Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2036101653', 'doi': 'https://doi.org/10.1002/pros.10261', 'title': 'Stable expression of full length human androgen receptor in PC‐3 prostate cancer cells enhances sensitivity to retinoic acid but not to 1α,25‐dihydroxyvitamin D<sub>3</sub>', 'display_name': 'Stable expression of full length human androgen receptor in PC‐3 prostate cancer cells enhances sensitivity to retinoic acid but not to 1α,25‐dihydroxyvitamin D<sub>3</sub>', 'publication_year': 2003, 'publication_date': '2003-07-01', 'ids': {'openalex': 'https://openalex.org/W2036101653', 'doi': 'https://doi.org/10.1002/pros.10261', 'mag': '2036101653', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12858358'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/pros.10261', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S197000376', 'display_name': 'The Prostate', 'issn_l': '0270-4137', 'issn': ['0270-4137', '1097-0045'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5090023762', 'display_name': 'Shalini Murthy', 'orcid': 'https://orcid.org/0000-0001-5517-9894'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shalini Murthy', 'raw_affiliation_strings': ['Departments of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016728412', 'display_name': 'Marco Marcelli', 'orcid': 'https://orcid.org/0000-0003-3935-4116'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Marco Marcelli', 'raw_affiliation_strings': ['Department of Medicine, Baylor College of Medicine, and VA Medical Center, Houston, Texas', 'Departments of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas', 'institution_ids': ['https://openalex.org/I181547552']}, {'raw_affiliation_string': 'Department of Medicine, Baylor College of Medicine, and VA Medical Center, Houston, Texas', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5061725261', 'display_name': 'Nancy L. Weigel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Nancy L. Weigel', 'raw_affiliation_strings': ['Departments of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas', 'institution_ids': ['https://openalex.org/I181547552']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5061725261'], 'corresponding_institution_ids': ['https://openalex.org/I181547552'], 'apc_list': {'value': 4380, 'currency': 'USD', 'value_usd': 4380, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.755, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.736156, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 82, 'max': 83}, 'biblio': {'volume': '56', 'issue': '4', 'first_page': '293', 'last_page': '304'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/growth-inhibition', 'display_name': 'Growth inhibition', 'score': 0.5097961}], 'concepts': [{'id': 'https://openalex.org/C2779723316', 'wikidata': 'https://www.wikidata.org/wiki/Q6459234', 'display_name': 'LNCaP', 'level': 4, 'score': 0.9085357}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.824538}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.6789266}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.661523}, {'id': 'https://openalex.org/C2781121885', 'wikidata': 'https://www.wikidata.org/wiki/Q425517', 'display_name': 'Retinoic acid', 'level': 3, 'score': 0.617591}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6092708}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.539283}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.5298854}, {'id': 'https://openalex.org/C2779707156', 'wikidata': 'https://www.wikidata.org/wiki/Q5611758', 'display_name': 'Growth inhibition', 'level': 3, 'score': 0.5097961}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5075201}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.4871099}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.48272845}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.4495923}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.43285453}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.42841485}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.42196628}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.2646424}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.25956017}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.13309082}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.08145848}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D014212', 'descriptor_name': 'Tretinoin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D014807', 'descriptor_name': 'Vitamin D', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D014807', 'descriptor_name': 'Vitamin D', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014212', 'descriptor_name': 'Tretinoin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014807', 'descriptor_name': 'Vitamin D', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/pros.10261', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S197000376', 'display_name': 'The Prostate', 'issn_l': '0270-4137', 'issn': ['0270-4137', '1097-0045'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12858358', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.74, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1487662609', 'https://openalex.org/W1533310838', 'https://openalex.org/W1582290662', 'https://openalex.org/W1601641038', 'https://openalex.org/W1604588411', 'https://openalex.org/W1966841156', 'https://openalex.org/W1967932707', 'https://openalex.org/W1968180643', 'https://openalex.org/W1972422162', 'https://openalex.org/W1973392312', 'https://openalex.org/W1986527803', 'https://openalex.org/W1988458537', 'https://openalex.org/W1988679331', 'https://openalex.org/W2013850508', 'https://openalex.org/W2016930558', 'https://openalex.org/W2020772481', 'https://openalex.org/W2041320158', 'https://openalex.org/W2042808371', 'https://openalex.org/W2061787180', 'https://openalex.org/W2065760788', 'https://openalex.org/W2066570340', 'https://openalex.org/W2071429904', 'https://openalex.org/W2077345661', 'https://openalex.org/W2095612244', 'https://openalex.org/W2099136937', 'https://openalex.org/W2099438166', 'https://openalex.org/W2101305429', 'https://openalex.org/W2103668415', 'https://openalex.org/W2107204091', 'https://openalex.org/W2109000648', 'https://openalex.org/W2118929543', 'https://openalex.org/W2139786881', 'https://openalex.org/W2141466699', 'https://openalex.org/W2147868370', 'https://openalex.org/W2148141122', 'https://openalex.org/W2150650070', 'https://openalex.org/W2151275516', 'https://openalex.org/W2155800082', 'https://openalex.org/W2157723631', 'https://openalex.org/W2409583397', 'https://openalex.org/W4242916091', 'https://openalex.org/W4253451087'], 'related_works': ['https://openalex.org/W2909034820', 'https://openalex.org/W2356769105', 'https://openalex.org/W2347235584', 'https://openalex.org/W2166399562', 'https://openalex.org/W2110155536', 'https://openalex.org/W2095873383', 'https://openalex.org/W2093382902', 'https://openalex.org/W2076586151', 'https://openalex.org/W2063882679', 'https://openalex.org/W2005564231'], 'abstract_inverted_index': {'Abstract': [0], 'BACKGROUND': [1], 'PC‐3': [2, 51, 69, 77, 115, 148, 168], 'prostate': [3, 30, 193], 'cancer': [4, 31, 194], 'cell': [5, 203], 'growth': [6, 41, 124, 159, 195], 'is': [7], 'inhibited': [8], 'by': [9, 46, 126, 197], '1α,25‐dihydroxyvitamin': [10], 'D': [11, 48, 73, 128, 154, 184, 199], '3': [12], '(1,25': [13], 'D)': [14], 'and': [15, 49, 74, 109, 121, 155, 165], 'retinoids,': [16, 107, 141], 'but': [17, 123], 'not': [18, 54, 130], 'to': [19, 71, 96, 101, 104, 119, 137, 145, 174, 182, 201], 'the': [20, 24, 66, 146, 180, 188], 'same': [21], 'extent': [22], 'as': [23], 'androgen': [25], 'receptor': [26], '(AR)': [27], 'positive': [28], 'LNCaP': [29, 44, 97], 'cells.': [32], 'Previous': [33], 'reports': [34], 'suggest': [35], 'a': [36], 'role': [37], 'for': [38], 'AR': [39, 63, 86, 91, 112, 163, 191], 'in': [40, 114, 143, 167, 171, 192], 'inhibition': [42, 125, 196], 'of': [43, 62, 68, 140, 152, 177, 190], 'cells': [45, 52, 70, 78, 89, 98, 116, 134, 169], '1,25': [47, 72, 105, 127, 153, 183, 198], 'retinoids.': [50, 75], 'do': [53], 'express': [55], 'AR.': [56], 'We': [57], 'therefore': [58], 'asked': [59], 'whether': [60], 're‐expression': [61, 113], 'would': [64], 'enhance': [65], 'response': [67, 103, 118, 181], 'METHODS': [76], 'were': [79, 99, 135], 'stably': [80], 'transfected': [81], 'with': [82], 'wild': [83], 'type': [84], 'human': [85], 'cDNA.': [87], 'Pooled': [88], 'expressing': [90], 'protein': [92], 'at': [93], 'levels': [94, 139, 151, 176], 'comparable': [95], 'used': [100], 'analyze': [102], 'D,': [106], 'androgens,': [108], 'anti‐androgens.': [110], 'RESULTS': [111], 'restored': [117], 'androgens': [120], 'anti‐androgens,': [122], 'was': [129], 'significantly': [131], 'altered.': [132], 'However,': [133], 'sensitized': [136], 'low': [138, 175], 'and,': [142], 'contrast': [144], 'parental': [147], 'cells,': [149], 'sub‐optimal': [150], 'retinoids': [156, 178], 'caused': [157], 'additive': [158], 'inhibition.': [160], 'CONCLUSIONS': [161], 'Restoring': [162], 'expression': [164], 'activity': [166], 'results': [170], 'enhanced': [172], 'sensitivity': [173], 'while': [179], 'remains': [185], 'unaltered.': [186], 'Thus,': [187], 'involvement': [189], 'appears': [200], 'be': [202], 'line': [204], 'specific.': [205], 'Prostate': [206], '56:': [207], '293–304,': [208], '2003.': [209], '©': [210], '2003': [211], 'Wiley‐Liss,': [212], 'Inc.': [213]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2036101653', 'counts_by_year': [{'year': 2021, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-17T15:59:47.953366', 'created_date': '2016-06-24'}