Title: Distribution of the antiseptic-resistance genes qacEΔ1 in 331 clinical isolates of Pseudomonas aeruginosa in China
Abstract: Many kinds of antiseptics and disinfectants are used in hospitals and several examples of antiseptic-resistant bacteria have been reported. The resistance determinants have been designated genes for resistance to quaternary ammonium compounds (qac) and small multidrug-resistance genes (smr). These genes mediate resistance to DNA-intercalating dyes (e.g. ethidium bromide) and to quaternary ammonium compounds (e.g. benzalkonium chloride), and it has been reported that these genes encode transmembrane proteins. Thus, mechanisms of resistance encoded by the genes qacA, smr and qacE were deduced to involve efflux systems. 1 Paulsen I.T. Brown M.H. Skurray R.A. Proton-dependent multidrug efflux systems. Microbiol Rev. 1996; 60: 575-608 Crossref PubMed Google Scholar Almost all antiseptic-resistance genes, such as qacA, qacB, smr and qacF, have been isolated from Gram-positive bacteria. Only three such genes, namely, qacE, qacEΔ1 and emrE, have been isolated from Gram-negative bacteria to date.
Publication Year: 2007
Publication Date: 2007-03-13
Language: en
Type: letter
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 10
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot