppard': [2332], 'P.C.': [2333], 'McQueen': [2334], 'Snoek': [2338], 'Hamel': [2340], 'Bock': [2342], 'M.E.': [2343], 'MacDonald': [2344], 'Nickel': [2346], 'B.E.': [2347], 'Chang': [2348], 'Liao': [2350], 'Cattini': [2352], 'P.A.': [2353], 'Matusik': [2354], '7:': [2359], '23-36Crossref': [2360], '(215)': [2363], '(pGCΔ9)': [2368], '(19Loreni': [2369], 'F.': [2370, 3593, 3616], 'Stavenhagen': [2371], 'Kalff': [2373], 'Robins': [2375, 2396], '1988;': [2380, 2420], '8:': [2381], '2350-2360Crossref': [2382], '(38)': [2385], '20Scheller': [2388], 'Scheinman': [2390], 'R.I.': [2391], 'Thompson': [2392], 'Scarlett': [2394], 'C.O.': [2395], '121:': [2402], '75-86Crossref': [2403], '(22)': [2406], '(21Chalepakis': [2411], 'Postma': [2413], 'J.P.M.': [2414], 'Beato': [2415], 'Nucleic': [2417], 'Acids': [2418], 'Res.': [2419], '16:': [2421], '10237-10247Crossref': [2422], '(28)': [2425], '22Gunzburg': [2428], 'W.H.': [2429], 'Salmons': [2430], 'Biochem.': [2432], '1992;': [2434], '283:': [2435], '625-632Crossref': [2436], '(77)': [2439], '23Cordingley': [2442], 'Riegel': [2444], 'A.T.': [2445], 'Hager': [2446], '1987;': [2449], '48:': [2450], '261-270Abstract': [2451], '(313)': [2457], 'role': [2461, 2727, 2923, 3641], 'effects': [2469, 3407], 'coactivation': [2472, 3034, 3093, 3506, 3545, 3774, 3787, 3826], 'determined': [2477], '(AR-FXXLF/WXXLF)': [2481], 'FXXAA,': [2490], 'AXXAA,': [2495], 'both': [2497, 2644, 3000, 3026, 3725], 'protein.': [2504], '(Fig.': [2514, 2523, 2556, 2594, 2621, 2640, 2663, 3124, 3274, 3314, 3350, 3777, 4250], 'A)': [2516, 3126, 3264, 3424], 'pGCΔ9': [2519, 2673, 2685, 3278], 'promoters': [2522], 'B)': [2525, 3276], '2–3-fold': [2528], 'coexpression.': [2531, 2955, 3018, 3488], 'Mutation': [2532, 4360], '(AR-FXXAA/WXXLF)': [2537], 'decreased': [2538, 2648], 'low': [2540], 'levels': [2541, 2908, 3970], 'reporters': [2549, 3267, 3280, 3331, 3498], 'coexpression': [2555, 2566, 2593, 2620, 2660, 2918], 'A).': [2558, 2623, 3316, 3474], 'This': [2559], 'decrease': [2560, 2736, 3759, 4078], 'recovered': [2564, 2813], 'TIF2.': [2568, 2979, 3110, 3541, 3789], 'contrast,': [2570, 2625, 3336], 'mutation': [2571, 2598, 2626, 2768, 3995, 4415], 'had': [2576, 2629, 3800], 'no': [2577, 4318, 4322], 'major': [2578], 'effect': [2579, 2632, 2670, 2804, 2868, 3009, 3024, 3844], 'B).': [2596, 2642, 3352, 3779], 'Surprisingly,': [2597], 'alone': [2603, 2723, 2773, 2960, 3123], '(AR-FXXLF/AXXAA)': [2604], 'enhancer/promoters,': [2613, 2655, 2688], 'little': [2631, 2669], 'Mutating': [2643], '(AR-FXXAA/AXXAA)': [2647], 'rescued': [2658], 'A),': [2665], 'again': [2666], 'promoters.': [2676], 'results': [2678, 2754, 2818, 2982, 3237, 3354, 3490, 3822, 3873, 4018], 'contrast': [2682, 3442], 'androgen.': [2715], 'increase': [2717, 2975, 3075, 3107, 3134, 3417, 4303, 4325], 'mutating': [2721, 2881], 'suggests': [2724, 3390], 'inhibitory': [2726, 2867, 3008, 3023], 'this': [2729], 'activity,': [2733], 'FXXAA': [2741], 'FXXAA/AXXAA': [2743], 'mutants': [2744, 3468, 4072], 'indicates': [2745, 3059], 'strong': [2747], 'agreement': [2757], 'primarily': [2762], 'mediating': [2763], 'abolish': [2776], 'detrimental': [2803], 'losing': [2808], 'overexpression.': [2816], 'support': [2819, 3355], 'insensitivity': [2824], 'syndrome': [2825], '(9Langley': [2827], 'critical': [2854, 3671], 'genes': [2860], 'vivo.': [2862], '142–337': [2898], 'deleted.': [2900], 'Deletion': [2901], 'resulted': [2904], 'nearly': [2906], 'background': [2907], '(Fig.2),': [2919], 'indicating': [2920], 'important': [2922], 'Introducing': [2929], '(AR-FXXAAΔ142–337)': [2934], 'plus': [2937], '(AR-FXXAA/AXXAAΔ142–337)': [2940], 'When': [2956], 'mutated': [2962, 3311], 'deletion': [2966, 3149], '(AR-FXXLF/AXXAAΔ142–337,': [2968], 'Fig.2),': [2969], 'there': [2970], 'only': [2972], 'small': [2974, 3007], 'Essentially': [2980], 'identical': [2981], 'obtained': [2984], 'probasin-Luc': [2987, 3328, 3426], '(data': [2989, 3268, 3281, 3332, 3499], 'shown).': [2991, 3334, 3501], 'conclude': [2993], 'AF1,': [2999], 'There': [3019], 'synergistic': [3022], 'possibly': [3028], 'reflecting': [3029], 