Title: 4‐Hydroxyalk‐2‐enals are substrates for glutathione transferase
Abstract: The 4‐hydroxyalk‐2‐enals are established products of lipid peroxidation that are conjugated with intracellular glutathione. Cytosolic glutathione transferases from rat liver were shown to give high specific activities with 4‐hydroxynonenal and 4‐hydroxydecenal. The isoenzyme giving the highest specific activity was glutathione transferase 4‐4. The rate of the spontaneous conjugation reaction is negligible in comparison with the rate calculated for the cellular concentration of the glutathione transferases. It is proposed that a major biological function of the glutathione transferases is to protect the cell against products of oxidative metabolism, such as epoxides, organic hydroperoxides, and 4‐hydroxyalkenals.
Publication Year: 1985
Publication Date: 1985-01-07
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 422
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