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[656], 'Consistent': [657], 'some,': [659], 'but': [660], 'not': [661, 741, 751, 806, 834, 1059, 1081], 'all,': [662], 'based': [665], 'excised': [668], 'analysis': [670, 1855], '15),': [673], 'suggest': [676], 'early': [678, 1043], 'course': [681, 723], 'acute': [683, 1148, 1153, 1264, 1503, 1813, 1865, 2036, 2130], 'injury,': [685, 784, 1080], 'make': [690], 'contributions': [692], 'Perhaps': [695], 'importantly,': [697], 'demonstrate': [700], 'utility': [702], 'used': [711, 749, 1035], 'visualize,': [713], 'vivo,': [715], 'spatial': [717], 'progression': [720], 'inflammation.Of': [722], 'there': [724], 'remaining': [727, 1109], 'questions.': [728], 'revealed': [742], 'study,': [745], 'since': [746], 'do': [750], 'adequate': [753], 'temporal': [754, 1683, 2192], 'resolution': [755], 'assess': [757], '(4).': [760], 'Another': [761], 'key': [762], 'question': [763, 814], 'dependent:': [770], 'different': [771, 774, 779, 786, 792], 'models,': [773], 'degrees': [775], 'severity,': [778], 'time': [780], 'courses': [781], 'will': [789], 'likely': [790], 'give': [791], 'results,': [793], 'so': [795], 'known': [798], 'topics': [801], 'differences': [804, 916], 'predictable.': [808], 'Probably': [809], 'pressing': [812], 'unanswered': [813], 'relative': [817], 'severe': [820], 'even': [823], 'was': [833, 873, 882, 927, 1058, 1073], 'specifically': [835, 1075], 'designed': [836, 1074], 'address': [838], 'question,': [840], 'instead': [841], 'focusing': [842], 'definitive': [845], 'easy': [864], 'summarily': [866], 'dismiss': [867], 'overdistention.': [871], 'cmH2O': [877], '17': [883, 958], 'ml/kg,': [884, 959], 'ranges': [885], 'previously': [886, 1063], 'shown': [887], 'noninjurious': [893], 'after': [894, 1309, 1689], '2': [895], 'h': [896], 'normal': [900, 924, 972, 1009, 1065, 1576], 'sheep': [901], 'lungs': [902, 980, 1010], '(6).': [903], 'Closer': [904], 'inspection,': [905], 'reveals': [907], 'single': [911], 'model,': [914], 'compliance': [919], 'resulted': [920], 'nonlavaged': [923], 'operating': [928], 'much': [931, 948], 'larger': [932, 949, 993], 'mean': [933], 'than': [935], 'left': [937], '(quite': [939], 'obvious': [940], 'Fig.': [942], '1)': [943], 'volume.': [951], 'At': [952], 'divided': [960], '77%': [961], 'into': [962], 'right': [964, 994, 1056], 'effective': [967], '26': [976], 'ml/kg': [977], 'if': [978], 'symmetric': [982], 'anatomic': [984], 'size,': [985], 'slightly': [986], 'less': [987], 'when': [988], 'accounting': [989], 'usually': [992], 'This': [996], 'entering': [998], 'range': [1000], 'thresholds': [1002], 'reported': [1003, 1064], 'induce': [1005, 2088], 'animals': [1013], '(2,': [1014], '9,': [1015], '13,': [1016], '16)': [1017], '(excluding': [1018], 'rodents,': [1019], 'susceptible': [1023], 'lower': [1028, 1138], 'volumes).': [1030], 'Given': [1031], 'sensitive': [1039], 'small': [1041], 'changes': [1044], 'inflammation,': [1046], 'remarkable': [1049], '18F-FDG': [1052], 'elevated': [1060], 'levels.The': [1066], 'fact': [1067], 'remains,': [1068], 'look': [1077], 'compare': [1083], 'mechanisms.': [1088], 'As': [1089], 'applied': [1094], 'further': [1096], 'future,': [1100], 'our': [1101], 'community': [1102], 'looks': [1103], 'forward': [1104], 'answers': [1106], 'questions': [1110], 'impact': [1112], 'management.DISCLOSURESConflict': [1115], 'interest': [1117], 'statement:': [1118], 'No': [1119], 'conflicts': [1120], 'interest,': [1122], 'financial': [1123], 'otherwise,': [1125], 'declared': [1127], 'authors.REFERENCES1.': [1130], 'Acute': [1131, 2110], 'Respiratory': [1132, 2111], 'Distress': [1133, 2112], 'Syndrome': [1134, 2113], 'Network.': [1135], 'Ventilation': [1136], 'traditional': [1144], 'respiratory': [1154, 1265, 1298, 1504, 1814, 2037, 2131], 'distress': [1155, 1266, 1505, 1815, 2038, 2132], 'syndrome.': [1156, 1267, 1816], 'N': [1157, 1268, 1412, 1555, 1970], 'Engl': [1158, 1269], 'J': [1159, 1206, 1270, 1313, 1433, 1450, 1469, 1508, 1591, 1607, 1640, 1665, 1692, 1764, 1817, 1869, 1928, 1947, 1998, 2012], 'Med': [1160, 1271, 1317, 1355, 1473, 1512, 1581, 1644, 1768, 1819, 1907, 2002, 2046], '342:': [1161], '1301–1308,': [1162], '2000.Crossref': [1163, 1358], '|': [1164, 1166, 1168, 1215, 1217, 1275, 1277, 1279, 1321, 1323, 1359, 1361, 1405, 1407, 1454, 1477, 1479, 1481, 1516, 1518, 1585, 1587, 1613, 1615, 1648, 1650, 1652, 1698, 1700, 1772, 1774, 1776, 1824, 1826, 1828, 1878, 1880, 1911, 1913, 1915, 1953, 1955, 1957, 2006, 2008, 2050, 2052, 2054, 2095, 2136, 2157, 2220], 'PubMed': [1165, 1276, 1478, 1649, 1773, 1825, 1912, 1954, 2051], 'ISI': [1167, 1216, 1278, 1322, 1360, 1406, 1480, 1517, 1586, 1614, 1651, 1699, 1775, 1827, 1879, 1914, 1956, 2007, 2053], 'Google': [1169, 1218, 1280, 1324, 1362, 1408, 1455, 1482, 1519, 1588, 1616, 1653, 1701, 1777, 1829, 1881, 1916, 1958, 2009, 2055], 'Scholar2.': [1170], 'Altemeier': [1171, 1886], 'WA': [1172, 1887], ',': [1173, 1176, 1179, 1182, 1185, 1188, 1222, 1225, 1228, 1231, 1234, 1237, 1240, 1243, 1246, 1249, 1252, 1284, 1287, 1290, 1293, 1328, 1331, 1334, 1337, 1340, 1366, 1369, 1372, 1375, 1378, 1381, 1384, 1413, 1416, 1419, 1422, 1425, 1428, 1431, 1434, 1459, 1486, 1489, 1492, 1523, 1526, 1529, 1532, 1535, 1538, 1541, 1544, 1547, 1550, 1553, 1556, 1559, 1562, 1565, 1592, 1595, 1620, 1623, 1626, 1657, 1660, 1663, 1666, 1669, 1672, 1675, 1678, 1705, 1708, 1711, 1714, 1717, 1720, 1723, 1726, 1729, 1732, 1735, 1738, 1741, 1744, 1747, 1750, 1781, 1784, 1787, 1791, 1794, 1797, 1800, 1833, 1836, 1839, 1842, 1845, 1848, 1851, 1885, 1888, 1891, 1920, 1923, 1926, 1929, 1962, 1965, 1968, 1971, 1974, 1977, 1980, 1983, 1986, 2013, 2016, 2019], 'Matute-Bello': [1174, 1889], 'G': [1175, 1236, 1368, 1421, 1728, 1890], 'Frevert': [1177, 1676], 'CW': [1178, 1677], 'Kawata': [1180], 'Y': [1181, 1549], 'Kajikawa': [1183, 1661], 'O': [1184, 1662, 1734], 'Martin': [1186], 'TR': [1187], 'Glenny': [1189], 'RW.': [1190], 'Mechanical': [1191], 'synergistically': [1197], 'increases': [1198], 'cytokine': [1200], 'response': [1201], 'systemic': [1203], 'endotoxin.': [1204], 'Am': [1205, 1312, 1468, 1507, 1639, 1763, 1818, 1868, 1997], 'Physiol': [1207, 1211, 1609, 1694, 1870, 1874], 'Lung': [1208, 1753, 1871, 2103, 2171, 2175], 'Cell': [1209, 1872], 'Mol': [1210, 1873], '287:': [1212], 'L533–L542,': [1213], '2004.Link': [1214], 'Scholar3.': [1219], 'Amato': [1220], 'MBP': [1221], 'Barbas': [1223], 'CSV': [1224], 'Medeiros': [1226], 'DM': [1227], 'Magaldi': [1229], 'RB': [1230, 1835], 'Schettino': [1232], 'GPP': [1233], 'Lorenzi-Filho': [1235], 'Kairalla': [1238], 'RA': [1239], 'Deheinzelin': [1241], 'D': [1242, 1458, 1719, 1964], 'Munoz': [1244], 'C': [1245, 1716, 1786, 1979], 'Oliveira': [1247], 'R': [1248, 1790], 'Takagaki': [1250], 'TY': [1251], 'Carvalho': [1253], 'CRR.': [1254], 'Effect': [1255, 1803], 'protective-ventilation': [1258], 'strategy': [1259, 2031], 'mortality': [1261], '338:': [1272], '347–354,': [1273], '1998.Crossref': [1274, 1476], 'Scholar4.': [1281], 'Baumgardner': [1282, 1679], 'JE': [1283], 'Markstaller': [1285, 1658], 'K': [1286, 1546, 1561, 1625, 1659], 'Pfeiffer': [1288, 1670], 'B': [1289, 1671], 'Doebrich': [1291], 'M': [1292, 1427, 1522, 1540, 1707, 1722, 1743, 1982], 'Otto': [1294, 1655], 'CM.': [1295], 'Effects': [1296, 1438], 'rate,': [1299], 'pressure,': [1301, 2026], 'positive': [1303, 2024], 'end-expiratory': [1304, 2025], 'pressure': [1305], 'PaO2': [1307], 'oscillations': [1308, 2087], 'lavage.': [1311], 'Respir': [1314, 1470, 1509, 1641, 1765, 1999], 'Crit': [1315, 1353, 1471, 1510, 1579, 1642, 1766, 1905, 2000, 2044], 'Care': [1316, 1354, 1472, 1511, 1580, 1643, 1767, 1906, 2001, 2045, 2121, 2177], '166:': [1318], '1556–1562,': [1319], '2002.Crossref': [1320], 'Scholar5.': [1325], 'Broccard': [1326], 'A': [1327, 1339, 1528, 1558, 1704, 1710, 1796, 2022], 'Shapiro': [1329], 'RS': [1330, 1377, 1430, 1668], 'Schmitz': [1332], 'LL': [1333], 'Adams': [1335], 'AB': [1336], 'Nahum': [1338], 'Marini': [1341], 'JJ.': [1342], 'Prone': [1343], 'positioning': [1344], 'attenuates': [1345, 1570], 'redistributes': [1347], 'dogs.': [1352], '28:': [1356, 1610], '295–303,': [1357], 'Scholar6.': [1363], 'Costa': [1364, 1414], 'EL': [1365], 'Musch': [1367, 1420], 'Winkler': [1370, 1423], 'T': [1371, 1374, 1418, 1424, 1525, 1594, 1713, 1847], 'Schroeder': [1373], 'Harris': [1376, 1429], 'Jones': [1379], 'HA': [1380], 'Venegas': [1382, 1432], 'JG': [1383, 1619], 'Vidal': [1385, 1435], 'Melo': [1386, 1436], 'MF.': [1387, 1437], 'Mild': [1388], 'endotoxemia': [1389], 'produces': [1393], 'spatially': [1394], 'pulmonary': [1396, 1444, 1605], 'neutrophilic': [1397], 'sheep.': [1400], 'Anesthesiology': [1401], '112:': [1402], '658–669,': [1403], '2010.Crossref': [1404], 'Scholar6a.': [1409], 'De': [1410, 1788], 'E': [1415, 1543, 1746], 'Wellman': [1417], 'Tucci': [1426], 'surfactant': [1440, 1690], 'Appl': [1451, 1608, 1693], 'Physiol;': [1452], 'doi:10.1152/japplphysiol.00311.2011.ISI': [1453], 'Scholar7.': [1456], 'Dreyfuss': [1457], 'Saumon': [1460], 'G.': [1461], 'Ventilator-induced': [1462], 'injury—lessons': [1464], 'experimental': [1466], 'studies.': [1467], '157:': [1474], '294–323,': [1475], 'Scholar8.': [1483], 'Gattinoni': [1484, 1751], 'L': [1485, 1740, 1919, 2018], 'Caironi': [1487], 'P': [1488, 1491, 1749, 1976, 1985], 'Pelosi': [1490], 'Goodman': [1493], 'LR.': [1494], 'What': [1495], 'computed': [1497], 'tomography': [1498], 'taught': [1499], 'us': [1500], 'about': [1501], 'syndrome?': [1506], '164:': [1513], '1701–1711,': [1514], '2001.Crossref': [1515], 'Scholar9.': [1520], 'Kotani': [1521, 1524], 'Ishizaka': [1527], 'Fujishima': [1530], 'S': [1531, 1537, 1725, 1731, 1737, 1961], 'Koh': [1533], 'H': [1534, 1552, 1973], 'Tasaka': [1536], 'Sawafuji': [1539], 'Ikeda': [1542], 'Moriyama': [1545], 'Kotake': [1548], 'Morisaki': [1551], 'Aikawa': [1554], 'Ohashi': [1557], 'Matsushima': [1560], 'Huang': [1563], 'YC': [1564], 'Takeda': [1566], 'J.': [1567, 2064], 'Neutrophil': [1568], 'interleukin-8': [1571], 'production': [1572], 'mild-overstretch': [1574], 'rabbit': [1577], '32:': [1582, 1908], '514–519,': [1583], '2004.Crossref': [1584, 1910], 'Scholar10.': [1589], 'Takishima': [1593], 'Leith': [1596], 'D.': [1597], 'Stress': [1598], 'lungs:': [1601], 'elasticity.': [1606], '596–608,': [1611], '1970.Link': [1612], 'Scholar11.': [1617], 'Muscedere': [1618], 'Mullen': [1621], 'JB': [1622], 'Gan': [1624], 'Slutsky': [1627, 1801, 1930], 'AS.': [1628, 1802, 1931], 'Tidal': [1629], 'airway': [1633, 2195], '149:': [1645], '1327–1334,': [1646], '1994.Crossref': [1647], 'Scholar12.': [1654], 'CM': [1656], 'Karmrodt': [1664], 'Syring': [1667], 'Good': [1673], 'VP': [1674], 'JE.': [1680], 'Spatial': [1681], 'heterogeneity': [1684], 'ventilator-associated': [1686], 'depletion.': [1691], '104:': [1695], '1485–1494,': [1696], '2008.Link': [1697], 'Scholar13.': [1702], 'Protti': [1703], 'Cressoni': [1706], 'Santini': [1709], 'Langer': [1712], 'Mietto': [1715], 'Febres': [1718], 'Chierichetti': [1721], 'Coppola': [1724], 'Conte': [1727], 'Gatti': [1730], 'Leopardi': [1733], 'Masson': [1736], 'Lombardi': [1739], 'Lazzerini': [1742], 'Rampoldi': [1745], 'Cadringher': [1748], 'L.': [1752], 'strain': [1756], 'ventilation:': [1759], 'safe': [1761], 'threshold?': [1762], '183:': [1769], '1354–1362,': [1770], '2011.Crossref': [1771], 'Scholar14.': [1778], 'Ranieri': [1779], 'VM': [1780], 'Suter': [1782], 'PM': [1783], 'Tortorella': [1785], 'Tullio': [1789], 'Dayer': [1792], 'JM': [1793], 'Brienza': [1795], 'Bruno': [1798], 'F': [1799, 1922], 'mediators': [1809], 'patients': [1811], 'Assoc': [1820], '282:': [1821], '54–61,': [1822], '1999.Crossref': [1823], 'Scholar15.': [1830], 'Simon': [1831], 'BA': [1832], 'Easley': [1834], 'Grigoryev': [1837], 'DN': [1838], 'Ma': [1840], 'SF': [1841], 'Ye': [1843], 'SQ': [1844], 'Lavoie': [1846], 'Tuder': [1849], 'RM': [1850, 2015], 'Garcia': [1852], 'JG.': [1853], 'Microarray': [1854], 'cellular': [1858], 'responses': [1859], 'local': [1861], '291:': [1875], 