'inhibition': [3030], 'endogenous': [3032, 3540], 'level': [3044], 'TIF2-stimulated': [3046, 3074], 'observed': [3049, 3118, 3325, 3492], 'more': [3062, 4410], 'effectively': [3063, 3106], 'WXXLF.': [3072], 'provides': [3083], 'inhibiting': [3092], 'even': [3096], 'though': [3097], 'itself': [3103], 'did': [3104, 3300, 3757], 'Enhancement': [3111], 'appeared': [3127], 'depend': [3129, 3369], 'because': [3132], 'apparent': [3139], 'when': [3140, 3798], 'combined': [3145], 'mutant.': [3150], 'To': [3151, 4441], 'evaluate': [3152], 'regionversus': [3166], 'promoter,': [3169], 'chimera': [3178], 'artificial': [3183], 'introduced': [3187, 4235], 'dexamethasone': [3227], '5-fold': [3240], 'slower': [3241], 'dissociation': [3242], 'half-time': [3243], '[3H]dexamethasone': [3245], 'GR.': [3249], '10': [3256, 4478], 'nm': [3257], 'dexamethasone,': [3258], 'stimulated': [3260, 3795], '(Fig.3': [3263], 'shown),': [3270, 3283], 'weakest': [3286], 'pGCΔ9.': [3289], 'caused': [3291], 'ligand-induced': [3293], 'GR,': [3301], 'GR(LXXAA)3': [3303], 'LXXAA': [3313], 'Similar': [3317, 3489], 'increases': [3318], 'MMTV-luciferase': [3340], 'chimeras': [3349], 'observations': [3356], 'optimal': [3376], 'enhancer/promoter.': [3382], 'shares': [3393], 'some': [3394, 3924], 'properties': [3395], 'elements': [3401], 'sensitive': [3404], 'next': [3413], '(Fig.4': [3423, 3473], 'TIF2,': [3444], 'TIF2m123,': [3445], 'LXXAA,': [3457], 'unable': [3459], 'coactivate': [3461], 'TIF2m123': [3480, 3528, 3547], 'control': [3485, 4260], 'suggest': [3504], 'each': [3510, 4242], 'enhance/promoters': [3513], 'acts': [3529], 'limited': [3532], 'extent': [3533], 'dominant': [3536], 'negative': [3537], 'lack': [3543], 'suggests,': [3548], '30Alen': [3590], 'Claessens': [3592, 3615], 'Verhoeven': [3594], 'Rombauts': [3596], 'W.': [3597], 'Peeters': [3598], '19:': [3604, 3625], '6085-6097Crossref': [3605], '(217)': [3608], '31Bevan': [3611], 'C.L.': [3612], 'Heery': [3617], '8383-8392Crossref': [3626], '(334)': [3629], 'sufficient': [3634], 'A': [3639], 'mutants.': [3659], 'Lysine': [3660], '720': [3661], 'helix': [3663, 3715], 'binding,': [3677], 'Glutamic': [3711], 'acid': [3712, 3912], '897': [3713], 'AR-FXXLF/WXXLF-K720A': [3756], 'blocked': [3773, 3786], 'AR-FXXLF/WXXLF-E897K': [3780], 'reduced': [3781, 4243], 'inherent': [3782], 'Furthermore,': [3790], 'either': [3801], 'interrupted': [3812], 'AF2.': [3832], 'Previously': [3833], 'used': [3835, 4454], 'assay': [3840, 4459], 'determine': [3842], 'AF2,': [3871, 4452], 'inconclusive': [3879], 'Extensive': [3902], '233-amino': [3911], 'AR·GST': [3913], 'raised': [3920], 'possibility': [3922], 'nonspecific': [3929], 'therefore': [3953], 'bound': [3967], '3-fold': [3968], 'higher': [3969], '35S-labeled': [3972, 4238], '624–919': [3978], 'DHT': [3987], '(Fig.5': [3988, 4011], 'A,': [3989, 4012, 4252], 'and5).': [3992], 'LF': [3998], 'AA': [4000], 'GST·AR-(412–460)WXXAA': [4006], 'eliminated': [4007, 4245], '6': [4014], '7).': [4016], 'manner.': [4033, 4440], 'predicted': [4035], 'α-helical': [4037], 'its': [4048], 'suggested': [4055], 'surface.': [4065, 4349], 'eliminate': [4080], '(4Nolte': [4085], '14He': [4206], 'E897K,': [4231, 4276], 'V716R': [4232, 4332], 'K720A': [4234, 4279, 4334], '9–22).': [4254], 'Signal': [4255], 'intensity': [4256], '2-,': [4267], '3-,': [4268], '4.5-fold': [4270], 'mutants,': [4280], 'respectively,': [4281], 'based': [4287], 'optical': [4289], 'scanning': [4290], 'film.': [4293], '2-fold': [4302], 'relative': [4315], 'control,': [4320], 'dependent': [4324], 'detectable': [4329], 'Residues': [4338], 'Glu-897,': [4339], 'Val-716,': [4340], 'Lys-720': [4342], 'part': [4344], 'Val-716': [4351], 'side': [4352], 'chain': [4353], 'cleft.': [4359], 'arginine': [4362], '(V716R)': [4363], 'disrupts': [4364], 'and,': [4369], 'disruptive': [4411], 'Glu-897': [4414], 'substantiate': [4443]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2036441940', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-14T01:20:11.953811', 'created_date': '2016-06-24'}
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