Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2035813221', 'doi': 'https://doi.org/10.7326/0003-4819-105-1-27', 'title': 'Iron Therapy for Hepatic Dysfunction in Erythropoietic Protoporphyria', 'display_name': 'Iron Therapy for Hepatic Dysfunction in Erythropoietic Protoporphyria', 'publication_year': 1986, 'publication_date': '1986-07-01', 'ids': {'openalex': 'https://openalex.org/W2035813221', 'doi': 'https://doi.org/10.7326/0003-4819-105-1-27', 'mag': '2035813221', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/3717807'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-105-1-27', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5012936630', 'display_name': 'Victor R. Gordeuk', 'orcid': 'https://orcid.org/0000-0003-4725-7295'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Victor R. Gordeuk', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002756352', 'display_name': 'Gary M. Brittenham', 'orcid': 'https://orcid.org/0000-0002-5667-7446'}, 'institutions': [{'id': 'https://openalex.org/I4210157264', 'display_name': 'MetroHealth Medical Center', 'ror': 'https://ror.org/05j4p5w63', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1299218025', 'https://openalex.org/I4210157264']}, {'id': 'https://openalex.org/I1299218025', 'display_name': 'MetroHealth', 'ror': 'https://ror.org/0377srw41', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1299218025']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gary M. Brittenham', 'raw_affiliation_strings': ['MetroHealth Medical Center Cleveland'], 'affiliations': [{'raw_affiliation_string': 'MetroHealth Medical Center Cleveland', 'institution_ids': ['https://openalex.org/I4210157264', 'https://openalex.org/I1299218025']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070900276', 'display_name': 'Curtis W. Hawkins', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1299218025', 'display_name': 'MetroHealth', 'ror': 'https://ror.org/0377srw41', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1299218025']}, {'id': 'https://openalex.org/I4210157264', 'display_name': 'MetroHealth Medical Center', 'ror': 'https://ror.org/05j4p5w63', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1299218025', 'https://openalex.org/I4210157264']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Curtis W. Hawkins', 'raw_affiliation_strings': ['MetroHealth Medical Center Cleveland'], 'affiliations': [{'raw_affiliation_string': 'MetroHealth Medical Center Cleveland', 'institution_ids': ['https://openalex.org/I1299218025', 'https://openalex.org/I4210157264']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082425428', 'display_name': 'Hasan Mukhtar', 'orcid': 'https://orcid.org/0000-0002-5358-077X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hasan Mukhtar', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109978711', 'display_name': 'David R. Bickers', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'David R. Bickers', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.544, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 62, 'citation_normalized_percentile': {'value': 0.935865, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '105', 'issue': '1', 'first_page': '27', 'last_page': '27'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12441', 'display_name': 'Porphyrin Metabolism and Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12441', 'display_name': 'Porphyrin Metabolism and Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11848', 'display_name': 'Heme Oxygenase-1 and Carbon Monoxide', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12068', 'display_name': 'Neonatal Health and Biochemistry', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/erythropoietic-protoporphyria', 'display_name': 'Erythropoietic protoporphyria', 'score': 0.9976462}, {'id': 'https://openalex.org/keywords/ferrochelatase', 'display_name': 'Ferrochelatase', 'score': 0.9129764}, {'id': 'https://openalex.org/keywords/liver-function', 'display_name': 'Liver function', 'score': 0.553336}], 'concepts': [{'id': 'https://openalex.org/C2777799353', 'wikidata': 'https://www.wikidata.org/wiki/Q1759600', 'display_name': 'Erythropoietic protoporphyria', 'level': 4, 'score': 0.9976462}, {'id': 'https://openalex.org/C2781149050', 'wikidata': 'https://www.wikidata.org/wiki/Q408712', 'display_name': 'Ferrochelatase', 'level': 4, 'score': 0.9129764}, {'id': 'https://openalex.org/C2778417259', 'wikidata': 'https://www.wikidata.org/wiki/Q619815', 'display_name': 'Protoporphyrin', 'level': 3, 'score': 0.8929161}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8890406}, {'id': 'https://openalex.org/C2992208098', 'wikidata': 'https://www.wikidata.org/wiki/Q1359801', 'display_name': 'Liver function', 'level': 2, 'score': 0.553336}, {'id': 'https://openalex.org/C81182388', 'wikidata': 'https://www.wikidata.org/wiki/Q353963', 'display_name': 'Complication', 'level': 2, 'score': 0.53636837}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5179443}, {'id': 'https://openalex.org/C512861765', 'wikidata': 'https://www.wikidata.org/wiki/Q1359801', 'display_name': 'Liver function tests', 'level': 2, 'score': 0.48206598}, {'id': 'https://openalex.org/C2994427840', 'wikidata': 'https://www.wikidata.org/wiki/Q970208', 'display_name': 'Liver failure', 'level': 2, 'score': 0.4349129}, {'id': 'https://openalex.org/C2777940757', 'wikidata': 'https://www.wikidata.org/wiki/Q271759', 'display_name': 'Porphyria', 'level': 2, 'score': 0.43034115}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.39404222}, {'id': 'https://openalex.org/C2776217839', 'wikidata': 'https://www.wikidata.org/wiki/Q189621', 'display_name': 'Heme', 'level': 3, 'score': 0.20674556}, {'id': 'https://openalex.org/C2779480358', 'wikidata': 'https://www.wikidata.org/wiki/Q422926', 'display_name': 'Porphyrin', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C75473681', 'wikidata': 'https://www.wikidata.org/wiki/Q188651', 'display_name': 'Photochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D007501', 'descriptor_name': 'Iron', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D008107', 'descriptor_name': 'Liver Diseases', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D009942', 'descriptor_name': 'Organometallic Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011164', 'descriptor_name': 'Porphyrias', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011166', 'descriptor_name': 'Porphyrins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011524', 'descriptor_name': 'Protoporphyrins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000284', 'descriptor_name': 'Administration, Oral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001219', 'descriptor_name': 'Aspartate Aminotransferases', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D001219', 'descriptor_name': 'Aspartate Aminotransferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004912', 'descriptor_name': 'Erythrocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004912', 'descriptor_name': 'Erythrocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005243', 'descriptor_name': 'Feces', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D005243', 'descriptor_name': 'Feces', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007501', 'descriptor_name': 'Iron', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D007501', 'descriptor_name': 'Iron', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054354', 'descriptor_name': 'Iron Carbonyl Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008107', 'descriptor_name': 'Liver Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008107', 'descriptor_name': 'Liver Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010787', 'descriptor_name': 'Photosensitivity Disorders', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011164', 'descriptor_name': 'Porphyrias', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011164', 'descriptor_name': 'Porphyrias', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011166', 'descriptor_name': 'Porphyrins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011524', 'descriptor_name': 'Protoporphyrins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-105-1-27', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/3717807', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.85, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1237293541', 'https://openalex.org/W1501090807', 'https://openalex.org/W1570707323', 'https://openalex.org/W1748793784', 'https://openalex.org/W1789041324', 'https://openalex.org/W1871045070', 'https://openalex.org/W1965320807', 'https://openalex.org/W1969758562', 'https://openalex.org/W1975920167', 'https://openalex.org/W1979455454', 'https://openalex.org/W1998006032', 'https://openalex.org/W2011040876', 'https://openalex.org/W2013716666', 'https://openalex.org/W2015264078', 'https://openalex.org/W2018303555', 'https://openalex.org/W2034611202', 'https://openalex.org/W2052687231', 'https://openalex.org/W2064224634', 'https://openalex.org/W2085194862', 'https://openalex.org/W2088575848', 'https://openalex.org/W2089053268', 'https://openalex.org/W2092444098', 'https://openalex.org/W2105275899', 'https://openalex.org/W2154227460', 'https://openalex.org/W2166660261', 'https://openalex.org/W2254790242', 'https://openalex.org/W2315107359', 'https://openalex.org/W2333643126', 'https://openalex.org/W2346944892', 'https://openalex.org/W2410527906', 'https://openalex.org/W2418317692'], 'related_works': ['https://openalex.org/W2978532957', 'https://openalex.org/W2954201585', 'https://openalex.org/W2914116548', 'https://openalex.org/W2353631980', 'https://openalex.org/W2156945629', 'https://openalex.org/W2050297680', 'https://openalex.org/W2044935454', 'https://openalex.org/W2035813221', 'https://openalex.org/W1975440986', 'https://openalex.org/W1975088301'], 'abstract_inverted_index': {'Erythropoietic': [0], 'protoporphyria,': [1], 'caused': [2], 'by': [3], 'an': [4], 'inherited': [5], 'deficiency': [6], 'of': [7, 52, 61, 84], 'ferrochelatase,': [8], 'results': [9, 60], 'in': [10, 15, 27, 32, 65, 75, 100], 'increased': [11], 'free': [12, 76], 'protoporphyrin': [13, 30, 80], 'concentrations': [14], 'erythrocytes': [16], 'and': [17, 58, 78], 'plasma.': [18], 'Cutaneous': [19], 'photosensitivity': [20], 'is': [21], 'the': [22, 33, 50], 'primary': [23], 'clinical': [24], 'manifestation,': [25], 'but': [26], 'some': [28], 'patients,': [29], 'accumulation': [31], 'liver': [34, 62, 85], 'may': [35], 'lead': [36], 'to': [37, 71, 87], 'fatal': [38, 97], 'hepatic': [39, 98], 'failure.': [40], 'No': [41], 'treatment': [42], 'exists': [43], 'for': [44, 94], 'this': [45], 'lethal': [46], 'complication.': [47], 'We': [48], 'report': [49], 'case': [51], 'a': [53, 72], 'patient': [54], 'with': [55, 82, 102], 'erythropoietic': [56, 103], 'protoporphyria': [57], 'abnormal': [59], 'function': [63, 86], 'tests': [64], 'whom': [66], 'oral': [67], 'iron': [68], 'therapy': [69, 90], 'led': [70], 'substantial': [73], 'decrease': [74], 'erythrocyte': [77], 'stool': [79], 'levels': [81], 'return': [83], 'normal.': [88], 'Iron': [89], 'should': [91], 'be': [92], 'considered': [93], 'preventing': [95], 'potentially': [96], 'failure': [99], 'patients': [101], 'protoporphyria.': [104]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2035813221', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-12-14T01:23:15.187825', 'created_date': '2016-06-24'}