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'(dRecQ4),': [57], 'we': [58], 'generated': [59], 'mutant': [60, 108, 132], 'alleles': [61], 'dRecQ4': [63, 74, 96, 131, 150, 172], 'using': [64], 'targeted': [66], 'gene': [67, 176], 'knock-out': [68], 'technique.': [69], 'Our': [70], 'data': [71], 'show': [72, 137, 170], 'mutants': [75], 'homozygous': [77], 'lethal': [78], 'with': [79], 'defects': [80], 'replication,': [83], 'cell': [84, 88, 192], 'cycle': [85, 193], 'progression': [86, 194], 'proliferation.': [89], 'Two': [90], 'sets': [91], 'experiments': [93, 135], 'suggest': [94], 'also': [97, 188], 'a': [99], 'double': [103], 'strand': [104, 123], 'break': [105], 'repair.': [106], 'First,': [107], 'animals': [109], 'exhibit': [110], 'sensitivity': [111], 'gamma': [113], 'irradiation.': [114], 'Second,': [115], 'efficiency': [117], 'DsRed': [119], 'reconstitution': [120], 'via': [121], 'single': [122], 'annealing': [124], 'repair': [125, 162, 190], 'is': [126, 157, 173], 'significantly': [127], 'reduced': [128], 'animals.': 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