'L851–L861,': [1876], '2006.Link': [1877], 'Scholar16.': [1882], 'Sinclair': [1883], 'SE': [1884], 'Chi': [1892], 'EY.': [1893], 'Augmented': [1894], 'due': [1897], 'interaction': [1899], 'hyperoxia': [1901], '2496–2501,': [1909], 'Scholar17.': [1917], 'Tremblay': [1918], 'Valenza': [1921], 'Ribeiro': [1924], 'SP': [1925], 'Li': [1927], 'Injurious': [1932], 'ventilatory': [1933, 2030], 'strategies': [1934], 'increase': [1935], 'cytokines': [1936], 'c-fos': [1938], 'm-RNA': [1939], 'expression': [1940], 'isolated': [1943], 'rat': [1944], 'model.': [1946], 'Clin': [1948], 'Invest': [1949], '99:': [1950], '944–952,': [1951], '1997.Crossref': [1952], 'Scholar18.': [1959], 'Tsuchida': [1960], 'Engelberts': [1963], 'Peltekova': [1966], 'V': [1967], 'Hopkins': [1969], 'Frndova': [1972], 'Babyn': [1975], 'McKerlie': [1978], 'Post': [1981], 'McLoughlin': [1984], 'Kavanagh': [1987], 'BP.': [1988], 'causes': [1990], 'alveolar': [1991, 2145], 'nonatelectatic': [1994], 'regions.': [1996], '174:': [2003], '279–289,': [2004], '2006.Crossref': [2005, 2049], 'Scholar19.': [2010], 'Villar': [2011], 'Kacmarek': [2014], 'Perez-Mendez': [2017], 'Aguirre-Jaime': [2020], 'A.': [2021], 'improves': [2032], 'outcome': [2033], 'persistent': [2035], 'syndrome:': [2039], 'randomized,': [2041], 'controlled': [2042], 'trial.': [2043], '34:': [2047], '1311–1318,': [2048], 'ScholarAUTHOR': [2056], 'NOTESAddress': [2057], 'reprint': [2059], 'requests': [2060], 'other': [2062], 'correspondence:': [2063], 'Baumgardner,': [2066], 'Oscillogy': [2067], '131': [2069], 'Milmont': [2070], 'Ave.,': [2071], 'PA': [2073], '19104': [2074], '(e-mail:': [2075], '[email': [2076], 'protected]com).': [2077], 'Download': [2078], 'Previous': [2080], 'Back': [2081], 'Top': [2083], 'Next': [2084], 'FiguresReferencesRelatedInformationCited': [2085], 'ByPO2': [2086], 'inflammation27': [2092], 'March': [2093, 2134], '2019': [2094], 'Critical': [2096, 2158], 'Care,': [2097, 2159], 'Vol.': [2098, 2123, 2138, 2160, 2179, 2225], '23,': [2099], 'No.': [2100, 2125, 2162, 2181, 2227], '1Does': [2101], 'Regional': [2102, 2107], 'Strain': [2104], 'Correlate': [2105], 'With': [2106], 'Inflammation': [2108, 2164], 'During': [2114], 'Nonprotective': [2115], 'Ventilation?': [2116], 'An': [2117], 'Experimental': [2118, 2173], 'Porcine': [2119], 'Study*Critical': [2120], 'Medicine,': [2122, 2178], '46,': [2124], '6Recent': [2126], 'advances': [2127], 'understanding': [2129], 'syndrome5': [2133], '2018': [2135], 'F1000Research,': [2137], '7Non-lobar': [2139], 'generates': [2141], 'structural': [2144], 'surrounding': [2149], 'healthy': [2150], 'ventilation9': [2154], 'September': [2155], '2014': [2156], '18,': [2161], '5Early': [2163], 'Mainly': [2165], 'Affects': [2166], 'Normally': [2167], 'Poorly': [2169], 'Aerated': [2170], 'Ventilator-Induced': [2174], 'Injury*Critical': [2176], '42,': [2180], '4Reabsorption': [2182], 'porcine': [2186], 'ARDS:': [2189], 'effects': [2193], 'closure,': [2196], 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